Life span extension by targeting a link between metabolism and histone acetylation in <i>Drosophila</i>

Name: Work Video:
Duration: 3 min 30 s
Shahaf Peleg; Christian Feller; Ignasi Forné; Evelyn Schiller; Daniel C. Sévin; Tamás Schauer; Catherine Regnard; Tobias Straub; Matthias Prestel; Caroline Klima; Melanie Schmitt Nogueira; Lore Becker; Thomas Klopstock; Uwe Sauer; Peter B. Becker; Axel Imhof; Andreas G. Ladurner
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3818, 3939, 3968, 4038, 4063, 4111, 4135], 'histone': [16, 1492, 1541, 1602, 1624, 1670, 1675, 1941, 2152, 3198], 'acetylation': [17, 1468, 1603, 1625, 1645, 1671, 1676, 1911, 1919, 1948, 1988, 2057, 3173, 3199, 3266, 3269, 3406, 3418, 3434, 3462, 3746, 3758, 4008, 4028, 4095, 4130, 4160, 4173], 'in': [18, 1440, 1473, 1504, 1511, 1582, 1608, 1614, 1648, 1665, 1678, 1696, 1714, 1741, 1776, 1819, 1834, 1856, 1872, 1902, 1961, 1975, 2018, 2040, 2049, 2062, 2089, 2099, 2132, 2147, 2179, 2215, 2235, 2247, 2310, 2334, 2343, 2371, 2396, 2421, 2439, 2455, 2480, 2562, 2571, 2593, 2648, 2683, 2700, 2756, 2769, 2795, 2805, 2817, 2859, 2871, 2891, 2914, 2931, 2955, 3059, 3115, 3167, 3190, 3212, 3216, 3271, 3302, 3317, 3327, 3362, 3487, 3510, 3513, 3524, 3722, 3741, 3756, 3759, 3808, 3815, 3879, 3882, 3913, 4043, 4045, 4055, 4059, 4081, 4099, 4145], 'Drosophila': [19, 1474, 1652, 1666, 1697, 1820, 2236, 2300, 2498, 3742], 'Shahaf': [20, 22, 603, 605, 1188], 'Peleg': [21, 23, 604, 606], 'Department': [24, 41, 69, 97, 194, 222, 250, 286, 314, 331, 361, 378, 435, 492, 522, 571, 607, 624, 652, 680, 777, 805, 833, 869, 897, 914, 944, 961, 1018, 1075, 1105, 1154, 1317], 'of': [25, 42, 70, 98, 135, 165, 195, 223, 251, 287, 315, 332, 362, 379, 407, 436, 471, 493, 523, 572, 608, 625, 653, 681, 718, 748, 778, 806, 834, 870, 898, 915, 945, 962, 990, 1019, 1054, 1076, 1106, 1155, 1230, 1247, 1273, 1290, 1318, 1344, 1390, 1400, 1435, 1528, 1539, 1569, 1578, 1585, 1650, 1669, 1690, 1717, 1723, 1766, 1780, 1795, 1804, 1817, 1843, 1882, 1912, 1935, 1964, 2022, 2028, 2076, 2112, 2119, 2160, 2166, 2210, 2263, 2299, 2321, 2352, 2383, 2496, 2519, 2528, 2533, 2552, 2678, 2693, 2820, 2831, 2840, 2874, 2879, 2908, 2934, 2948, 2966, 2984, 3007, 3013, 3023, 3028, 3034, 3043, 3100, 3111, 3123, 3134, 3141, 3225, 3243, 3292, 3306, 3338, 3365, 3367, 3393, 3407, 3516, 3533, 3544, 3552, 3608, 3616, 3719, 3744, 3772, 3783, 3795, 3832, 3843, 3862, 3885, 3897, 3920, 3929, 3975, 3986, 4014, 4025, 4096, 4104, 4115, 4120, 4158], 'Physiological': [26, 316, 363, 573, 609, 899, 946, 1156, 1231], 'Chemistry,': [27, 317, 364, 574, 610, 900, 947, 1157, 1232], 'Biomedical': [28, 45, 73, 101, 117, 198, 226, 254, 269, 290, 318, 335, 365, 382, 496, 526, 542, 575, 611, 628, 656, 684, 700, 781, 809, 837, 852, 873, 901, 918, 948, 965, 1079, 1109, 1125, 1158, 1233, 1250, 1266, 1310], 'Center': [29, 31, 46, 48, 74, 76, 102, 104, 143, 199, 201, 227, 229, 255, 257, 291, 293, 319, 321, 336, 338, 366, 368, 383, 385, 415, 445, 497, 499, 527, 529, 576, 578, 612, 614, 629, 631, 657, 659, 685, 687, 726, 782, 784, 810, 812, 838, 840, 874, 876, 902, 904, 919, 921, 949, 951, 966, 968, 998, 1028, 1080, 1082, 1110, 1112, 1159, 1161, 1234, 1236, 1251, 1253, 1281, 1327], 'for': [32, 49, 59, 77, 87, 105, 124, 144, 152, 184, 202, 212, 230, 240, 258, 276, 294, 304, 322, 339, 349, 369, 386, 396, 416, 424, 446, 453, 460, 480, 500, 510, 530, 550, 557, 579, 590, 597, 615, 632, 642, 660, 670, 688, 707, 727, 735, 767, 785, 795, 813, 823, 841, 859, 877, 887, 905, 922, 932, 952, 969, 979, 999, 1007, 1029, 1036, 1043, 1063, 1083, 1093, 1113, 1133, 1140, 1162, 1173, 1180, 1237, 1254, 1282, 1328, 1335, 1355, 1829, 1840, 1869, 1909, 1925, 2726, 2738, 2765, 2898, 3148, 3161, 3335, 3591, 3639, 3805, 3944, 4141], 'Integrated': [33, 50, 78, 106, 203, 231, 259, 295, 323, 340, 370, 387, 501, 531, 580, 616, 633, 661, 689, 786, 814, 842, 878, 906, 923, 953, 970, 1084, 1114, 1163, 1238, 1255], 'Protein': [34, 51, 79, 107, 114, 204, 232, 260, 296, 324, 341, 371, 388, 502, 532, 539, 581, 617, 634, 662, 690, 697, 787, 815, 843, 879, 907, 924, 954, 971, 1085, 1115, 1122, 1164, 1239, 1256], 'Science': [35, 52, 80, 108, 179, 205, 233, 261, 297, 325, 342, 372, 389, 503, 533, 582, 618, 635, 663, 691, 762, 788, 816, 844, 880, 908, 925, 955, 972, 1086, 1116, 1165, 1240, 1257, 1304], 'Munich,': [36, 53, 81, 109, 140, 206, 234, 262, 298, 326, 343, 373, 390, 412, 440, 449, 457, 504, 534, 554, 583, 594, 619, 636, 664, 692, 723, 789, 817, 845, 881, 909, 926, 956, 973, 995, 1023, 1032, 1040, 1087, 1117, 1137, 1166, 1177, 1241, 1258, 1278, 1322, 1331, 1339, 1365], 'Ludwig-Maximilians': [37, 54, 82, 110, 119, 207, 235, 263, 271, 299, 327, 344, 374, 391, 438, 505, 535, 544, 584, 620, 637, 665, 693, 702, 790, 818, 846, 854, 882, 