Publication Information

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3391, 3547, 3673, 3725, 3731], 'remote': [182, 2098], 'outpatient': [185, 539, 892, 1032], 'treatment': [186, 840, 999, 1208, 1389, 1649, 1659, 1672, 1699, 1760, 1765, 1826, 1929, 1995, 2038, 2103, 2149, 2266, 2450, 2773, 2852, 2994, 3272, 3385, 3668], 'alcohol': [188, 303, 442, 583, 947, 981, 994, 1056, 1720, 1733, 1739, 2094, 2101, 2472, 2503, 2545], 'use': [189, 584, 773, 908, 1204, 1667, 1718, 1734, 1740, 1877, 2127, 2143, 2569, 2615, 3190], 'disorder': [190, 3672], 'as': [191, 642, 1021, 1023, 1338, 1853, 1905, 1968, 2793, 3025, 3169, 3191], 'young': [193], 'adult.': [194], 'His': [195, 743], 'first': [196], 'episode': [197], 'depression': [200, 251, 274, 391, 1096, 1186, 1189, 1210, 1238, 1486, 1585, 1644, 1742, 1828, 1845, 2037, 2151, 2543], 'occurred': [201, 1904], 'at': [202, 239, 336, 424, 545], 'age': [203], '22': [204], 'association': [206], 'suicide': [209, 944, 1088], 'attempt': [210, 945], '(he': [211, 414, 585], 'jumped': [212], 'off': [213, 1848], 'four-story': [215], 'building)': [216], 'subsequent': [218, 236], 'hospitalization.': [219], 'Mr.': [220, 299, 402, 447, 507, 647, 763, 814, 867, 887, 962, 1024, 1083, 1428, 1636, 1681, 1693, 1753, 1788, 1906, 1966, 2090], 'A’s': [221, 263, 382, 561, 929, 1084, 1429, 1682, 1717, 1754, 2091], 'significant': [225], 'corrected': [227], 'hypothyroidism.': [228], 'The': [229, 998, 1077, 1223, 1304, 1546, 2247, 2985, 3163], 'prospective': [230, 1423], 'course': [231, 376, 1727], 'illness': [233], 'encompassed': [234], 'four': [235, 588], 'psychiatric': [237, 2509], 'admissions': [238, 576], 'our': [240, 800], 'center,': [242], 'annually': [243], 'from': [244, 330, 552, 574, 788, 883, 927, 1044, 1515, 2201, 2223], '2012': [245, 269], '2014,': [247, 572], 'illustrating': [248], 'clear': [249, 1884, 2067], 'treatment-resistant': [250, 1185, 2753, 2998, 3079, 3210, 3693], 'reemerging': [254], 'pattern': [255], 'substance': [257, 823, 1710, 2126, 2568], 'misuse': [258, 411, 1690, 2001, 2095], '(alcohol,': [259], 'benzodiazepines,': [260], 'ketamine).Mr.': [262], 'admission': [264, 333, 535, 563, 931], 'summer': [267], 'focused': [270], 'on': [271, 308, 323, 332, 344, 399, 430, 578, 771, 1152, 1575, 1597, 2342, 2367, 2428, 2760, 2781, 2801, 2831, 3048, 3093, 3125, 3236, 3273, 3304, 3541, 3659], 'consultation': [272], 'consideration': [276], 'ECT.': [278], 'Prior': [279], 'medication': [280, 860, 1037, 1126, 1356, 1463, 2058], 'trials': [281, 2297], 'optimal': [283, 1240], 'dose': [284, 2916, 3206], 'duration': [286], 'included': [287, 536, 618, 1053, 1806], 'trazodone,': [288], 'escitalopram,': [289], 'bupropion,': [290], 'mirtazapine': [292, 345, 354], 'lamotrigine': [294], 'aripiprazole': [296], 'augmentation': [297, 360, 1105], 'strategies.': [298], 'A': [300, 403, 448, 496, 508, 648, 764, 815, 843, 888, 953, 963, 1006, 1025, 1694, 1789, 1907, 2532, 2632, 2709, 2828, 3219, 3544, 3676], 'reported': [301, 404, 449, 473, 509, 586, 649, 677, 745, 831, 964, 979, 1948], 'negligible': [302], 'consumption': [304, 982, 2473], '(a': [305], 'single': [306, 467, 1785, 2362, 3205], 'drink': [307], 'rare': [309], 'occasions).': [310], 'He': [311, 338, 365, 554, 604, 676, 717, 912, 978, 1442], 'received': [312, 366, 465, 1443, 1908, 2198, 2220], 'seven': [313], 'bilateral': [314], 'ECT': [315, 363, 369, 375, 524, 2749], 'treatments,': [316], 'symptoms': [319, 1971], 'improved;': [320], 'score': [322], 'Hamilton': [325], 'Rating': [327], 'Scale': [328], 'declined': [329, 869], '37': [331], '8': [335, 3736], 'discharge.': [337], 'discharged': [340, 882], 'after': [341, 532, 687, 936, 1566], '18': [342], 'days': [343], 'monotherapy': [346], 'recommendations': [348, 531, 861, 1805], 'maximize': [350], 'dosing': [352, 2068], 'add': [357], 'lithium': [358], 'following': [361], 'course.': [364], 'three': [367, 987], 'additional': [368, 2116], 'treatments': [370, 1120], 'prior': [371], 'self-discontinuing': [373], 'being': [378, 1567, 1608, 1914, 2034], 'lost': [379], 'follow-up.Mr.': [381], '2013': [383], 'admission,': [384, 431, 523, 592, 665, 886, 939], '15': [385], 'months': [386, 568, 1049], 'later,': [387], 'suicidal': [393], 'ideation': [394], 'intent': [396], 'overdose': [398, 949], 'prescribed': [400, 423, 501, 512, 611, 653, 822, 910, 951, 1236, 1455, 1709, 