Title: Altered selenium transport and distribution influences thyroid hormone metabolism in transgenic SePP-KO mice
Abstract: Selenium (Se) is an essential trace element for mammals and highly enriched in brain, the reproductive and endocrine organs. We have genetically inactivated the gene for the Se-transport protein selenoprotein P (SePP). SePP-KO mice are characterised by a growth defect, a disturbed Se distribution and an altered expression of selenoproteins. Since activation of the prohormone T4 and inactivation of biologically active T3 and T4 are mediated by Se-dependent enzymes, we studied expression of Type I (5'DIO1) and Type II (5'DIO2) 5'deiodinase activities using 125-I-labeled rT3 as substrate. In parallel, serum thyroid hormone and TSH concentrations were analysed by RIAs adapted to mouse serum and Se concentrations were analysed by the DAN-fluorimetric method.
Publication Year: 2004
Publication Date: 2004-03-02
Language: en
Type: article
Indexed In: ['crossref']
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