Publication Information

{'id': 'https://openalex.org/W2304994032', 'doi': 'https://doi.org/10.18632/oncotarget.9122', 'title': 'Repurposing atovaquone: Targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells', 'display_name': 'Repurposing atovaquone: Targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells', 'publication_year': 2016, 'publication_date': '2016-04-30', 'ids': {'openalex': 'https://openalex.org/W2304994032', 'doi': 'https://doi.org/10.18632/oncotarget.9122', 'mag': '2304994032', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27136895', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5085139'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.9122', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=9122&path%5B%5D=27796', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=9122&path%5B%5D=27796', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5047846477', 'display_name': 'Marco Fiorillo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I28407311', 'display_name': 'University of Manchester', 'ror': 'https://ror.org/027m9bs27', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I28407311']}, {'id': 'https://openalex.org/I4210129527', 'display_name': 'Cancer Research UK Manchester Institute', 'ror': 'https://ror.org/037405c78', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I2801316944', 'https://openalex.org/I4210129527']}, {'id': 'https://openalex.org/I45204951', 'display_name': 'University of Calabria', 'ror': 'https://ror.org/02rc97e94', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45204951']}, {'id': 'https://openalex.org/I2799938689', 'display_name': 'Breast Cancer Now', 'ror': 'https://ror.org/02qa92s63', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2799938689']}], 'countries': ['GB', 'IT'], 'is_corresponding': False, 'raw_author_name': 'Marco Fiorillo', 'raw_affiliation_strings': ['The Breast Cancer Now Research Unit, Institute of Cancer Sciences, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK', 'The Department of Pharmacy, Health and Nutritional Sciences, The University of Calabria, Cosenza, Italy', 'The Manchester Centre for Cellular Metabolism (MCCM), Institute of Cancer Sciences, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK'], 'affiliations': [{'raw_affiliation_string': 'The Breast Cancer Now Research Unit, Institute of Cancer Sciences, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK', 'institution_ids': ['https://openalex.org/I28407311', 'https://openalex.org/I4210129527', 'https://openalex.org/I2799938689']}, {'raw_affiliation_string': 'The Manchester Centre for Cellular Metabolism (MCCM), Institute of Cancer Sciences, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK', 'institution_ids': ['https://openalex.org/I4210129527', 'https://openalex.org/I28407311']}, {'raw_affiliation_string': 'The Department of Pharmacy, Health and Nutritional Sciences, The University of Calabria, Cosenza, Italy', 'institution_ids': ['https://openalex.org/I45204951']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063499733', 'display_name': 'Rebecca Lamb', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210129527', 'display_name': 'Cancer Research UK Manchester Institute', 'ror': 'https://ror.org/037405c78', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I2801316944', 'https://openalex.org/I4210129527']}, {'id': 'https://openalex.org/I2799938689', 'display_name': 'Breast Cancer Now', 'ror': 'https://ror.org/02qa92s63', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2799938689']}, {'id': 'https://openalex.org/I28407311', 'display_name': 'University of Manchester', 'ror': 'https://ror.org/027m9bs27', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I28407311']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Rebecca Lamb', 'raw_affiliation_strings': ['The Breast Cancer Now Research Unit, Institute of Cancer Sciences, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK'], 'affiliations': [{'raw_affiliation_string': 'The Breast Cancer Now Research Unit, Institute of Cancer Sciences, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK', 'institution_ids': ['https://openalex.org/I4210129527', 'https://openalex.org/I2799938689', 