2035], 'medications.': [401], 'drinking': [405], '1–2': [406], 'beers': [407, 984], 'day': [409], 'lorazepam': [413, 542], 'taking': [416, 510], '5': [417], 'mg': [418, 426, 547], 'daily,': [419, 549], 'although': [420, 613], 'it': [421, 760, 1268, 1507], '1': [425, 546, 3762, 3768], 'twice': [427, 548], 'daily).': [428, 590], 'However,': [429, 646, 1314, 1752], 'urine': [433, 594, 621, 954], 'drug': [434, 595, 622, 955, 1145, 1320, 1876, 2158, 2274, 2423, 2597], 'abuse': [435, 596, 623, 995, 1305, 1333, 2405, 2504, 2705, 3187], 'test': [436, 597, 956], 'negative,': [438, 599, 958], 'including': [439, 600, 864, 959, 1031, 1322, 1504], 'absence': [440, 601], 'benzodiazepines.': [444], 'During': [445, 854], 'hospitalization,': [446, 856], 'that': [450, 678, 727, 746, 754, 817, 824, 965, 1014, 1082, 1131, 1361, 1380, 1497, 1510, 1697, 1704, 1711, 1817, 1862, 2065], 'earlier': [451], 'year,': [454], 'he': [455, 464, 472, 486, 667, 669, 755, 830, 880, 895, 905, 966, 971, 1969], 'participated': [456, 889, 1026], 'an': [458, 891, 922, 1124, 1339, 1354, 1653, 1856, 2340, 3192], 'out-of-state': [459, 628], 'research': [460, 1113, 1489, 1595, 2117], 'study': [461, 489, 3003, 3310], 'which': [463, 471, 666, 866, 1012, 1419, 1560, 1850], 'intravenous': [468, 3688], 'ketamine': [469, 494, 503, 513, 558, 608, 614, 656, 683, 721, 747, 768, 796, 807, 818, 837, 969, 1072, 1193, 1206, 1235, 1251, 1424, 1432, 1437, 1445, 1484, 1495, 1533, 1544, 1552, 1565, 1573, 1651, 1669, 1684, 1705, 1809, 1824, 1843, 1912, 1942, 1985, 1991, 2009, 2021, 2031, 2087, 2134, 2145, 2365, 2390, 2404, 2407, 2430, 2453, 2614, 2751, 2769, 2917, 3123, 3186, 3208, 3230, 3271, 3303, 3381, 3689], 'infusion,': [470], 'provided': [474], 'antidepressant': [475, 680, 1129, 1383, 1599, 1656, 1797, 3170], 'benefit': [476, 681], '4–5': [478], 'days.': [479], 'Because': [480], 'perceived': [483], 'mood': [484, 2268, 2327], 'improvement,': [485], 'left': [487], 'sought': [491], 'out': [492], 'prescriber.': [495], 'neurologist': [497, 1571], 'another': [499], 'state': [500, 1448], 'intranasal': [502, 720, 1177, 1319, 1451, 1505, 1564, 2429, 2452], 'depression,': [505, 566, 828, 933, 1674, 1931, 3094], 'intranasally': [514, 638], 'continued': [516, 907], 'benefit.': [517], 'In': [518, 1898], 'contrast': [519], 'previous': [522, 575, 877, 938], 'not': [526, 556, 617, 849, 1018, 1311, 1349, 1368, 1440, 1522, 1663, 1678, 1702, 1822, 1831, 1864, 1957, 2129], 'instituted': [527], '2013.': [529], 'Discharge': [530], '5-day': [534], 'follow-up': [537, 2005], 'prescribers,': [540], 'changing': [541], 'clonazepam': [544], 'abstinence': [551], 'alcohol.': [553, 603, 961], 'did': [555, 1677, 1701], 'receive': [557, 1481], 'while': [559, 784], 'hospitalized.Mr.': [560], 'next': [562], '3': [567, 1048, 3739], 'later': [569, 1724], 'early': [571, 1162, 1594, 2295], 'differed': [573], 'based': [577, 770, 1574], 'reemergence': [580], 'increasing': [582], 'consuming': [587], 'drinks': [589], 'On': [591], 'admitted': [605], 'using': [607, 650, 719, 785], 'beyond': [609], 'recommendations,': [612], 'screening': [615], 'test.': [624], 'We': [625, 798], 'contacted': [626], 'prescriber,': [629, 808], 'who': [630, 809, 1346, 1480, 1638, 1820], 'verified': [631], 'prescribing': [632, 1387, 1854, 2010, 2022, 2054], 'ketamine,': [633, 782, 1183, 1371], '150': [634], 'mg/mL,': [635], '0.5–1': [636], 'mL': [637], 'every': [639], '4': [640], 'hours': [641, 686], 'needed': [643, 670], 'depression.': [645, 1358, 1391, 2302, 2433], 'higher': [651], 'than': [652, 1102, 2074, 2110], 'doses': [654, 1458], 'frequently': [659], '(10–12': [660], 'times': [661, 737], 'day)': [663], 'before': [664, 1239], 'said': [668], 'relieve': [672], 'symptoms.': [675, 1979], 'lasted': [684], '2–3': [685], 'administration,': [688, 1244], 'but': [689, 894, 991, 1536, 1956], 'noted': [690], 'transient': [691], 'dissociative': [692], 'side': [693, 2794, 3200], 'effects': [694, 1130, 1287, 1384, 2360, 3120, 3201, 3301], 'lasting': [695], 'up': [696], '20': [698], 'minutes': [699], '(“feeling': [700], 'like': [701, 1635, 1650], 'I': [702, 740], 'am': [703], 'dreamy': [706], 'state”': [707], '“trippy': [709], 'effect': [710, 3088], '…': [711], 'can': [712], 'be': [713, 899, 1888, 2012, 2130, 2155], 'kind': [714], 'intense”).': [716], 'mentioned': [718], 'car': [724], 'stated': [726], 