Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2321038792', 'doi': 'https://doi.org/10.1091/mbc.e14-10-1469', 'title': 'Constitutively active ESCRT-II suppresses the MVB-sorting phenotype of ESCRT-0 and ESCRT-I mutants', 'display_name': 'Constitutively active ESCRT-II suppresses the MVB-sorting phenotype of ESCRT-0 and ESCRT-I mutants', 'publication_year': 2014, 'publication_date': '2014-12-11', 'ids': {'openalex': 'https://openalex.org/W2321038792', 'doi': 'https://doi.org/10.1091/mbc.e14-10-1469', 'mag': '2321038792', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25501366', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4310745'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1091/mbc.e14-10-1469', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S188085164', 'display_name': 'Molecular Biology of the Cell', 'issn_l': '1059-1524', 'issn': ['1059-1524', '1939-4586'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319721', 'host_organization_name': 'American Society for Cell Biology', 'host_organization_lineage': ['https://openalex.org/P4310319721'], 'host_organization_lineage_names': ['American Society for Cell Biology'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1091/mbc.e14-10-1469', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5066315803', 'display_name': 'Shrawan Kumar Mageswaran', 'orcid': 'https://orcid.org/0000-0002-0803-7129'}, 'institutions': [{'id': 'https://openalex.org/I223532165', 'display_name': 'University of Utah', 'ror': 'https://ror.org/03r0ha626', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I223532165']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shrawan Kumar Mageswaran', 'raw_affiliation_strings': ['Center for Cell and Genome Science and Department of Biology, University of Utah, Salt Lake City, UT 84112'], 'affiliations': [{'raw_affiliation_string': 'Center for Cell and Genome Science and Department of Biology, University of Utah, Salt Lake City, UT 84112', 'institution_ids': ['https://openalex.org/I223532165']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016281201', 'display_name': 'Natalie Johnson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I188538660', 'display_name': 'University of Colorado Boulder', 'ror': 'https://ror.org/02ttsq026', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I188538660']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Natalie K. Johnson', 'raw_affiliation_strings': ['Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80309'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80309', 'institution_ids': ['https://openalex.org/I188538660']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084440501', 'display_name': 'Greg Odorizzi', 'orcid': 'https://orcid.org/0000-0002-1143-1098'}, 'institutions': [{'id': 'https://openalex.org/I188538660', 'display_name': 'University of Colorado Boulder', 'ror': 'https://ror.org/02ttsq026', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I188538660']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Greg Odorizzi', 'raw_affiliation_strings': ['Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80309'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80309', 'institution_ids': ['https://openalex.org/I188538660']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5064172362', 'display_name': 'Markus Babst', 'orcid': 'https://orcid.org/0000-0001-8596-8958'}, 'institutions': [{'id': 'https://openalex.org/I223532165', 'display_name': 'University of Utah', 'ror': 'https://ror.org/03r0ha626', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I223532165']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Markus Babst', 'raw_affiliation_strings': ['Center for Cell and Genome Science and Department of Biology, University of Utah, Salt Lake City, UT 84112;'], 'affiliations': [{'raw_affiliation_string': 'Center for Cell and Genome Science and Department of Biology, University of Utah, Salt Lake City, UT 84112;', 'institution_ids': ['https://openalex.org/I223532165']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.064, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 24, 'citation_normalized_percentile': {'value': 0.867602, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '26', 'issue': '3', 'first_page': '554', 'last_page': '568'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10945', 'display_name': 'Lysosomal Storage Disorders Research', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13415', 'display_name': 'Calcium signaling and nucleotide metabolism', 'score': 0.9919, 'subfield': {'id': 'https://openalex.org/subfields/1314', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/escrt', 'display_name': 'ESCRT', 'score': 0.9975071}, {'id': 'https://openalex.org/keywords/transport-protein', 'display_name': 'Transport protein', 'score': 0.5070443}], 'concepts': [{'id': 'https://openalex.org/C143876685', 'wikidata': 'https://www.wikidata.org/wiki/Q22327705', 'display_name': 'ESCRT', 'level': 4, 'score': 0.9975071}, {'id': 'https://openalex.org/C102747710', 'wikidata': 'https://www.wikidata.org/wiki/Q824237', 'display_name': 'Endosome', 'level': 3, 'score': 0.8847189}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.70735574}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.67465115}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.54898614}, {'id': 'https://openalex.org/C57581600', 'wikidata': 'https://www.wikidata.org/wiki/Q2449730', 'display_name': 'Transport protein', 'level': 2, 'score': 0.5070443}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.18331787}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.16481987}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.07811928}], 'mesh': [{'descriptor_ui': 'D056827', 'descriptor_name': 'Endosomal Sorting Complexes Required for Transport', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D057146', 'descriptor_name': 'Multivesicular Bodies', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D021381', 'descriptor_name': 'Protein Transport', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D056827', 'descriptor_name': 'Endosomal Sorting Complexes Required for Transport', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D056827', 