'https://openalex.org/I28407311']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056625596', 'display_name': 'Herbert B. Tanowitz', 'orcid': 'https://orcid.org/0000-0002-5328-3783'}, 'institutions': [{'id': 'https://openalex.org/I129975664', 'display_name': 'Albert Einstein College of Medicine', 'ror': 'https://ror.org/05cf8a891', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I129975664', 'https://openalex.org/I4210112371']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Herbert B. Tanowitz', 'raw_affiliation_strings': ['Department of Medicine and Pathology, Albert Einstein College of Medicine, Bronx, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine and Pathology, Albert Einstein College of Medicine, Bronx, NY, USA', 'institution_ids': ['https://openalex.org/I129975664']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084519811', 'display_name': 'Luciano Mutti', 'orcid': 'https://orcid.org/0000-0002-1578-2637'}, 'institutions': [{'id': 'https://openalex.org/I54459138', 'display_name': 'University of Salford', 'ror': 'https://ror.org/01tmqtf75', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I54459138']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Luciano Mutti', 'raw_affiliation_strings': ['School of Environment and Life Sciences, University of Salford, Salford, UK'], 'affiliations': [{'raw_affiliation_string': 'School of Environment and Life Sciences, University of Salford, Salford, UK', 'institution_ids': ['https://openalex.org/I54459138']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027312995', 'display_name': 'Marija Krstic‐Demonacos', 'orcid': 'https://orcid.org/0000-0002-3914-4488'}, 'institutions': [{'id': 'https://openalex.org/I54459138', 'display_name': 'University of Salford', 'ror': 'https://ror.org/01tmqtf75', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I54459138']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Marija Krstic-Demonacos', 'raw_affiliation_strings': ['School of Environment and Life Sciences, University of Salford, Salford, UK'], 'affiliations': [{'raw_affiliation_string': 'School of Environment and Life Sciences, University of Salford, Salford, UK', 'institution_ids': ['https://openalex.org/I54459138']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021882845', 'display_name': 'Anna Rita Cappello', 'orcid': 'https://orcid.org/0000-0001-7824-3561'}, 'institutions': [{'id': 'https://openalex.org/I45204951', 'display_name': 'University of Calabria', 'ror': 'https://ror.org/02rc97e94', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45204951']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Anna Rita Cappello', 'raw_affiliation_strings': ['The Department of Pharmacy, Health and Nutritional Sciences, The University of Calabria, Cosenza, Italy'], 'affiliations': [{'raw_affiliation_string': 'The Department of Pharmacy, Health and Nutritional Sciences, The University of Calabria, Cosenza, Italy', 'institution_ids': ['https://openalex.org/I45204951']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077605764', 'display_name': 'Ubaldo Martinez‐Outschoorn', 'orcid': 'https://orcid.org/0000-0003-1483-4551'}, 'institutions': [{'id': 'https://openalex.org/I4210106595', 'display_name': 'Sidney Kimmel Cancer Center', 'ror': 'https://ror.org/010h6g454', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210106595']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ubaldo E. Martinez-Outschoorn', 'raw_affiliation_strings': ['The Sidney Kimmel Cancer Center, Philadelphia, PA, USA'], 'affiliations': [{'raw_affiliation_string': 'The Sidney Kimmel Cancer Center, Philadelphia, PA, USA', 'institution_ids': ['https://openalex.org/I4210106595']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091000979', 'display_name': 'Federica Sotgia', 'orcid': 'https://orcid.org/0000-0003-2826-4529'}, 'institutions': [{'id': 'https://openalex.org/I4210129527', 'display_name': 'Cancer Research UK Manchester Institute', 'ror': 'https://ror.org/037405c78', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I2801316944', 'https://openalex.org/I4210129527']}, {'id': 'https://openalex.org/I2799938689', 'display_name': 'Breast Cancer Now', 'ror': 'https://ror.org/02qa92s63', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2799938689']}, {'id': 