Publication Information

{'id': 'https://openalex.org/W2288358807', 'doi': 'https://doi.org/10.1111/fcp.12193', 'title': 'Allyl‐isatin suppresses cell viability, induces cell cycle arrest, and promotes cell apoptosis in hepatocellular carcinoma HepG2 cells', 'display_name': 'Allyl‐isatin suppresses cell viability, induces cell cycle arrest, and promotes cell apoptosis in hepatocellular carcinoma HepG2 cells', 'publication_year': 2016, 'publication_date': '2016-03-06', 'ids': {'openalex': 'https://openalex.org/W2288358807', 'doi': 'https://doi.org/10.1111/fcp.12193', 'mag': '2288358807', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26945926'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/fcp.12193', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S35226884', 'display_name': 'Fundamental and Clinical Pharmacology', 'issn_l': '0767-3981', 'issn': ['0767-3981', '1472-8206'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5082622208', 'display_name': 'Weihua Bian', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I134841294', 'display_name': 'Binzhou Medical University', 'ror': 'https://ror.org/008w1vb37', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I134841294']}, {'id': 'https://openalex.org/I151013683', 'display_name': 'Binzhou University', 'ror': 'https://ror.org/05frpfj73', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I151013683']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Weihua Bian', 'raw_affiliation_strings': ['Department of Cell Biology, Binzhou Medical University, Yantai 264003, Shandong Province, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, Binzhou Medical University, Yantai 264003, Shandong Province, China', 'institution_ids': ['https://openalex.org/I134841294', 'https://openalex.org/I151013683']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017568394', 'display_name': 'Yukuan An', 'orcid': 'https://orcid.org/0000-0001-8429-3979'}, 'institutions': [{'id': 'https://openalex.org/I151013683', 'display_name': 'Binzhou University', 'ror': 'https://ror.org/05frpfj73', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I151013683']}, {'id': 'https://openalex.org/I134841294', 'display_name': 'Binzhou Medical University', 'ror': 'https://ror.org/008w1vb37', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I134841294']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yukuan An', 'raw_affiliation_strings': ['Department of physical, Binzhou Medical University, Yantai 264003, Shandong Province, China'], 'affiliations': [{'raw_affiliation_string': 'Department of physical, Binzhou Medical University, Yantai 264003, Shandong Province, China', 'institution_ids': ['https://openalex.org/I151013683', 'https://openalex.org/I134841294']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084868964', 'display_name': 'Huiqing Qu', 'orcid': 'https://orcid.org/0000-0001-9818-5725'}, 'institutions': [{'id': 'https://openalex.org/I134841294', 'display_name': 'Binzhou Medical University', 'ror': 'https://ror.org/008w1vb37', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I134841294']}, {'id': 'https://openalex.org/I151013683', 'display_name': 'Binzhou University', 'ror': 'https://ror.org/05frpfj73', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I151013683']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Huiqing Qu', 'raw_affiliation_strings': ['Department of Blood Transfusion, Affiliated Hospital of Binzhou Medical University, Binzhou 256603, Shandong Province, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Blood Transfusion, Affiliated Hospital of Binzhou Medical University, Binzhou 256603, Shandong Province, China', 'institution_ids': ['https://openalex.org/I134841294', 'https://openalex.org/I151013683']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057924724', 'display_name': 'Yue Yang', 'orcid': 'https://orcid.org/0000-0002-6650-4573'}, 'institutions': [{'id': 'https://openalex.org/I134841294', 'display_name': 'Binzhou Medical University', 'ror': 'https://ror.org/008w1vb37', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I134841294']}, {'id': 'https://openalex.org/I151013683', 'display_name': 'Binzhou University', 'ror': 'https://ror.org/05frpfj73', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I151013683']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yue Yang', 'raw_affiliation_strings': ['Department of Cell Biology, Binzhou Medical University, Yantai 264003, Shandong Province, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, Binzhou Medical University, Yantai 264003, Shandong Province, China', 'institution_ids': ['https://openalex.org/I134841294', 'https://openalex.org/I151013683']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101020579', 'display_name': 'Yang Junhou', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I151013683', 'display_name': 'Binzhou University', 'ror': 'https://ror.org/05frpfj73', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I151013683']}, {'id': 'https://openalex.org/I134841294', 'display_name': 'Binzhou Medical University', 