Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2280345261', 'doi': 'https://doi.org/10.18632/oncotarget.5359', 'title': 'INPP4B is upregulated and functions as an oncogenic driver through SGK3 in a subset of melanomas', 'display_name': 'INPP4B is upregulated and functions as an oncogenic driver through SGK3 in a subset of melanomas', 'publication_year': 2015, 'publication_date': '2015-11-09', 'ids': {'openalex': 'https://openalex.org/W2280345261', 'doi': 'https://doi.org/10.18632/oncotarget.5359', 'mag': '2280345261', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26573229', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4741868'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.5359', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=5359&path%5B%5D=16818', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=5359&path%5B%5D=16818', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5102006933', 'display_name': 'Na Meng', 'orcid': 'https://orcid.org/0000-0002-5234-8872'}, 'institutions': [{'id': 'https://openalex.org/I78757542', 'display_name': 'University of Newcastle Australia', 'ror': 'https://ror.org/00eae9z71', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I78757542']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Meng Na Chi', 'raw_affiliation_strings': ['School of Medicine and Public Health, The University of Newcastle, NSW 2308, Australia'], 'affiliations': [{'raw_affiliation_string': 'School of Medicine and Public Health, The University of Newcastle, NSW 2308, Australia', 'institution_ids': ['https://openalex.org/I78757542']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085722199', 'display_name': 'Su Guo', 'orcid': 'https://orcid.org/0000-0002-7342-0108'}, 'institutions': [{'id': 'https://openalex.org/I78757542', 'display_name': 'University of Newcastle Australia', 'ror': 'https://ror.org/00eae9z71', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I78757542']}, {'id': 'https://openalex.org/I17721919', 'display_name': 'Shanxi Medical University', 'ror': 'https://ror.org/0265d1010', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I17721919']}], 'countries': ['AU', 'CN'], 'is_corresponding': False, 'raw_author_name': 'Su Tang Guo', 'raw_affiliation_strings': ['Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Affiliated Hospital of Shanxi Medical University, Taiyuan, Shanxi 030013, China', 'School of Biomedical Sciences and Pharmacy, The University of Newcastle, NSW 2308, Australia'], 'affiliations': [{'raw_affiliation_string': 'School of Biomedical Sciences and Pharmacy, The University of Newcastle, NSW 2308, Australia', 'institution_ids': ['https://openalex.org/I78757542']}, {'raw_affiliation_string': 'Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Affiliated Hospital of Shanxi Medical University, Taiyuan, Shanxi 030013, China', 'institution_ids': ['https://openalex.org/I17721919']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001606920', 'display_name': 'James S. Wilmott', 'orcid': 'https://orcid.org/0000-0002-6750-5244'}, 'institutions': [{'id': 'https://openalex.org/I2799732068', 'display_name': 'Royal Prince Alfred Hospital', 'ror': 'https://ror.org/05gpvde20', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799732068']}, {'id': 'https://openalex.org/I129604602', 'display_name': 'University of Sydney', 'ror': 'https://ror.org/0384j8v12', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I129604602']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'James S. Wilmott', 'raw_affiliation_strings': ['Discipline of Pathology, The University of Sydney, and Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW 2006, Australia'], 'affiliations': [{'raw_affiliation_string': 'Discipline of Pathology, The University of Sydney, and Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW 2006, Australia', 'institution_ids': ['https://openalex.org/I2799732068', 'https://openalex.org/I129604602']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101646937', 'display_name': 'Xiang Guo', 'orcid': 'https://orcid.org/0000-0001-8500-012X'}, 'institutions': [{'id': 'https://openalex.org/I78757542', 'display_name': 'University of Newcastle Australia', 'ror': 'https://ror.org/00eae9z71', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I78757542']}, {'id': 'https://openalex.org/I17721919', 'display_name': 'Shanxi Medical University', 'ror': 'https://ror.org/0265d1010', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I17721919']}], 'countries': ['AU', 'CN'], 'is_corresponding': False, 'raw_author_name': 