Publication Information

{'id': 'https://openalex.org/W2322836356', 'doi': 'https://doi.org/10.1515/bchm3.1996.377.3.195', 'title': 'Inactivation of the Very Strong HCMV Immediate Early Promoter by DNA CpG Methylation<i>In Vitro</i>', 'display_name': 'Inactivation of the Very Strong HCMV Immediate Early Promoter by DNA CpG Methylation<i>In Vitro</i>', 'publication_year': 1996, 'publication_date': '1996-01-01', 'ids': {'openalex': 'https://openalex.org/W2322836356', 'doi': 'https://doi.org/10.1515/bchm3.1996.377.3.195', 'mag': '2322836356', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8722321'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1515/bchm3.1996.377.3.195', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2754637932', 'display_name': 'Biological Chemistry Hoppe-Seyler', 'issn_l': '0177-3593', 'issn': ['0177-3593'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310313990', 'host_organization_name': 'De Gruyter', 'host_organization_lineage': ['https://openalex.org/P4310313990'], 'host_organization_lineage_names': ['De Gruyter'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5033195390', 'display_name': 'Susanna Prösch', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I39343248', 'display_name': 'Humboldt-Universität zu Berlin', 'ror': 'https://ror.org/01hcx6992', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I39343248']}, {'id': 'https://openalex.org/I4210091434', 'display_name': 'MSB Medical School Berlin', 'ror': 'https://ror.org/001vjqx13', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I4210091434']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'S Prösch', 'raw_affiliation_strings': ['Institute of Medical Virology, Humboldt University Medical School, Berlin, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Medical Virology, Humboldt University Medical School, Berlin, Germany.', 'institution_ids': ['https://openalex.org/I39343248', 'https://openalex.org/I4210091434']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081119848', 'display_name': 'Janet L. Stein', 'orcid': 'https://orcid.org/0000-0002-2474-6822'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'J Stein', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058013341', 'display_name': 'Kerstin Staak', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'K Staak', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110341588', 'display_name': 'C. Liebenthal', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'C Liebenthal', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049060150', 'display_name': 'Hans‐Dieter Volk', 'orcid': 'https://orcid.org/0000-0002-7743-6668'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'H D Volk', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5083753728', 'display_name': 'Detlev H. Krüger', 'orcid': 'https://orcid.org/0000-0001-6596-7624'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'D H Krüger', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.082, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 118, 'citation_normalized_percentile': {'value': 0.965171, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '377', 'issue': '3', 'first_page': '195', 'last_page': '202'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10981', 'display_name': 'Cytomegalovirus and herpesvirus research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10981', 'display_name': 'Cytomegalovirus and herpesvirus research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10112', 'display_name': 'HIV Research and Treatment', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2406', 'display_name': 'Virology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10625', 'display_name': 'Herpesvirus Infections and Treatments', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cpg-site', 'display_name': 'CpG site', 'score': 0.6765836}, {'id': 'https://openalex.org/keywords/bisulfite-sequencing', 'display_name': 'Bisulfite sequencing', 'score': 0.46170005}], 'concepts': [{'id': 'https://openalex.org/C33288867', 'wikidata': 'https://www.wikidata.org/wiki/Q518328', 'display_name': 'Methylation', 'level': 3, 'score': 0.79179823}, {'id': 'https://openalex.org/C111936080', 'wikidata': 'https://www.wikidata.org/wiki/Q913367', 'display_name': 'Enhancer', 