Publication Information

{'id': 'https://openalex.org/W2311660610', 'doi': 'https://doi.org/10.18632/oncotarget.8316', 'title': 'Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development', 'display_name': 'Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development', 'publication_year': 2016, 'publication_date': '2016-03-24', 'ids': {'openalex': 'https://openalex.org/W2311660610', 'doi': 'https://doi.org/10.18632/oncotarget.8316', 'mag': '2311660610', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27027349', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5190135'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.8316', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=8316&path%5B%5D=24653', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=8316&path%5B%5D=24653', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100702884', 'display_name': 'Lingzhi Wang', 'orcid': 'https://orcid.org/0000-0001-5585-5426'}, 'institutions': [{'id': 'https://openalex.org/I4210103786', 'display_name': 'National University Cancer Institute, Singapore', 'ror': 'https://ror.org/025yypj46', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I4210103786', 'https://openalex.org/I4210150261']}, {'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}, {'id': 'https://openalex.org/I4210150261', 'display_name': 'National University Health System', 'ror': 'https://ror.org/05tjjsh18', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I4210150261']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Lingzhi Wang', 'raw_affiliation_strings': ['Cancer Science Institute of Singapore, National University of Singapore, Singapore', 'Department of Pharmacology, National University Health System, Singapore'], 'affiliations': [{'raw_affiliation_string': 'Cancer Science Institute of Singapore, National University of Singapore, Singapore', 'institution_ids': ['https://openalex.org/I4210103786', 'https://openalex.org/I165932596']}, {'raw_affiliation_string': 'Department of Pharmacology, National University Health System, Singapore', 'institution_ids': ['https://openalex.org/I4210150261']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010543954', 'display_name': 'Do Dang Khoa Phan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210103786', 'display_name': 'National University Cancer Institute, Singapore', 'ror': 'https://ror.org/025yypj46', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I4210103786', 'https://openalex.org/I4210150261']}, {'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Do Dang Khoa Phan', 'raw_affiliation_strings': ['Cancer Science Institute of Singapore, National University of Singapore, Singapore', 'Department of Pharmacy, National University of Singapore, Singapore'], 'affiliations': [{'raw_affiliation_string': 'Cancer Science Institute of Singapore, National University of Singapore, Singapore', 'institution_ids': ['https://openalex.org/I4210103786', 'https://openalex.org/I165932596']}, {'raw_affiliation_string': 'Department of Pharmacy, National University of Singapore, Singapore', 'institution_ids': ['https://openalex.org/I165932596']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100435133', 'display_name': 'Jingwen Zhang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210150261', 'display_name': 'National University Health System', 'ror': 'https://ror.org/05tjjsh18', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I4210150261']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Jingwen Zhang', 'raw_affiliation_strings': ['Department of Pharmacology, National University Health System, Singapore'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, National University Health System, Singapore', 'institution_ids': ['https://openalex.org/I4210150261']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024980911', 'display_name': 'Pei-Shi Ong', 'orcid': 'https://orcid.org/0000-0003-1679-6640'}, 'institutions': [{'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Pei-Shi Ong', 'raw_affiliation_strings': ['Department of Pharmacy, National University of Singapore, Singapore'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacy, National University of Singapore, Singapore', 'institution_ids': ['https://openalex.org/I165932596']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108545900', 'display_name': 'Win Lwin Thuya', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210103786', 'display_name': 'National University Cancer Institute, Singapore', 'ror': 'https://ror.org/025yypj46', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I4210103786', 'https://openalex.org/I4210150261']}, {'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Win Lwin Thuya', 'raw_affiliation_strings': ['Cancer Science Institute of Singapore, National University of Singapore, Singapore', 'Department of Pharmacy, National University of Singapore, Singapore'], 'affiliations': [{'raw_affiliation_string': 