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67], 'USA': [38, 54, 68], ',': [39, 55], 'Choo': [42], 'F': [61], 'Kennedy': [62], 'Published': [69, 1828], 'Online:7': [70], 'Jun': [71], '2012https://doi.org/10.5144/0256-4947.2012.421SectionsPDF': [72], 'ToolsAdd': [73], 'to': [74, 138, 250, 263, 273, 357, 402, 445, 466, 499, 772, 820, 942, 950, 991, 1097, 1288, 1776], 'favoritesDownload': [75], 'citationTrack': [76], 'citations': [77], 'ShareShare': [78], 'onFacebookTwitterLinked': [79], 'InRedditEmail': [80], 'AboutAbstractA': [81], 'severe': [82, 691, 1282], 'paraneoplastic': [83, 895, 1626, 1654], 'form': [84, 251, 927], 'acute': [86, 350, 422], 'associated': [88, 452, 1101, 1112, 1296, 1356, 1413, 1656], 'antibodies': [90, 194, 312, 746, 752, 818, 845, 880, 1115, 1379, 1475, 1605, 1716, 1743], 'against': [91, 152, 313, 1380], 'the': [92, 153, 175, 188, 261, 271, 339, 372, 389, 392, 403, 528, 595, 634, 683, 717, 720, 750, 773, 790, 821, 837, 872, 920, 926, 934, 963, 969, 992, 1036, 1054, 1075, 1104, 1190, 1195, 1291, 1304, 1381, 1386, 1509], 'N-methyl': [93], 'D-aspartate': [94, 210], '(NMDA)': [95, 211], 'receptor': [96, 252, 1354, 1416, 1474, 1535, 1572, 1604, 1715, 1742, 1772, 1801], 'typically': [97, 1013, 1121], 'occurs': [98, 1285], 'individuals': [101], 'is': [103, 187, 305, 317, 395, 833, 881, 892, 904, 1094, 1116, 1120, 1140, 1294, 1840], 'associated,': [104], 'but': [105, 1029], 'not': [106, 1247], 'always,': [107], 'an': [109, 398, 649, 701, 1100], 'underlying': [110, 399], 'tumor.': [111], 'If': [112], 'diagnosed': [113], 'early,': [114], 'initiation': [115, 978, 1236], 'immunotherapy': [117, 1777], 'tumor': [119, 1102, 1133, 1141, 1165, 1191, 1200, 1775, 1808], 'removal': [120, 1201], '(if': [121], 'present)': [122], 'may': [123, 1065, 1253], 'result': [124, 1175], 'recovery.': [126], 'We': [127, 405], 'report': [128, 406], '25-year-old': [133, 425], 'woman': [135, 414], 'who': [136, 341, 1245], 'presented': [137, 197, 432], 'our': [139], 'medical': [140, 430], 'center': [141], 'psychosis.': [144], 'Treatment': [145, 1167], '(a': [148], 'chimeric': [149], 'monoclonal': [150], 'antibody': [151], 'protein': [154, 553, 1017], 'CD20)': [155], 'resulted': [156, 383], 'gradual': [158], 'improvement': [159, 386, 1206, 1232], 'mental': [161, 777], 'status': [162, 476, 778], 'resolution': [164], 'seizure': [166], 'activity': [167], 'episodes.': [168], 'A': [169], 'year': [170], 'after': [171, 1213, 1218, 1235, 1278], 'diagnosis': [172], 'treatment,': [174], 'patient': [176, 707, 756, 1410], 'was': [177, 205, 419, 483, 526, 567, 574, 655, 668, 685, 708, 726, 730, 757, 765, 770, 787, 793, 1220, 1233], 'doing': [178], 'well': [179, 957], 'without': [180, 1242, 1265, 1774, 1807], 'recurrences,': [181], 'no': [183, 428, 766], 'tumors': [184], 'appeared.': [185], 'This': [186, 394], 'first': [189], 'described': [190, 308, 1273], 'anti–NMDA-receptor': [193], 'that': [196, 232, 243, 326, 420, 441, 898, 986], 'initially': [198], 'disorder': [203, 1444], 'successfully': [206], 'rituximab.IntroductionN-methyl': [209], 'receptors': [212, 226, 282, 848], 'are': [213, 227, 1684], 'ligand-gated': [214], 'cation': [215], 