Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2305817506', 'doi': 'https://doi.org/10.53846/goediss-413', 'title': 'Molecular Mechanisms of Serotonergic Signaling: Role in Neuronal Outgrowth and Receptor Oligomerization', 'display_name': 'Molecular Mechanisms of Serotonergic Signaling: Role in Neuronal Outgrowth and Receptor Oligomerization', 'publication_year': 2010, 'publication_date': '2010-01-01', 'ids': {'openalex': 'https://openalex.org/W2305817506', 'doi': 'https://doi.org/10.53846/goediss-413', 'mag': '2305817506'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.53846/goediss-413', 'pdf_url': 'https://ediss.uni-goettingen.de/bitstream/11858/00-1735-0000-0006-ADDB-2/1/kobe.pdf', 'source': None, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'dissertation', 'type_crossref': 'dissertation', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://ediss.uni-goettingen.de/bitstream/11858/00-1735-0000-0006-ADDB-2/1/kobe.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5056319077', 'display_name': 'Fritz Kobe', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': True, 'raw_author_name': 'Fritz Kobe', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': ['https://openalex.org/A5056319077'], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 64}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10077', 'display_name': 'Neuroscience and Neuropharmacology Research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10056', 'display_name': 'Neurotransmitter Receptor Influence on Behavior', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/synaptogenesis', 'display_name': 'Synaptogenesis', 'score': 0.8521632}, {'id': 'https://openalex.org/keywords/5-ht7-receptor', 'display_name': '5-HT7 receptor', 'score': 0.5698625}, {'id': 'https://openalex.org/keywords/palmitoylation', 'display_name': 'Palmitoylation', 'score': 0.4583712}, {'id': 'https://openalex.org/keywords/neurotransmitter-receptor', 'display_name': 'Neurotransmitter receptor', 'score': 0.4228479}, {'id': 'https://openalex.org/keywords/neurite', 'display_name': 'Neurite', 'score': 0.41140482}], 'concepts': [{'id': 'https://openalex.org/C65232495', 'wikidata': 'https://www.wikidata.org/wiki/Q1813773', 'display_name': 'Synaptogenesis', 'level': 2, 'score': 0.8521632}, {'id': 'https://openalex.org/C195454581', 'wikidata': 'https://www.wikidata.org/wiki/Q18027451', 'display_name': '5-HT7 receptor', 'level': 5, 'score': 0.5698625}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.56630874}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5117693}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.4897635}, {'id': 'https://openalex.org/C37000724', 'wikidata': 'https://www.wikidata.org/wiki/Q50430226', 'display_name': 'Serotonergic', 'level': 4, 'score': 0.4887819}, {'id': 'https://openalex.org/C146727910', 'wikidata': 'https://www.wikidata.org/wiki/Q501620', 'display_name': 'Palmitoylation', 'level': 4, 'score': 0.4583712}, {'id': 'https://openalex.org/C25274449', 'wikidata': 'https://www.wikidata.org/wiki/Q1805481', 'display_name': 'Long-term potentiation', 'level': 3, 'score': 0.44121024}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.43676353}, {'id': 'https://openalex.org/C156927020', 'wikidata': 'https://www.wikidata.org/wiki/Q1187783', 'display_name': 'Neurotransmitter receptor', 'level': 3, 'score': 0.4228479}, {'id': 'https://openalex.org/C53910766', 'wikidata': 'https://www.wikidata.org/wiki/Q238516', 'display_name': '5-HT receptor', 'level': 4, 'score': 0.41624364}, {'id': 'https://openalex.org/C113246987', 'wikidata': 'https://www.wikidata.org/wiki/Q1534415', 'display_name': 'Neurite', 'level': 3, 'score': 0.41140482}, {'id': 'https://openalex.org/C2775864247', 'wikidata': 'https://www.wikidata.org/wiki/Q167934', 'display_name': 'Serotonin', 'level': 3, 'score': 