'Cancer Science Institute of Singapore, National University of Singapore, Singapore', 'institution_ids': ['https://openalex.org/I4210103786', 'https://openalex.org/I165932596']}, {'raw_affiliation_string': 'Department of Pharmacy, National University of Singapore, Singapore', 'institution_ids': ['https://openalex.org/I165932596']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032293215', 'display_name': 'Ross A. Soo', 'orcid': 'https://orcid.org/0000-0002-3053-3997'}, 'institutions': [{'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}, {'id': 'https://openalex.org/I4210150261', 'display_name': 'National University Health System', 'ror': 'https://ror.org/05tjjsh18', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I4210150261']}, {'id': 'https://openalex.org/I4210103786', 'display_name': 'National University Cancer Institute, Singapore', 'ror': 'https://ror.org/025yypj46', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I4210103786', 'https://openalex.org/I4210150261']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Ross Soo', 'raw_affiliation_strings': ['Cancer Science Institute of Singapore, National University of Singapore, Singapore', 'Department of Haematology-Oncology, National University Health System, Singapore'], 'affiliations': [{'raw_affiliation_string': 'Cancer Science Institute of Singapore, National University of Singapore, Singapore', 'institution_ids': ['https://openalex.org/I165932596', 'https://openalex.org/I4210103786']}, {'raw_affiliation_string': 'Department of Haematology-Oncology, National University Health System, Singapore', 'institution_ids': ['https://openalex.org/I4210150261']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109278779', 'display_name': 'Andrea Li-Ann Wong', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210150261', 'display_name': 'National University Health System', 'ror': 'https://ror.org/05tjjsh18', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I4210150261']}, {'id': 'https://openalex.org/I4210103786', 'display_name': 'National University Cancer Institute, Singapore', 'ror': 'https://ror.org/025yypj46', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I4210103786', 'https://openalex.org/I4210150261']}, {'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Andrea Li-Ann Wong', 'raw_affiliation_strings': ['Cancer Science Institute of Singapore, National University of Singapore, Singapore', 'Department of Haematology-Oncology, National University Health System, Singapore'], 'affiliations': [{'raw_affiliation_string': 'Department of Haematology-Oncology, National University Health System, Singapore', 'institution_ids': ['https://openalex.org/I4210150261']}, {'raw_affiliation_string': 'Cancer Science Institute of Singapore, National University of Singapore, Singapore', 'institution_ids': ['https://openalex.org/I4210103786', 'https://openalex.org/I165932596']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005798113', 'display_name': 'Wei Peng Yong', 'orcid': 'https://orcid.org/0000-0003-4404-3777'}, 'institutions': [{'id': 'https://openalex.org/I4210150261', 'display_name': 'National University Health System', 'ror': 'https://ror.org/05tjjsh18', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I4210150261']}, {'id': 'https://openalex.org/I4210103786', 'display_name': 'National University Cancer Institute, Singapore', 'ror': 'https://ror.org/025yypj46', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I4210103786', 'https://openalex.org/I4210150261']}, {'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Wei Peng Yong', 'raw_affiliation_strings': ['Cancer Science Institute of Singapore, National University of Singapore, Singapore', 'Department of Haematology-Oncology, National University Health System, Singapore'], 'affiliations': [{'raw_affiliation_string': 'Department of Haematology-Oncology, National University Health System, Singapore', 'institution_ids': ['https://openalex.org/I4210150261']}, {'raw_affiliation_string': 'Cancer Science Institute of Singapore, National University of Singapore, Singapore', 'institution_ids': ['https://openalex.org/I4210103786', 'https://openalex.org/I165932596']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033700679', 'display_name': 'Soo Chin Lee', 'orcid': 'https://orcid.org/0000-0002-5835-6419'}, 'institutions': [{'id': 'https://openalex.org/I4210103786', 'display_name': 'National University Cancer Institute, Singapore', 'ror': 'https://ror.org/025yypj46', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I4210103786', 'https://openalex.org/I4210150261']}, {'id': 'https://openalex.org/I4210150261', 'display_name': 'National University Health System', 'ror': 'https://ror.org/05tjjsh18', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I4210150261']}, {'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Soo Chin Lee', 'raw_affiliation_strings': ['Cancer Science