'descriptor_name': 'Endosomal Sorting Complexes Required for Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057146', 'descriptor_name': 'Multivesicular Bodies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050505', 'descriptor_name': 'Mutant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050505', 'descriptor_name': 'Mutant Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D021381', 'descriptor_name': 'Protein Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D029701', 'descriptor_name': 'Saccharomyces cerevisiae Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029701', 'descriptor_name': 'Saccharomyces cerevisiae Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D029701', 'descriptor_name': 'Saccharomyces cerevisiae Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1091/mbc.e14-10-1469', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S188085164', 'display_name': 'Molecular Biology of the Cell', 'issn_l': '1059-1524', 'issn': ['1059-1524', '1939-4586'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319721', 'host_organization_name': 'American Society for Cell Biology', 'host_organization_lineage': ['https://openalex.org/P4310319721'], 'host_organization_lineage_names': ['American Society for Cell Biology'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4310745', 'pdf_url': 'https://europepmc.org/articles/pmc4310745?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310745', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25501366', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1091/mbc.e14-10-1469', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S188085164', 'display_name': 'Molecular Biology of the Cell', 'issn_l': '1059-1524', 'issn': ['1059-1524', '1939-4586'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319721', 'host_organization_name': 'American Society for Cell Biology', 'host_organization_lineage': ['https://openalex.org/P4310319721'], 'host_organization_lineage_names': ['American Society for Cell Biology'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/14', 'score': 0.59, 'display_name': 'Life below water'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 51, 'referenced_works': ['https://openalex.org/W1523314824', 'https://openalex.org/W1531129165', 'https://openalex.org/W1964951207', 'https://openalex.org/W1965476757', 'https://openalex.org/W1966072209', 'https://openalex.org/W1966555780', 'https://openalex.org/W1973214920', 'https://openalex.org/W1974899198', 'https://openalex.org/W1981515958', 'https://openalex.org/W1982606786', 'https://openalex.org/W1986144618', 'https://openalex.org/W1987462880', 'https://openalex.org/W1991912355', 'https://openalex.org/W2003979167', 'https://openalex.org/W2010542476', 'https://openalex.org/W2014903163', 'https://openalex.org/W2018973985', 'https://openalex.org/W2019987740', 'https://openalex.org/W2025029519', 'https://openalex.org/W2035178600', 'https://openalex.org/W2036202997', 'https://openalex.org/W2041417196', 'https://openalex.org/W2042158953', 'https://openalex.org/W2042722403', 'https://openalex.org/W2043565517', 'https://openalex.org/W2052855401', 'https://openalex.org/W2065447689', 'https://openalex.org/W2072508525', 'https://openalex.org/W2075027086', 'https://openalex.org/W2075136068', 'https://openalex.org/W2076874733', 'https://openalex.org/W2079319844', 'https://openalex.org/W2080143331', 'https://openalex.org/W2083087230', 'https://openalex.org/W2089916390', 'https://openalex.org/W2094996600', 'https://openalex.org/W2099674108', 'https://openalex.org/W2102440675', 'https://openalex.org/W2111215350', 'https://openalex.org/W2121715051', 'https://openalex.org/W2127943293', 'https://openalex.org/W2130845654', 'https://openalex.org/W2136605585', 'https://openalex.org/W2137506335', 'https://openalex.org/W2145625720', 'https://openalex.org/W2150737519', 'https://openalex.org/W2152689946', 'https://openalex.org/W2166456692', 'https://openalex.org/W2167531619', 'https://openalex.org/W2170678054', 'https://openalex.org/W4238269746'], 'related_works': ['https://openalex.org/W91867460', 'https://openalex.org/W2971717878', 'https://openalex.org/W2606269606', 'https://openalex.org/W2144314464', 'https://openalex.org/W2109627615', 'https://openalex.org/W2074582729', 'https://openalex.org/W2026933690', 'https://openalex.org/W2021810154', 'https://openalex.org/W1973572007', 'https://openalex.org/W1965355812'], 'abstract_inverted_index': {'The': [0, 29], 'endosomal': [1], 'sorting': [2, 112], 'complex': [3], 'required': [4], 'for': [5, 25, 106], 'transport': [6], '(ESCRT)': [7], 'protein': [8], 'complexes': [9], 'function': [10, 45], 'at': [11], 'the': [12, 15, 26, 48, 51, 77, 99, 117], 'endosome': [13], 'in': [14, 38, 62], 'formation': [16, 61, 108], 'of': [17, 50, 72, 79, 116], 'intraluminal': [18], 'vesicles': [19], '(ILVs)': [20], 'containing': [21], 'cargo': [22, 39, 111], 'proteins': [23], 'destined': [24], 'vacuolar/lysosomal': [27], 'lumen.': [28], 'early': [30, 89, 118], 'ESCRTs': [31, 90], '(ESCRT-0': [32], 'and': [33, 43, 94], '-I)': [34], 'are': [35, 91], 'likely': [36], 'involved': [37], 'sorting,': [40], 'whereas': [41], 'ESCRT-III': [42, 60], 'Vps4': [44], 'to': [46], 'sever': [47], 'neck': [49], 'forming': [52], 'ILVs.': [53], 'ESCRT-II': [54, 73], 'links': [55], 'these': [56, 88], 'functions': [57], 'by': [58, 114], 'initiating': [59], 'an': [63, 80], 'ESCRT-I-regulated': [64], 'manner.': [65], 'We': [66], 'identify': [67], 'a': [68], 'constitutively': [69], 'active': [70], 'mutant': [71], 'that': [74, 87], 'partially': [75], 'suppresses': [76], 'phenotype': [78], 'ESCRT-I': [81], 'or': [82], 'ESCRT-0': [83], 'deletion': [84], 'strain,': [85], 'suggesting': [86], 'not': [92, 104], 'essential': [93], 'have': [95], 'redundant': [96], 'functions.': [97], 'However,': [98], 'ESCRT-III/Vps4': [100], 'system': [101], 'alone': [102], 'is': [103], 'sufficient': [105], 'ILV': [107], 'but': [109], 'requires': [110], 'mediated': [113], 'one': [115], 'ESCRTs.': [119]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2321038792', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2025-01-03T22:21:07.702672', 'created_date': '2016-06-24'}