'ror': 'https://ror.org/008w1vb37', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I134841294']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Junhou Yang', 'raw_affiliation_strings': ['Department of Cell Biology, Binzhou Medical University, Yantai 264003, Shandong Province, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, Binzhou Medical University, Yantai 264003, Shandong Province, China', 'institution_ids': ['https://openalex.org/I151013683', 'https://openalex.org/I134841294']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100956122', 'display_name': 'Yanyan Xu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I151013683', 'display_name': 'Binzhou University', 'ror': 'https://ror.org/05frpfj73', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I151013683']}, {'id': 'https://openalex.org/I134841294', 'display_name': 'Binzhou Medical University', 'ror': 'https://ror.org/008w1vb37', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I134841294']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Yanyan Xu', 'raw_affiliation_strings': ['Department of Cell Biology, Binzhou Medical University, Yantai 264003, Shandong Province, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, Binzhou Medical University, Yantai 264003, Shandong Province, China', 'institution_ids': ['https://openalex.org/I151013683', 'https://openalex.org/I134841294']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5100956122'], 'corresponding_institution_ids': ['https://openalex.org/I151013683', 'https://openalex.org/I134841294'], 'apc_list': {'value': 2990, 'currency': 'USD', 'value_usd': 2990, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.119, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 7, 'citation_normalized_percentile': {'value': 0.617008, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 83, 'max': 85}, 'biblio': {'volume': '30', 'issue': '3', 'first_page': '253', 'last_page': '262'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10294', 'display_name': 'Cell death mechanisms and regulation', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10526', 'display_name': 'HIV/AIDS drug development and treatment', 'score': 0.9943, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/propidium-iodide', 'display_name': 'Propidium iodide', 'score': 0.77887213}, {'id': 'https://openalex.org/keywords/viability-assay', 'display_name': 'Viability assay', 'score': 0.75761735}, {'id': 'https://openalex.org/keywords/rhodamine-123', 'display_name': 'Rhodamine 123', 'score': 0.4801966}, {'id': 'https://openalex.org/keywords/acridine-orange', 'display_name': 'Acridine orange', 'score': 0.4361881}], 'concepts': [{'id': 'https://openalex.org/C2775934118', 'wikidata': 'https://www.wikidata.org/wiki/Q424169', 'display_name': 'Propidium iodide', 'level': 4, 'score': 0.77887213}, {'id': 'https://openalex.org/C53227056', 'wikidata': 'https://www.wikidata.org/wiki/Q189152', 'display_name': 'Viability assay', 'level': 3, 'score': 0.75761735}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.6591884}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.59315664}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.5813746}, {'id': 'https://openalex.org/C88634738', 'wikidata': 'https://www.wikidata.org/wiki/Q24769543', 'display_name': 'Annexin', 'level': 3, 'score': 0.53703094}, {'id': 'https://openalex.org/C2778589691', 'wikidata': 'https://www.wikidata.org/wiki/Q3429577', 'display_name': 'Rhodamine 123', 'level': 4, 'score': 0.4801966}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4404869}, {'id': 'https://openalex.org/C2779102032', 'wikidata': 'https://www.wikidata.org/wiki/Q342717', 'display_name': 'Acridine orange', 'level': 3, 'score': 0.4361881}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.43092808}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.38950983}, {'id': 'https://openalex.org/C553184892', 'wikidata': 'https://www.wikidata.org/wiki/Q1141429', 'display_name': 'Flow cytometry', 'level': 2, 'score': 0.36922157}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.34299242}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3361276}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.18737102}, {'id': 'https://openalex.org/C133936738', 'wikidata': 'https://www.wikidata.org/wiki/Q643839', 'display_name': 'Multiple drug resistance', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D059447', 'descriptor_name': 'Cell Cycle Checkpoints', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D007510', 'descriptor_name': 'Isatin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D059447', 'descriptor_name': 'Cell Cycle Checkpoints', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059447', 'descriptor_name': 'Cell Cycle Checkpoints', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056945', 'descriptor_name': 'Hep G2 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007510', 'descriptor_name': 'Isatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D008996', 'descriptor_name': 'Monoamine