Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2280219571', 'doi': 'https://doi.org/10.1002/jat.3306', 'title': '<i>Neverland</i>regulates embryonic moltings through the regulation of ecdysteroid synthesis in the water flea<i>Daphnia magna</i>, and may thus act as a target for chemical disruption of molting', 'display_name': '<i>Neverland</i>regulates embryonic moltings through the regulation of ecdysteroid synthesis in the water flea<i>Daphnia magna</i>, and may thus act as a target for chemical disruption of molting', 'publication_year': 2016, 'publication_date': '2016-02-22', 'ids': {'openalex': 'https://openalex.org/W2280219571', 'doi': 'https://doi.org/10.1002/jat.3306', 'mag': '2280219571', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26898244'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jat.3306', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S81851855', 'display_name': 'Journal of Applied Toxicology', 'issn_l': '0260-437X', 'issn': ['0260-437X', '1099-1263'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5012845278', 'display_name': 'Eri Sumiya', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200475212', 'display_name': 'The Graduate University for Advanced Studies, SOKENDAI', 'ror': 'https://ror.org/0516ah480', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I200475212']}, {'id': 'https://openalex.org/I199525922', 'display_name': 'National Institutes of Natural Sciences', 'ror': 'https://ror.org/055n47h92', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I1319490839', 'https://openalex.org/I199525922']}, {'id': 'https://openalex.org/I4210097088', 'display_name': 'Okazaki Institute for Integrative Bioscience', 'ror': 'https://ror.org/00v3cq569', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097088']}, {'id': 'https://openalex.org/I138804964', 'display_name': 'National Institute for Basic Biology', 'ror': 'https://ror.org/05q8wtt20', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I1319490839', 'https://openalex.org/I138804964', 'https://openalex.org/I199525922']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Eri Sumiya', 'raw_affiliation_strings': ['Department of Basic Biology, Faculty of Life Science, SOKENDAI, (Graduate University for Advanced Studies, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi, 444-8787 Japan', 'Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi, 444-8787 Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Basic Biology, Faculty of Life Science, SOKENDAI, (Graduate University for Advanced Studies, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi, 444-8787 Japan', 'institution_ids': ['https://openalex.org/I200475212']}, {'raw_affiliation_string': 'Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi, 444-8787 Japan', 'institution_ids': ['https://openalex.org/I199525922', 'https://openalex.org/I4210097088', 'https://openalex.org/I138804964']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084410740', 'display_name': 'Yukiko Ogino', 'orcid': 'https://orcid.org/0000-0003-3414-1648'}, 'institutions': [{'id': 'https://openalex.org/I200475212', 'display_name': 'The Graduate University for Advanced Studies, SOKENDAI', 'ror': 'https://ror.org/0516ah480', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I200475212']}, {'id': 'https://openalex.org/I199525922', 'display_name': 'National Institutes of Natural Sciences', 'ror': 'https://ror.org/055n47h92', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I1319490839', 'https://openalex.org/I199525922']}, {'id': 'https://openalex.org/I4210097088', 'display_name': 'Okazaki Institute for Integrative Bioscience', 'ror': 'https://ror.org/00v3cq569', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097088']}, {'id': 'https://openalex.org/I138804964', 'display_name': 'National Institute for Basic Biology', 'ror': 'https://ror.org/05q8wtt20', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I1319490839', 'https://openalex.org/I138804964', 'https://openalex.org/I199525922']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yukiko Ogino', 'raw_affiliation_strings': ['Department of Basic Biology, Faculty of Life Science, SOKENDAI, (Graduate University for Advanced Studies, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi, 444-8787 Japan', 'Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi, 444-8787 Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Basic Biology, Faculty of Life Science, SOKENDAI, (Graduate University for Advanced Studies, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi, 444-8787 Japan', 'institution_ids': ['https://openalex.org/I200475212']}, {'raw_affiliation_string': 'Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi, 444-8787 Japan', 'institution_ids': ['https://openalex.org/I199525922', 'https://openalex.org/I4210097088', 'https://openalex.org/I138804964']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037545616', 'display_name': 'Kenji Toyota', 'orcid': 'https://orcid.org/0000-0001-8411-1389'}, 'institutions': [{'id': 'https://openalex.org/I199525922', 