910, 927, 957, 974, 1021, 1088, 1118, 1127, 1167, 1242, 1259, 1268, 1312, 1320], 'University,': [38, 55, 83, 111, 120, 208, 236, 264, 272, 300, 328, 345, 375, 392, 439, 506, 536, 545, 585, 621, 638, 666, 694, 703, 791, 819, 847, 855, 883, 911, 928, 958, 975, 1022, 1089, 1119, 1128, 1168, 1243, 1260, 1269, 1313, 1321], 'Planegg-Martinsried,': [39, 56, 84, 112, 121, 209, 237, 265, 273, 301, 329, 346, 376, 393, 507, 537, 546, 586, 622, 639, 667, 695, 704, 792, 820, 848, 856, 884, 912, 929, 959, 976, 1090, 1120, 1129, 1169, 1244, 1261, 1270, 1314], 'Germany': [40, 57, 85, 113, 122, 150, 210, 238, 266, 274, 302, 330, 347, 377, 394, 422, 441, 450, 458, 508, 538, 547, 555, 587, 595, 623, 640, 668, 696, 705, 733, 793, 821, 849, 857, 885, 913, 930, 960, 977, 1005, 1024, 1033, 1041, 1091, 1121, 1130, 1138, 1170, 1178, 1245, 1262, 1271, 1288, 1315, 1323, 1332, 1340, 1366], 'Molecular': [43, 71, 99, 166, 196, 224, 252, 288, 333, 380, 472, 494, 524, 626, 654, 682, 749, 779, 807, 835, 871, 916, 963, 1055, 1077, 1107, 1248, 1291, 1345], 'Biology,': [44, 72, 100, 168, 177, 197, 225, 253, 289, 334, 381, 474, 495, 525, 627, 655, 683, 751, 760, 780, 808, 836, 872, 917, 964, 1057, 1078, 1108, 1249, 1293, 1302, 1347], 'Search': [58, 86, 123, 151, 183, 211, 239, 275, 303, 348, 395, 423, 459, 479, 509, 556, 596, 641, 669, 706, 734, 766, 794, 822, 858, 886, 931, 978, 1006, 1042, 1062, 1092, 1139, 1179], 'more': [60, 88, 125, 153, 185, 213, 241, 277, 305, 350, 397, 425, 461, 481, 511, 558, 598, 643, 671, 708, 736, 768, 796, 824, 860, 888, 933, 980, 1008, 1044, 1064, 1094, 1141, 1181], 'papers': [61, 89, 126, 154, 186, 214, 242, 278, 306, 351, 398, 426, 462, 482, 512, 559, 599, 644, 672, 709, 737, 769, 797, 825, 861, 889, 934, 981, 1009, 1045, 1065, 1095, 1142, 1182], 'this': [63, 91, 128, 156, 188, 216, 244, 280, 308, 353, 400, 428, 464, 484, 514, 561, 601, 646, 674, 711, 739, 771, 799, 827, 863, 891, 936, 983, 1011, 1047, 1067, 1097, 1144, 1184, 2481, 2541, 2548, 2789, 3520, 3710, 4167], 'author': [64, 92, 129, 157, 189, 217, 245, 281, 309, 354, 401, 429, 465, 485, 515, 562, 602, 647, 675, 712, 740, 772, 800, 828, 864, 892, 937, 984, 1012, 1048, 1068, 1098, 1145, 1185, 1412], 'Christian': [65, 67, 648, 650, 1190], 'Feller': [66, 68, 649, 651], 'Ignasi': [93, 95, 676, 678, 1192], 'Forne': [94, 96, 677, 679], 'Analysis': [115, 540, 698, 1123, 1264], 'Unit,': [116, 268, 541, 699, 851, 1124, 1265, 1309], 'Center,': [118, 270, 543, 701, 853, 1126, 1267, 1311], 'Evelyn': [130, 132, 713, 715, 1194], 'Schiller': [131, 133, 714, 716], 'Institute': [134, 164, 406, 470, 717, 747, 989, 1053, 1343, 1354], 'Experimental': [136, 408, 719, 991, 1274], 'Genetics,': [137, 409, 720, 992, 1275], 'Helmholtz': [138, 410, 721, 993, 1276], 'Zentrum': [139, 411, 722, 994, 1277], 'German': [141, 413, 444, 724, 996, 1027, 1279, 1326], 'Research': [142, 414, 725, 997, 1280, 1359], 'Environment': [145, 417, 728, 1000, 1283], 'Health': [147, 419, 730, 1002, 1285], '(GmbH),': [148, 420, 731, 1003, 1286], 'Neuherberg,': [149, 421, 732, 1004, 1287], 'Daniel': [158, 161, 741, 744, 1196], 'C': [159, 162, 742, 745, 1197], 'Sévin': [160, 163, 743, 746], 'Systems': [167, 176, 454, 473, 551, 591, 750, 759, 1037, 1056, 1134, 1174, 1292, 1301, 1336, 1346], 'ETH': [169, 475, 752, 1058, 1294, 1348], 'Zürich,': [170, 171, 180, 181, 476, 477, 753, 754, 763, 764, 1059, 1060, 1295, 1296, 1305, 1306, 1349, 1350], 'Switzerland': [172, 182, 478, 755, 765, 1061, 1297, 1307, 1351], 'PhD': [173, 756], 'Program': [174, 757, 1299], 'on': [175, 758, 1300, 1521, 1990, 2461, 2483, 3195, 3470, 3738, 4149], 'Tamas': [190, 192, 773, 775, 1199], 'Schauer': [191, 193, 774, 776], 'Catherine': [218, 220, 801, 803, 1201], 'Regnard': [219, 221, 802, 804], 'Tobias': [246, 248, 829, 831, 1203], 'Straub': [247, 249, 830, 832], 'Bioinformatics': [267, 850], 'Matthias': [282, 284, 865, 867, 1205], 'Prestel': [283, 285, 866, 868], 'Caroline': [310, 312, 893, 895, 1207], 'Klima': [311, 313, 894, 896], 'Melanie': [355, 358, 938, 941, 1209], 'Schmitt': [356, 359, 939, 942, 1210], 'Nogueira': [357, 360, 940, 943], 'Lore': [402, 404, 985, 987, 1212], 'Becker': [403, 405, 488, 491, 986, 988, 1071, 1074], 'Thomas': [430, 432, 1013, 1015, 1214], 'Klopstock': [431, 433, 1014, 1016], 'Friedrich-Baur-Institut,': [434, 1017], 'Neurology,': [437, 1020, 1319], 'DZNE': [442, 1025], '–': [443, 1026, 1325], 'Neurodegenerative': [447, 1030, 1329], 'Diseases,': [448, 1031, 1330], 'Munich': [451, 548, 588, 1034, 1131, 1171], 'Cluster': [452, 549, 589, 1035, 1132, 1172, 1334], 'Neurology': [455, 552, 592, 1038, 1135, 1175, 1337], '(SyNergy),': [456, 553, 593, 1039, 1136, 1176, 1338], 'Uwe': [466, 468, 1049, 1051, 1216], 'Sauer': [467, 469, 1050, 1052], 'Peter': [486, 489, 1069, 1072, 1218], 