Title: Evaluation of Thyroid Hormone Changes in Non-Pregnant, Normotensive Pregnant and Pregnancy with Preeclampsia
Abstract: Objective: Normal Thyroid hormone level is essential in maintaining the normal fetal development.The objective of the study was to evaluate the thyroid hormone levels among healthy non-pregnant women with normotensive pregnant women and women with preeclampsia.Materials and methods: In these prospective study 90 women in the age group of 19 -36 are divided into 3 groups consisting of 30 healthy non-pregnant women, 30 healthy normotensive pregnant women and 30 pregnant women with preeclampsia and evaluated for thyroid profile.Results: Serum TT4 and TT3 levels in normotensive pregnant women and preeclamptic women were significantly higher compared to the levels in non-pregnant women.In comparison to the normotensive pregnant women, women with preeclampsia had a non significantly higher TT4 level and significantly lower TT3.In preeclamptic women serum FT4 was marginally raised than in normotensive pregnant subjects but was significantly raised than in nonpregnant subjects.The FT3 level was significantly lower in preeclamptic women than in normotensive pregnant women compared to nonpregnant subjects.TSH levels were significantly higher in both preeclamptic and normotensive pregnant women.Conclusion: The main finding of our study indicates that there is a state of hypothyroidism in normal pregnancy and in preeclampsia and so raised serum TSH occurs.Detection of any changes in thyroid profile in preeclampsia may of health in preventing the development of preeclampsia.