Publication Information

{'id': 'https://openalex.org/W2318580069', 'doi': None, 'title': 'Protease activity associated with excystation of Cryptosporidium parvum oocysts.', 'display_name': 'Protease activity associated with excystation of Cryptosporidium parvum oocysts.', 'publication_year': 1996, 'publication_date': '1996-12-01', 'ids': {'openalex': 'https://openalex.org/W2318580069', 'mag': '2318580069', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8973395'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8973395', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5032695622', 'display_name': 'John R. Forney', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I121980950', 'display_name': 'Utah State University', 'ror': 'https://ror.org/00h6set76', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I121980950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John R. Forney', 'raw_affiliation_strings': ['Department of Biology, College of Science, Utah State University, Logan 84322-5600, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology, College of Science, Utah State University, Logan 84322-5600, USA.', 'institution_ids': ['https://openalex.org/I121980950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101341799', 'display_name': 'Shiguang Yang', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Shiguang Yang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111819026', 'display_name': 'Mark C. Healey', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Mark C. Healey', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.994, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 61, 'citation_normalized_percentile': {'value': 0.818723, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '82', 'issue': '6', 'first_page': '889', 'last_page': '92'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11086', 'display_name': 'Parasitic Infections and Diagnostics', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2405', 'display_name': 'Parasitology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11086', 'display_name': 'Parasitic Infections and Diagnostics', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2405', 'display_name': 'Parasitology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10979', 'display_name': 'Breastfeeding Practices and Influences', 'score': 0.9766, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/diisopropyl-fluorophosphate', 'display_name': 'Diisopropyl fluorophosphate', 'score': 0.7528713}, {'id': 'https://openalex.org/keywords/aprotinin', 'display_name': 'Aprotinin', 'score': 0.7217501}, {'id': 'https://openalex.org/keywords/phenylmethylsulfonyl-fluoride', 'display_name': 'Phenylmethylsulfonyl Fluoride', 'score': 0.6356082}, {'id': 'https://openalex.org/keywords/cryptosporidium-parvum', 'display_name': 'Cryptosporidium parvum', 'score': 0.55458045}, {'id': 'https://openalex.org/keywords/cysteine-protease', 'display_name': 'Cysteine protease', 'score': 0.48286536}, {'id': 'https://openalex.org/keywords/cysteine-proteinase-inhibitors', 'display_name': 'Cysteine Proteinase Inhibitors', 'score': 0.43729824}], 'concepts': [{'id': 'https://openalex.org/C2780865716', 'wikidata': 'https://www.wikidata.org/wiki/Q411575', 'display_name': 'PMSF', 'level': 3, 'score': 0.9470166}, {'id': 'https://openalex.org/C2776714187', 'wikidata': 'https://www.wikidata.org/wiki/Q212410', 'display_name': 'Protease', 'level': 3, 'score': 0.82051903}, {'id': 'https://openalex.org/C182220744', 'wikidata': 'https://www.wikidata.org/wiki/Q7251226', 'display_name': 'Proteases', 'level': 3, 'score': 0.8059393}, {'id': 'https://openalex.org/C2777807008', 'wikidata': 'https://www.wikidata.org/wiki/Q87324999', 'display_name': 'Serine protease', 'level': 4, 'score': 0.7556701}, {'id': 'https://openalex.org/C2776873056', 'wikidata': 'https://www.wikidata.org/wiki/Q384993', 'display_name': 'Diisopropyl fluorophosphate', 'level': 3, 'score': 0.7528713}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7249119}, {'id': 'https://openalex.org/C2780799893', 'wikidata': 'https://www.wikidata.org/wiki/Q418625', 