'https://openalex.org/I28407311', 'display_name': 'University of Manchester', 'ror': 'https://ror.org/027m9bs27', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I28407311']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Federica Sotgia', 'raw_affiliation_strings': ['The Breast Cancer Now Research Unit, Institute of Cancer Sciences, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK', 'The Manchester Centre for Cellular Metabolism (MCCM), Institute of Cancer Sciences, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK'], 'affiliations': [{'raw_affiliation_string': 'The Breast Cancer Now Research Unit, Institute of Cancer Sciences, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK', 'institution_ids': ['https://openalex.org/I4210129527', 'https://openalex.org/I2799938689', 'https://openalex.org/I28407311']}, {'raw_affiliation_string': 'The Manchester Centre for Cellular Metabolism (MCCM), Institute of Cancer Sciences, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK', 'institution_ids': ['https://openalex.org/I28407311', 'https://openalex.org/I4210129527']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5016681558', 'display_name': 'Michael P. Lisanti', 'orcid': 'https://orcid.org/0000-0003-2034-1382'}, 'institutions': [{'id': 'https://openalex.org/I4210129527', 'display_name': 'Cancer Research UK Manchester Institute', 'ror': 'https://ror.org/037405c78', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I2801316944', 'https://openalex.org/I4210129527']}, {'id': 'https://openalex.org/I2799938689', 'display_name': 'Breast Cancer Now', 'ror': 'https://ror.org/02qa92s63', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2799938689']}, {'id': 'https://openalex.org/I28407311', 'display_name': 'University of Manchester', 'ror': 'https://ror.org/027m9bs27', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I28407311']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Michael P. Lisanti', 'raw_affiliation_strings': ['The Breast Cancer Now Research Unit, Institute of Cancer Sciences, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK', 'The Manchester Centre for Cellular Metabolism (MCCM), Institute of Cancer Sciences, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK'], 'affiliations': [{'raw_affiliation_string': 'The Breast Cancer Now Research Unit, Institute of Cancer Sciences, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK', 'institution_ids': ['https://openalex.org/I4210129527', 'https://openalex.org/I2799938689', 'https://openalex.org/I28407311']}, {'raw_affiliation_string': 'The Manchester Centre for Cellular Metabolism (MCCM), Institute of Cancer Sciences, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK', 'institution_ids': ['https://openalex.org/I28407311', 'https://openalex.org/I4210129527']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 7, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 7.838, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 192, 'citation_normalized_percentile': {'value': 0.999984, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '7', 'issue': '23', 'first_page': '34084', 'last_page': '34099'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11736', 'display_name': 'Histone Deacetylase Inhibitors Research', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/atovaquone', 'display_name': 'Atovaquone', 'score': 0.9268265}], 'concepts': [{'id': 'https://openalex.org/C2779124865', 'wikidata': 'https://www.wikidata.org/wiki/Q418179', 'display_name': 'Atovaquone', 'level': 4, 'score': 0.9268265}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.58710414}, {'id': 'https://openalex.org/C55427017', 'wikidata': 'https://www.wikidata.org/wiki/Q1638475', 'display_name': 'Cancer stem cell', 'level': 3, 'score': 0.5772289}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5678767}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.50984424}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.45212272}, {'id': 'https://openalex.org/C2779343474', 'wikidata': 'https://www.wikidata.org/wiki/Q3109175', 'display_name': 'Context (archaeology)', 'level': 2, 'score': 