Institute of Singapore, National University of Singapore, Singapore', 'Department of Haematology-Oncology, National University Health System, Singapore'], 'affiliations': [{'raw_affiliation_string': 'Cancer Science Institute of Singapore, National University of Singapore, Singapore', 'institution_ids': ['https://openalex.org/I4210103786', 'https://openalex.org/I165932596']}, {'raw_affiliation_string': 'Department of Haematology-Oncology, National University Health System, Singapore', 'institution_ids': ['https://openalex.org/I4210150261']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5114226859', 'display_name': 'Paul Chi-Lui Ho', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}, {'id': 'https://openalex.org/I4210103786', 'display_name': 'National University Cancer Institute, Singapore', 'ror': 'https://ror.org/025yypj46', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I4210103786', 'https://openalex.org/I4210150261']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Paul Chi-Lui Ho', 'raw_affiliation_strings': ['Cancer Science Institute of Singapore, National University of Singapore, Singapore', 'Department of Pharmacy, National University of Singapore, Singapore'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacy, National University of Singapore, Singapore', 'institution_ids': ['https://openalex.org/I165932596']}, {'raw_affiliation_string': 'Cancer Science Institute of Singapore, National University of Singapore, Singapore', 'institution_ids': ['https://openalex.org/I4210103786', 'https://openalex.org/I165932596']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034304968', 'display_name': 'Gautam Sethi', 'orcid': 'https://orcid.org/0000-0002-8677-8475'}, 'institutions': [{'id': 'https://openalex.org/I4210150261', 'display_name': 'National University Health System', 'ror': 'https://ror.org/05tjjsh18', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I4210150261']}], 'countries': ['SG'], 'is_corresponding': True, 'raw_author_name': 'Gautam Sethi', 'raw_affiliation_strings': ['Department of Pharmacology, National University Health System, Singapore'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, National University Health System, Singapore', 'institution_ids': ['https://openalex.org/I4210150261']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5043184297', 'display_name': 'Boon Cher Goh', 'orcid': 'https://orcid.org/0000-0002-4107-102X'}, 'institutions': [{'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}, {'id': 'https://openalex.org/I4210150261', 'display_name': 'National University Health System', 'ror': 'https://ror.org/05tjjsh18', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I4210150261']}, {'id': 'https://openalex.org/I4210103786', 'display_name': 'National University Cancer Institute, Singapore', 'ror': 'https://ror.org/025yypj46', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I4210103786', 'https://openalex.org/I4210150261']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Boon Cher Goh', 'raw_affiliation_strings': ['Cancer Science Institute of Singapore, National University of Singapore, Singapore', 'Department of Haematology-Oncology, National University Health System, Singapore', 'Department of Pharmacology, National University Health System, Singapore'], 'affiliations': [{'raw_affiliation_string': 'Cancer Science Institute of Singapore, National University of Singapore, Singapore', 'institution_ids': ['https://openalex.org/I165932596', 'https://openalex.org/I4210103786']}, {'raw_affiliation_string': 'Department of Pharmacology, National University Health System, Singapore', 'institution_ids': ['https://openalex.org/I4210150261']}, {'raw_affiliation_string': 'Department of Haematology-Oncology, National University Health System, Singapore', 'institution_ids': ['https://openalex.org/I4210150261']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5034304968'], 'corresponding_institution_ids': ['https://openalex.org/I4210150261'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.647, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 58, 'citation_normalized_percentile': {'value': 0.999737, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '7', 'issue': '28', 'first_page': '44790', 'last_page': '44802'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10952', 'display_name': 'PI3K/AKT/mTOR signaling in cancer', 'score': 0.9872, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10952', 'display_name': 'PI3K/AKT/mTOR signaling in cancer', 'score': 0.9872, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12685', 'display_name': 'Phytochemical compounds biological activities', 'score': 0.9756, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13779', 'display_name': 'Cancer Mechanisms and Therapy', 'score': 0.9706, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pharmacodynamics', 'display_name': 'Pharmacodynamics', 'score': 