0.36320123}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.32171738}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.10407567}, {'id': 'https://openalex.org/C2779201268', 'wikidata': 'https://www.wikidata.org/wiki/Q186474', 'display_name': 'Cysteine', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.53846/goediss-413', 'pdf_url': 'https://ediss.uni-goettingen.de/bitstream/11858/00-1735-0000-0006-ADDB-2/1/kobe.pdf', 'source': None, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.53846/goediss-413', 'pdf_url': 'https://ediss.uni-goettingen.de/bitstream/11858/00-1735-0000-0006-ADDB-2/1/kobe.pdf', 'source': None, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 159, 'referenced_works': ['https://openalex.org/W1492552461', 'https://openalex.org/W1502719441', 'https://openalex.org/W1514853588', 'https://openalex.org/W1559720000', 'https://openalex.org/W1571283914', 'https://openalex.org/W1571586310', 'https://openalex.org/W1585071559', 'https://openalex.org/W1594412667', 'https://openalex.org/W1595449036', 'https://openalex.org/W1603274157', 'https://openalex.org/W1604949247', 'https://openalex.org/W1654156243', 'https://openalex.org/W1677457722', 'https://openalex.org/W1800775388', 'https://openalex.org/W1832579829', 'https://openalex.org/W1897633092', 'https://openalex.org/W1963806203', 'https://openalex.org/W1966384693', 'https://openalex.org/W1968362922', 'https://openalex.org/W1968873990', 'https://openalex.org/W1969529880', 'https://openalex.org/W1973651880', 'https://openalex.org/W1976476429', 'https://openalex.org/W1977637450', 'https://openalex.org/W1979746078', 'https://openalex.org/W1984429646', 'https://openalex.org/W1986308794', 'https://openalex.org/W1991355251', 'https://openalex.org/W1997266942', 'https://openalex.org/W1998170691', 'https://openalex.org/W1999175477', 'https://openalex.org/W2000942012', 'https://openalex.org/W2008264122', 'https://openalex.org/W2008721272', 'https://openalex.org/W2010465386', 'https://openalex.org/W2010805571', 'https://openalex.org/W2011188320', 'https://openalex.org/W2011302529', 'https://openalex.org/W2011812102', 'https://openalex.org/W2012726689', 'https://openalex.org/W2014001501', 'https://openalex.org/W2015701831', 'https://openalex.org/W2015986915', 'https://openalex.org/W2023343746', 'https://openalex.org/W2023396177', 'https://openalex.org/W2033907545', 'https://openalex.org/W2034466289', 'https://openalex.org/W2035632600', 'https://openalex.org/W2036312511', 'https://openalex.org/W2036842366', 'https://openalex.org/W2037773086', 'https://openalex.org/W2038174426', 'https://openalex.org/W2038465216', 'https://openalex.org/W2038634187', 'https://openalex.org/W2039229115', 'https://openalex.org/W2039247434', 'https://openalex.org/W2039712591', 'https://openalex.org/W2041211150', 'https://openalex.org/W2041611018', 'https://openalex.org/W2043555322', 'https://openalex.org/W2046013863', 'https://openalex.org/W2046161078', 'https://openalex.org/W2047535883', 'https://openalex.org/W2048390573', 'https://openalex.org/W2048790339', 'https://openalex.org/W2049842274', 'https://openalex.org/W2051543649', 'https://openalex.org/W2052213011', 'https://openalex.org/W2053912448', 'https://openalex.org/W2053962612', 'https://openalex.org/W2054676102', 'https://openalex.org/W2056204017', 'https://openalex.org/W2059321099', 'https://openalex.org/W2061568866', 'https://openalex.org/W2061895982', 'https://openalex.org/W2062239193', 'https://openalex.org/W2062495736', 'https://openalex.org/W2063315973', 'https://openalex.org/W2064483656', 'https://openalex.org/W2065391976', 'https://openalex.org/W2066495105', 'https://openalex.org/W2066584584', 'https://openalex.org/W2067308061', 'https://openalex.org/W2067341830', 'https://openalex.org/W2070290419', 'https://openalex.org/W2071276554', 'https://openalex.org/W2071810655', 'https://openalex.org/W2074215405', 