'level': 4, 'score': 0.74877375}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.7304283}, {'id': 'https://openalex.org/C140173407', 'wikidata': 'https://www.wikidata.org/wiki/Q1138358', 'display_name': 'CpG site', 'level': 5, 'score': 0.6765836}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.5862934}, {'id': 'https://openalex.org/C37080517', 'wikidata': 'https://www.wikidata.org/wiki/Q18353747', 'display_name': 'Epigenetics of physical exercise', 'level': 5, 'score': 0.5712575}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5285025}, {'id': 'https://openalex.org/C54009773', 'wikidata': 'https://www.wikidata.org/wiki/Q1429031', 'display_name': 'Transfection', 'level': 3, 'score': 0.46938083}, {'id': 'https://openalex.org/C91965660', 'wikidata': 'https://www.wikidata.org/wiki/Q415875', 'display_name': 'Methyltransferase', 'level': 4, 'score': 0.46689165}, {'id': 'https://openalex.org/C189235521', 'wikidata': 'https://www.wikidata.org/wiki/Q4087270', 'display_name': 'Bisulfite sequencing', 'level': 5, 'score': 0.46170005}, {'id': 'https://openalex.org/C101762097', 'wikidata': 'https://www.wikidata.org/wiki/Q224093', 'display_name': 'Promoter', 'level': 4, 'score': 0.42469952}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.34230012}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3334074}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.23778433}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.17539334}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.1459412}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.13598228}], 'mesh': [{'descriptor_ui': 'D000956', 'descriptor_name': 'Antigens, Viral', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D003587', 'descriptor_name': 'Cytomegalovirus', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D015257', 'descriptor_name': 'DNA-Cytosine Methylases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015226', 'descriptor_name': 'Dinucleoside Phosphates', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D017874', 'descriptor_name': 'Immediate-Early Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000956', 'descriptor_name': 'Antigens, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001667', 'descriptor_name': 'Binding, Competitive', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003587', 'descriptor_name': 'Cytomegalovirus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015257', 'descriptor_name': 'DNA-Cytosine Methylases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015226', 'descriptor_name': 'Dinucleoside Phosphates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004742', 'descriptor_name': 'Enhancer Elements, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015967', 'descriptor_name': 'Gene Expression Regulation, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018922', 'descriptor_name': 'HL-60 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017874', 'descriptor_name': 'Immediate-Early Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008745', 'descriptor_name': 'Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013755', 'descriptor_name': 'Tetradecanoylphorbol Acetate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013755', 'descriptor_name': 'Tetradecanoylphorbol Acetate', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1515/bchm3.1996.377.3.195', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2754637932', 'display_name': 'Biological Chemistry Hoppe-Seyler', 'issn_l': '0177-3593', 'issn': ['0177-3593'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310313990', 'host_organization_name': 'De Gruyter', 'host_organization_lineage': ['https://openalex.org/P4310313990'], 'host_organization_lineage_names': ['De Gruyter'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8722321', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 50, 'referenced_works': ['https://openalex.org/W142428048', 'https://openalex.org/W146725350', 'https://openalex.org/W151363419', 'https://openalex.org/W1528329395', 'https://openalex.org/W1533255714', 'https://openalex.org/W1565293712', 'https://openalex.org/W1590429672', 'https://openalex.org/W1821654469', 'https://openalex.org/W1956232719', 'https://openalex.org/W1965087547', 'https://openalex.org/W1973681963', 