'mother': [729], 'had': [730, 756, 825, 967, 1712, 1970], 'concerns': [731, 801, 1688], 'about': [732, 1689, 2020, 2595, 2637], 'driving': [734, 783], 'during': [735], 'those': [736, 1782], '(“She': [738], 'thought': [739], 'swerving”).': [742], 'family': [744, 1078], '“ripping': [749], 'life': [751], 'apart”': [752], '“no': [757], 'control': [758], 'over': [759, 1061], '[ketamine': [761], 'use].”': [762], 'met': [765], 'criteria': [766], 'dependence': [769, 1296, 1801, 1945, 1986, 2506], 'increased': [775, 779], 'amounts': [776], 'tolerance': [780, 1973], 'despite': [786, 838], 'concern': [787], 'family,': [789], 'loss': [791], 'employment': [793], 'due': [794], 'use.': [797, 1943, 2598], 'discussed': [799, 858], 'patient': [804, 1562, 3005], 'agreed': [810], 'cease': [812], 'prescribing.': [813, 2088], 'insisted': [816], 'only': [821, 1363, 1708], 'helped': [826], 'intention': [833], 'seek': [835], 'team’s': [841, 1660], 'recommendations.': [842], 'petition': [844], 'civil': [846, 1004], 'commitment': [847, 1009, 1020], 'supported': [850, 1170], 'court.': [853], 'we': [857, 1932], 'alternative': [859], 'consider,': [863], 'ECT,': [865], 'because': [870, 920, 970], 'memory': [872], 'difficulties': [873], 'associated': [874, 941, 2913, 3202], 'treatment.': [878, 1730], 'After': [879, 2674], '7-day': [885], 'program,': [893], 'often': [896], 'appeared': [897], 'intoxicated': [900], 'group': [902, 918], 'sessions,': [903], 'acknowledged': [906], 'ketamine.': [911, 1148, 2114, 2638], 'occasionally': [914], 'asked': [915], 'leave': [917], 'sessions': [919], 'inability': [923], 'maintain': [925], 'sobriety': [926], 'ketamine.Mr.': [928], 'fourth': [930], 'month': [935], 'eszopiclone.': [952], 'discontinued': [968], 'unable': [973], 'obtain': [975], 'drug.': [977], 'moderate': [980], '(1–2': [983], 'two': [985], 'or': [986, 996, 1466, 1529, 1616, 1799, 1859, 1893, 2047, 2317], 'nights': [988], 'week)': [990], 'adamantly': [992], 'denied': [993], 'dependence.': [997, 1692, 2546], 'team': [1000, 1676, 1700], 'again': [1001], 'petitioned': [1002], 'commitment.': [1005], 'stay': [1007], 'granted,': [1011], 'meant': [1013], 'court': [1016], 'would': [1017, 1348], 'enforce': [1019], 'long': [1022], 'recommended': [1028], 'voluntary': [1029], 'treatment,': [1030, 1802], 'chemical': [1033], 'dependency': [1034], 'evaluation': [1035], 'management.We': [1038], 'were': [1039, 1075, 1687], 'notified': [1040], 'death': [1043, 1085], 'single-car': [1046], 'crash': [1047], 'later.': [1050], 'Autopsy': [1051], 'findings': [1052], 'blood': [1055], 'concentration': [1057], '0.133%': [1059], '(well': [1060], '0.08%': [1063], 'legal': [1064], 'limit),': [1065], 'tetrahydrocannabinol,': [1066], 'bupropion': [1068], '(prescribed);': [1069], 'tests': [1070], 'norketamine': [1074], 'negative.': [1076], 'indicated': [1079], 'belief': [1081], 'facilitated': [1089], 'alcohol.DiscussionThe': [1091], 'morbidity': [1092], 'mortality': [1094], 'are': [1097, 1132, 1196, 1498, 1513, 1521, 1603, 1744, 1773], 'staggeringly': [1098], 'clear.': [1099], 'Yet,': [1100], 'other': [1101, 2248, 2292, 2508, 3232], 'atypical': [1103], 'antipsychotic': [1104], 'transcranial': [1107], 'magnetic': [1108], 'stimulation': [1109], 'programs,': [1110], 'little': [1111], 'novel': [1112, 2324], 'has': [1114, 1139, 1310, 1863, 1946, 2175, 2197, 2219], 'been': [1115, 1140, 1166, 1249, 1312, 1865, 1947, 2176], 'proposed': [1116], 'develop': [1118], 'successful': [1119, 2449], '(1).': [1121], 'is': [1123, 1221, 1252, 1366, 1472, 1508, 1630, 1662, 1840, 1846, 1851, 1878, 1987, 2032], 'anesthetic': [1125, 1340], 'rapid': [1128, 1323], 'robust,': [1133], 'rapid,': [1134], 'nonsustained': [1136], '(2).': [1137], 'There': [1138], 'recent': [1141, 1557, 2483], 'interest': [1142, 1757], 'large-scale': [1144], 'development': [1146, 1171, 2322], 'While': [1149, 1192, 1282], 'debate': [1150], 'continues': [1151], 'therapeutic': [1154], 'mechanism': [1155, 1263, 2041], 'action': [1157, 1326], 'potential': [1159, 1229, 1306, 1334, 1999, 2080, 2790], 'liability': [1160, 2706], '(3),': [1161], 'clinical': [1163, 1201, 1215, 1376, 1400, 2029, 2139, 2296, 2715, 3108], 'data': [1164, 1402, 1596], 'have': [1165, 1169, 1248, 1350, 1539, 1639, 2105], 'impressive': [1167], 'large-scale,': [1173], 'well-designed': [1174], 'programs': [1175], 