'https://openalex.org/W2075975673', 'https://openalex.org/W2078708066', 'https://openalex.org/W2079052124', 'https://openalex.org/W2079054696', 'https://openalex.org/W2080461836', 'https://openalex.org/W2081117049', 'https://openalex.org/W2081163089', 'https://openalex.org/W2084155232', 'https://openalex.org/W2086606183', 'https://openalex.org/W2087471150', 'https://openalex.org/W2087931875', 'https://openalex.org/W2088620464', 'https://openalex.org/W2089393387', 'https://openalex.org/W2092437783', 'https://openalex.org/W2093598851', 'https://openalex.org/W2094590111', 'https://openalex.org/W2094832018', 'https://openalex.org/W2096791952', 'https://openalex.org/W2098053808', 'https://openalex.org/W2102312968', 'https://openalex.org/W2102463040', 'https://openalex.org/W2109014958', 'https://openalex.org/W2110469184', 'https://openalex.org/W2112927743', 'https://openalex.org/W2113638222', 'https://openalex.org/W2115476261', 'https://openalex.org/W2115584694', 'https://openalex.org/W2118950099', 'https://openalex.org/W2119335473', 'https://openalex.org/W2122925019', 'https://openalex.org/W2124233079', 'https://openalex.org/W2126541892', 'https://openalex.org/W2129105333', 'https://openalex.org/W2129972752', 'https://openalex.org/W2135455927', 'https://openalex.org/W2138743300', 'https://openalex.org/W2139846514', 'https://openalex.org/W2140465906', 'https://openalex.org/W2141114982', 'https://openalex.org/W2141367941', 'https://openalex.org/W2142891272', 'https://openalex.org/W2149184122', 'https://openalex.org/W2149678096', 'https://openalex.org/W2149773101', 'https://openalex.org/W2154527655', 'https://openalex.org/W2154865824', 'https://openalex.org/W2157959080', 'https://openalex.org/W2158080755', 'https://openalex.org/W2158207659', 'https://openalex.org/W2158403274', 'https://openalex.org/W2159380046', 'https://openalex.org/W2159736704', 'https://openalex.org/W2162254167', 'https://openalex.org/W2164697276', 'https://openalex.org/W2165697065', 'https://openalex.org/W2168909179', 'https://openalex.org/W2169473035', 'https://openalex.org/W2169702025', 'https://openalex.org/W2291655684', 'https://openalex.org/W4213393192', 'https://openalex.org/W4233523656', 'https://openalex.org/W4235182381', 'https://openalex.org/W4243131780', 'https://openalex.org/W4246584994', 'https://openalex.org/W4249590403', 'https://openalex.org/W4251828057', 'https://openalex.org/W4252610175', 'https://openalex.org/W4255576723', 'https://openalex.org/W4299496276', 'https://openalex.org/W4299606540', 'https://openalex.org/W4300532339'], 'related_works': ['https://openalex.org/W4313654191', 'https://openalex.org/W2803469638', 'https://openalex.org/W2795395565', 'https://openalex.org/W2591327009', 'https://openalex.org/W2407597967', 'https://openalex.org/W2072438443', 'https://openalex.org/W2012467082', 'https://openalex.org/W1966020275', 'https://openalex.org/W1559137512', 'https://openalex.org/W146028978'], 'abstract_inverted_index': {'Role': [0], 'of': [1, 17, 37, 46, 62, 77, 82, 88, 94, 103, 126, 141, 153, 172, 182, 194, 211, 249, 261, 276, 295, 300, 331, 338, 348, 364, 368, 371], '5-HT7/G12': [2, 78], 'signaling': [3, 79, 100, 144], 'in': [4, 116, 145, 203, 214, 220, 314, 354, 366], 'morpho-': [5], 'and': [6, 24, 85, 111, 130, 157, 199, 228, 235, 263, 319], 'synaptogenesis.': [7, 86], 'The': [8, 56, 298], 'neurotransmitter': [9], 'serotonin': [10, 40, 167, 196], '(5-hydroxytryptamine': [11], 'or': [12], '5-HT)': [13], 'modulates': [14], 'different': [15], 'aspects': [16], 'early': [18, 178], 'neuronal': [19, 109, 174], 'differentiation,': [20], 'including': [21], 'neurite': [22], 'outgrowth': [23], 'synaptogenesis,': [25], 'before': [26], 'it': [27], 'acts': [28], 'as': [29, 50, 52, 266, 268], 'a': [30, 162, 280], 'neurotransmitter.': [31], 'Here': [32], 'we': [33, 189, 289], 'report': [34], 'that': [35, 98, 123, 225, 236, 