'channels': [216], 'whose': [217, 415], 'function': [218], 'centers': [219], 'around': [220], 'synaptic': [221], 'transmission': [222, 865], 'plasticity.1': [224], 'The': [225, 352, 520, 570, 677, 706, 740, 755, 775, 875, 1009, 1062], 'heteromers': [228], 'NR1': [230, 246], 'subunits': [231, 242, 825], 'bind': [233, 244, 819], 'glycine': [234], 'NR2': [236, 248], '(A,': [237], 'B,': [238, 1315, 1529, 1729], 'C,': [239, 1461, 1562, 1564, 1672, 1678], 'or': [240, 823, 1045, 1071, 1079, 1172, 1178, 1184, 1212, 1299, 1302], 'D)': [241], 'glutamate.': [245], 'combine': [249], 'subtypes,': [253], 'their': [255, 885], 'pharmacological': [256], 'properties': [257], 'include': [258, 358, 912], 'localization': [259], 'ability': [262, 272], 'interact': [264, 274], 'intracellular': [266, 276], 'messengers;': [267], 'they': [268, 947], 'also': [269, 647, 738, 1271], 'have': [270, 327, 382, 1042], 'messengers.2': [277], 'Hyperactivity': [278], 'these': [280, 879], 'NMDA': [281, 827, 847, 1415, 1603, 1714, 1741], 'results': [283, 811, 1202], 'neuropsychiatric': [285, 813], 'excitotoxicity,': [286], 'which': [287, 482, 654, 911, 1162], 'can': [288, 967, 1163, 1263], 'manifest': [289], 'clinically': [290], 'epilepsy,': [292], 'dementia,': [293], 'stroke;': [295], 'whereas': [296], 'hypoactivity': [297], 'produces': [298], 'symptoms': [299, 1001, 1183], 'schizophrenia.3': [301], 'Anti-N-methyl-D-aspartate': [302], '(anti-NMDA)-receptor': [303], 'recently': [307], 'neurological': [309, 1205], 'condition': [310, 897], 'NR1-NR2': [314], 'heteromers.': [315], 'It': [316, 903], 'composed': [318], 'well-defined': [321], 'set': [322], 'clinical': [324, 353, 385, 417, 888, 965], 'features': [325], 'been': [328, 1272], 'characterized': [329, 905], 'adults,': [331], 'frequently': [332, 937], 'women,': [335], 'teratomas': [337], 'ovary': [340], 'develop': [342], 'changes': [343], 'mood,': [345], 'behavior,': [346], 'personality,': [348], 'resembling': [349], 'psychosis.4': [351], 'picture': [354], 'usually': [355, 1030, 1150], 'progresses': [356], 'seizures,': [359, 915], 'decreased': [361], 'level': [362], 'consciousness,': [364], 'dyskinesias,': [365, 955], 'autonomic': [366, 1160], 'instability,': [367, 1161], 'hypoventilation.5': [369], 'Removal': [370], 'teratoma,': [373], 'immunotherapy,': [374], 'plasma': [375, 592, 1170, 1223], 'exchange,': [376, 1171, 1224], 'intravenous': [377], 'immunoglobulin': [378], '(IVIG),': [379], 'corticosteroids': [381], 'regardless': [387], 'severity': [390], 'encephalitis.': [393, 676], 'suggestive': [396], 'autoimmune': [400], 'component': [401], 'pathogenesis.6': [404], 'anti-NMDA-receptor': [410, 751, 1007, 1138], 'initial': [416], 'presentation': [418, 966], 'psychosis.CASEA': [424], 'female': [426], 'significant': [429], 'history': [431], 'bizarre': [434], 'behavior': [435], 'recurrent': [437], 'seizures.': [438], 'She': [439, 458, 473, 494, 646, 792], 'stated': [440], '1': [442, 549, 712], 'week': [443, 762], 'prior': [444], 'admission,': [446], 'she': [447, 782], 'had': [448, 459, 498, 648], 'flu-like': [450], 'illness': [451], 'rhinorrhea': [454], 'generalized': [456, 479], 'malaise.': [457], 