'Xiang Yun Guo', 'raw_affiliation_strings': ['Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Affiliated Hospital of Shanxi Medical University, Taiyuan, Shanxi 030013, China', 'School of Biomedical Sciences and Pharmacy, The University of Newcastle, NSW 2308, Australia'], 'affiliations': [{'raw_affiliation_string': 'School of Biomedical Sciences and Pharmacy, The University of Newcastle, NSW 2308, Australia', 'institution_ids': ['https://openalex.org/I78757542']}, {'raw_affiliation_string': 'Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Affiliated Hospital of Shanxi Medical University, Taiyuan, Shanxi 030013, China', 'institution_ids': ['https://openalex.org/I17721919']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048927086', 'display_name': 'Xu Guang Yan', 'orcid': 'https://orcid.org/0000-0001-5995-8537'}, 'institutions': [{'id': 'https://openalex.org/I78757542', 'display_name': 'University of Newcastle Australia', 'ror': 'https://ror.org/00eae9z71', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I78757542']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Xu Guang Yan', 'raw_affiliation_strings': ['School of Medicine and Public Health, The University of Newcastle, NSW 2308, Australia'], 'affiliations': [{'raw_affiliation_string': 'School of Medicine and Public Health, The University of Newcastle, NSW 2308, Australia', 'institution_ids': ['https://openalex.org/I78757542']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100451091', 'display_name': 'Chunyan Wang', 'orcid': 'https://orcid.org/0000-0003-3218-2083'}, 'institutions': [{'id': 'https://openalex.org/I17721919', 'display_name': 'Shanxi Medical University', 'ror': 'https://ror.org/0265d1010', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I17721919']}, {'id': 'https://openalex.org/I78757542', 'display_name': 'University of Newcastle Australia', 'ror': 'https://ror.org/00eae9z71', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I78757542']}], 'countries': ['AU', 'CN'], 'is_corresponding': False, 'raw_author_name': 'Chun Yan Wang', 'raw_affiliation_strings': ['Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Affiliated Hospital of Shanxi Medical University, Taiyuan, Shanxi 030013, China', 'School of Biomedical Sciences and Pharmacy, The University of Newcastle, NSW 2308, Australia'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Affiliated Hospital of Shanxi Medical University, Taiyuan, Shanxi 030013, China', 'institution_ids': ['https://openalex.org/I17721919']}, {'raw_affiliation_string': 'School of Biomedical Sciences and Pharmacy, The University of Newcastle, NSW 2308, Australia', 'institution_ids': ['https://openalex.org/I78757542']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100394468', 'display_name': 'Xiaoying Liu', 'orcid': 'https://orcid.org/0000-0003-3450-5683'}, 'institutions': [{'id': 'https://openalex.org/I78757542', 'display_name': 'University of Newcastle Australia', 'ror': 'https://ror.org/00eae9z71', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I78757542']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Xiao Ying Liu', 'raw_affiliation_strings': ['School of Biomedical Sciences and Pharmacy, The University of Newcastle, NSW 2308, Australia'], 'affiliations': [{'raw_affiliation_string': 'School of Biomedical Sciences and Pharmacy, The University of Newcastle, NSW 2308, Australia', 'institution_ids': ['https://openalex.org/I78757542']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100607106', 'display_name': 'Lei Jin', 'orcid': 'https://orcid.org/0000-0001-7187-9671'}, 'institutions': [{'id': 'https://openalex.org/I78757542', 'display_name': 'University of Newcastle Australia', 'ror': 'https://ror.org/00eae9z71', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I78757542']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Lei Jin', 'raw_affiliation_strings': ['School of Medicine and Public Health, The University of Newcastle, NSW 2308, Australia'], 'affiliations': [{'raw_affiliation_string': 'School of Medicine and Public Health, The University of Newcastle, NSW 2308, Australia', 'institution_ids': ['https://openalex.org/I78757542']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041063715', 'display_name': 'Hsin‐Yi Tseng', 'orcid': 'https://orcid.org/0000-0002-7499-7515'}, 'institutions': [{'id': 'https://openalex.org/I78757542', 'display_name': 'University of Newcastle Australia', 'ror': 'https://ror.org/00eae9z71', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I78757542']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Hsin-Yi