Title: A spreadsheet for deriving a confidence interval, mechanistic inference and clinical inference from a P value
Abstract: The null-hypothesis significance test based only on a p value can be a misleading approach to making an inference about the true (population or largesample) value of an effect statistic. Inferences based directly on the uncertainty in the true magnitude of the statistic are more comprehensible and practical but are not provided by statistical packages. I present here a spreadsheet that uses the p value, the observed value of the effect and smallest substantial values for the effect to make two kinds of magnitude-based inference: mechanistic and clinical. For a mechanistic inference the spreadsheet shows the effect as unclear if the confidence interval, which represents uncertainty about the true value, overlaps values that are substantial in a positive and negative sense; the effect is otherwise characterized with a statement about the chance that it is trivial, positive or negative. For a clinical inference the effect is shown as unclear if its chance of benefit is at least promising but its risk of harm is unacceptable; the effect is otherwise characterized with a statement about the chance that it is trivial, beneficial or harmful. The spreadsheet allows the researcher to choose the level of confidence (default, 90%) for mechanistic inferences and the threshold chances of benefit (default, 25%) and harm (default, 0.5%) for clinical inferences. The spreadsheet can be used for the most common effect statistics: raw, percent and factor differences in means; ratios of rates, risks, odds, and standard deviations; and correlations. The calculations are based on the same assumption of a normal or t sampling distribution that underlies the calculation of the p value for these statistics.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
Access and Citation
Cited By Count: 476
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot