Abstract: An efficient cinchona alkaloid squaramide catalyzed asymmetric sulfa-Michael conjugate addition of thiols to trans-chalcones is described. Chen and co-workers applied the cinchona squaramide catalyst developed by Rawal's group (J. P. Malerich, K. Hagihara, V. H. Rawal J. Am. Chem. Soc. 2008, 130, 14416) to sulfa-Michael reactions and the products were obtained in moderate to good yields as well as moderate to high enantioselectivities under mild reaction conditions.
Publication Year: 2010
Publication Date: 2010-10-21
Language: en
Type: article
Indexed In: ['crossref']
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