Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2289646458', 'doi': 'https://doi.org/10.1093/jac/18.supplement_b.85', 'title': 'Extended acyclovir therapy for herpes genitalis: changes in virus sensitivity and strain variation', 'display_name': 'Extended acyclovir therapy for herpes genitalis: changes in virus sensitivity and strain variation', 'publication_year': 1986, 'publication_date': '1986-10-01', 'ids': {'openalex': 'https://openalex.org/W2289646458', 'doi': 'https://doi.org/10.1093/jac/18.supplement_b.85', 'mag': '2289646458', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/3025158'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/jac/18.supplement_b.85', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S124275759', 'display_name': 'Journal of Antimicrobial Chemotherapy', 'issn_l': '0305-7453', 'issn': ['0305-7453', '1460-2091'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5072104655', 'display_name': 'Sandra Nusinoff Lehrman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1309191912', 'display_name': 'Research Triangle Park Foundation', 'ror': 'https://ror.org/03eqttr49', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1309191912']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sandra Nusinoff Lehrman', 'raw_affiliation_strings': ['Wellcome Research Laboratories, 3030 Cornwallis Road, Research Triangle Park, NC 27709'], 'affiliations': [{'raw_affiliation_string': 'Wellcome Research Laboratories, 3030 Cornwallis Road, Research Triangle Park, NC 27709', 'institution_ids': ['https://openalex.org/I1309191912']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112187667', 'display_name': 'Edgar L. Hill', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1309191912', 'display_name': 'Research Triangle Park Foundation', 'ror': 'https://ror.org/03eqttr49', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1309191912']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Edgar L. Hill', 'raw_affiliation_strings': ['Wellcome Research Laboratories, 3030 Cornwallis Road, Research Triangle Park, NC 27709'], 'affiliations': [{'raw_affiliation_string': 'Wellcome Research Laboratories, 3030 Cornwallis Road, Research Triangle Park, NC 27709', 'institution_ids': ['https://openalex.org/I1309191912']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049620208', 'display_name': 'James F. Rooney', 'orcid': 'https://orcid.org/0000-0003-3261-0711'}, 'institutions': [{'id': 'https://openalex.org/I4210134534', 'display_name': 'National Institute of Allergy and Infectious Diseases', 'ror': 'https://ror.org/043z4tv69', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210134534']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James F. Rooney', 'raw_affiliation_strings': ['Laboratory of Medical Virology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20205, U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Medical Virology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20205, U.S.A.', 'institution_ids': ['https://openalex.org/I4210134534']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069802186', 'display_name': 'Mark Ellis', 'orcid': 'https://orcid.org/0000-0001-6076-5994'}, 'institutions': [{'id': 'https://openalex.org/I1309191912', 'display_name': 'Research Triangle Park Foundation', 'ror': 'https://ror.org/03eqttr49', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1309191912']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'M. Nixon Ellis', 'raw_affiliation_strings': ['Wellcome Research Laboratories, 3030 Cornwallis Road, Research Triangle Park, NC 27709'], 'affiliations': [{'raw_affiliation_string': 'Wellcome Research Laboratories, 3030 Cornwallis Road, Research Triangle Park, NC 27709', 'institution_ids': ['https://openalex.org/I1309191912']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112185438', 'display_name': 'David W. Barry', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1309191912', 'display_name': 'Research Triangle Park Foundation', 'ror': 'https://ror.org/03eqttr49', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1309191912']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David W. Barry', 'raw_affiliation_strings': ['Wellcome Research Laboratories, 3030 Cornwallis Road, Research Triangle Park, NC 27709'], 'affiliations': [{'raw_affiliation_string': 'Wellcome Research Laboratories, 3030 Cornwallis Road, Research Triangle Park, NC 27709', 'institution_ids': ['https://openalex.org/I1309191912']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111598177', 'display_name': 'Stephen E. Straus', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210134534', 'display_name': 'National Institute of Allergy and Infectious Diseases', 'ror': 'https://ror.org/043z4tv69', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210134534']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stephen E. Straus', 'raw_affiliation_strings': ['Laboratory of Medical Virology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20205, U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Medical Virology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20205, U.S.A.', 'institution_ids': ['https://openalex.org/I4210134534']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2627, 'currency': 'GBP', 'value_usd': 3222, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.372, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 24, 'citation_normalized_percentile': {'value': 0.787046, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '18', 'issue': 'Supplement_B', 'first_page': '85', 'last_page': '94'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10625', 'display_name': 'Herpesvirus Infections and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10625', 'display_name': 'Herpesvirus Infections and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10981', 'display_name': 'Cytomegalovirus and herpesvirus research', 'score': 0.9934, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11560', 'display_name': 'Animal Disease Management