Tseng', 'raw_affiliation_strings': ['School of Biomedical Sciences and Pharmacy, The University of Newcastle, NSW 2308, Australia'], 'affiliations': [{'raw_affiliation_string': 'School of Biomedical Sciences and Pharmacy, The University of Newcastle, NSW 2308, Australia', 'institution_ids': ['https://openalex.org/I78757542']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100338067', 'display_name': 'Tao Liu', 'orcid': 'https://orcid.org/0000-0001-6244-7316'}, 'institutions': [{'id': 'https://openalex.org/I4210112315', 'display_name': "Children's Cancer Institute Australia", 'ror': 'https://ror.org/01x784220', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210112315']}, {'id': 'https://openalex.org/I31746571', 'display_name': 'UNSW Sydney', 'ror': 'https://ror.org/03r8z3t63', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I31746571']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Tao Liu', 'raw_affiliation_strings': ["Children's Cancer Institute Australia for Medical Research, The University of New South Wales, Sydney, NSW 2052, Australia"], 'affiliations': [{'raw_affiliation_string': "Children's Cancer Institute Australia for Medical Research, The University of New South Wales, Sydney, NSW 2052, Australia", 'institution_ids': ['https://openalex.org/I4210112315', 'https://openalex.org/I31746571']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034549592', 'display_name': 'Amanda Croft', 'orcid': 'https://orcid.org/0009-0001-9285-2408'}, 'institutions': [{'id': 'https://openalex.org/I78757542', 'display_name': 'University of Newcastle Australia', 'ror': 'https://ror.org/00eae9z71', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I78757542']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Amanda Croft', 'raw_affiliation_strings': ['School of Biomedical Sciences and Pharmacy, The University of Newcastle, NSW 2308, Australia'], 'affiliations': [{'raw_affiliation_string': 'School of Biomedical Sciences and Pharmacy, The University of Newcastle, NSW 2308, Australia', 'institution_ids': ['https://openalex.org/I78757542']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048022663', 'display_name': 'Ralph Bradshaw', 'orcid': 'https://orcid.org/0000-0003-3807-2985'}, 'institutions': [{'id': 'https://openalex.org/I78757542', 'display_name': 'University of Newcastle Australia', 'ror': 'https://ror.org/00eae9z71', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I78757542']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Hubert Hondermarck', 'raw_affiliation_strings': ['School of Biomedical Sciences and Pharmacy, The University of Newcastle, NSW 2308, Australia'], 'affiliations': [{'raw_affiliation_string': 'School of Biomedical Sciences and Pharmacy, The University of Newcastle, NSW 2308, Australia', 'institution_ids': ['https://openalex.org/I78757542']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083653505', 'display_name': 'Richard A. Scolyer', 'orcid': 'https://orcid.org/0000-0002-8991-0013'}, 'institutions': [{'id': 'https://openalex.org/I2799732068', 'display_name': 'Royal Prince Alfred Hospital', 'ror': 'https://ror.org/05gpvde20', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799732068']}, {'id': 'https://openalex.org/I129604602', 'display_name': 'University of Sydney', 'ror': 'https://ror.org/0384j8v12', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I129604602']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Richard A. Scolyer', 'raw_affiliation_strings': ['Discipline of Pathology, The University of Sydney, and Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW 2006, Australia'], 'affiliations': [{'raw_affiliation_string': 'Discipline of Pathology, The University of Sydney, and Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW 2006, Australia', 'institution_ids': ['https://openalex.org/I2799732068', 'https://openalex.org/I129604602']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058536744', 'display_name': 'Chen Chen Jiang', 'orcid': 'https://orcid.org/0000-0001-9133-6391'}, 'institutions': [{'id': 'https://openalex.org/I78757542', 'display_name': 'University of Newcastle Australia', 'ror': 'https://ror.org/00eae9z71', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I78757542']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Chen Chen Jiang', 'raw_affiliation_strings': ['School of Medicine and Public Health, The University of Newcastle, NSW 2308, Australia'], 'affiliations': [{'raw_affiliation_string': 'School of Medicine and Public Health, The