'given': [460], 'birth': [461], 'by': [462, 884, 906], 'normal': [463, 518, 1044], 'vaginal': [464], 'delivery': [465], 'healthy': [468], 'boy': [469], '2': [470, 803], 'months': [471, 804, 1280], 'ago.': [472], 'subsequently': [474], 'developed': [475, 495], 'epilepticus': [477], 'tonic-clonic': [480], 'activity,': [481], 'lorazepam': [486], '4': [487], 'mg': [488, 492, 799], 'phenytoin': [490], '1000': [491], 'intravenously.': [493], 'hypoventilation': [496, 1327], 'be': [500, 1004], 'intubated.': [501], 'Her': [502], 'vital': [503], 'signs': [504, 998], 'were': [505, 601, 611, 629, 643, 737, 747, 753, 815], 'stable,': [506], 'physical': [508], 'examination,': [509], 'routine': [510], 'hematologic,': [511], 'studies': [512], 'urine': [514], 'toxicology': [515], 'screening': [516], 'provided': [517], 'results.': [519], 'head': [521], 'computed': [522], 'tomography': [523, 1092], '(CT)': [524], 'scan': [525, 642], 'unremarkable;': [527], 'cerebrospinal': [529], 'fluid': [530], '(CSF)': [531], 'analysis': [532, 1010, 1507, 1601, 1652], 'showed': [533, 690], 'white': [534, 1084], 'blood': [535, 547], 'cell': [536, 548], 'count': [537], '111': [539, 568], 'cells/mL': [540], '(normal': [541, 551, 556, 562, 577], '0–3': [542], 'cells/mL)': [543], '[lymphocytes': [544], '95%],': [545], 'red': [546], 'cell/mL': [550], 'o);': [552], '61': [554], 'mg/dL': [555, 561], '15–45': [557], 'mg/dL);': [558], 'glucose': [559, 566], '64': [560], '50–80': [563], 'mg/dl).': [564], 'Serum': [565], 'mg/dL.': [569], 'erythrocyte': [571], 'sedimentation': [572], 'rate': [573], '75': [575], 'millimeters/hour': [576], '3–5': [578], 'mm/hr);': [579], 'antinuclear': [580], 'antibody,': [581], 'negative;': [582, 590, 748], 'rapid': [583, 591, 1122], 'human': [584], 'immunodeficiency': [585], 'virus': [586, 674], 'enzyme-linked': [587], 'immunosorbent': [588], 'assay,': [589], 'reagin': [593], 'Venereal': [596], 'Disease': [597], 'Research': [598], 'Laboratory': [599], 'test,': [600], 'negative.': [602, 612, 630, 686, 739], 'Tests': [603], 'for': [604, 657, 671, 1006, 1099, 1157], 'Lyme': [605], 'disease,': [606, 935], 'Epstein-Barr': [607], 'virus,': [608], 'arboviruses': [610], 'An': [613, 687], 'autoimmunity': [614], 'panel': [615], 'tests': [617], '(including,': [618], 'among': [619], 'others,': [620], 'anti-double-stranded': [621], 'DNA,': [622], 'thyroid': [623], 'peroxidase,': [624], 'anti-neutrophil': [626], 'cytoplasmic': [627], 'antibodies)': [628], 'CT': [631], 'scans': [632], 'chest,': [635], 'abdomen,': [636], 'pelvis;': [638], 'PET': [641], 'all': [644, 987], 'unremarkable.': [645], 'endoscopy': [650], 'jejunal': [652], 'biopsy,': [653], 'negative': [656], 'Tropheryma': [658], 'whippelii.': [659], 'Acyclovir': [660], '10': [661], 'mg/kg': [662], 'body': [663], 'weight': [664], 'every': [665], '8': [666], 'hours': [667], 'started': [669, 709, 758], 'empirically': [670], 'herpes': [672], 'simplex': [673], '(HSV)': [675], 'magnetic': [678], 'resonance': [679], 'imaging': [680], '(MRI)': [681], 'brain': [684, 1037, 1047, 1063, 1107], 'electroencephalogram': [688], '(EEG)': [689], 'diffuse': [692, 697, 1033], 'slowing': [693, 1034], 