0.4297285}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.36409348}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3580194}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3532526}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.32190388}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.28704965}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.23622534}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.11947563}, {'id': 'https://openalex.org/C2778371730', 'wikidata': 'https://www.wikidata.org/wiki/Q311383', 'display_name': 'Plasmodium falciparum', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C2778048844', 'wikidata': 'https://www.wikidata.org/wiki/Q12156', 'display_name': 'Malaria', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C151730666', 'wikidata': 'https://www.wikidata.org/wiki/Q7205', 'display_name': 'Paleontology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D053626', 'descriptor_name': 'Atovaquone', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D010085', 'descriptor_name': 'Oxidative Phosphorylation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053626', 'descriptor_name': 'Atovaquone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058492', 'descriptor_name': 'Drug Repositioning', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014450', 'descriptor_name': 'Electron Transport Complex III', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014450', 'descriptor_name': 'Electron Transport Complex III', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061986', 'descriptor_name': 'MCF-7 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010085', 'descriptor_name': 'Oxidative Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.9122', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=9122&path%5B%5D=27796', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5085139', 'pdf_url': 'https://europepmc.org/articles/pmc5085139?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085139', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27136895', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.9122', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=9122&path%5B%5D=27796', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.85, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 47, 'referenced_works': ['https://openalex.org/W1532133662', 'https://openalex.org/W1536698969', 'https://openalex.org/W1546117988', 'https://openalex.org/W1707356941', 'https://openalex.org/W1802480460', 'https://openalex.org/W1821144537', 'https://openalex.org/W1892036645', 'https://openalex.org/W1897724420', 'https://openalex.org/W1965124339', 'https://openalex.org/W1980806488', 'https://openalex.org/W1990574061', 'https://openalex.org/W1996070288', 'https://openalex.org/W1997227711', 'https://openalex.org/W2005609755', 'https://openalex.org/W2007561244', 'https://openalex.org/W2025605230', 'https://openalex.org/W2025781604', 'https://openalex.org/W2028593825', 'https://openalex.org/W2036168963', 'https://openalex.org/W2039109621', 'https://openalex.org/W2040017417', 'https://openalex.org/W2040665226', 'https://openalex.org/W2041506162', 'https://openalex.org/W2052077267', 'https://openalex.org/W2052569390', 'https://openalex.org/W2059613997', 'https://openalex.org/W2064442490', 'https://openalex.org/W2068125083', 'https://openalex.org/W2073693069', 'https://openalex.org/W2086828029', 'https://openalex.org/W2088767666', 'https://openalex.org/W2089986767', 'https://openalex.org/W2095568712', 'https://openalex.org/W2101885447', 'https://openalex.org/W2105267564', 'https://openalex.org/W2106028964', 'https://openalex.org/W2107503279', 'https://openalex.org/W2120656656', 'https://openalex.org/W2129173330', 'https://openalex.org/W2135331361', 'https://openalex.org/W2138488546', 'https://openalex.org/W2151166944', 'https://openalex.org/W2157592907', 'https://openalex.org/W2159640574', 'https://openalex.org/W2161080156', 'https://openalex.org/W2181288376', 'https://openalex.org/W2316165330'], 'related_works': ['https://openalex.org/W4200356915', 'https://openalex.org/W2898962596', 'https://openalex.org/W2602673417', 'https://openalex.org/W2415623504', 'https://openalex.org/W2378375764', 'https://openalex.org/W2339474595', 'https://openalex.org/W2170059940', 'https://openalex.org/W1990845261', 'https://openalex.org/W1964532785', 