304, 324], 'activation': [36], 'the': [38, 47, 63, 70, 74, 92, 107, 124, 139, 170, 177, 186, 191, 195, 209, 237, 242, 259, 273, 286, 292, 344, 362, 369], '5-HT7': [39, 64, 128, 155], 'receptor': [41, 65, 129, 156, 198, 212, 239, 296, 359], 'promotes': [42], 'dendritic': [43, 83, 104], 'branching,': [44], 'formation': [45, 81, 102, 171], 'new': [48], 'synapses': [49], 'well': [51, 267], 'spontaneous': [53], 'synaptic': [54], 'activity.': [55], 'morphological': [57], 'effects': [58, 140], 'obtained': [59], 'upon': [60], 'stimulation': [61], 'were': [66, 148], 'mediated': [67, 328, 346], 'solely': [68], 'by': [69, 165, 329, 336, 357], 'G12': [71, 131, 158], 'protein,': [72], 'demonstrating': [73, 361], 'critical': [75], 'role': [76, 210], 'for': [80, 309], 'filopodia': [84], 'Analysis': [87], 'organotypic': [89], 'preparation': [90], 'from': [91], 'hippocampus': [93], 'juvenile': [95], 'mice': [96, 147], 'demonstrate': [97], '5-HT7R/G12': [99], 'potentiates': [101], 'spines,': [105], 'increases': [106], 'basal': [108, 173], 'excitability': [110], 'leads': [112], 'to': [113, 316, 340], 'robust': [114], 'changes': [115], 'long-term': [117], 'potentiation': [118], '(LTP).': [119], 'We': [120, 206], 'also': [121, 207, 290], 'found': [122], 'expression': [125, 152], 'both': [127, 154, 226], 'protein': [132, 159], 'was': [133, 327, 351], 'significantly': [134, 312], 'reduced': [135], 'during': [136, 176], 'development.': [137, 180], 'Accordingly': [138], '5-': [142], 'HT7/G12': [143], 'adult': [146], 'abolished.': [149], 'Thus,': [150], 'regulated': [151], 'may': [160], 'represent': [161], 'molecular': [163], 'mechanisms': [164], 'which': [166], 'specifically': [168], 'modulate': [169], 'connections': [175], 'postnatal': [179], 'Oligomerization': [181], '5-HT1A': [183, 197, 231, 270], 'receptor.': [184], 'In': [185, 342], 'present': [187], 'study': [188], 'analyzed': [190], 'oligomerization': [192, 201, 301], 'state': [193], 'studied': [200], 'dynamics': [202, 302], 'living': [204, 277], 'cells.': [205, 278], 'investigated': [208], 'palmitoylation': [213, 365], 'this': [215, 325], 'process.': [216], 'Biochemical': [217], 'analysis': [218, 288, 299], 'performed': [219], 'neuroblastoma': [221], 'N1E-115': [222], 'cells': [223], 'demonstrated': [224], 'palmitoylated': [227, 230], 'non': [229], 'receptors': [232, 271], 'form': [233], 'homo-oligomers': [234], 'prevalent': [238], 'species': [240], 'at': [241, 272], 'plasma': [243, 274], 'membrane': [244, 275], 'are': [245], 'dimers.': [246], 'A': [247], 'combination': [248], 'an': [250], 'acceptor-photobleaching': [251], 'FRET': [252, 282, 306, 349], 'approach': [253], 'with': [254], 'fluorescence': [255], 'lifetime': [256], 'measurements': [257], 'verified': [258], 'interaction': [260], 'CFP-': [262], 'YFP-labeled': [264], 'wild-type': [265, 310], 'acylation-deficient': [269], 'Using': [279], 'novel': [281], 'technique': [283], 'based': [284], 'on': [285], 'spectral': [287], 'confirmed': [291], 'specific': [293], 'nature': [294], 'oligomerization.': [297], 'revealed': [303], 'apparent': [305], 'efficiency': [307], 'measured': [308], 'oligomers': [311, 339, 355], 'decreased': [313], 'response': [315], 'agonist': [317, 345], 'stimulation,': [318], 'our': [320], 'combined': [321], 'results': [322], 'suggest': [323], 'decrease': [326, 347], 'accumulation': [330], 'FRET-negative': [332], 'complexes': [333], 'rather': [334], 'than': [335], 'dissociation': [337], 'monomers.': [341], 'contrast,': [343], 'signal': [350], 'completely': [352], 'abolished': [353], 'composed': [356], 'non-palmitoylated': [358], 'mutants,': [360], 'importance': [363], 'modulation': [367], 'structure': [370], 'oligomers.': [372]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2305817506', 'counts_by_year': [], 'updated_date': '2024-12-06T03:03:30.055305', 'created_date': '2016-06-24'}