'consistent': [694], 'encephalopathic': [698], 'state': [699], 'absence': [702, 1105, 1305], 'epileptiform': [704, 1027], 'activity.': [705], 'on': [710, 759, 796], 'methylprednisolone': [711], 'g': [713], 'IV': [714], 'daily.': [715], 'On': [716], 'CSF': [718, 741, 1012], 'analysis,': [719], 'HSV': [721], 'polymerase': [722], 'chain': [723], 'reaction': [724], '(PCR)': [725], 'negative,': [727], 'acyclovir': [729], 'discontinued.': [731], 'Cytomegalovirus': [732], 'West': [734], 'Nile': [735], 'PCR': [736], 'anti-Ma': [742], 'anti-voltage-gated': [744], 'potassium-channel': [745], 'however,': [749, 1149], 'positive.': [754], 'plasmapharesis.': [760], 'One': [761], 'later,': [763, 805], 'there': [764, 1119], 'improvement;': [767], 'therefore,': [768], 'added': [771], 'regimen.': [774], "patient's": [776], 'gradually': [779], 'improved,': [780], 'became': [783], 'more': [784], 'alert': [785], 'weaned': [788], 'off': [789], 'ventilator.': [791], 'discharged': [794], 'home': [795], 'levetiracetam': [797], '500': [798], 'twice': [800], 'daily;': [801], 'her': [806], 'cognitive': [807], 'functions,': [808], 'memory,': [809], 'evaluation': [814], 'completely': [816], 'normal.DISCUSSIONSAnti-NMDA-receptor': [817], 'NR2B': [822, 829], 'NR2A': [824], 'receptor.': [828], 'binds': [830], 'glutamate': [831, 870], 'avidly': [834], 'expressed': [835], 'hippocampal': [838], 'forebrain': [840], 'neurons': [841, 1384], 'humans.': [843], 'These': [844], 'inhibit': [846], 'presynaptic': [850], 'gamma-aminobutyric': [851], 'acid': [852], '(GABA)ergic': [853], 'interneurons,': [854], 'resulting': [855], 'reduced': [857], 'GABA': [858], 'release': [859, 868], 'disinhibition': [861], 'postsynaptic': [863], 'glutamatergic': [864], 'excessive': [867], 'prefrontal/subcortical': [873], 'structures.': [874], 'pathogenic': [876], 'role': [877], 'further': [882], 'strengthened': [883], 'disappearance': [886], 'during': [887, 1194], 'improvement.7': [889], 'Anti–NMDA-receptor': [890], 'treatable': [894], 'neurologic': [896, 1182, 1259], 'predominantly': [899], 'affects': [900], 'women.': [902], 'constellation': [908], 'symptoms,': [910, 1325], 'psychotic': [913], 'encephalopathy,': [914], 'abnormal': [917], 'movements': [918], 'trunk': [921], 'face,': [923], 'particularly': [924, 1095], 'jaw': [929], 'dystonia.8': [930], 'With': [931], 'progression': [932], 'patients': [936, 989, 1277, 1292], 'become': [938], 'catatonic': [939], 'unresponsive': [941], 'verbal': [943], 'commands,': [944], 'then': [946], 'commonly': [948], 'begin': [949], 'display': [951], 'hyperkinesias': [952], 'lingual-facial-buccal': [954], 'hypoventilation.9': [959], 'Early': [960], 'recognition': [961], 'typical': [964, 1250], 'increase': [968], 'index': [970], 'suspicion': [972], 'facilitate': [974], 'early': [975], 'prompt': [977], 'appropriate': [980], 'therapy.': [981], 'Prüss': [982, 1586], 'et': [983, 1350, 1439, 1468, 1500, 1532, 1569, 1598, 1649, 1679, 1767, 1798], 'al': [984], 'recommended': [985], 'admitted': [990], 'intensive': [993, 1155], 'care': [994, 1156], 'unit': [995], 'encephalitic': [997], '(like': [999], 'psychiatric': [1000, 1324], 'seizures)': [1003], 