Title: Direct measurement of vagal release of gastrin.
Abstract: The concentration of gastrin in the antral venous blood of dogs was measured by radioimmunoassay during direct electrical stimulation of the branches of the vagus to the gastric antrum. In addition, we have studied the effects on the vagal release of gastrin caused by changes in antral pH and changes in the duration and magnitude of electrical stimuli. The gastrin response to electrical vagal stimulation was almost immediate. Acidification of the antrum greatly diminished the gastrin response to electrical stimulation of the vagus (5 v.) but did not abolish it. The increase in antral venous gastrin after stimulation with higher voltage (10 v.) was inhibited only slightly by antral acidification. When the antral pH was changed to pH 7.0, the concentration of gastrin rose rapidly. Stimulation of the antral vagus for two minutes resulted in release of gastrin from the isolated antrum for at least 30 minutes. These studies directly confirm the vagal release of gastrin and provide some data for quantification of the amount released.
Publication Year: 1974
Publication Date: 1974-01-01
Language: en
Type: article
Indexed In: ['pubmed']
Access and Citation
Cited By Count: 27
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