Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2317843840', 'doi': 'https://doi.org/10.1385/ct:4:4:375', 'title': 'The Oxygen Radical Generator Pyrogallol Impairs Cardiomyocyte Contractile Function Via a Superoxide and p38 MAP Kinase-Dependent Pathway: Protection by Anisodamine and Tetramethylpyrazine', 'display_name': 'The Oxygen Radical Generator Pyrogallol Impairs Cardiomyocyte Contractile Function Via a Superoxide and p38 MAP Kinase-Dependent Pathway: Protection by Anisodamine and Tetramethylpyrazine', 'publication_year': 2004, 'publication_date': '2004-01-01', 'ids': {'openalex': 'https://openalex.org/W2317843840', 'doi': 'https://doi.org/10.1385/ct:4:4:375', 'mag': '2317843840', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15531780'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1385/ct:4:4:375', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S181810612', 'display_name': 'Cardiovascular Toxicology', 'issn_l': '1530-7905', 'issn': ['1530-7905', '1559-0259'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5020140572', 'display_name': 'Lucy B. Esberg', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I114493937', 'display_name': 'Creighton University', 'ror': 'https://ror.org/05wf30g94', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I114493937']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lucy B. Esberg', 'raw_affiliation_strings': ['Creighton University School of Medicine, Omaha, NE'], 'affiliations': [{'raw_affiliation_string': 'Creighton University School of Medicine, Omaha, NE', 'institution_ids': ['https://openalex.org/I114493937']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5007706452', 'display_name': 'Jun Ren', 'orcid': 'https://orcid.org/0000-0002-0275-0783'}, 'institutions': [{'id': 'https://openalex.org/I12834331', 'display_name': 'University of Wyoming', 'ror': 'https://ror.org/01485tq96', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I12834331']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Jun Ren', 'raw_affiliation_strings': ['Division of Pharmaceutical Sciences and Graduate Neuroscience Program, University of Wyoming College of Health Sciences, 82071-3375, Laramie, WY'], 'affiliations': [{'raw_affiliation_string': 'Division of Pharmaceutical Sciences and Graduate Neuroscience Program, University of Wyoming College of Health Sciences, 82071-3375, Laramie, WY', 'institution_ids': ['https://openalex.org/I12834331']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5007706452'], 'corresponding_institution_ids': ['https://openalex.org/I12834331'], 'apc_list': {'value': 3390, 'currency': 'EUR', 'value_usd': 4390, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.423, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 30, 'citation_normalized_percentile': {'value': 0.852102, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '4', 'issue': '4', 'first_page': '375', 'last_page': '384'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11057', 'display_name': 'Pathophysiology of Myocardial Reperfusion Injury', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11057', 'display_name': 'Pathophysiology of Myocardial Reperfusion Injury', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10217', 'display_name': 'Molecular Mechanisms of Cardiac Arrhythmias', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11922', 'display_name': 'Diagnosis and Management of Arrhythmogenic Right Ventricular Cardiomyopathy', 'score': 0.9831, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pyrogallol', 'display_name': 'Pyrogallol', 'score': 0.86794555}, {'id': 'https://openalex.org/keywords/tetramethylpyrazine', 'display_name': 'Tetramethylpyrazine', 'score': 0.84050727}, {'id': 'https://openalex.org/keywords/anisodamine', 'display_name': 'Anisodamine', 'score': 0.618013}, {'id': 'https://openalex.org/keywords/cardioprotection', 'display_name': 'Cardioprotection', 'score': 0.506265}], 'concepts': [{'id': 'https://openalex.org/C2776344562', 'wikidata': 'https://www.wikidata.org/wiki/Q388692', 'display_name': 'Pyrogallol', 'level': 2, 'score': 0.86794555}, {'id': 'https://openalex.org/C2778208062', 'wikidata': 'https://www.wikidata.org/wiki/Q11319317', 'display_name': 'Tetramethylpyrazine', 'level': 3, 'score': 0.84050727}, {'id': 'https://openalex.org/C2780795997', 'wikidata': 'https://www.wikidata.org/wiki/Q413283', 'display_name': 'Superoxide', 'level': 3, 'score': 0.71238595}, {'id': 'https://openalex.org/C2779686630', 'wikidata': 'https://www.wikidata.org/wiki/Q4765340', 'display_name': 'Anisodamine', 'level': 2, 'score': 0.618013}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.56852156}, {'id': 'https://openalex.org/C48349386', 'wikidata': 'https://www.wikidata.org/wiki/Q424361', 'display_name': 'Reactive oxygen species', 'level': 2, 'score': 0.5260881}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.50809956}, {'id': 'https://openalex.org/C2778004101', 'wikidata': 'https://www.wikidata.org/wiki/Q133948', 'display_name': 'Antioxidant', 'level': 2, 'score': 0.49882483}, {'id': 'https://openalex.org/C2775838275', 'wikidata': 'https://www.wikidata.org/wiki/Q410776', 'display_name': 'Superoxide dismutase', 'level': 3, 'score': 0.48881122}, {'id': 'https://openalex.org/C139066938', 