University of Newcastle, NSW 2308, Australia', 'institution_ids': ['https://openalex.org/I78757542']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5072813429', 'display_name': 'Xu Dong Zhang', 'orcid': 'https://orcid.org/0000-0001-9457-8003'}, 'institutions': [{'id': 'https://openalex.org/I78757542', 'display_name': 'University of Newcastle Australia', 'ror': 'https://ror.org/00eae9z71', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I78757542']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Xu Dong Zhang', 'raw_affiliation_strings': ['School of Biomedical Sciences and Pharmacy, The University of Newcastle, NSW 2308, Australia', 'School of Medicine and Public Health, The University of Newcastle, NSW 2308, Australia'], 'affiliations': [{'raw_affiliation_string': 'School of Medicine and Public Health, The University of Newcastle, NSW 2308, Australia', 'institution_ids': ['https://openalex.org/I78757542']}, {'raw_affiliation_string': 'School of Biomedical Sciences and Pharmacy, The University of Newcastle, NSW 2308, Australia', 'institution_ids': ['https://openalex.org/I78757542']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 6, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.359, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 43, 'citation_normalized_percentile': {'value': 0.865308, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '6', 'issue': '37', 'first_page': '39891', 'last_page': '39907'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10952', 'display_name': 'mTOR Signaling in Growth and Disease', 'score': 0.9876, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10952', 'display_name': 'mTOR Signaling in Growth and Disease', 'score': 0.9876, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12104', 'display_name': 'Protein Tyrosine Phosphatases in Human Health and Disease', 'score': 0.9865, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10831', 'display_name': 'Integrin Signaling in Inflammation and Cancer', 'score': 0.9835, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pi3k/akt-pathway', 'display_name': 'PI3K/AKT pathway', 'score': 0.472209}], 'concepts': [{'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.84974873}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.71922743}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.7153465}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6876148}, {'id': 'https://openalex.org/C2777658100', 'wikidata': 'https://www.wikidata.org/wiki/Q180614', 'display_name': 'Melanoma', 'level': 2, 'score': 0.6129513}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.4862672}, {'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.43943816}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4060521}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.35122588}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.2547977}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.235753}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.21600103}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.21239695}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.09359434}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.08356246}], 'mesh': [{'descriptor_ui': 'D008545', 'descriptor_name': 'Melanoma', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010744', 'descriptor_name': 'Phosphoric Monoester Hydrolases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015151', 'descriptor_name': 'Immunoblotting', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008545', 'descriptor_name': 'Melanoma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008545', 'descriptor_name': 'Melanoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008545', 'descriptor_name': 'Melanoma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010744', 'descriptor_name': 'Phosphoric Monoester Hydrolases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010744', 'descriptor_name': 'Phosphoric Monoester Hydrolases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D034622', 'descriptor_name': 'RNA Interference', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014183', 'descriptor_name': 'Transplantation, Heterologous', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047368', 'descriptor_name': 'Tumor Burden', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D047368', 'descriptor_name': 'Tumor Burden', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.5359', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=5359&path%5B%5D=16818', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4741868', 'pdf_url': 'https://europepmc.org/articles/pmc4741868?