'B': [487, 490, 1070, 1073, 1219], 'Axel': [516, 520, 1099, 1103, 1221], 'Imhof': [517, 521, 1100, 1104, 1222], 'Corresponding': [518, 566, 1101, 1149], 'Author': [519, 567, 1102, 1150, 1186], 'Andreas': [563, 568, 1146, 1151, 1225], 'G': [564, 569, 1147, 1152, 1226], 'Ladurner': [565, 570, 1148, 1153, 1227], 'Information': [1187], 'Peleg1,2,': [1189], 'Feller2,11,': [1191], 'Forne2,3,': [1193], 'Schiller4,': [1195], 'Sévin5,6,': [1198], 'Schauer2,': [1200], 'Regnard2,': [1202], 'Straub2,7,': [1204], 'Prestel2,12,': [1206], 'Klima1,2,': [1208], 'Nogueira1,2,': [1211], 'Becker4,': [1213], 'Klopstock8,9,10,': [1215], 'Sauer5,': [1217], 'Becker2,': [1220], '2,3,10,‡': [1223], '1,10,‡': [1228], '1Department': [1229], '2Department': [1246], '3Protein': [1263], '4Institute': [1272], '5Institute': [1289], '6PhD': [1298], '7Bioinformatics': [1308], '8Friedrich-Baur-Institut,': [1316], '9DZNE': [1324], '10Munich': [1333], '11Present': [1341], 'address:': [1342, 1353], '12Present': [1352], 'Stroke': [1356], 'Dementia': [1358], '(ISD),': [1360], 'Klinikum': [1361], 'der': [1362], 'Universität': [1363], 'München,': [1364], '‡Co-senior': [1367], 'authors': [1368], '*Corresponding': [1369, 1377], 'author.': [1370, 1378], 'Tel:': [1371, 1379], '+49': [1372, 1380], '89218075420;': [1373], 'E-mail:': [1374, 1382], '[email': [1375, 1383], 'protected]': [1376, 1384], '89218077095;': [1381], 'EMBO': [1385], 'Reports': [1386], '(2016)17:455-469https://doi.org/10.15252/embr.201541132': [1387], 'PDFDownload': [1388], 'PDF': [1389], 'article': [1391], 'text': [1392], 'main': [1394], 'figures.': [1395], 'Peer': [1396], 'ReviewDownload': [1397], 'summary': [1399], 'the': [1401, 1505, 1526, 1529, 1537, 1540, 1554, 1575, 1583, 1615, 1618, 1661, 1688, 1691, 1721, 1747, 1801, 1809, 1815, 1835, 1903, 1910, 1940, 1957, 1962, 1965, 1970, 1984, 1991, 1997, 2006, 2019, 2026, 2036, 2120, 2158, 2167, 2208, 2228, 2240, 2266, 2304, 2327, 2353, 2368, 2406, 2414, 2418, 2434, 2440, 2462, 2484, 2517, 2534, 2550, 2553, 2563, 2572, 2754, 2758, 2767, 2818, 2848, 2872, 2905, 2926, 2932, 2935, 2982, 2994, 3001, 3005, 3014, 3038, 3041, 3044, 3063, 3103, 3121, 3138, 3149, 3158, 3187, 3223, 3226, 3250, 3263, 3290, 3303, 3308, 3339, 3363, 3368, 3378, 3391, 3471, 3514, 3531, 3539, 3593, 3598, 3606, 3609, 3728, 3765, 3769, 3773, 3776, 3779, 3784, 3789, 3796, 3825, 3829, 3833, 3836, 3839, 3844, 3849, 3857, 3863, 3883, 3892, 3907, 3918, 3921, 4022, 4030, 4090, 4105, 4142], 'editorial': [1402, 1406], 'decision': [1403, 1407], 'including': [1405], 'letters,': [1408], 'reviewer': [1409], 'comments': [1410], 'responses': [1413], 'to': [1414, 1417, 1477, 1491, 1755, 1771, 1789, 1847, 1874, 1969, 2005, 2043, 2085, 2176, 2187, 2254, 2270, 2289, 2567, 2598, 2604, 2627, 2653, 2659, 2714, 2787, 2846, 2990, 3000, 3073, 3081, 3095, 3325, 3423, 3481, 3538, 3542, 3555, 3708, 3891, 3895, 4051, 4089], 'feedback.': [1415], 'ToolsAdd': [1416], 'favoritesDownload': [1418], 'CitationsTrack': [1419], 'CitationsPermissions': [1420], 'ShareFacebookTwitterLinked': [1421], 'InMendeleyWechatReddit': [1422], 'Figures': [1423], '&': [1424], 'Info': [1425], 'Abstract': [1426], 'Old': [1427], 'age': [1428, 2527, 2542, 3615, 3928], 'is': [1429, 1445, 1898, 1920, 2014, 2332, 2424, 2698, 2836, 2844, 3037, 3395, 3522, 3786, 3846, 4009, 4136], 'associated': [1430, 1517, 1586, 3370], 'with': [1431, 1574, 1612, 1746, 1791, 1889, 2265, 2326, 2398, 3131, 3205, 3249, 3371, 3775, 3835], 'progressive': [1433], 'decline': [1434, 2245, 2555], 'mitochondrial': [1436, 1704, 1732, 1742, 2407, 2427, 2456, 3078, 3150], 'function': [1437, 1705, 1733, 1881, 2061], 'changes': [1439, 1503, 1557, 1568, 1581, 1613, 1631, 1811, 1960, 2017, 2034, 2071, 2131, 2169, 2214, 2294, 2464, 2890, 3321, 3326, 3361, 4044], 'nuclear': [1441, 1933], 'chromatin.': [1442], 'However,': [1443, 1738, 2012, 2164, 3932], 'little': [1444], 'known': [1446, 2084, 2226], 'about': [1447], 'how': [1448, 1463, 2198, 2291], 'metabolic': [1449, 1798, 1928, 2020, 2044, 2052, 2070, 2242, 2292, 2330, 3151, 3297, 3373, 3399, 3409, 3720, 3809, 4016, 4133], 'activity': [1450, 1527, 1584, 1686, 1743, 1799, 1963, 2054, 2293, 2331, 2380, 2450, 2625, 2692, 3017], 'epigenetic': [1452, 2081, 2148], 'modifications': [1453, 1871], 'change': [1454, 1469, 2278], 'as': [1455, 1495, 1514, 1516, 1800, 1862, 1867, 1930, 1932, 2142, 2151, 2227, 2283, 2318, 2543, 2896, 3179, 3376, 3446, 4101], 'organisms': [1456, 1781], 'reach': [1457, 1497, 2285, 2367, 2516, 3181, 3605, 3917], 'their': [1458, 1703, 2544], 'midlife.': [1459, 1498, 2638, 2672, 2946, 3054, 3201], 'Here,': [1460], 'we': [1461, 1480, 1524, 2212, 2302, 2338, 2473, 3107, 3229, 3331, 3357, 4019, 4152, 4169], 'assessed': [1462], 'cellular': [1464, 1708, 1718, 1890, 3098], 'protein': [1467, 