Title: THE EFFECTS OF IMMUNO-CHEMOTHERAPY, HYPERTHERMIA AND IRRADIATION ON THE GROWTH OF HUMAN RENAL CELL CARCINOMA
Abstract: In order to investigate more effective treatments for advanced renal cell carcinoma, experiments were performed as to inhibitory effects on the growth of KPK 1 cells derived from a human renal carcinoma. IFN-β, IFN-γ, vinca alkaloids (VBL, VCR, VDS), hyperthermia and irradiation inhibited the growth of KPK 1 cells. Both IFN-β and IFN-γ showed concentration dependent and time dependent inhibitory effects, and IFN-β was significantly more intensive in action than IFN-γ. All of vinca alkaloids inhibited the cell growth remarkably but there was no difference among these three drugs. Hyperthermia was inhibitory over 43°C and irradiation showed a remarkable inhibition at not less than 500 rads. But IFN-α and hormones had no inhibitory effect.These results imply that multidisciplinary treatments in combination of immuno-chemotherapy with IFN-β, IFN-γ or vinca alkaloids, hyperthermia and irradiation should be applied for advanced renal cell carcinoma.