Title: Histomonastatic Activity of Nifursol in Turkeys
Abstract: ALTHOUGH activity against blackhead disease (histomoniasis) in chickens and turkeys has been proved for several structurally diverse compounds during the past 20 years, this disease remains one of the most costly to turkey producers. Among the most noteworthy types of these compounds are certain arsonic acids, nitrothiazoles, quinolines, imidazoles and nitrofurans. McGregor (1953) reported that furazolidone, when administered at one part in 8,000 parts of feed, had a small degree of prophylactic value. One of six other nitrofurans tested (NF-153) was of slight value when administered from two days prior to infection and continued for 29 days. Furazolidone has not been used extensively by poultrymen, however, because other compounds have provided better efficacy at less cost. During our investigation of nitrofuran derivatives, a new compound was discovered which affords excellent protection against blackhead disease at low feed concentrations and which has a high margin of safety in recipient turkeys. This…