1644, 2200, 3176, 3196, 3328, 3417, 3433, 3461, 3482, 3757, 3858, 4027, 4094, 4129, 4159, 4172], 'during': [1470, 1572, 1606, 1814, 2127, 2470, 2904, 2925, 3200, 3276], 'early': [1471, 2297, 2471], 'aging': [1472, 1573, 1818, 1830, 1950, 2007, 2037, 2077, 2267, 3394], 'melanogaster.': [1475], 'Contrary': [1476], 'common': [1478], 'assumptions,': [1479], 'find': [1481, 1547], 'that': [1482, 1548, 1566, 1588, 1597, 1620, 1730, 1812, 1825, 1959, 1986, 1999, 2123, 2190, 2329, 2345, 2366, 2417, 2433, 2465, 2981, 3289, 3389, 3390, 3767, 3827, 4128, 4154], 'flies': [1483, 1501, 2284, 2336, 2344, 2400, 2499, 2515, 2535, 2606, 2620, 2661, 2773, 2799, 2811, 2865, 3024, 3117, 3169, 3180, 3218, 3346, 3414, 3604, 3694, 3726, 3912, 3935, 4075, 4122], 'increase': [1484, 1660, 2282, 2454, 3189, 3211, 3275, 3509, 3521, 3755, 3878, 4058, 4080], 'oxygen': [1485, 1662, 2306, 2503, 2801, 2833, 2849, 2855, 2892, 2976, 2985, 2991, 3511, 3880], 'consumption': [1486, 1663, 2307, 2504, 2585, 2640, 2802, 2816, 2850, 2856, 2870, 2986, 3512, 3881], 'become': [1488], 'less': [1489, 4078], 'sensitive': [1490], 'deacetylase': [1493, 3500, 4000, 4033], 'inhibitors': [1494, 1656, 4002, 4035, 4050], 'they': [1496], 'Further,': [1499], 'midlife': [1500, 1607, 1627, 1651, 1679, 2286, 2372, 2435, 2489, 2497, 2649, 2684, 2701, 2725, 2737, 2798, 2864, 2919, 2958, 3116, 3168, 3182, 3217, 3246, 3345, 3467, 3525, 3572, 3578, 3725, 3760, 4074, 4121, 4146], 'show': [1502, 2375, 2621, 2675, 2952, 3415, 3936], 'metabolome,': [1506, 2216], 'elevated': [1507, 3082, 3401, 4106], 'acetyl-CoA': [1508, 1599, 1628, 1993, 2280, 2679, 3112, 3163, 3191, 3402, 4107], 'levels,': [1509, 1629, 1637, 3329, 3403], 'alterations': [1510, 2469], 'protein—notably': [1512], 'histone—acetylation,': [1513], 'well': [1515, 1931], 'transcriptome': [1518, 1630, 2221], 'changes.': [1519], 'Based': [1520, 4148], 'these': [1522, 1549, 1883, 2467, 2841, 3293, 3320, 4048, 4097, 4150], 'observations,': [1523], 'decreased': [1525, 2591, 4117], 'acetyl-CoA-synthesizing': [1530], 'enzyme': [1531, 2053, 3159], 'ATP': [1532, 1683, 2708, 3126, 3154], 'citrate': [1533, 1640, 1684, 2694, 2704, 2709, 3143, 3155], 'lyase': [1534, 1685, 3156], '(ATPCL)': [1535], 'or': [1536, 1687, 2030, 2156], 'levels': [1538, 1600, 1689, 1994, 2281, 2674, 2677, 2893, 2903, 3110, 3122, 3133, 3334, 3364, 3747, 3804, 4108, 4157], 'H4': [1542], 'K12-specific': [1543], 'acetyltransferase': [1544, 1692], 'Chameau.': [1545], 'We': [1546, 1806, 2431, 2539, 3069, 3085, 3183], 'targeted': [1550], 'interventions': [1551], 'both': [1552, 2073, 3142], 'alleviate': [1553], 'observed': [1555, 2246, 3188], 'aging-associated': [1556], 'promote': [1559, 1848, 2271], 'longevity.': [1560, 1849], 'Our': [1561, 4113], 'findings': [1562], 'reveal': [1563, 3388], 'pathway': [1565], 'couples': [1567, 1886], 'intermediate': [1570], 'chromatin-mediated': [1576], 'regulation': [1577], 'transcription': [1579, 2125], 'enzymes': [1587, 1619, 1929, 2154, 4017, 4098], 'modulate': [1589], 'organismal': [1590], 'life': [1591, 1634, 1735, 1757, 1774, 1976, 2087, 2272, 3739, 3941, 4163], 'span.': [1592, 1635, 3942, 4164], 'Synopsis': [1593], 'This': [1594, 2978, 4085], 'study': [1595, 2482], 'shows': [1596, 2104, 2500, 2589, 2644, 3801], 'metabolism,': [1598, 2199], 'are': [1604, 1646, 1787, 1858, 2072, 2083, 2184, 2205, 2346, 2443, 2536, 3165, 3300], 'increased': [1605, 1647, 2105, 2502, 2646, 2676, 2699, 3077, 3109, 3398, 4143, 4171], 'Drosophila,': [1609], 'which': [1610, 1712, 2039, 2180, 2238, 4065], 'correlates': [1611], 'transcriptome.': [1616], 'Depleting': [1617], 'reduces': [1626, 2413], 'increases': [1633, 3178, 3732], 'Acetyl-CoA': [1636, 1897], 'ATPCL': [1638, 2697], 'synthase': [1641, 2695, 2705, 3144], 'activity,': [1642, 3152], 'heads': [1649, 2423, 2596, 2651, 2819, 2873, 2951, 3248, 3515, 3884, 4053], 'males.': [1653, 1698, 2959], 'Lysine': [1654, 1918, 3999], 'deactylase': [1655], 'rapidly': [1657], 'transiently': [1659], 'rate': [1664, 2308, 2505, 2551, 2586, 2641, 2803, 2851, 2857, 2983], 'heads.': [1667, 2922], 'Quantitation': [1668], 'reveals': [1672, 3288, 3752], 'transformed': [1674], 'signature': [1677], 'male': [1680, 2772, 2920, 2950, 3693, 3911], 'flies.': [1681, 2490, 2600, 2629, 2655, 2685, 2702, 2716, 2822, 2876, 3443, 3526, 3761, 3821, 3887, 4147], 'Reducing': [1682], 'Chameau': [1693], 'extends': [1694], 'lifespan': [1695], 'Introduction': [1699], 'When': [1700], 'animals': [1701], 'age,': [1702], 'hence': [1707], 'systematically': [1710], 'decline,': [1711], 'results': [1713], 'loss': [1716], 'homeostasis': [1719, 1895], 'occurrence': [1722], 'multiple': [1724, 4068], 'disorders': [1725], '1.': [1726, 2492], 'Consistently,': [1727], 'many': [1728, 1852, 1926, 2090, 2165, 4015], 