'esketamine,': [1178, 1918], 'S(+)': [1180], 'enantiomer': [1181], 'suicidality.': [1191], 'esketamine': [1195, 2147, 2771, 2792], 'available': [1197], 'highly': [1199], 'regulated': [1200, 2086], 'trials,': [1202, 2030], 'chronic': [1212], 'pain': [1213], 'practice,': [1216], 'various': [1218, 3307], 'delivery': [1219, 2424, 3071], 'models,': [1220], 'increasing.': [1222], 'case': [1224, 1935, 1964, 2014, 2077, 2447, 2620], 'presented': [1225], 'here': [1226], 'illustrates': [1227, 2078], 'unintended': [1230], 'consequences': [1231], 'risks': [1233], 'dosing,': [1241], 'routes': [1242], 'specific': [1246], 'indications': [1247], 'established.Pharmacologically,': [1250], 'derivative': [1254], 'phencyclidine,': [1256], 'addition': [1259], 'its': [1261, 1332, 2343, 3189], 'primary': [1262], 'N-methyl-d-aspartate': [1265], 'receptor': [1266, 2395, 3167], 'antagonism,': [1267], 'may': [1269, 1288, 1330, 1421, 1612, 1622, 1815, 2104, 2128], 'also': [1270], 'increase': [1271, 1331], 'levels': [1272], 'dopamine,': [1274, 2368], 'norepinephrine,': [1275], 'serotonin': [1277], 'brain': [1280], '(4).': [1281], 'likely': [1283, 1509, 1775], 'multifactorial,': [1284], 'ketamine’s': [1285, 1381, 1598], 'dopaminergic': [1286], 'promote': [1289, 1938], 'euphoria': [1290], 'contribute': [1292], 'risk': [1294], 'via': [1297], 'dopamine': [1299], 'reward': [1300, 3129], 'pathway': [1301], '(5,': [1302], '6).': [1303], 'different': [1308], 'formulations': [1309, 1454, 1496, 3308], 'determined.': [1313], 'pharmacokinetic': [1316], 'properties': [1317], 'delivery,': [1321], 'onset': [1324], 'improved': [1328], 'bioavailability,': [1329], '(7).Ketamine’s': [1335], 'established': [1336], 'availability': [1337], 'presents': [1341], 'dilemma': [1343, 1619], 'prescribers': [1345, 1425, 1621], 'otherwise': [1347], 'prescription': [1351], 'access': [1352, 1430, 1530, 1592, 1611], 'investigational': [1355], 'Many': [1359], 'argue': [1360], 'current': [1364], 'recommendation': [1365], 'simply': [1367, 1829], 'prescribe': [1370, 1823], 'given': [1372], 'lack': [1374, 1396, 1755], 'evidence.': [1377], 'Others': [1378], 'believe': [1379], 'robust': [1382, 1655], 'warrant': [1385], 'immediate': [1386], 'Current': [1392], 'unregulated': [1393], 'practice': [1394], 'phase': [1398, 3687], 'III': [1399, 1921, 2057], 'trial': [1401, 2535], 'challenge': [1403], 'each': [1404, 1459], 'recommendation.An': [1405], 'Internet': [1406, 1587], 'search': [1407], 'words': [1410], '“ketamine': [1411], 'pharmacy”': [1413], 'yields': [1414], 'multiple': [1415, 1457, 2617], 'web': [1416], 'sites': [1417], 'through': [1418], 'patients': [1420, 1479, 1590, 1607, 1625, 1634, 2121], 'contact': [1422], 'pharmacies.': [1427, 1517], 'experience': [1434, 1647], 'prescriber': [1438], 'unique.': [1441], 'monthly': [1444, 1909], 'shipments,': [1446], 'across': [1447, 3306], 'boundaries,': [1449], 'sublingual': [1453], 'day,': [1460], 'infrequent': [1462], 'management': [1464, 3077], 'appointments': [1465], 'telephone': [1467], 'calls': [1468], 'prescriber.It': [1471], 'impossible': [1473], 'know': [1475], 'number': [1477], 'prescriptions': [1482, 1512], 'outside': [1487], 'settings.': [1490, 2025], 'Given': [1491, 1997], 'types': [1493], 'typically': [1499], 'dispensed': [1500], 'community,': [1503], 'formulations,': [1506], 'most': [1511], 'sold': [1514], 'compounding': [1516, 1534, 1537, 1549], 'Traditional': [1518], 'retail': [1519], 'pharmacies': [1520, 1538, 1550], 'able': [1523], 'manipulate': [1525], 'dosage': [1527, 1860], 'form': [1528, 1861], 'raw': [1532], 'powder,': [1535], 'infrastructure': [1541], 'create': [1543], 'formulations.': [1545], 'role': [1547], 'highlighted': [1554], 'report': [1558, 1936, 2015, 2043, 2250], 'obtained': [1563], 'referred': [1568], 'her': [1576, 1583], 'migraines': [1579], 'treat': [1582], 'severe': [1584], '(8).The': [1586], 'provides': [1588], 'today’s': [1589], 'easy': [1591], 'effects.': [1600], 'Although': [1601], 'there': [1602, 1686], 'positive': [1604, 2046], 'aspects': [1605], 'informed,': [1609], 'amplify': [1613], 'pressure': [1615], 'arguable': [1617], 'ethical': [1618], 'some': [1620], 'feel': [1623], 'when': [1624, 1804], 'request': [1626], 'cutting-edge': [1627], 'treatments.': [1628], 'This': [1629, 1961, 2076], 'particularly': [1631, 1803], 'challenging': [1632, 1766], 'A,': [1637, 1967], 