'display_name': 'Aprotinin', 'level': 2, 'score': 0.7217501}, {'id': 'https://openalex.org/C2909400048', 'wikidata': 'https://www.wikidata.org/wiki/Q411575', 'display_name': 'Phenylmethylsulfonyl Fluoride', 'level': 4, 'score': 0.6356082}, {'id': 'https://openalex.org/C25642318', 'wikidata': 'https://www.wikidata.org/wiki/Q1992532', 'display_name': 'Incubation', 'level': 2, 'score': 0.61810756}, {'id': 'https://openalex.org/C2775883766', 'wikidata': 'https://www.wikidata.org/wiki/Q11350119', 'display_name': 'Leupeptin', 'level': 4, 'score': 0.60350674}, {'id': 'https://openalex.org/C2777795018', 'wikidata': 'https://www.wikidata.org/wiki/Q134734', 'display_name': 'Cryptosporidium parvum', 'level': 2, 'score': 0.55458045}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.55326134}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.53801507}, {'id': 'https://openalex.org/C2776414213', 'wikidata': 'https://www.wikidata.org/wiki/Q183290', 'display_name': 'Serine', 'level': 3, 'score': 0.50006104}, {'id': 'https://openalex.org/C2777283782', 'wikidata': 'https://www.wikidata.org/wiki/Q419343', 'display_name': 'Cysteine protease', 'level': 4, 'score': 0.48286536}, {'id': 'https://openalex.org/C2908725733', 'wikidata': 'https://www.wikidata.org/wiki/Q419343', 'display_name': 'Cysteine Proteinase Inhibitors', 'level': 5, 'score': 0.43729824}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.37895656}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.34761822}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.044801235}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C98424977', 'wikidata': 'https://www.wikidata.org/wiki/Q25805', 'display_name': 'Caspase', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D016785', 'descriptor_name': 'Cryptosporidium parvum', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D010450', 'descriptor_name': 'Endopeptidases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011480', 'descriptor_name': 'Protease Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007611', 'descriptor_name': 'Aprotinin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007611', 'descriptor_name': 'Aprotinin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D002364', 'descriptor_name': 'Caseins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002364', 'descriptor_name': 'Caseins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016785', 'descriptor_name': 'Cryptosporidium parvum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016785', 'descriptor_name': 'Cryptosporidium parvum', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D016785', 'descriptor_name': 'Cryptosporidium parvum', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010450', 'descriptor_name': 'Endopeptidases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006868', 'descriptor_name': 'Hydrolysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007531', 'descriptor_name': 'Isoflurophate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007531', 'descriptor_name': 'Isoflurophate', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007930', 'descriptor_name': 'Leucine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007930', 'descriptor_name': 'Leucine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007930', 'descriptor_name': 'Leucine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D010664', 'descriptor_name': 'Phenylmethylsulfonyl Fluoride', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010664', 'descriptor_name': 'Phenylmethylsulfonyl Fluoride', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011480', 'descriptor_name': 'Protease Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000515', 'descriptor_name': 'alpha 1-Antitrypsin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000515', 'descriptor_name': 'alpha 1-Antitrypsin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8973395', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.4, 'display_name': 'Life below water', 'id': 'https://metadata.un.org/sdg/14'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 20, 'referenced_works': ['https://openalex.org/W1496420574', 