Title: Antigen-Negative Meningitis due to Group A Neisseria meningitidis
Abstract: Cerebrospinal fluid from 15% of patients in whom a clinical diagnosis of meningitis due to Neisseria meningitidis had been made was sterile on culture and negative for meningococcal antigen on countercurrent immunoelectrophoresis. Evidence of active meningococcal infection was found in all 18 of these patients who were studied in detail. Initial samples of serum from antigen-negative patients frequently contained high titers of HA antibody, suggesting that these patients belong to a group of subjects capable of a rapid immune response to meningococcal infection. This view is supported by the observation that antigen-negative patients develop few of the serious complications of meningococcal meningitis.
Publication Year: 1974
Publication Date: 1974-02-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 21
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