Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2303984487', 'doi': None, 'title': 'Thyrotropin-releasing hormone stimulates rapid breakdown of phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate in GH3 pituitary tumor cells.', 'display_name': 'Thyrotropin-releasing hormone stimulates rapid breakdown of phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate in GH3 pituitary tumor cells.', 'publication_year': 1984, 'publication_date': '1984-03-01', 'ids': {'openalex': 'https://openalex.org/W2303984487', 'mag': '2303984487', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/6321942'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/6321942', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5010886250', 'display_name': 'Colin H. Macphee', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'C H Macphee', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5110295579', 'display_name': 'Alan H. Drummond', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'A H Drummond', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 16.912, 'has_fulltext': False, 'cited_by_count': 78, 'citation_normalized_percentile': {'value': 0.768237, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '25', 'issue': '2', 'first_page': '193', 'last_page': '200'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10748', 'display_name': 'Growth Hormone and Insulin-like Growth Factors', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10748', 'display_name': 'Growth Hormone and Insulin-like Growth Factors', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10293', 'display_name': 'Thyroid Disorders and Treatments', 'score': 0.9935, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12226', 'display_name': 'Neuroblastoma Research and Treatments', 'score': 0.9647, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/phosphatidylinositol-4,5-bisphosphate', 'display_name': 'Phosphatidylinositol 4,5-bisphosphate', 'score': 0.71867883}, {'id': 'https://openalex.org/keywords/second-messenger-system', 'display_name': 'Second messenger system', 'score': 0.53175795}], 'concepts': [{'id': 'https://openalex.org/C2780610907', 'wikidata': 'https://www.wikidata.org/wiki/Q2273248', 'display_name': 'Phosphatidylinositol', 'level': 3, 'score': 0.9257318}, {'id': 'https://openalex.org/C36020004', 'wikidata': 'https://www.wikidata.org/wiki/Q106951674', 'display_name': 'Diacylglycerol kinase', 'level': 4, 'score': 0.90537184}, {'id': 'https://openalex.org/C2777427919', 'wikidata': 'https://www.wikidata.org/wiki/Q407997', 'display_name': 'Inositol', 'level': 3, 'score': 0.7545941}, {'id': 'https://openalex.org/C2776909261', 'wikidata': 'https://www.wikidata.org/wiki/Q66000256', 'display_name': 'Phosphatidic acid', 'level': 4, 'score': 0.73723096}, {'id': 'https://openalex.org/C2777853560', 'wikidata': 'https://www.wikidata.org/wiki/Q3083814', 'display_name': 'Phosphatidylinositol 4,5-bisphosphate', 'level': 4, 'score': 0.71867883}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.6325296}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6204624}, {'id': 'https://openalex.org/C2778918659', 'wikidata': 'https://www.wikidata.org/wiki/Q186915', 'display_name': 'Phospholipid', 'level': 3, 'score': 0.6167627}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.59769523}, {'id': 'https://openalex.org/C163235415', 'wikidata': 'https://www.wikidata.org/wiki/Q899814', 'display_name': 'Second messenger system', 'level': 3, 'score': 0.53175795}, {'id': 'https://openalex.org/C2778597717', 'wikidata': 'https://www.wikidata.org/wiki/Q420248', 'display_name': 'Phospholipase C', 'level': 3, 'score': 0.50563455}, {'id': 'https://openalex.org/C53009064', 'wikidata': 'https://www.wikidata.org/wiki/Q167', 'display_name': 'Pi', 'level': 2, 'score': 0.4432914}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.35430413}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2762792}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.25389934}, {'id': 'https://openalex.org/C195794163', 'wikidata': 'https://www.wikidata.org/wiki/Q420877', 'display_name': 'Protein kinase C', 'level': 3, 'score': 0.22380587}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.12989298}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.09440181}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.092793435}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D010716', 'descriptor_name': 'Phosphatidylinositols', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010902', 'descriptor_name': 'Pituitary Gland', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013973', 'descriptor_name': 'Thyrotropin-Releasing Hormone', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002448', 'descriptor_name': 'Cell Adhesion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004075', 'descriptor_name': 