and Epidemiology', 'score': 0.9771, 'subfield': {'id': 'https://openalex.org/subfields/1102', 'display_name': 'Agronomy and Crop Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/herpes-genitalis', 'display_name': 'Herpes Genitalis', 'score': 0.7748673}, {'id': 'https://openalex.org/keywords/strain', 'display_name': 'Strain (injury)', 'score': 0.48601824}, {'id': 'https://openalex.org/keywords/herpes-virus', 'display_name': 'Herpes virus', 'score': 0.42970255}], 'concepts': [{'id': 'https://openalex.org/C2909813250', 'wikidata': 'https://www.wikidata.org/wiki/Q7476596', 'display_name': 'Herpes Genitalis', 'level': 5, 'score': 0.7748673}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.7289594}, {'id': 'https://openalex.org/C2778022156', 'wikidata': 'https://www.wikidata.org/wiki/Q576145', 'display_name': 'Strain (injury)', 'level': 2, 'score': 0.48601824}, {'id': 'https://openalex.org/C2992174592', 'wikidata': 'https://www.wikidata.org/wiki/Q5743653', 'display_name': 'Herpes virus', 'level': 3, 'score': 0.42970255}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.42214215}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.416008}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.37083262}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3705174}, {'id': 'https://openalex.org/C2781196997', 'wikidata': 'https://www.wikidata.org/wiki/Q655331', 'display_name': 'Herpes simplex virus', 'level': 3, 'score': 0.3169859}, {'id': 'https://openalex.org/C2778498788', 'wikidata': 'https://www.wikidata.org/wiki/Q7476596', 'display_name': 'Genital herpes', 'level': 4, 'score': 0.16592014}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.09966263}], 'mesh': [{'descriptor_ui': 'D000212', 'descriptor_name': 'Acyclovir', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D006558', 'descriptor_name': 'Herpes Genitalis', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D018139', 'descriptor_name': 'Simplexvirus', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000212', 'descriptor_name': 'Acyclovir', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000212', 'descriptor_name': 'Acyclovir', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000284', 'descriptor_name': 'Administration, Oral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004279', 'descriptor_name': 'DNA, Viral', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D004279', 'descriptor_name': 'DNA, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004352', 'descriptor_name': 'Drug Resistance, Microbial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006558', 'descriptor_name': 'Herpes Genitalis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012008', 'descriptor_name': 'Recurrence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018139', 'descriptor_name': 'Simplexvirus', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018139', 'descriptor_name': 'Simplexvirus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/jac/18.supplement_b.85', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S124275759', 'display_name': 'Journal of Antimicrobial Chemotherapy', 'issn_l': '0305-7453', 'issn': ['0305-7453', '1460-2091'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/3025158', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.83, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2378659525', 'https://openalex.org/W2312175987', 'https://openalex.org/W2265352544', 'https://openalex.org/W2146206816', 'https://openalex.org/W2087205763', 'https://openalex.org/W2068902580', 'https://openalex.org/W1993339219', 'https://openalex.org/W1993052581', 'https://openalex.org/W1562336285', 'https://openalex.org/W1501017079'], 'abstract_inverted_index': {'Journal': [0, 205], 'Article': [1], 'Extended': [2], 'acyclovir': [3], 'therapy': [4], 'for': [5, 35, 65, 99, 129, 159, 193], 'herpes': [6], 'genitalis:': [7], 'changes': [8], 'in': [9], 'virus': [10], 'sensitivity': [11], 'and': [12, 91, 185], 'strain': [13], 'variation': [14], 'Get': [15], 'access': [16], 'Sandra': [17, 20], 'Nusinoff': [18, 21], 'Lehrman,': [19], 'Lehrman': [22], 'Wellcome': [23, 53, 117, 147], 'Research': [24, 29, 54, 59, 118, 123, 148, 153], 'Laboratories,': [25, 55, 119, 149], '3030': [26, 56, 120, 150], 'Cornwallis': [27, 57, 121, 151], 'Road,': [28, 58, 122, 152], 'Triangle': [30, 60, 124, 154], 'Park,': [31, 61, 125, 155], 'NC': [32, 62, 126, 156], '27709;': [33, 63, 127, 157], 'Search': [34, 64, 98, 128, 158, 192], 'other': [36, 66, 100, 130, 160, 194], 'works': [37, 67, 101, 131, 161, 195], 'by': [38, 68, 102, 132, 162, 196], 'this': [39, 69, 103, 133, 163, 197], 'author': [40, 70, 104, 134, 164, 198], 'on:': [41, 71, 105, 135, 165, 199], 'Oxford': [42, 72, 106, 136, 166, 200], 'Academic': [43, 73, 107, 137, 167, 201], 'PubMed': [44, 74, 108, 138, 168, 202], 'Google': [45, 75, 109, 139, 169, 203], 'Scholar': [46, 76, 110, 140, 170, 204], 'Edgar': [47, 50], 'L.': [48, 51], 'Hill,': [49], 'Hill': [52], 'James': [77, 80], 'F.': [78, 81], 'Rooney,': [79], 'Rooney': [82], 'Laboratory': [83, 177], 'of': [84, 89, 178, 183, 206], 'Medical': [85, 179], 'Virology,': [86, 180], 'National': [87, 181], 'Institute': [88, 182], 'Allergy': [90, 184], 'Infectious': [92, 186], 'Diseases,': [93, 187], 'Bethesda,': [94, 188], 'MD': [95, 189], '20205,': [96, 190], 'U.S.A.': [97, 191], 'M.': [111, 114], 'Nixon': [112, 115], 'Ellis,': [113], 'Ellis': [116], 'David': [141, 144], 'W.': [142, 145], 'Barry,': [143], 'Barry': [146], 'Stephen': [171, 174], 'E.': [172, 175], 'Straus': [173, 176], 'Antimicrobial': [207], 'Chemotherapy,': [208], 'Volume': [209], '18,': [210], 'Issue': [211], 'Supplement_B,': [212], 'October': [213, 220], '1986,': [214], 'Pages': [215], '85–94,': [216], 'https://doi.org/10.1093/jac/18.Supplement_B.85': [217], 'Published:': [218], '01': [219], '1986': [221]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2289646458', 'counts_by_year': [{'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-12-11T13:00:40.282648', 'created_date': '2016-06-24'}