'tested': [1005], 'antibodies.10': [1008], 'reveals': [1014], 'pleocytosis,': [1015], 'increased': [1016], 'concentration,': [1018], 'high': [1021], 'IgG': [1022], 'index.11': [1023], 'EEGs': [1024], 'occasionally': [1025], 'show': [1026, 1066], 'abnormalities,': [1028], 'reveal': [1031], 'only': [1032], 'waves.12': [1038], 'Most': [1039], 'cases': [1040, 1540], '(75%)': [1041], 'either': [1043], 'atypical': [1046], 'MRI': [1048, 1064, 1108], 'findings': [1049], 'mild': [1051], 'abnormalities': [1052, 1073], 'surrounding': [1053], 'medial': [1055], 'temporal': [1056], 'lobes,': [1057], 'often': [1058, 1295], 'cortical': [1060, 1076], 'enhancement.': [1061], 'transient': [1067], 'fluid-attenuated': [1068], 'inversion': [1069], 'recovery': [1070, 1269], 'contrast-enhancing': [1072], '(brain,': [1077], 'cerebellum)': [1078], 'subcortical': [1080], '(hippocampus,': [1081], 'basal': [1082], 'ganglia,': [1083], 'matter)': [1085], 'regions.': [1086], 'Hybrid': [1087], 'F-18': [1088], 'fluorodeoxyglucose': [1089], 'positron': [1090], 'emission': [1091], '(PET)': [1093], 'useful': [1096], 'screen': [1098], 'findings.': [1109], 'Though': [1110], 'NMDA-receptor': [1114], 'potentially': [1117], 'fatal,': [1118], 'symptomatic': [1123], 'relief': [1124], 'immunosuppressive': [1126], 'therapy,': [1127], 'it': [1129], 'resolves': [1130], 'entirely': [1131], 'removal.13The': [1134], 'ideal': [1135], 'management': [1136], 'resection': [1142], 'immunotherapy.': [1144], 'Patients': [1145, 1239], 'this': [1147], 'disorder,': [1148], 'require': [1151], 'ventilatory': [1152], 'support': [1153], 'seizures': [1158], 'delay': [1164], 'removal.14': [1166], 'methylprednisolone,': [1169], 'IVIG': [1173, 1227], 'might': [1174], 'partial': [1177], 'complete': [1179], 'amelioration': [1180], 'stabilization': [1186], 'allowing': [1187], 'resection,': [1188], 'although': [1189], 'could': [1192], 'grow': [1193], 'delay.15': [1196], 'In': [1197], 'some': [1198], 'patients,': [1199], 'noticeable': [1204], 'matter': [1209], 'days': [1211], 'several': [1214, 1279], 'weeks.': [1215], 'Our': [1216], 'patient,': [1217], 'diagnosis,': [1219], 'steroids,': [1225], 'minimal': [1229], 'improvement.': [1230], 'Dramatic': [1231], 'noted': [1234], 'rituximab.': [1238], '(often,': [1240], 'those': [1241], 'tumor)': [1244], 'do': [1246], 'improve': [1248, 1254], 'first-line': [1251], 'therapies': [1252], 'and/or': [1257], 'cyclophosphamide.16Progressive': [1258], 'deterioration': [1260], 'death': [1262], 'occur': [1264], 'treatment.': [1266], 'However,': [1267], 'spontaneous': [1268], 'has': [1270], 'few': [1276], 'symptoms.': [1283], 'Relapse': [1284], '15%': [1287], '20%': [1289], 'occult': [1298], 'relapsing': [1300], 'teratoma': [1301], 'tumor.17ARTICLE': [1308], 'REFERENCES:1.': [1309], 'Vitaliani': [1310], 'R,': [1311, 1766], 'Mason': [1312], 'W,': [1313, 1432], 'Ances': [1314], 'Zwerdling': [1316], 'T,': [1317, 1648, 1787, 1791, 1793], 'Jiang': [1318], 'Z,': [1319], 'Dalmau': [1320, 1338, 1373, 1407, 1458, 1488, 1588, 1705], 'J.': [1321, 1374, 1408, 1708], '"Paraneoplastic': [1322, 1352], 'encephalitis,': [1323], 'ovarian': [1329, 1358, 1446, 1658], 'teratoma"': [1330, 