'mutations': [1729, 2146], 'impair': [1731], 'shorten': [1734], '2.': [1737, 3412], 'reduction': [1740], 'through': [1744, 1768, 4029], 'interference': [1745, 1844, 2264], 'electron': [1748], 'transport': [1749], 'chain': [1750, 2409], 'has': [1751, 1826, 1951, 2058, 3192, 3735], 'also': [1752, 1866], 'been': [1753, 1827, 1953, 2171], 'shown': [1754], 'extend': [1756], '34.': [1759], 'Similarly,': [1760], 'caloric': [1761, 2143], 'restriction': [1762], '(the': [1763], 'reduced': [1764, 2378, 2448, 2623, 3420, 3937], 'intake': [1765], 'energy': [1767, 1863, 3083], 'nutrition)': [1769], 'leads': [1770, 2042, 3080], 'longer': [1773], 'expectancy': [1775], 'broad': [1778], 'range': [1779], '56.': [1782], 'These': [1783, 2129, 2250, 3384], 'seemingly': [1784], 'contradictory': [1785], 'observations': [1786], 'difficult': [1788], 'reconcile': [1790], 'simple': [1793], 'model': [1794, 1823, 2091], 'generally': [1796], 'declined': [1797], 'predominant': [1802], 'cause': [1803, 2466], 'aging.': [1805, 2128], 'therefore': [1807, 3086], 'investigated': [1808, 2172], 'molecular': [1810, 2033, 2463, 2478], 'occur': [1813], 'onset': [1816, 2209, 3392], 'melanogaster,': [1821, 2237], 'organism': [1824, 2024], 'exploited': [1828], 'research': [1833], 'past': [1836], 'lends': [1838], 'itself': [1839], 'variety': [1842], 'regimes,': [1845], 'aiming': [1846], 'In': [1850, 2287, 2511], 'eukaryotes,': [1851], 'key': [1853, 1900, 1922, 3097, 3408], 'metabolites': [1854, 3099], 'generated': [1855], 'mitochondria': [1857], 'used': [1859, 2764, 3230, 3590], 'not': [1860, 3128, 3175, 3323], 'only': [1861, 3279], 'source,': [1864], 'but': [1865, 3174, 3519], 'substrate': [1868], 'posttranslational': [1870], 'response': [1873, 3422], 'internal': [1875], 'external': [1877], 'stimuli.': [1878], 'The': [1879, 2838, 2923, 3498, 3527, 3762, 3781, 3822, 3841], 'dual': [1880], 'molecules': [1884], 'directly': [1885], 'central': [1887, 1904, 3770, 3830], 'signaling': [1891], 'networks': [1892], 'regulates': [1894], '7.': [1896], 'metabolite': [1901], 'cofactor': [1908], 'lysine': [1913, 1947, 1987, 2010, 2056, 3499, 3745, 4007, 4032], 'residues': [1914], '(and': [1915], 'other': [1916, 2032, 2900], 'amines).': [1917], 'regulatory': [1923, 4012], 'modification': [1924, 4013], 'cytoplasmic': [1927], 'regulators': [1934, 2082], 'gene': [1936, 2065, 2097, 2133, 2203], 'expression,': [1937], 'most': [1938, 2437, 3318, 3366], 'notably': [1939], 'proteins': [1942, 3215, 3238, 3274, 3295, 3337, 3369, 3721, 3806], '78.': [1943], 'A': [1944, 2094, 3874], 'connection': [1945], 'already': [1952, 2185, 2358], 'suggested': [1954], 'before': [1955, 3004], 'observation': [1958, 2328, 4114], 'NAD+-dependent': [1966], 'deacetylases': [1967], 'belonging': [1968], 'sirtuin': [1971], 'class': [1972], 'can': [1973, 2135], 'result': [1974, 2979, 4042, 4103], '910.': [1979], 'Their': [1980], 'NAD+': [1981], 'dependency': [1982], 'fact': [1985], 'relies': [1989], 'intracellular': [1992], '11': [1995, 3617, 3635], 'support': [1996], 'hypothesis': [1998], 'basic': [2000], 'could': [2002], 'be': [2003, 2136, 2194, 4087], 'coupled': [2004, 2206], 'via': [2009], 'acetylation.': [2011], 'it': [2013], 'unclear': [2015], 'whether': [2016, 2031, 3075, 3186, 4021], 'state': [2021, 4093], 'an': [2023, 2188, 2296, 2319, 2452, 2501, 2508, 2526, 2645, 2824, 3076, 3210, 3877, 4010], 'trigger': [2025], 'aging,': [2029, 2211, 2301, 2472, 3277], 'induce': [2035], 'process,': [2038], 'turn': [2041], 'alterations.': [2045], 'Besides': [2046], 'its': [2047], 'role': [2048], 'reversibly': [2050], 'regulating': [2051, 2064], '12,': [2055], 'major': [2060], 'epigenetically': [2063], 'expression.': [2066], 'Transcriptional': [2067], 'deregulation': [2068], 'considered': [2074], 'hallmarks': [2075], '13': [2078], 'several': [2080], 'affect': [2086, 4003], 'systems': [2092], '1415.': [2093], 'comparison': [2095, 2397, 2485], 'expression': [2098, 2134, 2204], 'young': [2100, 2175, 2399, 2487, 2599, 2612, 2628, 2633, 2654, 2667, 2715, 2720, 2732, 2796, 2806, 2860, 2917, 2941, 2956, 3049, 3244, 3343, 3465, 3517, 3562, 3567, 3723, 3886], 'old': [2102, 2177, 2248, 2335, 2594, 2810], 'tissues': [2103], 'transcriptional': [2106], 'noise': [2107], '161718': [2108], 'aberrant': [2110], 'maturation': [2111], 'RNAs': [2113], '1920,': [2114], 'suggesting': [2115, 2416], 'general': [2117, 2241, 3372, 3754, 4026], 'deterioration': [2118], 'chromatin': [2121], 'organization': [2122], 'underlies': [2124], 'control': [2126, 2878, 3621, 3640, 3945], 'age-dependent': [2130, 2168], 'attenuated': [2137], 'environmental': [2139], 'influences': [2140], 'such': [2141, 2150, 3375], 'restriction,': [2144], 'regulators,': [2149], 'modifying': [2153], '102122,': [2155], 'overexpression': [2159], 