Title: Effects of Sub-minimum Inhibitory Concentrations of Gatifloxacin on the Inhibition of Staphylococcus aureus and Escherichia coli Adherence
Abstract: The aim of this study was to investigate the capacity of subinhibitory concentrations of the newly developed fluoroquinolone antibiotic gatifloxacin (CAS 160738-57-8) to interfere with the mechanism of bacterial adhesion. Human buccal epithelial cells were incubated with different strains of both <i>Staphylococcus aureus</i> and <i>Escherichia coli,</i> grown in the presence of subinhibitory gatifloxacin concentrations varying from 1/2 MIC (minimum inhibitory concentration) to 1/128 MIC. A significant decrease was observed in the adherence of <i>S. aureus</i> and <i>E. coli</i> to buccal cells at drug MICs of 1/2 to 1/32 and 1/2 to 1/64, respectively. A large number of filamentous forms of different lengths and shapes were observed in the case of <i>E. coli,</i> whereas there was an abnormal increase in the diameter of the cells in the case of <i>S. aureus.</i> The interpolation of these pharmacodynamic findings with the pharmacokinetic curve indicate that the effect of subinhibitory concentrations of gatifloxacin can prolong its antimicrobial effects against <i>S. aureus</i> and <i>E. coli</i> for as long as 30 h and 37 h, respectively, after the MIC values have been reached.
Publication Year: 2011
Publication Date: 2011-12-26
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 1
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