'https://openalex.org/W1974521186', 'https://openalex.org/W1975613076', 'https://openalex.org/W1975791071', 'https://openalex.org/W1976980117', 'https://openalex.org/W1977418399', 'https://openalex.org/W1978172569', 'https://openalex.org/W1988213501', 'https://openalex.org/W1991127901', 'https://openalex.org/W1992586885', 'https://openalex.org/W2003920409', 'https://openalex.org/W2004855923', 'https://openalex.org/W2008396924', 'https://openalex.org/W2020824064', 'https://openalex.org/W2027703149', 'https://openalex.org/W2033162367', 'https://openalex.org/W2045715127', 'https://openalex.org/W2046219854', 'https://openalex.org/W2046895191', 'https://openalex.org/W2047264397', 'https://openalex.org/W2065775893', 'https://openalex.org/W2067978135', 'https://openalex.org/W2076711524', 'https://openalex.org/W2081250614', 'https://openalex.org/W2081770936', 'https://openalex.org/W2098473439', 'https://openalex.org/W2104252491', 'https://openalex.org/W2105618070', 'https://openalex.org/W2107815610', 'https://openalex.org/W2119386841', 'https://openalex.org/W2119930315', 'https://openalex.org/W2121542842', 'https://openalex.org/W2123127762', 'https://openalex.org/W2125045982', 'https://openalex.org/W2144337817', 'https://openalex.org/W2153090288', 'https://openalex.org/W2153782423', 'https://openalex.org/W2156222305', 'https://openalex.org/W2162938473', 'https://openalex.org/W4230479687'], 'related_works': ['https://openalex.org/W3133179331', 'https://openalex.org/W2584039926', 'https://openalex.org/W2471736877', 'https://openalex.org/W2362561464', 'https://openalex.org/W2168125442', 'https://openalex.org/W2063541015', 'https://openalex.org/W2040474954', 'https://openalex.org/W2009988167', 'https://openalex.org/W2008284862', 'https://openalex.org/W1975609775'], 'abstract_inverted_index': {'The': [0], 'influence': [1], 'of': [2, 10, 29, 36, 63, 75, 83, 99, 116, 137, 160], 'DNA': [3], 'methylation': [4, 35, 62, 104, 159], 'in': [5, 66, 89, 133, 163, 176], 'vitro': [6], 'on': [7, 96], 'the': [8, 11, 37, 44, 55, 64, 70, 100, 134, 143, 161], 'activity': [9, 57, 88], 'very': [12], 'strong': [13, 81], 'human': [14], 'cytomegalovirus': [15], '(HCMV)': [16], 'major': [17, 38, 85, 145], 'immediate': [18], 'early': [19], '(IE)': [20], 'modulator/enhancer/promoter': [21], 'region': [22], 'was': [23, 58], 'investigated': [24], 'by': [25, 61, 105, 111, 158], 'transient': [26], 'transfection': [27], 'experiments': [28], 'premonocytic': [30, 90], 'HL-60': [31, 91], 'cells.': [32], 'While': [33], 'sequence-specific': [34], 'IE': [39, 86, 101, 146], 'enhancer': [40], 'and/or': [41], 'modulator': [42], 'with': [43, 69, 113], 'cytosine': [45, 65], 'methyl-transferases': [46], 'FnuDII,': [47], 'HhaI': [48], 'and': [49], 'HaeIII': [50], 'had': [51, 93], 'no': [52, 94], 'significant': [53], 'effect,': [54], 'promoter': [56, 148], 'completely': [59], 'repressed': [60], "5'-CpG": [67], 'sites': [68], 'Spiroplasma': [71], 'methyltransferase': [72], 'SssI.': [73], 'Addition': [74], 'TNF-alpha': [76], 'or': [77], 'PMA': [78], 'which': [79], 'are': [80], 'stimulators': [82], 'HCMV': [84, 138, 144], 'enhancer/promoter': [87, 102, 139], 'cells': [92], 'effect': [95, 136], 'repression.': [97], 'Inactivation': [98], 'via': [103], 'M.SssI': [106], 'could': [107], 'be': [108, 153], 'partially': [109], 'alleviated': [110], 'co-transfection': [112], 'an': [114], 'excess': [115], 'untranscribable': [117], 'highly': [118], 'methylated': [119], 'DNA.': [120], 'These': [121], 'results': [122], 'indicate': [123], 'that': [124, 168], 'a': [125, 166, 173], 'methyl-CpG': [126], 'binding': [127], 'factor': [128], 'is': [129, 169], 'involved': [130], 'as': [131], 'mediator': [132], 'inhibitory': [135], 'methylation.': [140], 'Taken': [141], 'together,': [142], 'enhancer/': [147], 'has': [149], 'been': [150], 'shown': [151], 'to': [152, 155, 171], 'susceptible': [154], 'transcriptional': [156], 'inactivation': [157], 'cytosines': [162], 'CpG': [164], 'dinucleotides,': [165], 'process': [167], 'proposed': [170], 'play': [172], 'modulatory': [174], 'role': [175], 'viral': [177], 'latency.': [178]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2322836356', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-13T00:18:12.152592', 'created_date': '2016-06-24'}