Title: Stimulation with anti-CD3/CD28 beads and TGF-β in the non-inflammatory milieu converts CD4+T cells into Helios+Foxp3+regulatoryT cells
Abstract: CD4 + Foxp3 + regulatory T cells (Tregs) control various immune responses including contact hypersensitivity and autoimmune diseases, and adoptive therapy by Tregs of such diseases has been proposed. The clinical use of Tregs will require large numbers of cells. There are two options to achieve this purpose. One is to expand Tregs. Another is to convert antigen-specific CD4 + T cells into CD4 + Foxp3 + Tregs. In both options, it is important to obtain Tregs that possess a steadily suppressive function. Tregs are divided into two subpopulations based on the expression of transcription factor Helios. All of the thymic Tregs express Helios. In contrast, only 70% of the peripheral Tregs express Helios and remaining 30% do not. Helios + Foxp3 + Tregs are highly suppressive and express higher levels of CD25, CD103, GITR, and CTLA-4. Therefore, to generate Helios + Foxp3 + Tregs in vitro will be a promising method for the adoptive cell therapy. JSID AbstractsJournal of Dermatological ScienceVol. 69Issue 2Preview Full-Text PDF
Publication Year: 2013
Publication Date: 2013-02-01
Language: en
Type: article
Indexed In: ['crossref']
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