Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis

Name: Work Video:
Duration: 3 min 30 s
Description: Neutralization of tumor necrosis factor α (TNF-α) for three to six months reduces the symptoms and signs of rheumatoid arthritis. However, the capacity of this approach to effect a more sustained benefit and its effect on joint damage are not known.
Peter E. Lipsky; Désirée van der Heijde; E. William St. Clair; Daniel E. Fürst; Ferdinand C. Breedveld; Joachim R. Kalden; Josef S Smolen; Michael H. Weisman; Paul Emery; Marc Feldmann; Gregory R. Harriman; Ravinder N. Maini
{'id': 'https://openalex.org/W2319957449', 'doi': 'https://doi.org/10.1056/nejm200011303432202', 'title': 'Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis', 'display_name': 'Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis', 'publication_year': 2000, 'publication_date': '2000-11-30', 'ids': {'openalex': 'https://openalex.org/W2319957449', 'doi': 'https://doi.org/10.1056/nejm200011303432202', 'mag': '2319957449', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11096166'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1056/nejm200011303432202', 'pdf_url': 'https://www.nejm.org/doi/pdf/10.1056/NEJM200011303432202?articleTools=true', 'source': {'id': 'https://openalex.org/S62468778', 'display_name': 'New England Journal of Medicine', 'issn_l': '0028-4793', 'issn': ['0028-4793', '1533-4406'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320239', 'host_organization_name': 'Massachusetts Medical Society', 'host_organization_lineage': ['https://openalex.org/P4310320239'], 'host_organization_lineage_names': ['Massachusetts Medical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.nejm.org/doi/pdf/10.1056/NEJM200011303432202?articleTools=true', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5043874873', 'display_name': 'Peter E. Lipsky', 'orcid': 'https://orcid.org/0000-0002-9287-1676'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Peter E. Lipsky', 'raw_affiliation_strings': ['University of Texas Southwestern Medical Center at Dallas, Dallas'], 'affiliations': [{'raw_affiliation_string': 'University of Texas Southwestern Medical Center at Dallas, Dallas', 'institution_ids': ['https://openalex.org/I867280407']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104506506', 'display_name': 'Désirée van der Heijde', 'orcid': 'https://orcid.org/0000-0002-5781-158X'}, 'institutions': [{'id': 'https://openalex.org/I2800191616', 'display_name': 'Maastricht University Medical Centre', 'ror': 'https://ror.org/02d9ce178', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800191616']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Desiree M.F.M. van der Heijde', 'raw_affiliation_strings': ['University Hospital Maastricht, Maastricht, the Netherlands'], 'affiliations': [{'raw_affiliation_string': 'University Hospital Maastricht, Maastricht, the Netherlands', 'institution_ids': ['https://openalex.org/I2800191616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013156684', 'display_name': 'E. William St. Clair', 'orcid': 'https://orcid.org/0000-0003-1181-0650'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'E. William St. Clair', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052078671', 'display_name': 'Daniel E. Fürst', 'orcid': 'https://orcid.org/0000-0002-4018-7629'}, 'institutions': [{'id': 'https://openalex.org/I1317886745', 'display_name': 'Virginia Mason Medical Center', 'ror': 'https://ror.org/00cm2cb35', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1317886745', 'https://openalex.org/I2802797007', 'https://openalex.org/I4210118434']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daniel E. Furst', 'raw_affiliation_strings': ['Virginia Mason Research Center, Seattle'], 'affiliations': [{'raw_affiliation_string': 'Virginia Mason Research Center, Seattle', 'institution_ids': ['https://openalex.org/I1317886745']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110445652', 'display_name': 'Ferdinand C. Breedveld', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I121797337', 'display_name': 'Leiden University', 'ror': 'https://ror.org/027bh9e22', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I121797337']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Ferdinand C. Breedveld', 'raw_affiliation_strings': ['University of Leiden, Leiden, the Netherlands'], 'affiliations': [{'raw_affiliation_string': 'University of Leiden, Leiden, the Netherlands', 'institution_ids': ['https://openalex.org/I121797337']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5105366464', 'display_name': 'Joachim R. Kalden', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210145647', 'display_name': 'Fraunhofer Institute for Cell Therapy and Immunology', 'ror': 'https://ror.org/04x45f476', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210145647', 'https://openalex.org/I4923324']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Joachim R. Kalden', 'raw_affiliation_strings': ['Institute for Clinical Immunology, Erlangen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute for Clinical Immunology, Erlangen, Germany', 'institution_ids': ['https://openalex.org/I4210145647']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111657027', 'display_name': 'Josef S Smolen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I129774422', 'display_name': 'University of Vienna', 'ror': 'https://ror.org/03prydq77', 'country_code': 'AT', 'type': 'education', 'lineage': ['https://openalex.org/I129774422']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Josef S. Smolen', 