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741868', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/1959.4/unsworks_40051', 'pdf_url': 'https://unsworks.unsw.edu.au/bitstreams/f3f21719-f8ea-4695-be9b-fcc620d4b557/download', 'source': {'id': 'https://openalex.org/S4306401737', 'display_name': 'UNSWorks (University of New South Wales, Sydney, Australia)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I40053085', 'host_organization_name': 'Australian Defence Force Academy', 'host_organization_lineage': ['https://openalex.org/I40053085'], 'host_organization_lineage_names': ['Australian Defence Force Academy'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/1959.13/1314949', 'pdf_url': 'https://ogma.newcastle.edu.au:443/vital/access/services/Download/uon:22865/ATTACHMENT02', 'source': {'id': 'https://openalex.org/S4306401391', 'display_name': 'NOVA (University of Newcastle, Australia)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I78757542', 'host_organization_name': 'University of Newcastle Australia', 'host_organization_lineage': ['https://openalex.org/I78757542'], 'host_organization_lineage_names': ['University of Newcastle Australia'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26573229', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.5359', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=5359&path%5B%5D=16818', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 56, 'referenced_works': ['https://openalex.org/W1851044857', 'https://openalex.org/W1967342065', 'https://openalex.org/W1972178925', 'https://openalex.org/W1973155168', 'https://openalex.org/W1979284427', 'https://openalex.org/W1986426976', 'https://openalex.org/W1989408768', 'https://openalex.org/W1993312761', 'https://openalex.org/W2001616285', 'https://openalex.org/W2003787585', 'https://openalex.org/W2006771504', 'https://openalex.org/W2007530728', 'https://openalex.org/W2009364489', 'https://openalex.org/W2012116166', 'https://openalex.org/W2015235010', 'https://openalex.org/W2023525322', 'https://openalex.org/W2023543654', 'https://openalex.org/W2024085992', 'https://openalex.org/W2025605504', 'https://openalex.org/W2027814240', 'https://openalex.org/W2028626714', 'https://openalex.org/W2029729683', 'https://openalex.org/W2033801757', 'https://openalex.org/W2041061216', 'https://openalex.org/W2043865307', 'https://openalex.org/W2047146433', 'https://openalex.org/W2049180064', 'https://openalex.org/W2051118426', 'https://openalex.org/W2059259875', 'https://openalex.org/W2059794606', 'https://openalex.org/W2062144817', 'https://openalex.org/W2065566217', 'https://openalex.org/W2072697288', 'https://openalex.org/W2081295565', 'https://openalex.org/W2084136291', 'https://openalex.org/W2088467967', 'https://openalex.org/W2088781211', 'https://openalex.org/W2092645471', 'https://openalex.org/W2092676832', 'https://openalex.org/W2105194463', 'https://openalex.org/W2106278322', 'https://openalex.org/W2111223585', 'https://openalex.org/W2128542677', 'https://openalex.org/W2130767958', 'https://openalex.org/W2135256659', 'https://openalex.org/W2139992910', 'https://openalex.org/W2144185275', 'https://openalex.org/W2145169016', 'https://openalex.org/W2149146453', 'https://openalex.org/W2150536104', 'https://openalex.org/W2154853638', 'https://openalex.org/W2159801541', 'https://openalex.org/W2161018320', 'https://openalex.org/W2163188200', 'https://openalex.org/W2164139183', 'https://openalex.org/W4242171364'], 'related_works': ['https://openalex.org/W4247833810', 'https://openalex.org/W4242240318', 'https://openalex.org/W3183179750', 'https://openalex.org/W3127487613', 'https://openalex.org/W3116479654', 'https://openalex.org/W3048105303', 'https://openalex.org/W2904239912', 'https://openalex.org/W2070783513', 'https://openalex.org/W2024933597', 'https://openalex.org/W1968932537'], 'abstract_inverted_index': {'//': [0], 'Meng': [1], 'Na': [2], 'Chi': [3], '1,': [4, 73], '*': [5, 12, 163], ',': [6, 13, 18, 23, 28, 34, 39, 43, 47, 51, 55, 59, 64, 69], 'Su': [7], 'Tang': [8], 'Guo': [9, 21], '2,': [10, 32], '3,': [11], 'James': [14], 'S.': [15], 'Wilmott': [16], '4': [17, 63, 123], 'Xiang': [19], 'Yun': [20], '3': [22, 33, 103, 255], 'Xu': [24, 70, 174], 'Guang': [25], 'Yan': [26, 30], '1': [27, 42, 68, 75], 'Chun': [29], 'Wang': [31], 'Xiao': [35], 'Ying': [36], 'Liu': [37, 49], '2': [38, 46, 54, 58, 74, 89], 'Lei': [40], 'Jin': [41], 'Hsin-Yi': [44], 'Tseng': [45], 'Tao': [48], '5': [50, 