Abstract: MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression in the post- transcription level. About 3% of human genes encode for miRNAs, and up to 30% of human protein coding genes may be regulated by miRNAs. MicroRNAs play a key role in diverse biological processes, including development, cell proliferation, differentiation and apoptosis, and the change of miRNA expression is correlated with many human diseases, including tumor. In this review, we will summarize the biological characterization of miRNA and its relationship with the carcinogenesis, as well as the various techniques for miRNA investigation.
Publication Year: 2008
Publication Date: 2008-08-20
Language: en
Type: article
Indexed In: ['pubmed']
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