Title: Mast Cells and Angiogenesis Evaluation in Potentially Malignant Lesions and in Oral Squamous Cell Carcinoma
Abstract: Angiogenesis is essential for tumor growth by providing nutrition and oxygen to cells. Mast cells (MC) may be involved because they help regulate blood vessels. This study evaluated angiogenesis and MC density in oral epithelial dysplasia (ED) and in squamous cell carcinoma (SCC). The MC evaluation sample consisted of SCC (n = 30), ED (n = 23) and normal mucosa (NM) (n = 20) as control. For angiogenesis the sample was 24 SCCs, 19 EDs, and 22 NMs. Immunohistochemical analysis was performed using anti-tryptase, anti-CD31, and anti-CD34. The MC sample showed lower density in SCC compared to NM and ED. In the angiogenesis sample, CD31 showed differences between SCC and ED, and SCC and NM, with a greater percentage of vessels in SCC, whereas CD34 showed no differences. The increase of vascularization in oral SCC suggests that angiogenesis is necessary for tumor growth. No correlation was found between MC and angiogenesis.
Publication Year: 2014
Publication Date: 2014-02-01
Language: en
Type: article
Indexed In: ['crossref']
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