'experienced': [1640], 'varying': [1641], 'degrees': [1642], 'then': [1646], 'immediate,': [1654], 'effect.Although': [1657], 'position': [1661], 'recommend': [1665], 'off-label': [1666, 2596], 'maintenance': [1671], 'interfere': [1679], 'receiving': [1683], 'until': [1685], 'expressed': [1695], 'frustration': [1696], 'understand': [1703, 1832], 'ever': [1713], 'treated': [1714], 'depression.Mr.': [1716], 'became': [1721], 'apparent': [1723, 1977], 'Underreporting': [1731], '(9)': [1735], 'co-occurrence': [1737, 2500], '(10)': [1743], 'both': [1745], 'common': [1746, 1879, 2590], 'consistent': [1748], 'literature.': [1751], 'addiction': [1759, 2102], 'made': [1761, 2106], 'dual': [1763, 1771], 'diagnosis': [1764, 1786], '(11).': [1767], 'Additionally,': [1768, 2089], 'individuals': [1769, 2996], 'diagnoses': [1772], 'die': [1777], 'accidents': [1779], 'compared': [1780], '(12).': [1787], 'unwilling': [1791], 'consider': [1793], 'changes': [1794], 'regimen': [1798], 'initiate': [1800], 'ending': [1807], 'prescription.': [1810], 'Patients': [1811], 'situation': [1814], 'perceive': [1816], 'practitioner': [1819], 'does': [1821, 1830, 1924, 2053], 'extent': [1834], 'their': [1836, 2593], 'suffering,': [1837], 'thereby': [1839], 'withholding': [1841], 'treatment.Prescribing': [1842], 'currently': [1847, 2033], 'label,': [1849], 'defined': [1852], 'indication,': [1857], 'dosage,': [1858], 'approved': [1866], 'Food': [1869], 'Drug': [1871, 2681, 2761, 2782, 2802], 'Administration': [1872, 3146], '(FDA)': [1873], '(13).': [1874], 'Off-label': [1875], 'psychiatry;': [1881], 'however,': [1882], 'monitoring': [1885, 1903, 1941, 2007], 'plan': [1886], 'should': [1887, 2016], 'place': [1890], 'avoid': [1892], 'manage': [1894], 'serious': [1895], 'adverse': [1896], 'events.': [1897], 'particular': [1900], 'case,': [1901], 'minimal': [1902], 'supplies': [1910], 'without': [1913, 1974], 'seen': [1915], 'follow-up.If': [1917], 'schedule': [1920, 2056], 'controlled': [1922], 'substance,': [1923], 'attain': [1925], 'FDA': [1926], 'approval': [1927], 'hope': [1933], 'will': [1937, 2011, 2154], 'discussion': [1939], 'literature': [1951], 'descriptions': [1953], 'tolerance,': [1955], 'withdrawal': [1959, 1978], '(14).': [1960], 'any': [1975], 'specific,': [1976], 'Knowing': [1980], 'warning': [1982], 'signs': [1983], 'important,': [1988], 'especially': [1989], 'if': [1990], 'becomes': [1992], 'mainstream': [1994], 'method.': [1996], 'addiction,': [2003], 'close': [2004], 'essential.This': [2013], 'encourage': [2017], 'ongoing': [2018], 'dialogue': [2019], 'non-research': [2024], 'Outside': [2026], 'registered': [2028], 'no': [2040, 2251], 'outcomes,': [2044], 'either': [2045], 'negative': [2048], '(15).': [2049], 'what': [2051], 'point': [2052], 'addictive': [2060, 2789], 'potential,': [2061], 'manner': [2064], 'lacks': [2066], 'parameters,': [2069], 'lead': [2070], 'harm': [2073, 2081], 'benefit?': [2075], 'current,': [2083], 'off-label,': [2084], 'poorly': [2085], 'him': [2107], 'less': [2109], 'ideal': [2111], 'candidate': [2112], 'Without': [2115], 'safety': [2119, 2767, 2849, 3378], 'data,': [2120], 'good': [2131], 'candidates': [2132], 'therapy.': [2135], 'Continued': [2136], 'scientific,': [2137], 'registered,': [2138], 'investigation': [2140], 'regarding': [2141], 'suicidality': [2153, 3305], 'critical': [2156], 'development.Department': [2159], 'Psychiatry': [2161, 2305, 2436, 2457, 2518, 2549, 2641, 3650], 'Psychology,': [2163], 'Mayo': [2164, 2216, 2599], 'Clinic,': [2165], 'Rochester,': [2166], 'Minn.Address': [2167], 'correspondence': [2168], 'Dr.': [2170], 'Schak': [2171], '([email': [2172], 'protected]).Dr.': [2173], 'Frye': [2174, 2259], 'consultant': [2178], '(unpaid)': [2179], 'Allergan,': [2181], 'Merck,': [2182], 'Myriad,': [2183, 2202], 'Sanofi-Aventis,': [2184], 'Sunovion,': [2185], 'Supernus': [2186], 'Pharmaceuticals,': [2187, 2192, 3155], 'Takeda': [2188], 'Global': [2189], 'Research,': [2190, 2662, 2719, 3195], 'Teva': [2191], 'United': [2194], 'Biosource': [2195], 'Corporation;': [2196], 'grant': [2199], 'support': [2200, 2222], 'Pfizer,': [2203], 'NARSAD,': [2204], 'NIMH,': [2205], 'National': [2207, 2513], 'Institute': [2208], 'Alcohol': [2210, 3029], 'Abuse': [2211], 'Alcoholism,': [2213], 'Foundation;': [2217], 'travel': [2221], 'Chilean': [2225], 'Society': [2226, 