'heterochromatin': [2161], 'components': [2162], '23.': [2163], 'have': [2170, 2356, 3296], 'comparing': [2174, 3856], 'animals,': [2178], 'all': [2181, 2757, 2899], 'physiological': [2182, 2244, 2261, 2322, 2468], 'functions': [2183, 3298], 'compromised': [2186], 'extent': [2189], 'causal': [2191], 'effects': [2192], 'cannot': [2193], 'derived.': [2195], 'To': [2196, 2458, 3221, 4165], 'investigate': [2197], 'function,': [2201], 'at': [2207, 2222, 2295, 2525, 3040, 3613, 3925, 4137], 'analyzed': [2213, 3341, 3475], 'proteome,': [2217], 'acetylome,': [2218], 'epigenome,': [2219], 'critical': [2224], 'period': [2225], '"premortality': [2229, 2521], 'plateau"': [2230], '(or': [2231], 'midlife)': [2232], 'phase': [2233, 3612, 3924], '24': [2234, 2671, 2945, 3629], 'precedes': [2239], 'age.': [2249], 'measurements': [2251, 3386], 'allowed': [2252], 'us': [2253], 'identify': [2255], 'validate': [2257], 'potential': [2258], 'genetic': [2259], 'points': [2262], 'program': [2268], 'extension.': [2274], 'Results': [2275], 'Metabolic': [2276], 'profiles': [2277, 2804, 2858], 'order': [2288], 'measure': [2290], 'stage': [2298], 'measured': [2303, 2419, 2988], "fly's": [2305], '(OCR)': [2309, 2587, 2642, 2852], 'whole': [2311, 2595, 2650], 'head': [2312, 2494], 'tissue,': [2313], 'rather': [2314], 'than': [2315], 'isolated': [2316, 4052], 'mitochondria,': [2317], 'indicator': [2320], 'oxidative': [2323, 3312, 3382, 4004], 'metabolism.': [2324], 'Consistent': [2325, 3130], 'lower': [2333, 2341, 2815], '1,': [2337], 'detect': [2339, 3332, 3358], 'OCR': [2342, 2395, 2420, 2592, 2647, 3421, 3733, 4060, 4069, 4082, 4144], '7': [2347, 2632, 2736, 3048, 3577], 'weeks': [2348, 2382], 'old,': [2349], 'when': [2350], '75%': [2351], 'initial': [2354], 'populations': [2355], 'died': [2357], '(Figs': [2359, 2401, 3282, 4061], '1A': [2360, 2386], 'B,': [2362], 'EV1A).': [2364], 'Flies': [2365], 'premortality': [2369, 3610, 3922], 'plateau': [2370, 2522, 3611, 3923], '(90%': [2373], 'survival)': [2374], 'markedly': [2377], 'physical': [2379, 2449, 2624], '(4': [2381], 'age;': [2384], 'Figs': [2385], 'C,': [2388, 3350], 'EV1G),': [2390], 'yet': [2391], 'display': [2392], 'higher': [2394, 2869, 3132, 3166, 3416, 4091], '1D': [2402], 'EV1B–E).': [2404], 'Inhibiting': [2405], 'respiratory': [2408, 2995, 4118], 'rotenone': [2411], 'administration': [2412], 'OCR,': [2415], 'fly': [2422, 2441, 2921, 2949, 3247], 'mediated': [2425], 'respiration': [2428, 3079], '(Fig': [2429, 3118, 3170, 3219, 3347, 4083, 4109], 'EV1F).': [2430], 'conclude': [2432], 'stage—where': [2436], 'individuals': [2438], 'population': [2442, 2554, 3916], 'alive—is': [2444], 'characterized': [2445, 3396], 'unexpected': [2453], 'respiration.': [2457], 'shed': [2459], 'light': [2460], 'thus': [2474, 3387], 'focused': [2475], 'our': [2476], 'systematic': [2477], 'analyses': [2479], 'Figure': [2491, 2791, 3411, 3712], 'Whole': [2493], 'tissue': [2495], 'displays': [2507], 'altered': [2509, 3432, 3460], 'mixed': [2513, 2778, 3699, 3914], 'population,': [2514], 'end': [2518, 3607, 3919], 'phase"': [2523], '(PMP)': [2524], '4': [2529, 3930], 'weeks,': [2530], 'where': [2531, 3234], '90%': [2532, 3620], 'still': [2537], 'alive.': [2538], 'define': [2540], '"midlife"': [2545], 'point.': [2546], 'At': [2547, 2618], 'stage,': [2549], 'accelerates': [2556], 'from': [2557, 2776, 3236, 3241, 3697, 4073], '1%': [2558], '(plateau)': [2559], 'per': [2560, 2569, 2689, 2963, 3453, 3493, 3868, 3902], 'day': [2561, 2570], 'previous': [2564], '10': [2565, 2574, 2832, 2842], 'days': [2566], '3.5%': [2568], 'following': [2573, 3031], 'days.': [2575, 3618, 3636], 'Median': [2576, 3637], 'survival': [2577, 3638], '=': [2578, 2582, 2610, 2615, 2631, 2636, 2665, 2670, 2687, 2718, 2723, 2730, 2735, 2939, 2944, 2961, 3047, 3052, 3451, 3491, 3560, 3565, 3570, 3576, 3622, 3628, 3634, 3641, 3647, 3653, 3656, 3674, 3677, 3685, 3866, 3900, 3946, 3952, 3958, 3961, 3979, 3990], '39': [2579], 'days,': [2580, 3624, 3630, 3643, 3649, 3948, 3954], 'N': [2581, 2609, 2614, 2630, 2635, 2664, 2669, 2686, 2717, 2722, 2729, 2734, 2938, 2943, 2960, 3046, 3051, 3450, 3490, 3559, 3564, 3569, 3575, 3655, 3865, 3899, 3960], '260.': [2583], 'Oxygen': [2584, 2639, 2902], 'quantification': [2588, 2643], 'compared': [2597, 2626, 2652], 'Data': [2601, 2656, 2711, 2740, 2997, 3055, 3535, 3690, 3888], 'were': [2602, 2657, 2712, 2763, 2774, 2912, 2998, 3239, 3322, 3536, 3589, 3695, 3889], 'normalized': [2603, 2658, 2713, 2999, 3537, 3890], '1-week-old': [2605, 2660, 3438, 3816], '(young': [2607, 2662], 'flies).': [2608, 2663], '14': [2611], 'vs.': [2613, 2634, 2668, 2721, 2733], '12': [2616], 'old.': [2617], 'midlife,': [2619, 4100], '5': [2637, 2967, 3053, 3492, 3867, 3901], '21': [2666, 2940], 