'raw_affiliation_strings': ['University of Vienna, Vienna, Austria'], 'affiliations': [{'raw_affiliation_string': 'University of Vienna, Vienna, Austria', 'institution_ids': ['https://openalex.org/I129774422']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030335777', 'display_name': 'Michael H. Weisman', 'orcid': 'https://orcid.org/0000-0001-5568-388X'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael Weisman', 'raw_affiliation_strings': ['University of California at San Diego, San Diego'], 'affiliations': [{'raw_affiliation_string': 'University of California at San Diego, San Diego', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018678002', 'display_name': 'Paul Emery', 'orcid': 'https://orcid.org/0000-0002-7429-8482'}, 'institutions': [{'id': 'https://openalex.org/I130828816', 'display_name': 'University of Leeds', 'ror': 'https://ror.org/024mrxd33', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I130828816']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Paul Emery', 'raw_affiliation_strings': ['Research School of Medicine, University of Leeds, Leeds, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Research School of Medicine, University of Leeds, Leeds, United Kingdom', 'institution_ids': ['https://openalex.org/I130828816']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057580992', 'display_name': 'Marc Feldmann', 'orcid': 'https://orcid.org/0000-0003-0800-7840'}, 'institutions': [{'id': 'https://openalex.org/I2802369498', 'display_name': 'Charing Cross Hospital', 'ror': 'https://ror.org/02gcp3110', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I153355300', 'https://openalex.org/I2802369498']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Marc Feldmann', 'raw_affiliation_strings': ['Kennedy Institute of Rheumatology and the Imperial College School of Medicine at Charing Cross Hospital, London'], 'affiliations': [{'raw_affiliation_string': 'Kennedy Institute of Rheumatology and the Imperial College School of Medicine at Charing Cross Hospital, London', 'institution_ids': ['https://openalex.org/I2802369498']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046048546', 'display_name': 'Gregory R. Harriman', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Gregory R. Harriman', 'raw_affiliation_strings': ['Centocor, Malvern, Pa.'], 'affiliations': [{'raw_affiliation_string': 'Centocor, Malvern, Pa.', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111772241', 'display_name': 'Ravinder N. Maini', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802369498', 'display_name': 'Charing Cross Hospital', 'ror': 'https://ror.org/02gcp3110', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I153355300', 'https://openalex.org/I2802369498']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Ravinder N. Maini', 'raw_affiliation_strings': ['Kennedy Institute of Rheumatology and the Imperial College School of Medicine at Charing Cross Hospital, London'], 'affiliations': [{'raw_affiliation_string': 'Kennedy Institute of Rheumatology and the Imperial College School of Medicine at Charing Cross Hospital, London', 'institution_ids': ['https://openalex.org/I2802369498']}]}], 'institution_assertions': [], 'countries_distinct_count': 5, 'institutions_distinct_count': 8, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 105.92, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 2992, 'citation_normalized_percentile': {'value': 0.999788, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '343', 'issue': '22', 'first_page': '1594', 'last_page': '1602'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10200', 'display_name': 'Rheumatoid Arthritis Research and Therapies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10200', 'display_name': 'Rheumatoid Arthritis Research and Therapies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11616', 'display_name': 'Autoimmune and Inflammatory Disorders Research', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10308', 'display_name': 'Systemic Lupus Erythematosus Research', 'score': 0.9959, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.9573577}, {'id': 'https://openalex.org/C2777138892', 'wikidata': 'https://www.wikidata.org/wiki/Q415264', 'display_name': 'Infliximab', 'level': 3, 'score': 0.93748045}, {'id': 'https://openalex.org/C2777575956', 'wikidata': 'https://www.wikidata.org/wiki/Q187255', 'display_name': 'Rheumatoid arthritis', 'level': 2, 'score': 0.9137635}, {'id': 'https://openalex.org/C2781059491', 'wikidata': 'https://www.wikidata.org/wiki/Q422232', 'display_name': 'Methotrexate', 'level': 2, 'score': 0.8816808}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.60140544}, {'id': 'https://openalex.org/C2777077863', 'wikidata': 'https://www.wikidata.org/wiki/Q170990', 'display_name': 'Arthritis', 'level': 2, 'score': 0.5290488}, {'id': 'https://openalex.org/C198451711', 'wikidata': 'https://www.wikidata.org/wiki/Q327657', 'display_name': 'Rheumatology', 'level': 2, 'score': 0.49948812}, {'id': 'https://openalex.org/C27081682', 'wikidata': 'https://www.wikidata.org/wiki/Q269829', 'display_name': 'Placebo', 'level': 3, 'score': 0.48782662}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.46204895}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.44592795}, {'id': 'https://openalex.org/C17991360', 'wikidata': 'https://www.wikidata.org/wiki/Q21173843', 'display_name': 'Tumor necrosis factor alpha', 'level': 2, 'score': 0.26422167}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.10511711}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D018501', 'descriptor_name': 