Oxidase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/fcp.12193', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S35226884', 'display_name': 'Fundamental and Clinical Pharmacology', 'issn_l': '0767-3981', 'issn': ['0767-3981', '1472-8206'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26945926', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.61, 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320324174', 'funder_display_name': 'Natural Science Foundation of Shandong Province', 'award_id': 'ZR2013CL004'}], 'datasets': [], 'versions': [], 'referenced_works_count': 29, 'referenced_works': ['https://openalex.org/W121359198', 'https://openalex.org/W1554971051', 'https://openalex.org/W1601706257', 'https://openalex.org/W1692825366', 'https://openalex.org/W1939411505', 'https://openalex.org/W1966086881', 'https://openalex.org/W1970258702', 'https://openalex.org/W1970945068', 'https://openalex.org/W1972640379', 'https://openalex.org/W1974759226', 'https://openalex.org/W1978650247', 'https://openalex.org/W1984947563', 'https://openalex.org/W1994284245', 'https://openalex.org/W2010091844', 'https://openalex.org/W2015495445', 'https://openalex.org/W2016526517', 'https://openalex.org/W2017356765', 'https://openalex.org/W2040092432', 'https://openalex.org/W2073315333', 'https://openalex.org/W2081752376', 'https://openalex.org/W2086668210', 'https://openalex.org/W2100036142', 'https://openalex.org/W2110651280', 'https://openalex.org/W2129837065', 'https://openalex.org/W2130246788', 'https://openalex.org/W2130866079', 'https://openalex.org/W2151792234', 'https://openalex.org/W2313209411', 'https://openalex.org/W2331033061'], 'related_works': ['https://openalex.org/W4385687789', 'https://openalex.org/W3135269592', 'https://openalex.org/W2548469661', 'https://openalex.org/W2414266434', 'https://openalex.org/W2393858372', 'https://openalex.org/W2385858018', 'https://openalex.org/W2375889511', 'https://openalex.org/W2365320098', 'https://openalex.org/W2184277213', 'https://openalex.org/W2047478958'], 'abstract_inverted_index': {'The': [0], 'anticancer': [1], 'effect': [2], 'of': [3, 53, 75, 80, 147, 164, 170, 208], 'the': [4, 42, 51, 56, 73, 78, 112, 139, 145, 157, 162, 183, 206, 214], 'newly': [5], 'synthesized': [6], 'isatin': [7], 'derivative,': [8], 'N-allyl-isatin': [9], '(Allyl-I),': [10], 'was': [11, 23, 38, 47, 69], 'evaluated': [12], 'in': [13, 96, 108, 144, 202], 'vitro': [14], 'with': [15, 213], 'human': [16], 'hepatocellular': [17], 'carcinoma': [18], 'HepG2': [19, 93, 109, 203], 'cells.': [20, 204], 'Cell': [21], 'viability': [22, 95], 'detected': [24], 'by': [25], 'cell': [26, 43, 57, 94, 105, 192, 195, 200], 'counting': [27], 'kit-8': [28], '(CCK8)': [29], 'assay.': [30], 'Acridine': [31], 'orange': [32], '(AO)/ethidium': [33], 'bromide': [34], '(EB)': [35], 'double': [36, 123, 135], 'staining': [37, 136, 151], 'used': [39, 48], 'to': [40, 49, 71], 'observe': [41], 'morphology.': [44], 'Flow': [45], 'cytometry': [46], 'assess': [50], 'effects': [52], 'Allyl-I': [54, 90, 102, 154, 159, 179, 190], 'on': [55, 77], 'cycle,': [58], 'apoptosis': [59, 201, 209], 'rate,': [60], 'and': [61, 87, 99, 131, 173, 198], 'mitochondrial': [62, 165, 215], 'membrane': [63], 'potential': [64], '(MMP).': [65], 'Western': [66], 'blot': [67], 'analysis': [68], 'performed': [70], 'detect': [72], 'influence': [74], 'Ally1-I': [76], 'expression': [79, 163], 'cytochrome': [81], 'c': [82, 172], '(cyt': [83], 'c),': [84], 'Bax,': [85], 'Bcl-2,': [86], 'cleaved': [88, 174], 'caspase-3.': [89], 'significantly': [91, 142], 'inhibited': [92], 'a': [97], 'time-': [98], 'dose-dependent': [100], 'manner.': [101], 'can': [103, 155], 'induce': [104], 'cycle': [106, 196], 'arrest': [107], 'cells': [110], 'at': [111], 'G2/M': [113], 'phase.': [114], 'Apoptotic': [115], 'nuclear': [116], 'morphological': [117], 'changes': [118], 'were': [119, 176], 'observed': [120], 'after': [121], 'AO/EB': [122], 'staining.': [124], 'Fluorescein': [125], 'isothiocyanate-conjugated': [126], 'Annexin': [127], 'V': [128], '(Annexin': [129], 'V-FITC)': [130], 'propidium': [132], 'iodide': [133], '(PI)': [134], 'showed': [137], 'that': [138, 153, 189], 'apoptotic': [140], 'rates': [141], 'increased': [143], 'presence': [146], 'Allyl-I.': [148], 'Rhodamine': [149], '123': [150], 'indicated': [152], 'decrease': [156], 'MMP.': [158], 'also': [160], 'altered': [161], 'apoptosis-related': [166], 'proteins.': [167], 'Protein': [168], 'levels': [169], 'cyt': [171], 'caspase-3': [175], 'upregulated': [177], 'following': [178], 'treatment.': [180], 'By': [181], 'contrast,': [182], 'Bcl-2/Bax': [184], 'ratio': [185], 'decreased.': [186], 'Results': [187], 'suggest': [188], 'suppresses': [191], 'viability,': [193], 'induces': [194], 'arrest,': [197], 'promotes': [199], 'Furthermore,': [205], 'induction': [207], 'might': [210], 'be': [211], 'correlated': [212], 'pathway.': [216]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2288358807', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-12-24T12:58:14.691553', 'created_date': '2016-06-24'}