'Metabolite': [2673], 'citrate/isocitrate': [2681, 3114, 3135], 'compound': [2682], '6': [2688, 2731], 'group.': [2690, 2964, 3454, 3494, 3869, 3903], 'Enzymatic': [2691], 'CS,': [2703], '(Kdn);': [2706], 'ATPCL,': [2707], 'lyase.': [2710], '8': [2719, 3253, 3566, 4040], '9': [2724, 3561, 3571], 'CS': [2727], 'ATPCL.': [2739], 'information:': [2741, 3056, 3691], '*P': [2742], '<': [2743, 2746, 2749, 3581, 3584, 3688, 3982, 3993], '0.05,': [2744], '**P': [2745, 3580], '0.01': [2747], '***P': [2748, 3583], '0.001.': [2750, 3585], 'Error': [2751, 3057, 3595, 3904], 'bars': [2752, 3058, 3596], 'indicate': [2753, 3062, 3597], 'SEM': [2755, 3908], 'graphs.': [2759], 'Unpaired': [2760, 3586], 'two-tailed': [2761, 3587], 't-tests': [2762, 3588], 'calculating': [2766, 3592], 'P-values': [2768], '(B–F).': [2770], 'All': [2771, 3692], 'collected': [2775, 3548, 3696], 'male/female': [2779, 3700, 3915], 'population.': [2780, 3701], 'Download': [2781, 2783, 3065, 3067, 3702, 3704, 3995, 3997], 'figure': [2782, 3066, 3703, 3996], 'PowerPoint': [2784, 3068, 3705, 3998], 'Click': [2785, 3706], 'here': [2786, 3707], 'expand': [2788, 3709], 'figure.': [2790, 3711], 'EV1.': [2792], 'Technical': [2793], 'parameters': [2794], 'Representative': [2800, 2854, 3426], '(blue': [2807, 2861], 'circles)': [2808, 2862], '(black': [2812], 'squares),': [2813, 2867], 'showing': [2814, 2868, 3429, 3459], '7-week-old': [2821], 'During': [2823], 'assay': [2825, 3018], 'lasting': [2826], '2': [2827], 'min,': [2828], 'series': [2830, 2911], 'submeasurements': [2834], '(ticks)': [2835], 'taken.': [2837], 'slope': [2839], 'ticks': [2843], 'calculated': [2845], 'generate': [2847], 'measurement.': [2853], '(red': [2866], '4-week-old': [2875, 3441, 3819], 'Negative': [2877], 'wells': [2880, 2887, 2915, 2933], 'containing': [2881, 2916], 'buffer': [2882], 'without': [2883], 'any': [2884], 'tissue.': [2885], 'Background': [2886], 'showed': [2888, 3209, 4076], 'no': [2889, 3359], 'served': [2895, 3445], 'background': [2897], 'measurements.': [2901, 4070], 'first': [2906, 2927, 3070], 'tick': [2907, 2928], 'each': [2909, 3060], 'measurement': [2910, 3540, 3893], 'similar': [2913, 2930, 2953, 3333, 3717, 3802, 3927], 'pH': [2924], 'was': [2929], 'two': [2936], 'groups.': [2937], 'Measurements': [2947], 'weight': [2954], '6–7': [2962], 'Addition': [2965], 'μM': [2968], 'rotenone,': [2969], 'complex': [2971], 'I': [2972], 'inhibitor,': [2973], 'significantly': [2974], 'decreases': [2975], 'consumption.': [2977], 'demonstrates': [2980], 'being': [2987], 'relates': [2989], 'consumed': [2992], 'complexes.': [2996], 'data': [3002, 3774, 3834], 'point': [3003], 'addition': [3006, 3012, 3532, 3543, 3896], 'rotenone.': [3008], 'Dashed': [3009], 'line': [3010, 3529, 3777, 3837], 'indicates': [3011, 3530, 3716, 3906], 'drug.': [3015], 'Fly': [3016], 'after': [3019, 3479, 3549, 4067], '3': [3020, 3032], 's.': [3021], 'Distribution': [3022], 'across': [3025], 'four': [3026], 'sections': [3027], 'vial': [3030], 's': [3033, 4175], 'flipping': [3035], '(Q4': [3036], 'section': [3039], 'top': [3042], 'vial).': [3045], 'graph': [3061], 'SEM.': [3064, 3599], 'set': [3071], 'out': [3072], 'ask': [3074], 'production.': [3084], 'applied': [3087], 'non-targeted': [3089], 'mass': [3090, 3258, 3749], 'spectrometry-based': [3091], 'metabolomic': [3092], 'profiling': [3093], '252627': [3094], 'quantitate': [3096], 'glycolysis': [3101], 'TCA': [3104, 3309, 3379], 'cycle.': [3105], 'Interestingly,': [3106], 'detected': [3108], '1D),': [3119], 'while': [3120, 3278], 'acetate': [3124], 'do': [3127], 'change.': [3129, 3497, 3872], 'acetyl-CoA,': [3137], 'specific': [3139], 'activities': [3140], '(CS/Kdn),': [3145], 'marker': [3147], '(ATPCL),': [3157], 'responsible': [3160, 4140], 'cytosolic': [3162], 'synthesis,': [3164], '1E).': [3171], 'Proteome': [3172, 3793, 3853], 'abundance': [3177], 'next': [3184], 'tested': [3185], 'consequence': [3194], 'Head': [3202], 'extracts': [3203, 3242], 'probed': [3204], 'pan-acetyl-lysine': [3207, 3251], 'antibody': [3208, 3252], 'some': [3213], 'acetylated': [3214, 3237], '2A).': [3220], 'resolve': [3222], 'identity': [3224], 'hyper-acetylated': [3227, 3294], 'proteins,': [3228], 'proteomic': [3232], 'approach': [3233], 'peptides': [3235], 'enriched': [3240], 'quantified': [3255], 'label-free': [3257], 'spectrometry': [3259, 3750], '(Dataset': [3260, 3314], 'EV1).': [3261, 3315], 'Among': [3262], '217': [3264], 'high-confidence': [3265], 'sites,': [3267], '79': [3268], 'sites': [3270, 3463], '49': [3272], 'distinct': [3273], 'three': [3280], 'decrease': [3281], '2B': [3283], 'EV2A).': [3285], 'GO': [3286], 'analysis': [3287, 3715, 3794], 'majority': [3291], 'involved': [3301, 3807], 'final': [3304], 'steps': [3305], 