Title: Functional Activitiy of Brain Monoamine Oxidase
Abstract: A characteristic behaviour, namely hyperactivity syndrome, is observed when rats are pretreated with an irreversible non-specific monoamine oxidase (MAO) inhibitor e.g. tranylcypromine followed by L-tryptophan or L-Dopa (L-3,4-dihydroxyphenylalanine). The occurrence of hyperactivity is dependent on the increased rates of brain 5-hydroxytryptamine (5-HT) or dopamine (DA) synthesis as a result of MAO inhibition. The extent of MAO inhibition required is 85% of total enzyme activity, because with selective MAO inhibitors clorgyline and deprenyl, which can fully inhibit either MAO 'type A' or 'type B' respectively, hyperactivity syndrome with L-tryptophan or L-Dopa are not observed. The pharmacological and behavioural changes are seen only when the remaining 15% of total 'functionally active MAO' is inhibited. The relevance of this finding to the use of MAO inhibitors as antidepressants, alone or in combination with 5-HT precursors and in the potentiation of antiakinetic property of L-Dopa in parkinson's disease is highly pertinent.
Publication Year: 1979
Publication Date: 1979-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
Access and Citation
Cited By Count: 1
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