2238], 'Neurology,': [2228], 'Psychiatry,': [2229, 2700, 2908, 2989, 3372, 3511, 3528, 3597, 3637, 3711], 'Neurosurgery,': [2231], 'Advanced': [2232], 'Health': [2233, 2575, 3312, 3681], 'Media,': [2234], 'GlaxoSmithKline,': [2235], 'Colombian': [2237], 'Neuropsychopharmacology,': [2240, 3066, 3139], 'AstraZeneca,': [2241], 'Bristol-Myers': [2242], 'Squibb,': [2243], 'Otsuka,': [2244], 'Sanofi-Aventis.': [2246], 'authors': [2249], 'financial': [2252], 'relationships': [2253], 'commercial': [2255], 'interests.References1': [2256], 'Li': [2257], 'X,': [2258], 'MA,': [2260], 'Shelton': [2261], 'RC:': [2262], 'Review': [2263, 3546], 'pharmacological': [2265], 'disorders': [2269, 2510], 'future': [2271], 'directions': [2272], 'development.': [2275], 'Neuropsychopharmacology': [2276, 2329], '2012;': [2277, 2602], '37:77–101Crossref,': [2278], 'Medline,': [2279, 2332, 2350, 2382, 2417, 2439, 2488, 2521, 2580, 2604, 2627], 'Google': [2280, 2308, 2333, 2351, 2383, 2418, 2440, 2460, 2489, 2522, 2552, 2581, 2605, 2628, 2644], 'Scholar2': [2281], 'Newport': [2282], 'DJ,': [2283], 'Carpenter': [2284], 'LL,': [2285], 'McDonald': [2286], 'WM,': [2287], 'et': [2288, 2468, 2497, 2530, 2560], 'al.:': [2289, 2469, 2498, 2531, 2561], 'NMDA': [2293, 2725, 3166], 'antagonists:': [2294], 'possible': [2299], 'mechanisms': [2300, 3184], 'Am': [2303, 2547, 2622, 2639], 'J': [2304, 2345, 2434, 2548, 2573, 2623, 2640], '2015;': [2306, 2330, 2415, 2437, 2625], '172:950–966Link,': [2307], 'Scholar3': [2309], 'Sanacora': [2310], 'G,': [2311, 2336], 'Schatzberg': [2312, 2630], 'AF:': [2313, 2631], 'Ketamine:': [2314, 2339], 'promising': [2315], 'path': [2316], 'false': [2318], 'prophecy': [2319], 'therapeutics': [2325, 3074], 'disorders?': [2328], '40:1307Crossref,': [2331], 'Scholar4': [2334], 'Bokor': [2335], 'Anderson': [2337], 'PD:': [2338], 'update': [2341], 'abuse.': [2344], 'Pharm': [2346], 'Pract': [2347], '2014;': [2348, 2458, 2642], '27:582–586Crossref,': [2349], 'Scholar5': [2352], 'Lindefors': [2353], 'N,': [2354], 'Barati': [2355], 'S,': [2356, 2465], 'O’Connor': [2357], 'WT:': [2358], 'Differential': [2359], 'repeated': [2364, 3380], 'administration': [2366, 2391], 'serotonin,': [2369], 'GABA': [2371], 'transmission': [2372], 'rat': [2374], 'medial': [2375], 'prefrontal': [2376], 'cortex.': [2377], 'Brain': [2378, 3194], 'Res': [2379, 2577], '1997;': [2380, 2519], '759:205–212Crossref,': [2381], 'Scholar6': [2384], 'Xu': [2385], 'K,': [2386], 'Lipsky': [2387], 'RH:': [2388], 'Repeated': [2389, 3145], 'alters': [2392], 'N-methyl-D-aspartic': [2393], 'acid': [2394], 'subunit': [2396], 'gene': [2397], 'expression:': [2398], 'implication': [2399], 'genetic': [2401], 'vulnerability': [2402], 'psychosis': [2408], 'humans.': [2410], 'Exp': [2411], 'Biol': [2412], 'Med': [2413], '(Maywood)': [2414], '240:145–155Crossref,': [2416], 'Scholar7': [2419], 'Andrade': [2420], 'C:': [2421], 'Intranasal': [2422], 'neuropsychiatry:': [2426], 'focus': [2427], 'refractory': [2432], 'Clin': [2435, 2456, 2600], '76:628–631Crossref,': [2438], 'Scholar8': [2441], 'Clark': [2442], 'P:': [2443], 'Treatment-refractory': [2444], 'depression:': [2445, 2999, 3387, 3675], '10%.': [2454], 'Ann': [2455], '26:145Medline,': [2459], 'Scholar9': [2461], 'Stockwell': [2462], 'T,': [2463], 'Donath': [2464], 'Cooper-Stanbury': [2466], 'M,': [2467], 'Under-reporting': [2470], 'household': [2475], 'surveys:': [2476], 'comparison': [2478, 2741], 'quantity-frequency,': [2480], 'graduated-frequency,': [2481], 'recall.': [2484], 'Addiction': [2485, 2832], '2004;': [2486, 2578], '99:1024–1033Crossref,': [2487], 'Scholar10': [2490], 'Kessler': [2491], 'RC,': [2492], 'Crum': [2493], 'RM,': [2494], 'Warner': [2495], 'LA,': [2496], 'Lifetime': [2499], 'DSM-III-R': [2502], 'Comorbidity': [2514], 'Survey.': [2515], 'Arch': [2516], 'Gen': [2517], '54:313–321Crossref,': [2520], 'Scholar11': [2523], 'Pettinati': [2524], 'HM,': [2525], 'Oslin': [2526], 'DW,': [2527], 'Kampman': [2528], 'KM,': [2529], 'double-blind,': [2533], 'placebo-controlled': [2534], 'combining': [2536], 'sertraline': [2537], 'naltrexone': [2539], 'treating': [2541], 'co-occurring': [2542], '2010;': [2550], '167:668–675Link,': [2551], 'Scholar12': [2553], 'Dickey': [2554], 'B,': [2555, 2557], 'Dembling': [2556], 'Azeni': [2558], 'H,': [2559], 'Externally': [2562], 