'Antirheumatic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D008727', 'descriptor_name': 'Methotrexate', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018501', 'descriptor_name': 'Antirheumatic Agents', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D018501', 'descriptor_name': 'Antirheumatic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': False}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001175', 'descriptor_name': 'Arthrography', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018450', 'descriptor_name': 'Disease Progression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004359', 'descriptor_name': 'Drug Therapy, Combination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069285', 'descriptor_name': 'Infliximab', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007275', 'descriptor_name': 'Injections, Intravenous', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007596', 'descriptor_name': 'Joints', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007596', 'descriptor_name': 'Joints', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008727', 'descriptor_name': 'Methotrexate', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D008727', 'descriptor_name': 'Methotrexate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1056/nejm200011303432202', 'pdf_url': 'https://www.nejm.org/doi/pdf/10.1056/NEJM200011303432202?articleTools=true', 'source': {'id': 'https://openalex.org/S62468778', 'display_name': 'New England Journal of Medicine', 'issn_l': '0028-4793', 'issn': ['0028-4793', '1533-4406'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320239', 'host_organization_name': 'Massachusetts Medical Society', 'host_organization_lineage': ['https://openalex.org/P4310320239'], 'host_organization_lineage_names': ['Massachusetts Medical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11096166', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1056/nejm200011303432202', 'pdf_url': 'https://www.nejm.org/doi/pdf/10.1056/NEJM200011303432202?articleTools=true', 'source': {'id': 'https://openalex.org/S62468778', 'display_name': 'New England Journal of Medicine', 'issn_l': '0028-4793', 'issn': ['0028-4793', '1533-4406'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320239', 'host_organization_name': 'Massachusetts Medical Society', 'host_organization_lineage': ['https://openalex.org/P4310320239'], 'host_organization_lineage_names': ['Massachusetts Medical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.82}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 39, 'referenced_works': ['https://openalex.org/W1596381381', 'https://openalex.org/W1967815894', 'https://openalex.org/W1976128207', 'https://openalex.org/W1985004174', 'https://openalex.org/W1985763670', 'https://openalex.org/W1988572067', 'https://openalex.org/W1993771266', 'https://openalex.org/W1995798331', 'https://openalex.org/W1996472975', 'https://openalex.org/W2010900664', 'https://openalex.org/W2017720269', 'https://openalex.org/W2026990996', 'https://openalex.org/W2031504111', 'https://openalex.org/W2033299724', 'https://openalex.org/W2037377025', 'https://openalex.org/W2040505385', 'https://openalex.org/W2060408250', 'https://openalex.org/W2065344034', 'https://openalex.org/W2097564087', 'https://openalex.org/W2101951838', 'https://openalex.org/W2106989209', 'https://openalex.org/W2111540856', 'https://openalex.org/W2131658103', 'https://openalex.org/W2142273705', 'https://openalex.org/W2169817209', 'https://openalex.org/W2171505815', 'https://openalex.org/W2314052274', 'https://openalex.org/W2321453230', 'https://openalex.org/W2328587823', 'https://openalex.org/W2331320446', 'https://openalex.org/W2408791573', 'https://openalex.org/W2415591033', 'https://openalex.org/W2438063247', 'https://openalex.org/W24568342', 'https://openalex.org/W2518120927', 'https://openalex.org/W4239140282', 'https://openalex.org/W4292806894', 'https://openalex.org/W4313347683', 'https://openalex.org/W614531583'], 'related_works': ['https://openalex.org/W4283524728', 'https://openalex.org/W3030711132', 'https://openalex.org/W2411121127', 'https://openalex.org/W2396165291', 'https://openalex.org/W2366611537', 'https://openalex.org/W2314544353', 'https://openalex.org/W2227428044', 'https://openalex.org/W2138243862', 'https://openalex.org/W2106806370', 'https://openalex.org/W2020756831'], 'abstract_inverted_index': {'Neutralization': [0], 'of': [1, 17, 23], 'tumor': [2], 'necrosis': [3], 'factor': [4], 'α': [5], '(TNF-α)': [6], 'for': [7], 'three': [8], 'to': [9, 26], 'six': [10], 'months': [11], 'reduces': [12], 'the': [13, 21], 'symptoms': [14], 'and': [15, 32], 'signs': [16], 'rheumatoid': [18], 'arthritis.': [19], 'However,': [20], 'capacity': [22], 'this': [24], 'approach': [25], 'effect': [27, 34], 'a': [28], 'more': [29], 'sustained': [30], 'benefit': [31], 'its': [33], 'on': [35], 'joint': [36], 'damage': [37], 'are': [38], 'not': [39], 'known.': [40]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2319957449', 'counts_by_year': [{'year': 2024, 'cited_by_count': 24}, {'year': 2023, 'cited_by_count': 39}, {'year': 2022, 'cited_by_count': 35}, {'year': 2021, 'cited_by_count': 47}, {'year': 2020, 'cited_by_count': 61}, {'year': 2019, 'cited_by_count': 49}, {'year': 2018, 'cited_by_count': 69}, {'year': 2017, 'cited_by_count': 67}, {'year': 2016, 'cited_by_count': 87}, {'year': 2015, 'cited_by_count': 105}, {'year': 2014, 'cited_by_count': 117}, {'year': 2013, 'cited_by_count': 117}, {'year': 2012, 'cited_by_count': 109}], 'updated_date': '2024-12-19T02:34:27.592570', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