0.539315}], 'concepts': [{'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.6278625}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5935117}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.5467686}, {'id': 'https://openalex.org/C111113717', 'wikidata': 'https://www.wikidata.org/wiki/Q725307', 'display_name': 'Pharmacodynamics', 'level': 3, 'score': 0.539315}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.498919}, {'id': 'https://openalex.org/C2780394083', 'wikidata': 'https://www.wikidata.org/wiki/Q539568', 'display_name': 'Angiogenesis', 'level': 2, 'score': 0.48317948}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.46547955}, {'id': 'https://openalex.org/C556039675', 'wikidata': 'https://www.wikidata.org/wiki/Q771035', 'display_name': 'Traditional medicine', 'level': 1, 'score': 0.40993044}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.27714634}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.1973665}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.16888064}], 'mesh': [{'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D009389', 'descriptor_name': 'Neovascularization, Pathologic', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D031601', 'descriptor_name': 'Azadirachta', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D036701', 'descriptor_name': 'Limonins', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000098', 'qualifier_name': 'blood supply', 'is_major_topic': False}, {'descriptor_ui': 'D008517', 'descriptor_name': 'Phytotherapy', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D010936', 'descriptor_name': 'Plant Extracts', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.8316', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=8316&path%5B%5D=24653', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5190135', 'pdf_url': 'https://europepmc.org/articles/pmc5190135?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190135', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27027349', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.8316', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=8316&path%5B%5D=24653', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.82, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 88, 'referenced_works': ['https://openalex.org/W141804032', 'https://openalex.org/W1494453148', 'https://openalex.org/W1567268334', 'https://openalex.org/W1571663644', 'https://openalex.org/W1616121322', 'https://openalex.org/W1663154925', 'https://openalex.org/W1934957927', 'https://openalex.org/W1963904011', 'https://openalex.org/W1964784448', 'https://openalex.org/W1968820371', 'https://openalex.org/W1969681477', 'https://openalex.org/W1974208182', 'https://openalex.org/W1975834732', 'https://openalex.org/W1981781914', 'https://openalex.org/W1983134103', 'https://openalex.org/W1983457932', 'https://openalex.org/W1984621921', 'https://openalex.org/W1984778420', 'https://openalex.org/W1987302928', 'https://openalex.org/W1992089537', 'https://openalex.org/W1993216157', 'https://openalex.org/W1999177172', 'https://openalex.org/W1999268263', 'https://openalex.org/W2001439351', 'https://openalex.org/W2004171945', 'https://openalex.org/W2009244520', 'https://openalex.org/W2012235333', 'https://openalex.org/W2020439083', 'https://openalex.org/W2021551397', 'https://openalex.org/W2022146354', 'https://openalex.org/W2026070762', 'https://openalex.org/W2027516572', 'https://openalex.org/W2028300044', 'https://openalex.org/W2030385223', 'https://openalex.org/W2031981401', 'https://openalex.org/W2032189618', 'https://openalex.org/W2032458681', 'https://openalex.org/W2038258563', 'https://openalex.org/W2041480076', 'https://openalex.org/W2045617306', 'https://openalex.org/W2049789861', 'https://openalex.org/W2052828768', 'https://openalex.org/W2055194666', 'https://openalex.org/W2062133163', 'https://openalex.org/W2062943475', 'https://openalex.org/W2067955906', 'https://openalex.org/W2068216479', 'https://openalex.org/W2068471435', 'https://openalex.org/W2068721684', 'https://openalex.org/W2072248255', 'https://openalex.org/W2073095285', 'https://openalex.org/W2075152619', 'https://openalex.org/W2076627309', 'https://openalex.org/W2076812013', 'https://openalex.org/W2077796580', 'https://openalex.org/W2081233941', 'https://openalex.org/W2082633436', 'https://openalex.org/W2084480843', 'https://openalex.org/W2089171551', 'https://openalex.org/W2092084997', 'https://openalex.org/W2092191109', 'https://openalex.org/W2099786386', 'https://openalex.org/W2102790879', 'https://openalex.org/W2109827027', 'https://openalex.org/W2111608472', 'https://openalex.org/W2121030616', 'https://openalex.org/W2124802947', 'https://openalex.org/W2128697833', 'https://openalex.org/W2128846014', 'https://openalex.org/W2132369839', 'https://openalex.org/W2132411546', 'https://openalex.org/W2134887638', 'https://openalex.org/W2143548516', 