Publication Information

{'id': 'https://openalex.org/W2304569214', 'doi': 'https://doi.org/10.1038/srep22722', 'title': 'The identification of age-associated cancer markers by an integrative analysis of dynamic DNA methylation changes', 'display_name': 'The identification of age-associated cancer markers by an integrative analysis of dynamic DNA methylation changes', 'publication_year': 2016, 'publication_date': '2016-03-07', 'ids': {'openalex': 'https://openalex.org/W2304569214', 'doi': 'https://doi.org/10.1038/srep22722', 'mag': '2304569214', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26949191', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4779991'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/srep22722', 'pdf_url': 'https://www.nature.com/articles/srep22722.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.nature.com/articles/srep22722.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100428930', 'display_name': 'Yihan Wang', 'orcid': 'https://orcid.org/0000-0002-1163-4610'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yihan Wang', 'raw_affiliation_strings': ['College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China'], 'affiliations': [{'raw_affiliation_string': 'College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China', 'institution_ids': ['https://openalex.org/I156144747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100335751', 'display_name': 'Jingyu Zhang', 'orcid': 'https://orcid.org/0000-0003-4820-577X'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}, {'id': 'https://openalex.org/I4210156501', 'display_name': 'First Affiliated Hospital of Harbin Medical University', 'ror': 'https://ror.org/05vy2sc54', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210156501']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jingyu Zhang', 'raw_affiliation_strings': ['Department of Gerontology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Gerontology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China', 'institution_ids': ['https://openalex.org/I156144747', 'https://openalex.org/I4210156501']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102209671', 'display_name': 'Xingjun Xiao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210132813', 'display_name': 'Second Affiliated Hospital of Harbin Medical University', 'ror': 'https://ror.org/03s8txj32', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210132813']}, {'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xingjun Xiao', 'raw_affiliation_strings': ['Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Harbin, 150086, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Harbin, 150086, China', 'institution_ids': ['https://openalex.org/I4210132813', 'https://openalex.org/I156144747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045576282', 'display_name': 'Hongbo Liu', 'orcid': 'https://orcid.org/0000-0002-0733-8616'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hongbo Liu', 'raw_affiliation_strings': ['College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China'], 'affiliations': [{'raw_affiliation_string': 'College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China', 'institution_ids': ['https://openalex.org/I156144747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100321414', 'display_name': 'Fang Wang', 'orcid': 'https://orcid.org/0000-0002-4781-8673'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Fang Wang', 'raw_affiliation_strings': ['College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China'], 'affiliations': [{'raw_affiliation_string': 'College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China', 'institution_ids': ['https://openalex.org/I156144747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100448184', 'display_name': 'Song Li', 'orcid': 'https://orcid.org/0000-0001-7679-1548'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Song Li', 'raw_affiliation_strings': ['College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China'], 'affiliations': [{'raw_affiliation_string': 'College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China', 'institution_ids': ['https://openalex.org/I156144747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002048484', 'display_name': 'Yanhua Wen', 'orcid': 'https://orcid.org/0000-0001-8677-5680'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yanhua Wen', 'raw_affiliation_strings': ['College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China'], 'affiliations': [{'raw_affiliation_string': 'College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China', 'institution_ids': ['https://openalex.org/I156144747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056869329', 'display_name': 'Yanjun Wei', 'orcid': 'https://orcid.org/0000-0003-4200-2859'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yanjun Wei', 'raw_affiliation_strings': ['College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China'], 'affiliations': [{'raw_affiliation_string': 'College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China', 