Abstract: <h2>Abstract</h2> <i>Sir:</i> In a recent paper, Garrett <i>et al.</i> (1) further elucidated the kinetics of hydrolysis of several important barbiturates. In their studies, they discovered the rather surprising fact that diethylmalonuric acid (V) (Scheme I) in basic solution may cyclize to form the parentsubstituted barbituric acid, barbital (IV). Previous workers (2, 3) assumed that the hydrolysis of the parent barbiturate to the corresponding malonuric acid was irreversible, and various degradation schemes were predicated on that assumption. Hegarty and Bruice (4) also reported a similar reaction in the cyclization of 2-ureidobenzoic acid.
Publication Year: 1973
Publication Date: 1973-06-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 11
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