'https://openalex.org/W2143904175', 'https://openalex.org/W2144707486', 'https://openalex.org/W2148525194', 'https://openalex.org/W2153161557', 'https://openalex.org/W2158021558', 'https://openalex.org/W2160345685', 'https://openalex.org/W2166888255', 'https://openalex.org/W2167445715', 'https://openalex.org/W2168411134', 'https://openalex.org/W2170523250', 'https://openalex.org/W2170853272', 'https://openalex.org/W2324288236', 'https://openalex.org/W2336449142', 'https://openalex.org/W4243935942', 'https://openalex.org/W43308025'], 'related_works': ['https://openalex.org/W73242545', 'https://openalex.org/W3152246802', 'https://openalex.org/W31401667', 'https://openalex.org/W2561802298', 'https://openalex.org/W2369345461', 'https://openalex.org/W2254638634', 'https://openalex.org/W2127463799', 'https://openalex.org/W2123707479', 'https://openalex.org/W2075734225', 'https://openalex.org/W2042474810'], 'abstract_inverted_index': {'//': [0, 101, 106], 'Lingzhi': [1], 'Wang': [2], '1,2': [3], ',': [4, 10, 14, 18, 23, 27, 32, 37, 42, 47, 99, 104], 'Do': [5], 'Dang': [6], 'Khoa': [7], 'Phan': [8], '1,3': [9, 22], 'Jingwen': [11], 'Zhang': [12], '2': [13, 50, 67], 'Pei-Shi': [15], 'Ong': [16], '3': [17, 46, 76], 'Win': [19], 'Lwin': [20], 'Thuya': [21], 'Ross': [24], 'Soo': [25, 38], '1,4': [26, 31, 36, 41], 'Andrea': [28], 'Li-Ann': [29], 'Wong': [30], 'Wei': [33], 'Peng': [34], 'Yong': [35], 'Chin': [39], 'Lee': [40], 'Paul': [43], 'Chi-Lui': [44], 'Ho': [45], 'Gautam': [48, 102], 'Sethi': [49, 103], 'and': [51, 155, 171, 195, 197, 232, 238, 276, 280, 288], 'Boon': [52, 96], 'Cher': [53, 97], 'Goh': [54, 98], '1,2,4': [55], '1': [56], 'Cancer': [57], 'Science': [58], 'Institute': [59], 'of': [60, 64, 69, 78, 82, 87, 134, 142, 169, 183, 185, 190, 193, 199, 227, 252, 271, 284, 295, 297], 'Singapore,': [61, 65, 83], 'National': [62, 71, 80, 89], 'University': [63, 72, 81, 90], 'Singapore': [66, 75, 84, 93], 'Department': [68, 77, 86], 'Pharmacology,': [70], 'Health': [73, 91], 'System,': [74, 92], 'Pharmacy,': [79], '4': [85], 'Haematology-Oncology,': [88], 'Correspondence': [94], 'to:': [95], 'email:': [100, 105], 'Keywords': [107], ':': [108, 116, 121, 126], 'nimbolide,': [109], 'anticancer': [110, 164, 275], 'property,': [111], 'pharmacodynamics,': [112], 'pharmacokinetics,': [113], 'toxicology': [114], 'Received': [115], 'January': [117], '10,': [118], '2016': [119, 124, 129], 'Accepted': [120], 'March': [122, 127], '07,': [123], 'Published': [125], '24,': [128], 'Abstract': [130], 'Nimbolide': [131], 'is': [132, 212], 'one': [133], 'the': [135, 139, 215, 219, 225, 245, 250, 268, 282, 293], 'main': [136, 181], 'components': [137], 'in': [138, 153, 156, 177, 218, 243, 291], 'leaf': [140], 'extract': [141], 'Azadirachta': [143], 'indica': [144, 147], '(': [145], 'A.': [146], ').': [148], 'Accumulating': [149], 'evidence': [150], 'from': [151], 'various': [152, 304], 'vitro': [154], 'vivo': [157], 'studies': [158, 206, 231, 240, 290], 'indicates': [159], 'that': [160], 'nimbolide': [161, 186, 211, 253, 272, 298], 'possesses': [162], 'potent': [163], 'activity': [165, 176], 'against': [166, 303], 'several': [167], 'types': [168], 'cancer': [170], 'also': [172], 'shows': [173], 'potential': [174], 'chemopreventive': [175, 277], 'animal': [178], 'models.': [179], 'The': [180], 'mechanisms': [182], 'action': [184], 'include': [187], 'anti-proliferation,': [188], 'induction': [189], 'apoptosis,': [191], 'inhibition': [192], 'metastasis': [194], 'angiogenesis,': [196], 'modulation': [198], 'carcinogen-metabolizing': [200], 'enzymes.': [201], 'Although': [202], 'multiple': [203], 'pharmacodynamic': [204], '(PD)': [205], 'have': [207], 'been': [208], 'carried': [209], 'out,': [210], 'still': [213], 'at': [214], 'infant': [216], 'stage': [217], 'drug': [220], 'development': [221], 'pipeline': [222], 'due': [223], 'to': [224, 248], 'lack': [226], 'systematic': [228, 285], 'pharmacokinetic': [229], '(PK)': [230], 'long-term': [233], 'toxicological': [234, 239, 289], 'studies.': [235], 'Preclinical': [236], 'PK': [237, 287], 'are': [241], 'vital': [242], 'determining': [244], 'dosage': [246], 'range': [247], 'support': [249], 'safety': [251], 'for': [254, 267], 'first-in-human': [255], 'clinical': [256], 'trials.': [257], 'In': [258], 'this': [259], 'review,': [260], 'we': [261], 'will': [262], 'provide': [263], 'a': [264, 300], 'comprehensive': [265], 'summary': [266], 'current': [269], 'status': [270], 'as': [273, 299], 'an': [274], 'lead': [278], 'compound,': [279], 'highlight': [281], 'importance': [283], 'preclinical': [286], 'accelerating': [292], 'process': [294], 'application': [296], 'therapeutic': [301], 'agent': [302], 'malignancies.': [305]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2311660610', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}], 'updated_date': '2024-12-24T12:53:22.017453', 'created_date': '2016-06-24'}