'institution_ids': ['https://openalex.org/I156144747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083159278', 'display_name': 'Jianzhong Su', 'orcid': 'https://orcid.org/0000-0002-1172-7411'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jianzhong Su', 'raw_affiliation_strings': ['College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China'], 'affiliations': [{'raw_affiliation_string': 'College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China', 'institution_ids': ['https://openalex.org/I156144747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013514007', 'display_name': 'Yunming Zhang', 'orcid': 'https://orcid.org/0000-0001-7120-7760'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}, {'id': 'https://openalex.org/I4210156501', 'display_name': 'First Affiliated Hospital of Harbin Medical University', 'ror': 'https://ror.org/05vy2sc54', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210156501']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yunming Zhang', 'raw_affiliation_strings': ['Department of Gerontology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Gerontology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China', 'institution_ids': ['https://openalex.org/I156144747', 'https://openalex.org/I4210156501']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100456347', 'display_name': 'Yan Zhang', 'orcid': 'https://orcid.org/0000-0002-9625-2581'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yan Zhang', 'raw_affiliation_strings': ['College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China'], 'affiliations': [{'raw_affiliation_string': 'College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China', 'institution_ids': ['https://openalex.org/I156144747']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1890, 'currency': 'EUR', 'value_usd': 2190, 'provenance': 'doaj'}, 'apc_paid': {'value': 1890, 'currency': 'EUR', 'value_usd': 2190, 'provenance': 'doaj'}, 'fwci': 1.663, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 24, 'citation_normalized_percentile': {'value': 0.833945, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '6', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11928', 'display_name': 'Genetic Syndromes and Imprinting', 'score': 0.9855, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11983', 'display_name': 'Identity, Memory, and Therapy', 'score': 0.9605, 'subfield': {'id': 'https://openalex.org/subfields/3204', 'display_name': 'Developmental and Educational Psychology'}, 'field': {'id': 'https://openalex.org/fields/32', 'display_name': 'Psychology'}, 'domain': {'id': 'https://openalex.org/domains/2', 'display_name': 'Social Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/identification', 'display_name': 'Identification', 'score': 0.6007347}], 'concepts': [{'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.8393885}, {'id': 'https://openalex.org/C116834253', 'wikidata': 'https://www.wikidata.org/wiki/Q2039217', 'display_name': 'Identification (biology)', 'level': 2, 'score': 0.6007347}, {'id': 'https://openalex.org/C33288867', 'wikidata': 'https://www.wikidata.org/wiki/Q518328', 'display_name': 'Methylation', 'level': 3, 'score': 0.5413051}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.5394218}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.50361365}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.42563018}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.4175688}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.40519935}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.34339464}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.2302222}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.13372457}, {'id': 'https://openalex.org/C18903297', 'wikidata': 'https://www.wikidata.org/wiki/Q7150', 'display_name': 'Ecology', 'level': 1, 'score': 0.0676091}], 'mesh': [{'descriptor_ui': 'D000375', 'descriptor_name': 'Aging', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': True}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044127', 'descriptor_name': 'Epigenesis, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055815', 'descriptor_name': 'Young Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/srep22722', 'pdf_url': 'https://www.nature.com/articles/srep22722.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4779991', 'pdf_url': 'https://europepmc.org/articles/pmc4779991?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779991', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26949191', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/srep22722', 'pdf_url': 'https://www.nature.com/articles/srep22722.