Title: Differential antimicrobial activities of Human Beta-Defensins against Methicillin Resistant (MRSA) and Methicillin sensitive (MSSA) <i>Staphylococcus aureus</i>
Abstract:Science and Technology Against Microbial Pathogens, pp. 9-12 (2011) No AccessDifferential antimicrobial activities of Human Beta-Defensins against Methicillin Resistant (MRSA) and Methicillin sensitiv...Science and Technology Against Microbial Pathogens, pp. 9-12 (2011) No AccessDifferential antimicrobial activities of Human Beta-Defensins against Methicillin Resistant (MRSA) and Methicillin sensitive (MSSA) Staphylococcus aureusN.D.S. Herathge, J.T. George, and D.A. RowleyN.D.S. HerathgeSchool of Health and Bioscience, University of East London, Stratford Campus, Water Lane, London, E15 4LZ, UK, J.T. GeorgeSchool of Health and Bioscience, University of East London, Stratford Campus, Water Lane, London, E15 4LZ, UK, and D.A. RowleySchool of Health and Bioscience, University of East London, Stratford Campus, Water Lane, London, E15 4LZ, UKhttps://doi.org/10.1142/9789814354868_0003Cited by:1 PreviousNext AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsRecommend to Library ShareShare onFacebookTwitterLinked InRedditEmail Abstract: Human beta-defensins (hBDs) are an intrinsic part of the innate immune response. These peptides have been shown to possess varying potencies against a wide spectrum of bacteria, viruses and fungi. Due to increasing resistance to traditional antimicrobials, interest is being shown in these peptides as possible therapeutic molecules. In this study, the bactericidal activity of two peptides (human beta defensin-2: hBD-2, and human beta defensin-3: hBD-3) was assessed against a range of Staphylococcus aureus (S. aureus) strains, including MRSA, using a standard bactericidal assay. The antibiotic sensitive strains of S. aureus were more susceptible to killing and exhibited a dose response to the test peptides reaching 99% kill at the highest concentration. In comparison the MRSA clinical isolates although still susceptible to the peptides showed lower percentage kill at all the concentrations examined, reaching a maximum at 68% kill. Importantly, here we show for the first time a clear and significant difference in bactericidal activity of defensins towards Methicillin sensitive and Methicillin resistant strains of S. aureus. Keywords: MRSAHBD-2HBD-3Bactericidal activity FiguresReferencesRelatedDetailsCited By 1A Novel Biocompatible Titanium–Gadolinium Quantum Dot as a Bacterial Detecting Agent with High Antibacterial ActivityVishma Pratap Sur, Aninda Mazumdar, Amirmansoor Ashrafi, Atripan Mukherjee and Vedran Milosavljevic et al.17 April 2020 | Nanomaterials, Vol. 10, No. 4 Science and Technology Against Microbial PathogensMetrics History KeywordsMRSAHBD-2HBD-3Bactericidal activityPDF downloadRead More
Publication Year: 2011
Publication Date: 2011-07-01
Language: en
Type: article
Indexed In: ['crossref']
Access and Citation
Cited By Count: 1
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