Immobilization of urease to modified dialdehydestarch with gelatin for removal of urea.

Name: Work Video:
Duration: 3 min 30 s
Nobuo Nakabayashi; Naoko Hasegawa; Tadao Akisawa; Shozo Koshikawa
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'https://openalex.org/W2025976774'], 'abstract_inverted_index': {'ゼラチン被覆酸化デシプシ': [0], '(DAS-gelatin)': [1], 'の尿素処理能を改善するために,': [2], 'DAS-gelatin': [3], '粒子表層部に残存しているアルデヒド基にウレアーゼを固定化する試みを行った.': [4], 'DAS-gelatinは腎不全患者の尿素除去剤としての有効性は報告されているが,': [5], 'その吸着速度は遅く,': [6], '飽和に達するのに1日を必要とする.': [7], 'DASは尿素よりもアンモニアを速く結合する.': [8], 'DASにウレアーゼを固定化しても酵素活性を示さないが,': [9], 'DAS-gelatin-ureaseは酵素活性を有し,': [10], '尿素をアンモニアに加水分解し,': [11], 'このアンモニアはDASによって短時間に処理できる.': [12], 'DAS-gelatin-ureaseの尿素処理量はDAS-gelatinの約2倍である.': [13], 'in': [14], 'vitroでは吸着能が劣るにもかかわらず,': [15], '経口投与されたDAS-gelatinは,': [16], '腸内で大腸菌の産生するウレアーゼによって加水分解されたアンモニアを吸収するために,': [17], 'DAS-gelatinは臨床において経口投与剤として有効に働くと考えられる.': [18], 'DAS-gelatin-ureaseはpH1.2で失活するところから,': [19], '経ロ投与を前提とする場合,': [20], 'DAS-gelatinにあえてウレアーゼを固定化する必要はない.': [21], 'DAS-gelatinは生理活性蛋白質の固定化担体としての利用も考えられる.': [22]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2320363194', 'counts_by_year': [{'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-08T23:02:55.521283', 'created_date': '2016-06-24'}
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