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/16', 'display_name': 'Peace, justice, and strong institutions', 'score': 0.51}, {'id': 'https://metadata.un.org/sdg/10', 'display_name': 'Reduced inequalities', 'score': 0.47}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 60, 'referenced_works': ['https://openalex.org/W1504303645', 'https://openalex.org/W1506647222', 'https://openalex.org/W1877872530', 'https://openalex.org/W1965646659', 'https://openalex.org/W1969905245', 'https://openalex.org/W1973788578', 'https://openalex.org/W1974047233', 'https://openalex.org/W1975892804', 'https://openalex.org/W1982273978', 'https://openalex.org/W1984562049', 'https://openalex.org/W1984807040', 'https://openalex.org/W1985444222', 'https://openalex.org/W1986462247', 'https://openalex.org/W1990958459', 'https://openalex.org/W1991959431', 'https://openalex.org/W1993749239', 'https://openalex.org/W2004172747', 'https://openalex.org/W2006287843', 'https://openalex.org/W2007144721', 'https://openalex.org/W2014945558', 'https://openalex.org/W2020871542', 'https://openalex.org/W2023639434', 'https://openalex.org/W2023739300', 'https://openalex.org/W2036986058', 'https://openalex.org/W2039669402', 'https://openalex.org/W2042087070', 'https://openalex.org/W2042913529', 'https://openalex.org/W2048338967', 'https://openalex.org/W2055237681', 'https://openalex.org/W2058337538', 'https://openalex.org/W2060853689', 'https://openalex.org/W2066772704', 'https://openalex.org/W2070541344', 'https://openalex.org/W2077359776', 'https://openalex.org/W2080644309', 'https://openalex.org/W2082565035', 'https://openalex.org/W2085683078', 'https://openalex.org/W2095682261', 'https://openalex.org/W2105767248', 'https://openalex.org/W2108947463', 'https://openalex.org/W2114080249', 'https://openalex.org/W2116061337', 'https://openalex.org/W2120453034', 'https://openalex.org/W2121091193', 'https://openalex.org/W2121417064', 'https://openalex.org/W2130523009', 'https://openalex.org/W2131971406', 'https://openalex.org/W2134555277', 'https://openalex.org/W2136970997', 'https://openalex.org/W2137499573', 'https://openalex.org/W2139031446', 'https://openalex.org/W2146794662', 'https://openalex.org/W2149585679', 'https://openalex.org/W2151052080', 'https://openalex.org/W2151807108', 'https://openalex.org/W2165101781', 'https://openalex.org/W2167021978', 'https://openalex.org/W2169286052', 'https://openalex.org/W2169556367', 'https://openalex.org/W4285719527'], 'related_works': ['https://openalex.org/W2902329290', 'https://openalex.org/W2221018455', 'https://openalex.org/W2151182744', 'https://openalex.org/W2107880877', 'https://openalex.org/W2054863651', 'https://openalex.org/W2052355316', 'https://openalex.org/W2046964473', 'https://openalex.org/W2024490794', 'https://openalex.org/W1998349112', 'https://openalex.org/W1455488868'], 'abstract_inverted_index': {'Abstract': [0], 'As': [1], 'one': [2], 'of': [3, 53, 76, 80, 170, 181, 185, 195], 'the': [4, 35, 51, 54, 58, 74, 86, 168, 179, 182, 193], 'most': [5], 'widely': [6], 'studied': [7], 'epigenetic': [8, 183], 'modifications,': [9], 'DNA': [10, 24, 64, 151], 'methylation': [11, 25, 55, 65, 98, 120], 'has': [12], 'an': [13, 42], 'important': [14], 'influence': [15], 'on': [16, 50, 91, 147, 187], 'human': [17], 'traits': [18], 'and': [19, 32, 44, 57, 104, 126, 189], 'cancers.': [20], 'Dynamic': [21], 'variations': [22], 'in': [23, 29, 107, 129, 167, 192], 'have': [26], 'been': [27], 'reported': [28], 'malignant': [30], 'neoplasm': [31], 'aging;': [33], 'however,': [34], 'mechanisms': [36], 'remain': [37], 'poorly': [38], 'understood.': [39], 'By': [40], 'constructing': [41], 'age-associated': [43], 'cancer-related': [45], 'weighted': [46], 'network': [47], '(ACWN)': [48], 'based': [49, 90, 146], 'correlation': [52], 'level': [56], 'protein-protein': [59], 'interaction,': [60], 'we': [61], 'found': [62], 'that': [63, 100, 122, 162], 'changes': [66], 'associated': [67], 'with': [68, 102, 111, 124, 132, 138], 'age': [69, 166], 'were': [70, 105, 127, 144, 155, 163], 'closely': [71], 'related': [72], 'to': [73], 'occurrence': [75], 'cancer.': [77], 'Additional': [78], 'analysis': [79], '102': [81], 'module': [82], 'genes': [83, 143, 154], 'mined': [84], 'from': [85], 'ACWN': [87], 'revealed': [88], 'discrimination': [89], 'two': [92], 'main': [93], 'patterns.': [94], 'One': [95], 'pattern': [96, 118], 'involved': [97, 119], 'levels': [99, 121], 'increased': [101], 'aging': [103, 125, 186], 'higher': [106], 'cancer': [108, 130, 159, 197], 'patients': [109], 'compared': [110, 131], 'normal': [112, 133], 'controls': [113], '(HH': [114], 'pattern).': [115, 135], 'The': [116], 'other': [117], 'decreased': [123], 'lower': [128], '(LL': [134], 'Upon': [136], 'incorporation': [137], 'gene': [139], 'expression': [140], 'levels,': [141], '25': [142], 'filtered': [145], 'negative': [148], 'regulation': [149], 'by': [150, 165], 'methylation.': [152], 'These': [153], 'regarded': [156], 'as': [157], 'potential': [158], 'risk': [160], 'markers': [161], 'influenced': [164], 'process': [169], 'carcinogenesis.': [171], 'Our': [172], 'results': [173], 'will': [174, 190], 'facilitate': [175], 'further': [176], 'studies': [177], 'regarding': [178], 'impact': [180], 'effects': [184], 'diseases': [188], 'aid': [191], 'development': [194], 'tailored': [196], 'preventive': [198], 'strategies.': [199]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2304569214', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 2}], 'updated_date': '2024-12-08T03:11:59.067550', 'created_date': '2016-06-24'}