1359, 1659], '.': [1331, 1360, 1388, 1418, 1449, 1481, 1513, 1546, 1579, 1611, 1628, 1660, 1693, 1720, 1747, 1780, 1810], 'Ann': [1332, 1361, 1580], 'Neurol.': [1333, 1362, 1422, 1483, 1515, 1581, 1750], '2005;': [1334], '58:594-604.': [1335], 'Google': [1336, 1365, 1395, 1425, 1454, 1486, 1518, 1555, 1584, 1615, 1635, 1665, 1699, 1724, 1753, 1784, 1814], 'Scholar2.': [1337], 'J,': [1339, 1345, 1404, 1459, 1489, 1589, 1706, 1733], 'Tüzün': [1340, 1399], 'E,': [1341, 1400], 'Wu': [1342], 'HY,': [1343], 'Masjuan': [1344, 1707], 'Rossi': [1346, 1466, 1494, 1621, 1703], 'JE,': [1347, 1467, 1495, 1704], 'Voloschin': [1348], 'A,': [1349, 1434, 1463, 1525, 1727, 1731, 1764], 'al.': [1351, 1440, 1469, 1501, 1533, 1570, 1599, 1650, 1680, 1768, 1799], 'anti-N-methyl-D-aspartate': [1353], '2007;': [1363, 1393, 1423, 1663], '61:25-36.': [1364], 'Scholar3.': [1366], 'Shimazaki': [1367], 'H,': [1368, 1587, 1640, 1756], 'Ando': [1369], 'Y,': [1370, 1638, 1642, 1676], 'Nakano': [1371], 'I,': [1372, 1646], '"Reversible': [1375], 'limbic': [1376, 1711], 'membranes': [1382], 'hippocampus"': [1387], 'J': [1389, 1548, 1629, 1661, 1748], 'Neurol': [1390, 1630], 'Neurosurg': [1391, 1631], 'Psychiatry.': [1392, 1632], '78:324-5.': [1394], 'Scholar4.': [1396], 'Sansing': [1397], 'LH,': [1398], 'Ko': [1401], 'MW,': [1402], 'Baccon': [1403], 'Lynch': [1405], 'DR,': [1406], '"A': [1409], 'antibodies"': [1417, 1512], 'Nat': [1419], 'Clin': [1420, 1549], 'Pract': [1421], '3:291-6.': [1424], 'Scholar5.': [1426], 'Kleinig': [1427], 'TJ,': [1428], 'Thompson': [1429], 'PD,': [1430], 'Matar': [1431], 'Duggins': [1433], 'Kimber': [1435], 'TE,': [1436], 'Morris': [1437], 'JG,': [1438], '"The': [1441], 'distinctive': [1442], 'movement': [1443], 'teratoma-associated': [1447], 'encephalitis"': [1448, 1545], 'Mov': [1450], 'Disord.': [1451], '2008;': [1452, 1516, 1722, 1782, 1812], '23:1256-61.': [1453], 'Scholar6.': [1455], 'Niehusmann': [1456], 'P,': [1457], 'Rudlowski': [1460], 'Vincent': [1462], 'Elger': [1464], 'CE,': [1465], '"Diagnostic': [1470], 'value': [1471], 'N-methyl-D-aspartate': [1473], 'women': [1477], 'new-onset': [1479], 'epilepsy"': [1480], 'Arch': [1482], '2009;': [1484, 1553, 1582], '66:458-64.': [1485], 'Scholar7.': [1487], 'Gleichman': [1490], 'AJ,': [1491], 'Hughes': [1492], 'EG,': [1493], 'Peng': [1496], 'X,': [1497], 'Lai': [1498], 'M,': [1499, 1593, 1644, 1760, 1762, 1797], '"Anti-NMDA-receptor': [1502], 'encephalitis:': [1503, 1536], 'Case': [1504], 'series': [1505], 'effects': [1510], 'Lancet': [1514], '7:1091-8.': [1517], 'Scholar8.': [1519], 'Gable': [1520], 'MS,': [1521], 'Gavali': [1522], 'S,': [1523, 1568, 1758, 1795], 'Radner': [1524], 'Tilley': [1526], 'DH,': [1527], 'Lee': [1528], 'Dyner': [1530], 'L,': [1531, 1566, 1591], '"Anti-NMDA': [1534, 1800], 'Report': [1537], 'ten': [1539], 'comparison': [1542], 'viral': [1544], 'Eur': [1547], 'Microbiol': [1550], 'Infect': [1551], 'Dis.': [1552], '28:1421-9.': [1554], 'Scholar9.': [1556], 'Florance': [1557], 'NR,': [1558], 'Davis': [1559], 'RL,': [1560], 'Lam': [1561], 'Szperka': [1563], 'Zhou': [1565], 'Ahmad': [1567], 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