145], 'Amanda': [52], 'Croft': [53], 'Hubert': [56], 'Hondermarck': [57], 'Richard': [60], 'A.': [61], 'Scolyer': [62], 'Chen': [65, 66, 179, 180], 'Jiang': [67], 'Dong': [71, 175], 'Zhang': [72], 'School': [76, 90], 'of': [77, 84, 91, 98, 105, 115, 125, 129, 155, 222, 235, 250, 272, 284, 296, 304, 313, 326, 342, 361, 369, 374, 392], 'Medicine': [78], 'and': [79, 94, 111, 131, 134, 213, 252, 266, 277, 280, 335, 351, 381, 384], 'Public': [80], 'Health,': [81], 'The': [82, 96, 127, 153], 'University': [83, 97, 128, 154], 'Newcastle,': [85, 99], 'NSW': [86, 100, 142, 160], '2308,': [87, 101], 'Australia': [88, 102, 144, 149, 162], 'Biomedical': [92], 'Sciences': [93], 'Pharmacy,': [95], 'Department': [104], 'Molecular': [106], 'Biology,': [107], 'Shanxi': [108, 116, 120], 'Cancer': [109, 147], 'Hospital': [110, 114], 'Institute,': [112], 'Affiliated': [113], 'Medical': [117, 151], 'University,': [118], 'Taiyuan,': [119], '030013,': [121], 'China': [122], 'Discipline': [124], 'Pathology,': [126], 'Sydney,': [130, 141, 159], 'Tissue': [132], 'Pathology': [133], 'Diagnostic': [135], 'Oncology,': [136], 'Royal': [137], 'Prince': [138], 'Alfred': [139], 'Hospital,': [140], '2006,': [143], "Children's": [146], 'Institute': [148], 'for': [150, 378], 'Research,': [152], 'New': [156], 'South': [157], 'Wales,': [158], '2052,': [161], 'These': [164], 'authors': [165], 'have': [166, 226], 'contributed': [167], 'equally': [168], 'to': [169, 294, 319], 'this': [170], 'work': [171], 'Correspondence': [172], 'to:': [173], 'Zhang,': [176], 'e-mail:': [177, 182], '[email protected]': [178], 'Jiang,': [181], '[email protected]': [183], 'Keywords:': [184], 'INPP4B,': [185, 331, 347], 'SGK3,': [186], 'melanoma,': [187], 'miRNA-494,': [188], 'miRNA-599': [189], 'Received:': [190], 'May': [191], '06,': [192], '2015': [193, 197, 201], 'Accepted:': [194], 'October': [195], '27,': [196], 'Published:': [198], 'November': [199], '09,': [200], 'ABSTRACT': [202], 'Inositol': [203], 'polyphosphate': [204], '4-phosphatase': [205], 'type': [206], 'II': [207], '(INPP4B)': [208], 'negatively': [209], 'regulates': [210], 'PI3K/Akt': [211], 'signalling': [212], 'has': [214], 'a': [215, 233, 372], 'tumour': [216], 'suppressive': [217], 'role': [218], 'in': [219, 232, 257, 306, 371, 389], 'some': [220], 'types': [221], 'cancers.': [223], 'However,': [224], 'we': [225, 238], 'found': [227], 'that': [228, 240], 'it': [229], 'is': [230], 'upregulated': [231, 346], 'subset': [234, 373], 'melanomas.': [236], 'Here': [237], 'report': [239], 'INPP4B': [241, 260, 273, 305, 362, 380, 396], 'can': [242], 'function': [243], 'as': [244, 363, 386], 'an': [245, 364], 'oncogenic': [246, 365], 'driver': [247], 'through': [248, 367], 'activation': [249, 295, 368], 'serum-': [251], 'glucocorticoid-regulated': [253], 'kinase': [254], '(SGK3)': [256], 'melanoma.': [258], 'While': [259], 'knockdown': [261], 'inhibited': [262, 336], 'melanoma': [263, 268, 275, 288, 307, 337, 353], 'cell': [264, 276, 289, 338, 354], 'proliferation': [265, 279, 290], 'retarded': [267], 'xenograft': [269], 'growth,': [270], 'overexpression': [271, 325], 'enhanced': [274, 348], 'melanocyte': [278], 'triggered': [281], 'anchorage-independent': [282], 'growth': [283], 'melanocytes.': [285], 'Noticeably,': [286], 'INPP4B-mediated': [287], 'was': [291, 299, 309], 'not': [292], 'related': [293], 'Akt,': [297], 'but': [298], 'mediated': [300], 'by': [301], 'SGK3.': [302], 'Upregulation': [303], 'cells': [308], 'associated': [310], 'with': [311, 376, 394], 'loss': [312], 'miRNA': [314], '(miR)-494': [315], 'and/or': [316], 'miR-599': [317, 329, 385], 'due': [318], 'gene': [320], 'copy': [321], 'number': [322], 'reduction.': [323], 'Indeed,': [324], 'miR-494': [327, 383], 'or': [328, 344], 'downregulated': [330], 'reduced': [332], 'SGK3': [333, 349, 370], 'activation,': [334, 350], 'proliferation,': [339], 'whereas': [340], 'introduction': [341], 'anti-miR-494': [343], 'anti-miR-599': [345], 'promoted': [352], 'proliferation.': [355], 'Collectively,': [356], 'these': [357], 'results': [358], 'identify': [359], 'upregulation': [360], 'mechanism': [366], 'melanomas,': [375], 'implications': [377], 'targeting': [379], 'restoring': [382], 'novel': [387], 'approaches': [388], 'the': [390], 'treatment': [391], 'melanomas': [393], 'high': [395], 'expression.': [397]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2280345261', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 5}], 'updated_date': '2024-09-11T17:04:27.665888', 'created_date': '2016-06-24'}