Publication Information

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'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W34130030', 'https://openalex.org/W308918215', 'https://openalex.org/W2956410943', 'https://openalex.org/W2313768682', 'https://openalex.org/W2090037185', 'https://openalex.org/W2088984017', 'https://openalex.org/W2069330406', 'https://openalex.org/W2062141712', 'https://openalex.org/W2053696251', 'https://openalex.org/W2047862729', 'https://openalex.org/W2042123289', 'https://openalex.org/W2038204713', 'https://openalex.org/W2037562476', 'https://openalex.org/W2027427234', 'https://openalex.org/W2025178030', 'https://openalex.org/W2011405727', 'https://openalex.org/W171950487', 'https://openalex.org/W1577309641', 'https://openalex.org/W1558505633', 'https://openalex.org/W1494409196'], 'abstract_inverted_index': {'INTRODUCTION:': [0], 'Wound': [1], 'healing': [2, 38, 55, 85], 'involves': [3], 'a': [4, 77, 115, 122, 175, 316, 372], 'complex': [5], 'sequence': [6], 'of': [7, 15, 32, 74, 83, 92, 114, 121, 160, 192, 214, 253, 280, 285, 296, 303, 322, 343, 355, 361, 377], 'interactions': [8], 'leading': [9], 'to': [10, 21, 52, 80, 119, 202, 294, 346], 'tissue': [11, 172], 'repair': [12, 173], 'and': [13, 27, 36, 46, 56, 59, 108, 154, 171, 182, 190, 227, 251, 273, 283, 309, 363], 'resolution': [14], 'injury.': [16], 'Some': [17], 'injuries,': [18], 'however,': [19, 351], 'fail': [20], 'resolve,': [22], 'resulting': [23], 'in': [24, 95, 103, 143, 149, 157, 331, 379, 387], 'chronic': [25], 'scarring': [26, 35, 57], 'fibrosis.': [28], 'A': [29, 125], 'common': [30], 'goal': [31], 'groups': [33, 94], 'investigating': [34], 'wound': [37, 84], 'is': [39, 146, 155], 'understanding': [40], 'the': [41, 54, 65, 81, 90, 112, 130, 150, 158, 188, 270, 300, 332, 344, 347, 364], 'mechanisms': [42], 'differentiating': [43], 'between': [44], 'scarred': [45], 'scar-free': [47], 'healing.': [48], 'Fibroblasts': [49, 199], 'are': [50, 70], 'central': [51], 'both': [53], 'processes': [58, 163], 'have': [60, 99], 'distinct': [61], 'phenotypes': [62], 'depending': [63], 'on': [64, 178], 'site': [66], 'from': [67], 'which': [68], 'they': [69, 382], 'isolated.': [71], 'The': [72, 184], 'importance': [73], 'fibroblasts': [75], 'with': [76, 111, 206], 'myofibroblastic': [78, 116, 277], 'phenotype': [79, 117, 181], 'progression': [82], 'has': [86], 'been': [87, 338], 'emphasised': [88], 'by': [89, 194, 204, 212, 242, 248, 259, 319, 368], 'work': [91], 'several': [93], 'recent': [96], 'years.': [97], 'We': [98], 'recently': [100], 'investigated': [101, 187], 'differences': [102], 'glycosaminoglycan': [104], '(GAG)': [105], 'synthesis,': [106], 'structure': [107], 'function': [109], 'associated': [110], 'possession': [113], 'compared': [118], 'that': [120, 129, 289, 353], 'normal': [123], 'fibroblast.': [124], 'major': [126], 'finding': [127], 'was': [128, 137, 210, 222, 246, 257, 267, 291, 358], 'important': [131], 'linear': [132], 'polysaccharide,': [133], 'hyaluronan': [134, 234], '(HA)': [135], 'synthesis': [136, 189, 209, 302], 'more': [138, 265, 326, 374], 'than': [139], '4': [140, 263], 'fold': [141, 264], 'increased': [142, 301], 'myofibroblasts.': [144, 320], 'HA': [145, 193, 208, 220, 249, 266, 308, 312, 365], 'ubiquitously': [147], 'distributed': [148], 'extracellular': [151], 'matrix': [152, 275], '(ECM)': [153], 'implicated': [156], 'regulation': [159], 'diverse': [161], 'biological': [162], 'including': [164], 'morphogenesis,': [165], 'angiogenesis,': [166], 'tumourigenesis,': [167], 'inflammation,': [168], 'cellular': [169], 'transformation': [170], 'through': [174], 'direct': [176], 'effect': [177], 'cell': [179], 'proliferation,': [180], 'migration.': [183], 'present': [185], 'study': [186], 'turnover': [191], 'these': [195], 'cells.': [196], '.': [197], 'METHODS:': [198], 'were': [200, 240, 313, 383], 'differentiated': [201], 'myofibroblasts': [203], 'treatment': [205], 'TGFβ1.': [207], 'measured': [211], 'incorporation': [213], '3': [215, 254], 'Hglucosamine': [216], 'over': [217], '24': [218], 'hrs.': [219], 'size': [221, 228], 'determined': [223], 'following': [224, 276], 'ion': [225], 'exchange': [226], 'exclusion': [229], 'chromatography.': [230], 'mRNA': [231, 286], 'levels': [232], 'for': [233], 'synthases': [235], '(HAS)': [236], 'or': [237, 299, 340], 'hyaluronidases': [238], '(HYAL)': [239], 'assessed': [241], 'RT-PCR.': [243], 'HYAL': [244, 256, 327, 329, 348], 'activity': [245, 282], 'visualised': [247], 'zymography': [250], 'degradation': [252], 'H-HA.': [255], 'localized': [258], 'immunohistochemistry': [260], 'RESULTS:': [261], 'Upto': [262], 'secreted': [268], 'into': [269], 'culture': [271, 323], 'medium': [272, 334, 345], 'pericellular': [274], 'differentiation.': [278], 'Inhibition': [279], 'HAS': [281, 297], 'analysis': [284], 'levels,': [287], 'showed': [288, 352, 371], 'this': [290, 356], 'not': [292], 'due': [293], 'induction': [295], 'enzymes': [298], 'HA.': [304], 'Rather': [305], 'exogenously': [306], 'supplied': [307], 'endogenously': [310], 'synthesised': [311], 'degraded': [314], 'at': [315], 'reduced': [317], 'rate': [318], 'Immunoblotting': [321], 'supernatants': [324], 'demonstrated': [325], '1and': [328], '2': [330], 'myofibroblast': [333], 'suggesting': [335], 'it': [336], 'had': [337], 'shed': [339], 'secreted.': [341], 'Acidification': [342], 'pH': [349], 'optimum,': [350], 'most': [354], 'enzyme': [357], 'inactive.': [359], 'Immunolocalisation': [360], 'HYALs': [362], 'receptor': [366], 'CD44': [367], 'confocal': [369], 'microscopy': [370], 'much': [373], 'diffuse': [375], 'pattern': [376], 'expression': [378], 'myofibroblasts,': [380], 'while': [381], 'very': [384], 'discretely': [385], 'localised': [386], 'fibroblasts.': [388], 'DISCUSSION': [389], '&': [390], 'CONCLUSIONS:': [391]}, 'cited_by_api_url': 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