Title: Homocysteine-lowering Treatment in Reduction of Stroke and Coronary Vascular Risk – Do Not Give Up
Abstract: Homocysteine (Hcy) is a non-essential, non-protein-forming amino acid that originates in methionine via a transmethylation reaction. Hcy is catabolized into methionine or cysteine. Methionine synthase and its co-factor, methylcobalamin, enhance the methylation of Hcy into methionine, where 5-methyl tetrahydrofolate donates its methyl group to Hcy. The trans-sulfuration pathway of Hcy catabolism is mediated via cystathionine beta synthase (CBS) and cystathionase, both of which are vitamin-B6-dependent.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 1
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