'https://openalex.org/W135882869'], 'abstract_inverted_index': {'Atovaquone': [0, 32, 143], 'is': [1, 19, 33, 46, 57, 164, 174, 236, 265], 'an': [2, 132, 228], 'FDA-approved': [3], 'anti-malarial': [4], 'drug,': [5], 'which': [6, 173], 'first': [7, 81], 'became': [8], 'clinically': [9], 'available': [10], 'in': [11, 29, 150, 193, 217, 222, 238, 245, 274], 'the': [12, 21, 70, 80, 126, 140, 169, 185, 232, 256], 'year': [13], '2000.': [14], 'Currently,': [15], 'its': [16, 270], 'main': [17], 'usage': [18], 'for': [20, 79, 206, 241], 'treatment': [22, 101], 'of': [23, 37, 72, 102, 128, 134, 153, 171, 187, 258], 'pneumocystis': [24], 'pneumonia': [25], '(PCP)': [26], 'and/or': [27], 'toxoplasmosis': [28], 'immune-compromised': [30], 'patients.': [31], 'a': [34, 47, 62], 'hydroxy-1,4-naphthoquinone': [35], 'analogue': [36], 'ubiquinone,': [38], 'also': [39, 85, 144, 190], 'known': [40], 'as': [41, 61, 117, 119, 137, 227, 255], 'Co-enzyme': [42], 'Q10': [43], '(CoQ10).': [44], 'It': [45], 'well-tolerated': [48, 237], 'drug': [49], 'that': [50, 83, 99, 161, 234], 'does': [51], 'not': [52, 165], 'cause': [53], 'myelo-suppression.': [54], 'Mechanistically,': [55], 'it': [56, 210, 235], 'thought': [58], 'to': [59, 167, 183, 203], 'act': [60], 'potent': [63], 'and': [64, 109, 148, 155, 197, 248], 'selective': [65], 'OXPHOS': [66], 'inhibitor,': [67], 'by': [68], 'targeting': [69, 184], 'CoQ10-dependence': [71], 'mitochondrial': [73, 179], 'complex': [74], 'III.': [75], 'Here,': [76], 'we': [77, 97], 'show': [78], 'time': [82], 'atovaquone': [84, 100, 123, 189], 'has': [86, 211], 'anti-cancer': [87], 'activity,': [88], 'directed': [89], 'against': [90], 'Cancer': [91], 'Stem-like': [92], 'Cells': [93], '(CSCs).': [94], 'More': [95], 'specifically,': [96], 'demonstrate': [98], 'MCF7': [103], 'breast': [104], 'cancer': [105], 'cells': [106], 'inhibits': [107, 125], 'oxygen-consumption': [108], 'metabolically': [110], 'induces': [111, 191], 'aerobic': [112], 'glycolysis': [113, 162], '(the': [114], 'Warburg': [115], 'effect),': [116], 'well': [118], 'oxidative': [120], 'stress.': [121], 'Remarkably,': [122], 'potently': [124], 'propagation': [127], 'MCF7-derived': [129], 'CSCs,': [130, 172, 188], 'with': [131, 231], 'IC-50': [133, 257], '1': [135], 'μM,': [136], 'measured': [138], 'using': [139], 'mammosphere': [141], 'assay.': [142], 'maintains': [145], 'this': [146, 223], 'selectivity': [147], 'potency': [149], 'mixed': [151], 'populations': [152], 'CSCs': [154, 262], 'non-CSCs.': [156], 'Importantly,': [157], 'these': [158], 'results': [159], 'indicate': [160], 'itself': [163], 'sufficient': [166], 'maintain': [168], 'proliferation': [170, 186], 'instead': [175], 'strictly': [176], 'dependent': [177], 'on': [178, 214, 261], 'function.': [180], 'In': [181], 'addition': [182], 'apoptosis': [192], 'both': [194], 'CD44+/CD24low/-': [195], 'CSC': [196, 199], 'ALDH+': [198], 'populations,': [200], 'during': [201], 'exposure': [202], 'anchorage-independent': [204], 'conditions': [205], '12': [207], 'hours.': [208], 'However,': [209], 'no': [212], 'effect': [213], 'oxygen': [215], 'consumption': [216], 'normal': [218], 'human': [219, 249], 'fibroblasts': [220], 'and,': [221], 'cellular': [224], 'context,': [225], 'behaves': [226], 'anti-inflammatory,': [229], 'consistent': [230], 'fact': [233], 'patients': [239], 'treated': [240], 'infections.': [242], 'Future': [243], 'studies': [244], 'xenograft': [246], 'models': [247], 'clinical': [250], 'trials': [251], 'may': [252], 'be': [253], 'warranted,': [254], "atovaquone's": [259], 'action': [260], '(1': [263], 'μM)': [264], '>50': [266], 'times': [267], 'less': [268], 'than': [269], 'average': [271], 'serum': [272], 'concentration': [273], 'humans.': [275]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2304994032', 'counts_by_year': [{'year': 2024, 'cited_by_count': 13}, {'year': 2023, 'cited_by_count': 20}, {'year': 2022, 'cited_by_count': 24}, {'year': 2021, 'cited_by_count': 33}, {'year': 2020, 'cited_by_count': 33}, {'year': 2019, 'cited_by_count': 21}, {'year': 2018, 'cited_by_count': 24}, {'year': 2017, 'cited_by_count': 20}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-12-24T12:53:50.273286', 'created_date': '2016-06-24'}