Publication Information

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'https://openalex.org/W2128435287', 'https://openalex.org/W2133289462', 'https://openalex.org/W2154747383', 'https://openalex.org/W2406583270', 'https://openalex.org/W4238378335', 'https://openalex.org/W88096824'], 'related_works': ['https://openalex.org/W2465849052', 'https://openalex.org/W2418242542', 'https://openalex.org/W2406596309', 'https://openalex.org/W2395625575', 'https://openalex.org/W2325796893', 'https://openalex.org/W2162323079', 'https://openalex.org/W2158558125', 'https://openalex.org/W1984564944', 'https://openalex.org/W1968285251', 'https://openalex.org/W1605195192'], 'abstract_inverted_index': {'Epstein―Barr': [0], 'virus(EBV)は1964年にアフリカのバー': [1], 'キットリンパ腫培養細胞から発見された.その後,上咽頭': [2], 'がんや胃がんなどとの関わりも明らかにされ,歴史的に最': [3], 'も活発に研究がなされてきたヒトがんウイルス': [4], 'human': [5], 'cancer': [6], 'virus': [7], 'であると言える.その明らかな発癌との関連': [8], 'にも関わらず,EBVは高度に普遍的なウイルスでもある.': [9], 'EBVは主に唾液を関した母子感染によって伝播されると': [10], '考えられる.わが国の25歳以上の成人人口においては,ほ': [11], 'ぼ100%に近い感染率を示すとされる.': [12], 'EBVと血液リンパ系疾患との関わりは深い.表1に,': [13], '主なEBV関連血液リンパ系疾患を示す.知られる限りリ': [14], 'ンパ系疾患が主体であり,顆粒球系など他系統': [15], 'lineage': [16], 'の': [17], '血液細胞には余り関与しないようである.通常,EBVは': [18], 'B細胞に潜伏(latent)感染することから想像されるよう': [19], 'に,多くの疾患はB細胞性である.一方,T細胞や': [20], 'natural': [21], 'killer(NK)細胞由来のリンパ増殖性疾患にもEBVは': [22], '関わりを有する.幼児期までのEBV初感染はほとんど': [23], 'が無症状で終わるが,少年期以降におけるEBV初感染': [24], 'は,伝染性単核球症': [25], 'infectious': [26], 'mononucleosis(IM)とし': [27], 'て発症する.思春期に多く,ときに': [28], 'kissing': [29], 'disease': [30], 'とも': [31], '呼ばれる.また,稀ではあるがEBV初感染は,ウイルス': [32], '関連血球貪食症候群の原因となる.さらに伴性劣性リン': [33], 'パ増殖性疾患X―linked': [34], 'lymphproliferative': [35], 'disorderや慢': [36], '性活動性EBV感染症などの致死的な病態を呈する場合': [37], 'もある.また,ごく最近では,IM発症者におけるEBV': [38], '陽性ホジキンリンパ腫の発症リスクが非発症者と比較して': [39], '有意に高いという興味深い疫学データが確認された.': [40], 'EBVとリンパ増殖性疾患(lymphproliferative': [41], 'disorder;': [42], 'LPD)との関わりは非常に複雑で,多岐に亘るものであ': [43], 'ると言える.': [44], '本項の主題である加齢性EBV関連': [45], 'B細胞リンパ増殖異': [46], '常症': [47], 'senile': [48], 'EBV―associated': [49], 'B―cell': [50], 'LPDは,免疫不全関連': [51], 'リンパ腫と最も深い関わりがあるものである.': [52]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2317878199', 'counts_by_year': [], 'updated_date': '2024-12-13T20:19:01.464880', 'created_date': '2016-06-24'}