'caused': [2563], 'deaths': [2564], 'adults': [2566, 3691], 'mental': [2571], 'disorders.': [2572], 'Behav': [2574], 'Serv': [2576], '31:75–85Crossref,': [2579], 'Scholar13': [2582], 'Wittich': [2583], 'CM,': [2584, 2586], 'Burkle': [2585], 'Lanier': [2587], 'WL:': [2588], 'Ten': [2589], 'questions': [2591], '(and': [2592], 'answers)': [2594], 'Proc': [2601], '87:982–990Crossref,': [2603], 'Scholar14': [2606], 'Liu': [2607], 'JX,': [2608], 'Zerbo': [2609], 'E,': [2610], 'Ross': [2611], 'S:': [2612], 'Intensive': [2613], 'years:': [2618], 'report.': [2621], 'Addict': [2624], '24:7–9Crossref,': [2626], 'Scholar15': [2629], 'word': [2633], 'wise': [2636], '171:262–264Link,': [2643], 'Scholar': [2645], 'FiguresReferencesCited': [2646], 'byDetailsCited': [2647], 'byIncreased': [2648], 'Demand': [2649], 'Infusions': [2652], 'Associated': [2654], 'Complexities1': [2655], 'January': [2656], '2023': [2657], '|': [2658, 2696, 2734, 2757, 2778, 2798, 2818, 2841, 2862, 2904, 2921, 2984, 3009, 3034, 3062, 3112, 3138, 3154, 3265, 3287, 3368, 3405, 3507, 3524, 3593, 3707, 3718], 'Journal': [2659, 2698, 2863, 2906, 2987, 3064, 3083, 3370, 3509, 3526, 3595, 3613, 3648, 3709], 'Pain': [2661], 'Vol.': [2663, 2701, 2720, 2739, 2763, 2784, 2804, 2821, 2844, 2866, 2909, 2924, 2990, 3012, 3039, 3067, 3086, 3116, 3140, 3156, 3176, 3196, 3215, 3225, 3268, 3289, 3295, 3299, 3314, 3373, 3396, 3408, 3416, 3512, 3529, 3598, 3602, 3609, 3611, 3617, 3638, 3644, 3654, 3662, 3683, 3698, 3712, 3721, 3727, 3733], 'Volume': [2664, 3737], '16A': [2665, 2740], 'Prolonged': [2668], 'Mania,': [2669], 'Psychosis,': [2670], 'Severe': [2672], 'Psilocybin': [2675], 'Use:': [2676], 'Implications': [2677, 2877], 'Increased': [2679], 'Psychedelic': [2680], 'AvailabilityGregory': [2682], 'Barber,': [2683], 'Charles': [2685], 'B.': [2686, 3518], 'Nemeroff,': [2687, 3519], 'Ph.D.,': [2689, 3334, 3337, 3340, 3356, 3361, 3439, 3454, 3472, 3558, 3572, 3579], 'Steven': [2690], 'Siegel,': [2691], 'Ph.D.1': [2693, 3521], 'December': [2694, 3007, 3032, 3263], '2022': [2695, 2733, 2756, 2777, 2797, 2817, 2840, 2861], 'American': [2697, 2905, 3369, 3508, 3525, 3594, 3708], '179,': [2702], 'No.': [2703, 2765, 2786, 2806, 2823, 2846, 2868, 2911, 2926, 2992, 3014, 3069, 3118, 3142, 3158, 3227, 3291, 3316, 3375, 3410, 3418, 3514, 3531, 3600, 3604, 3619, 3640, 3646, 3656, 3664, 3685, 3714, 3723, 3729, 3735], '12The': [2704], 'ketamine:': [2708], 'scoping': [2710], 'review': [2711, 3677], 'preclinical': [2713], 'studiesJournal': [2716], 'Psychiatric': [2718], '151Promises': [2721], 'Pitfalls': [2723], 'Receptor': [2726, 3043, 3325], 'Antagonists': [2727, 3624], 'Treating': [2729], 'Violent': [2730], 'Aggression21': [2731], 'June': [2732], 'Frontiers': [2735, 3035], 'Behavioral': [2737, 3037], 'Neuroscience,': [2738, 3038, 3643], 'safety,': [2744], 'feasibility,': [2745], 'tolerability': [2747], 'depression14': [2754], 'March': [2755, 3136, 3285, 3634, 3740, 3763, 3769], 'Expert': [2758, 2779, 2799], 'Opinion': [2759, 2780, 2800, 3658], 'Safety,': [2762, 2783, 2803], '21,': [2764, 2785, 2805, 3655], '6Long-term': [2766], 'depression19': [2775], 'April': [2776, 3505, 3522], '6Craving': [2787], 'effects?4': [2795], 'May': [2796, 3060, 3716], '6Praktische': [2807], 'Aspekte': [2808], 'der': [2809], 'Ketaminbehandlung': [2810], '–': [2811], 'Sicherheit,': [2812], 'Kombinationstherapien': [2813], 'und': [2814], 'Komorbiditäten16': [2815], 'February': [2816, 2839, 2860, 2919], 'Der': [2819], 'Nervenarzt,': [2820], '93,': [2822], '3Non-parenteral': [2824], 'Depression:': [2827], 'Practical': [2829], 'Discussion': [2830], 'Potential': [2833, 2870], 'Recommendations': [2835, 2938], 'Judicious': [2837], 'Prescribing14': [2838], 'CNS': [2842], 'Drugs,': [2843, 3661], '36,': [2845, 2867], '3Efficacy': [2847], 'psilocybin-assisted': [2851], 'disorder:': [2856], 'Prospective': [2857], '12-month': [2858], 'follow-up15': [2859], 'Psychopharmacology,': [2865, 3288], '2KetamineA': [2869], 'Acute': [2873], 'Withdrawal:': [2875], 'Treatment': [2880, 3027], 'Refractory': [2882], 'DepressionNichole': [2883], 'Roxas,': [2884], 'M.P.H.,': [2886, 2893], 'Chaarushi': [2887], 'Ahuja,': [2888], 'B.S.,': [2889, 3343, 3346, 3349], 'Jessica': [2890, 3347], 'Isom,': [2891], 'Samuel': [2894], 'T.': [2895, 3552], 'Wilkinson,': [2896, 3553], 'Noah': [2898], 'Capurso,': [2899], 