'https://openalex.org/W1522561094', 'https://openalex.org/W1978039635', 'https://openalex.org/W1981754939', 'https://openalex.org/W2009304073', 'https://openalex.org/W2019402469', 'https://openalex.org/W2038120139', 'https://openalex.org/W2069752715', 'https://openalex.org/W2083799571', 'https://openalex.org/W2085889718', 'https://openalex.org/W2087017424', 'https://openalex.org/W2111036859', 'https://openalex.org/W2126992425', 'https://openalex.org/W2144475103', 'https://openalex.org/W2147174062', 'https://openalex.org/W2169251827', 'https://openalex.org/W2176557328', 'https://openalex.org/W2312668654', 'https://openalex.org/W2315217144', 'https://openalex.org/W2415499904'], 'related_works': ['https://openalex.org/W2318580069', 'https://openalex.org/W2312668654', 'https://openalex.org/W2114627102', 'https://openalex.org/W2089198843', 'https://openalex.org/W2068788987', 'https://openalex.org/W2065392476', 'https://openalex.org/W2061568535', 'https://openalex.org/W2049621837', 'https://openalex.org/W1993729483', 'https://openalex.org/W1804691901'], 'abstract_inverted_index': {'A': [0], 'Cryptosporidium': [1], 'parvum': [2, 125], 'homogenate': [3], '(CPH),': [4], 'prepared': [5], 'from': [6], 'partially': [7], 'excysted': [8], 'oocysts,': [9], 'was': [10, 25, 55, 114, 171], 'examined': [11], 'for': [12, 117], 'proteolytic': [13, 160], 'activity': [14, 54, 161, 170], 'capable': [15], 'of': [16, 93, 100, 112, 123, 156, 165, 194, 197], 'hydrolyzing': [17], 'azocasein.': [18], 'Protease': [19], 'activity,': [20], 'measured': [21, 104], 'at': [22, 36, 139], 'pH': [23], '7.0,': [24], 'not': [26], 'detected': [27], 'in': [28, 105], 'fresh': [29], 'oocysts': [30], 'but': [31, 45, 180], 'increased': [32], 'progressively': [33, 46], 'with': [34, 48, 212], 'incubation': [35, 44, 50, 144], '37': [37], 'C.': [38, 124], 'Activity': [39], 'peaked': [40], 'after': [41], '60': [42], 'min': [43], 'decreased': [47], 'extended': [49], 'intervals.': [51], 'Cryptosporidial': [52], 'protease': [53, 64, 78, 88, 169, 178, 183, 202], 'significantly': [56, 132, 185], 'inhibited': [57, 97, 133, 186], '(P': [58, 134], '<': [59, 135], '0.01)': [60], 'by': [61], 'the': [62, 76, 91, 101], 'serine': [63, 175, 182, 199, 207], 'inhibitors': [65, 113, 184], 'phenylmethylsulfonyl': [66], 'fluoride': [67], '(PMSF),': [68], 'diisopropyl': [69], 'fluorophosphate': [70], '(DIFP),': [71], 'aprotinin,': [72, 129], 'alpha-1-antitrypsin': [73], '(AAT),': [74], 'and': [75, 95, 130, 142, 176, 200, 204], 'cysteine': [77, 177, 201], 'inhibitor': [79, 84], 'L-trans-epoxysuccinyl-leucylamido-(4-guanidino)-butane': [80], '(E-64).': [81], 'No': [82], 'single': [83], 'completely': [85], 'blocked': [86], 'CPH-associated': [87], 'activity;': [89], 'however,': [90], 'combination': [92], 'PMSF': [94], 'E-64': [96, 146], '>': [98], '95%': [99], 'azocasein': [102], 'hydrolysis': [103], 'untreated': [106], 'control': [107], 'samples.': [108], 'The': [109, 154], 'same': [110], 'group': [111], 'further': [115], 'evaluated': [116], 'their': [118], 'ability': [119], 'to': [120, 173], 'inhibit': [121], 'excystation': [122, 138], 'oocysts.': [126], 'PMSF,': [127], 'DIFP,': [128], 'AAT': [131], '0.05)': [136], 'oocyst': [137, 187], '15-,': [140], '30-,': [141], '60-min': [143], 'intervals;': [145], 'had': [147], 'no': [148], 'significant': [149], 'inhibitory': [150], 'effect': [151], 'on': [152], 'excystation.': [153, 166, 188, 213], 'results': [155], 'this': [157], 'study': [158], 'demonstrate': [159], 'during': [162], 'peak': [163], 'periods': [164], 'Further,': [167], 'cryptosporidial': [168, 195], 'sensitive': [172], 'both': [174, 198], 'inhibitors,': [179], 'only': [181], 'These': [189], 'findings': [190], 'provide': [191], 'preliminary': [192], 'evidence': [193], 'proteases': [196], 'classes': [203], 'suggest': [205], 'that': [206], 'protease(s)': [208], 'are': [209], 'functionally': [210], 'associated': [211]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2318580069', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2025-01-16T03:15:52.447546', 'created_date': '2016-06-24'}