'glycolysis,': [3307, 3377], 'cycle,': [3310, 3380], 'phosphorylation': [3313], 'Importantly,': [3316], 'cases,': [3319], 'due': [3324, 4088], 'since': [3330], '1,138': [3336], '1,238': [3340], 'EV2B': [3348], 'Datasets': [3352], 'EV1': [3353], 'EV2).': [3355], 'Notably,': [3356], 'significant': [3360], 'pathways,': [3374], 'phosphorylation.': [3383], 'quantitative': [3385], 'rate,': [3400], 'enhanced': [3405], 'enzymes.': [3410], 'Midlife': [3413], 'KDACi': [3424], 'treatment': [3425, 4126], 'Western': [3427], 'blot': [3428], 'mildly': [3431], 'pattern': [3435], '(anti-AcK)': [3436], '(young)': [3439, 3817], '(midlife)': [3442, 3820], 'Tubulin': [3444], 'loading': [3448], 'control.': [3449], '4–5': [3452], 'Tub,': [3455], 'Tubulin.': [3456], 'Heat': [3457], 'map': [3458, 3855], 'flies,': [3468, 3518], 'based': [3469], 'acetyl-lysine-enriched': [3472], 'peptide': [3473], 'fractions': [3474], 'MS': [3477, 3800], 'normalization': [3480], 'input': [3483, 3797], '(detailed': [3484], 'statistical': [3485], 'method': [3486], 'extended': [3488], '4).': [3489], 'fc,': [3495, 3870], 'fold': [3496, 3871], 'inhibitor': [3501, 3730, 4125], '(KDACi)': [3502], 'sodium': [3503, 3601, 4036], 'butyrate': [3504, 3602, 4037], '(SB)': [3505], 'induces': [3506, 3876], 'rapid': [3508, 4057], 'milder': [3523], 'dashed': [3528], 'SB.': [3534, 3579], 'prior': [3541, 3894], 'SB': [3545, 3627, 3633, 3646, 3652, 3668, 3679], '(100%)': [3546], 'five': [3550], 'cycles': [3551], 'measurements,': [3553], 'corresponding': [3554], 'approximately': [3556], '33': [3557], 'min.': [3558], 'vehicle,': [3563, 3573, 3963], 'SB,': [3568], '0.01,': [3582], 'P-values.': [3594], 'High': [3600], '(SB)-treated': [3603], 'earlier': [3614], 'Survival': [3619, 3943], '26': [3623], '15': [3625, 3644, 3669], 'mM': [3626, 3632, 3645, 3651, 3661, 3666, 3670, 3681], '150': [3631, 3650, 3680], '45': [3642], '41': [3648], '30.': [3654], '357': [3657], '(vehicle),': [3658], '294': [3659], '(15': [3660], 'SB),': [3662], '320': [3664], '(150': [3665], 'SB).': [3667], 'log-rank': [3671, 3682], 'test,': [3672, 3683], 'χ2': [3673, 3684, 3978, 3989], '14.83,': [3675], 'P': [3676, 3687, 3981, 3992], '0.0001.': [3678, 3689, 3983, 3994], '151.1,': [3686], 'EV2.': [3713], 'Proteomic': [3714], 'profile': [3718], 'KDAC': [3729, 4049, 4124], 'TSA': [3731, 3951, 3957, 4039], 'negative': [3736], 'impact': [3737], 'Quantification': [3743], '(MS)': [3751], 'box': [3763, 3823], 'represents': [3764, 3824], 'interval': [3766, 3826], 'contains': [3768, 3828], '50%': [3771, 3831], 'indicating': [3778, 3838], 'median.': [3780, 3840], 'length': [3782, 3842], 'whiskers': [3785, 3845], '1.5': [3787, 3847], 'times': [3788, 3848], 'interquartile': [3790, 3850], 'distance': [3791, 3851], '(IQD).': [3792, 3852], 'samples': [3798], 'absolute': [3803], '(in)': [3810], 'non-metabolic': [3812], '(out)': [3813], 'processes': [3814, 4134], 'heat': [3854], 'intensities': [3859], '(see': [3860], '2.2)': [3861], 'input.': [3864], 'Trichostatin': [3873], '(TSA)': [3875], 'TSA.': [3898], 'bar': [3905], '400-nM': [3909, 3933], 'TSA-treated': [3910, 3934], 'weeks.': [3931], 'median': [3938], 'maximal': [3940], '53': [3947], '40': [3949], 'nM': [3950, 3956, 3966, 3971], '47': [3953], '400': [3955], '45,': [3959], '368': [3962], '296': [3964], '(40': [3965], 'TSA)': [3967], '326': [3969], '(400': [3970], 'TSA).': [3972], 'Log-rank': [3973, 3984], 'test': [3974, 3985, 4166], 'TSA40': [3976], 'nM,': [3977, 3988], '24.33,': [3980], 'TSA400': [3987], '79.55,': [3991], '(KDAC)': [4001, 4034], 'Because': [4006], 'important': [4011], '8282930,': [4018], 'wondered': [4020], 'pharmacological': [4023], 'elevation': [4024], 'global': [4031], 'would': [4041], 'OCR.': [4046], 'Adding': [4047], 'resulted': [4054], '2C': [4062], 'EV2D),': [4064], 'subsided': [4066], 'Heads': [4071], 'prepared': [4072], 'pronounced': [4079], '2C).': [4084], 'may': [4086, 4131], 'ground': [4092], '2A': [4110], 'B).': [4112], 'responsiveness': [4119], 'upon': [4123], 'suggests': [4127], 'regulate': [4132], 'least': [4138], 'partly': [4139], 'results,': [4151], 'hypothesized': [4153], 'sustained': [4155], 'high': [4156], 'might': [4161], 'restrict': [4162], 'prediction,': [4168], 'pharmacologically': [4170]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2290069354', 'counts_by_year': [{'year': 2024, 'cited_by_count': 11}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 15}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 16}, {'year': 2019, 'cited_by_count': 15}, {'year': 2018, 'cited_by_count': 13}, {'year': 2017, 'cited_by_count': 20}, {'year': 2016, 'cited_by_count': 15}], 'updated_date': '2025-01-15T19:36:21.448860', 'created_date': '2016-06-24'}
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