'M.H.S.16': [2901], 'July': [2902, 3152], '2021': [2903, 2920], '178,': [2910], '7Hypomania': [2912], 'high': [2915], 'treatment24': [2918], 'Bipolar': [2922], 'Disorders,': [2923, 3214, 3608, 3697], '23,': [2925, 3068], '4The': [2927, 3532], 'Canadian': [2928, 2986], 'Network': [2929], 'Mood': [2931], 'Anxiety': [2933], 'Treatments': [2934], '(CANMAT)': [2935], 'Task': [2936], 'Force': [2937], 'Racemic': [2943], 'Adults': [2946], 'Major': [2948], 'Depressive': [2949], 'Disorder:': [2950], 'Recommandations': [2951], 'Du': [2952, 2956], 'Groupe': [2953], 'De': [2954, 2962, 2965, 2970, 2978], 'Travail': [2955], 'Réseau': [2957], 'Canadien': [2958], 'Pour': [2959], 'Les': [2960, 2975], 'Traitements': [2961], 'L’humeur': [2963], 'Et': [2964], 'L’anxiété': [2966], '(Canmat)': [2967], 'Concernant': [2968], 'L’utilisation': [2969], 'La': [2971], 'Kétamine': [2972], 'Racémique': [2973], 'Chez': [2974], 'Adultes': [2976], 'Souffrant': [2977], 'Trouble': [2979], 'Dépressif': [2980], 'Majeur11': [2981], 'November': [2982, 3754, 3758], '2020': [2983, 3008, 3033, 3061, 3111, 3137, 3153, 3264], '66,': [2991], '2Ketamine': [2993], 'longitudinal': [3000], 'qualitative': [3001], 'interview': [3002], 'experiences7': [3006], 'BJPsych': [3010], 'Open,': [3011], '7,': [3013, 3684], '1Neural': [3015], 'Mechanisms': [3016], 'Underlying': [3017], 'Rewarding': [3019], 'Therapeutic': [3021], 'Effects': [3022, 3320, 3388], 'Disorder10': [3031], '14Effects': [3040], 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'Alan': [3362, 3432], 'F.': [3363], 'Schatzberg,': [3364], 'M.D.29': [3365], 'August': [3366, 3705, 3750], '2018': [3367, 3404, 3506, 3523], '175,': [3374, 3513, 3530, 3599], '12On': [3376], 'infusions': [3382], 'sex': [3390], 'developmental': [3392], 'periodsNeurobiology': [3393], 'Stress,': [3395], '9Lucy': [3397], 'sky': [3400], 'ketamine15': [3402], 'October': [3403, 3591], 'EMBO': [3406], 'reports,': [3407], '19,': [3409, 3618], '11NeuromodulationPsychiatric': [3411], 'Clinics': [3412], 'North': [3414], 'America,': [3415], '41,': [3417], '3Can': [3419], 'Framework': [3421], 'Be': [3422], 'Established': [3423], 'Safe': [3426], 'Ketamine?Robert': [3429], 'Freedman,': [3430, 3703], 'S.': [3433, 3466, 3481], 'Brown,': [3434], 'Tyrone': [3436], 'Cannon,': [3438], 'Benjamin': [3440], 'Druss,': [3442], 'Felton': [3444], 'J.': [3445, 3565], 'Earls,': [3446], 'Javier': [3448], 'Escobar,': [3449], 'Yasmin': [3451], 'Hurd,': [3453], 'Lewis,': [3457], 'Carlos': [3459, 3583], 'López-Jaramillo,': [3460], 'Joan': [3462], 'Luby,': [3463], 'Helen': [3465], 'Mayberg,': [3467], 'Terrie': [3469], 'E.': [3470], 'Moffitt,': [3471], 'Maria': [3473], 'Oquendo,': [3474], 'Roy': [3476], 'H.': [3477, 3560], 'Perlis,': [3478], 'Daniel': [3480], 'Pine,': [3482], 'John': [3485], 'Rush,': [3486], 'Carol': [3488], 'Tamminga,': [3490], 'Mauricio': [3492], 'Tohen,': [3493], 'Eduard': [3495], 'Vieta,': [3496], 'Katherine': [3498], 'Wisner,': [3500], 'Yu': [3502], 'Xin,': [3503], 'M.D.16': [3504], '7Ketamine:': [3515], 'Quo': [3516], 'Vadis?Charles': [3517], 'Effect': [3533], 'Single': [3536], 'Dose': [3537], 'Intravenous': [3539], 'Suicidal': [3542], 'Ideation:': [3543], 'Systematic': [3545], 'Individual': [3548], 'Participant': [3549], 'Data': [3550], 'Meta-AnalysisSamuel': [3551], 'Elizabeth': [3555], 'Ballard,': [3557], 'Michael': [3559], 'Bloch,': [3561], 'M.S.,': [3563], 'Sanjay': [3564], 'Mathew,': [3566], 'James': [3568], 'W.': [3569], 'Murrough,': [3570], 'Adriana': 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'1601,': [3722], '1Depression': [3724], 'Anxiety,': [3726, 3732], '33,': [3728, 3734], '8Depression': [3730], '173Issue': [3738], '01,': [3741], '2016Pages': [3742], '215-218': [3743], 'Metrics': [3744], 'PDF': [3745], 'download': [3746], 'History': [3747], 'Received': [3748], '24': [3749], '2015': [3751, 3755, 3759], 'Revised': [3752], '17': [3753], 'Accepted': [3756], '30': [3757], 'Published': [3760, 3765], 'online': [3761], 'print': [3767]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2289004134', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 10}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 14}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 12}, {'year': 2016, 'cited_by_count': 6}], 'updated_date': '2024-12-20T20:35:41.968721', 'created_date': '2016-06-24'}