'wikidata': 'https://www.wikidata.org/wiki/Q185056', 'display_name': 'Radical', 'level': 2, 'score': 0.4537192}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.4353925}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.34608835}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.3303942}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.32673532}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.32030076}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.19088128}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.07789391}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D016166', 'descriptor_name': 'Free Radical Scavengers', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D009200', 'descriptor_name': 'Myocardial Contraction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D032383', 'descriptor_name': 'Myocytes, Cardiac', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D011748', 'descriptor_name': 'Pyrogallol', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D013481', 'descriptor_name': 'Superoxides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D048051', 'descriptor_name': 'p38 Mitogen-Activated Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004336', 'descriptor_name': 'Drug Antagonism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004365', 'descriptor_name': 'Drugs, Chinese Herbal', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004365', 'descriptor_name': 'Drugs, Chinese Herbal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016166', 'descriptor_name': 'Free Radical Scavengers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009200', 'descriptor_name': 'Myocardial Contraction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009200', 'descriptor_name': 'Myocardial Contraction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D032383', 'descriptor_name': 'Myocytes, Cardiac', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D032383', 'descriptor_name': 'Myocytes, Cardiac', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D011719', 'descriptor_name': 'Pyrazines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011719', 'descriptor_name': 'Pyrazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011725', 'descriptor_name': 'Pyridines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011725', 'descriptor_name': 'Pyridines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011748', 'descriptor_name': 'Pyrogallol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011748', 'descriptor_name': 'Pyrogallol', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012991', 'descriptor_name': 'Solanaceous Alkaloids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012991', 'descriptor_name': 'Solanaceous Alkaloids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D013481', 'descriptor_name': 'Superoxides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048051', 'descriptor_name': 'p38 Mitogen-Activated Protein Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D048051', 'descriptor_name': 'p38 Mitogen-Activated Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1385/ct:4:4:375', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S181810612', 'display_name': 'Cardiovascular Toxicology', 'issn_l': '1530-7905', 'issn': ['1530-7905', '1559-0259'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15531780', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.49, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 34, 'referenced_works': ['https://openalex.org/W1483108854', 'https://openalex.org/W1556814137', 'https://openalex.org/W1965210088', 'https://openalex.org/W1972370207', 'https://openalex.org/W1976400973', 'https://openalex.org/W1983855526', 'https://openalex.org/W1985865805', 'https://openalex.org/W1993514258', 'https://openalex.org/W1996424362', 'https://openalex.org/W2003203834', 'https://openalex.org/W2006554180', 'https://openalex.org/W2006970238', 'https://openalex.org/W2013951623', 'https://openalex.org/W2020072198', 'https://openalex.org/W2045277748', 'https://openalex.org/W2054220851', 'https://openalex.org/W2057341667', 'https://openalex.org/W2060260408', 'https://openalex.org/W2064696975', 'https://openalex.org/W2085404383', 'https://openalex.org/W2088866343', 'https://openalex.org/W2092685208', 'https://openalex.org/W2115346863', 'https://openalex.org/W2128217373', 'https://openalex.org/W2135140753', 'https://openalex.org/W2138062920', 'https://openalex.org/W2145930882', 'https://openalex.org/W2153721469', 'https://openalex.org/W2155154270', 'https://openalex.org/W2162079638', 'https://openalex.org/W2265529073', 'https://openalex.org/W2380118335', 'https://openalex.org/W2413647702', 'https://openalex.org/W65348624'], 'related_works': ['https://openalex.org/W2416610957', 'https://openalex.org/W2394124840', 'https://openalex.org/W2367720160', 'https://openalex.org/W2359788887', 'https://openalex.org/W2317843840', 'https://openalex.org/W2153721469', 'https://openalex.org/W2151402939', 'https://openalex.org/W2025010179', 'https://openalex.org/W1992192734', 'https://openalex.org/W1987840298'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2317843840', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-08-15T14:06:14.686277', 'created_date': '2016-06-24'}