Abstract: Background: Methamphetamine abuse and methamphetamine induced psychosis is a growing problem.Objective: To illustrate the efficacy of Electro Convulsive Therapy (ECT) as a suitable option in the treatment of methamphetamine psychosis.Results: ECT was successfully employed in the management of severe methamphetamine psychosis.Discussion: This case study indicates although medications are effective in treating methamphetamine induced psychosis, however, ECT is more influential and faster than medications. This is a fascinating finding.Conclusion: To our knowledge we can say that ECT could be an appropriate alternative in the treatment of severe methamphetamine psychosis, therefore this experience of an Iranian patient could add novel information to the literature.