'Diglycerides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004075', 'descriptor_name': 'Diglycerides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008563', 'descriptor_name': 'Membrane Lipids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008563', 'descriptor_name': 'Membrane Lipids', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010712', 'descriptor_name': 'Phosphatidic Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010712', 'descriptor_name': 'Phosphatidic Acids', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010716', 'descriptor_name': 'Phosphatidylinositols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010902', 'descriptor_name': 'Pituitary Gland', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013973', 'descriptor_name': 'Thyrotropin-Releasing Hormone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014280', 'descriptor_name': 'Triglycerides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014280', 'descriptor_name': 'Triglycerides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010738', 'descriptor_name': 'Type C Phospholipases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010738', 'descriptor_name': 'Type C Phospholipases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/6321942', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W847086474', 'https://openalex.org/W732740', 'https://openalex.org/W2404365298', 'https://openalex.org/W2303984487', 'https://openalex.org/W214847410', 'https://openalex.org/W2090469070', 'https://openalex.org/W2078512742', 'https://openalex.org/W2075825702', 'https://openalex.org/W2037652810', 'https://openalex.org/W1991187152'], 'abstract_inverted_index': {'Thyrotropin-releasing': [0], 'hormone': [1], '(TRH)': [2], 'induced': [3], 'a': [4, 38, 58, 116, 156, 185, 222, 240], 'rapid': [5], 'breakdown': [6, 229], 'of': [7, 29, 32, 52, 60, 67, 88, 127, 155, 171, 197, 207, 224, 230], 'phosphatidylinositol': [8, 13, 53], '4,5-bisphosphate': [9], '(PtdIns': [10, 15], '4,5P2)': [11], 'and': [12, 45, 99, 109, 139], '4-phosphate': [14], '4P)': [16], 'in': [17, 42, 48, 103, 107, 115, 133, 137, 142, 148, 226], 'GH3': [18, 80, 111], 'cells': [19], 'labeled': [20], 'to': [21, 73, 105, 177], 'isotopic': [22], 'equilibrium': [23], 'with': [24, 119, 145, 173], '[3H]inositol.': [25], 'Within': [26], '10': [27, 123], 'sec': [28, 124], 'the': [30, 64, 68, 79, 128, 146, 149, 153, 195, 205, 208, 228, 231, 246], 'addition': [31, 126, 196], 'TRH': [33, 106, 203, 220], '(1': [34], 'microM),': [35], 'there': [36], 'was': [37, 140, 212], 'maximal': [39], '60%': [40], 'decrease': [41, 47, 147], 'PtdIns': [43, 49, 82, 233, 237], '4,5P2': [44, 234], '40%': [46], '4P.': [50], 'Breakdown': [51], '(PtdIns)': [54], 'occurred': [55], 'only': [56], 'after': [57, 125, 168, 194, 202], 'lag': [59], '30': [61], 'sec.': [62], 'While': [63], 'reduced': [65], 'levels': [66, 101, 135, 161, 178, 183], 'polyphosphoinositides': [69], 'had': [70], 'almost': [71], 'returned': [72], 'control': [74, 165], 'values': [75, 166], 'by': [76, 239], '5': [77], 'min,': [78], 'cell': [81], 'content': [83], 'remained': [84], 'at': [85, 91], 'around': [86], '85%': [87], 'controls': [89], 'for': [90], 'least': [92], '2': [93], 'hr.': [94], 'Both': [95], 'phosphatidic': [96], 'acid': [97], '(PA)': [98], '1,2-diacylglycerol': [100, 134], 'increased': [102], 'response': [104], '[32P]PO4-': [108], '[3H]glycerol-labeled': [110], 'cells.': [112], '1,2-Diacylglycerol': [113, 160], 'accumulated': [114], 'biphasic': [117], 'manner': [118], 'an': [120], 'early': [121, 131], 'peak': [122, 186], 'peptide.': [129], 'This': [130], 'rise': [132], 'coincided': [136], 'time': [138], 'equivalent': [141], 'lipid': [143], 'mass': [144], 'polyphosphoinositide': [150], 'content,': [151], 'suggesting': [152], 'involvement': [154], 'phospholipase': [157, 241], 'C-type': [158], 'enzyme.': [159], 'subsequently': [162], 'fell': [163], 'toward': [164], 'and,': [167, 235], '3': [169], 'min': [170, 193], 'treatment': [172], 'TRH,': [174], 'rose': [175], 'again': [176], '50%': [179], 'above': [180, 190], 'normal.': [181], 'PA': [182], 'reached': [184], 'value': [187], 'approximately': [188], '2-fold': [189], 'normal': [191], '1': [192], 'TRH.': [198], 'At': [199], 'all': [200], 'times': [201], 'addition,': [204], 'bulk': [206], 'inositol': [209], 'phospholipid': [210], 'lost': [211], 'recovered': [213], 'as': [214], '1,2-diacylglycerol.': [215], 'These': [216], 'results': [217], 'suggest': [218], 'that': [219], 'stimulates': [221], 'cycle': [223], 'events': [225], 'which': [227], 'polyphosphoinositides,': [232], 'perhaps,': [236], '4P': [238], 'C': [242], 'enzyme': [243], 'could': [244], 'be': [245], 'initiating': [247], 'event.': [248]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2303984487', 'counts_by_year': [], 'updated_date': '2024-12-09T08:07:39.834322', 'created_date': '2016-06-24'}