'display_name': 'National Institutes of Natural Sciences', 'ror': 'https://ror.org/055n47h92', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I1319490839', 'https://openalex.org/I199525922']}, {'id': 'https://openalex.org/I4210097088', 'display_name': 'Okazaki Institute for Integrative Bioscience', 'ror': 'https://ror.org/00v3cq569', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097088']}, {'id': 'https://openalex.org/I138804964', 'display_name': 'National Institute for Basic Biology', 'ror': 'https://ror.org/05q8wtt20', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I1319490839', 'https://openalex.org/I138804964', 'https://openalex.org/I199525922']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kenji Toyota', 'raw_affiliation_strings': ['Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi, 444-8787 Japan'], 'affiliations': [{'raw_affiliation_string': 'Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi, 444-8787 Japan', 'institution_ids': ['https://openalex.org/I199525922', 'https://openalex.org/I4210097088', 'https://openalex.org/I138804964']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045064533', 'display_name': 'Hitoshi Miyakawa', 'orcid': 'https://orcid.org/0000-0002-3361-8443'}, 'institutions': [{'id': 'https://openalex.org/I207399273', 'display_name': 'Utsunomiya University', 'ror': 'https://ror.org/05bx1gz93', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I207399273']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hitoshi Miyakawa', 'raw_affiliation_strings': ['Center for Bioscience Research and Education, Utsunomiya University, 350 Mine-machi, Utsunomiya, Tochigi, 321-8505 Japan'], 'affiliations': [{'raw_affiliation_string': 'Center for Bioscience Research and Education, Utsunomiya University, 350 Mine-machi, Utsunomiya, Tochigi, 321-8505 Japan', 'institution_ids': ['https://openalex.org/I207399273']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103168669', 'display_name': 'Shinichi Miyagawa', 'orcid': 'https://orcid.org/0000-0001-6627-1290'}, 'institutions': [{'id': 'https://openalex.org/I138804964', 'display_name': 'National Institute for Basic Biology', 'ror': 'https://ror.org/05q8wtt20', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I1319490839', 'https://openalex.org/I138804964', 'https://openalex.org/I199525922']}, {'id': 'https://openalex.org/I200475212', 'display_name': 'The Graduate University for Advanced Studies, SOKENDAI', 'ror': 'https://ror.org/0516ah480', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I200475212']}, {'id': 'https://openalex.org/I199525922', 'display_name': 'National Institutes of Natural Sciences', 'ror': 'https://ror.org/055n47h92', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I1319490839', 'https://openalex.org/I199525922']}, {'id': 'https://openalex.org/I4210097088', 'display_name': 'Okazaki Institute for Integrative Bioscience', 'ror': 'https://ror.org/00v3cq569', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097088']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shinichi Miyagawa', 'raw_affiliation_strings': ['Department of Basic Biology, Faculty of Life Science, SOKENDAI, (Graduate University for Advanced Studies, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi, 444-8787 Japan', 'Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi, 444-8787 Japan'], 'affiliations': [{'raw_affiliation_string': 'Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi, 444-8787 Japan', 'institution_ids': ['https://openalex.org/I138804964', 'https://openalex.org/I199525922', 'https://openalex.org/I4210097088']}, {'raw_affiliation_string': 'Department of Basic Biology, Faculty of Life Science, SOKENDAI, (Graduate University for Advanced Studies, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi, 444-8787 Japan', 'institution_ids': ['https://openalex.org/I200475212']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5005360431', 'display_name': 'Taisen Iguchi', 'orcid': 'https://orcid.org/0000-0002-6020-0704'}, 'institutions': [{'id': 'https://openalex.org/I199525922', 'display_name': 'National Institutes of Natural Sciences', 'ror': 'https://ror.org/055n47h92', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I1319490839', 'https://openalex.org/I199525922']}, {'id': 'https://openalex.org/I4210097088', 'display_name': 'Okazaki Institute for Integrative Bioscience', 'ror': 'https://ror.org/00v3cq569', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097088']}, {'id': 'https://openalex.org/I138804964', 'display_name': 'National Institute for Basic Biology', 'ror': 'https://ror.org/05q8wtt20', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I1319490839', 'https://openalex.org/I138804964', 'https://openalex.org/I199525922']}, {'id': 'https://openalex.org/I200475212', 'display_name': 'The Graduate University for Advanced Studies, SOKENDAI', 'ror': 'https://ror.org/0516ah480', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I200475212']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Taisen Iguchi', 'raw_affiliation_strings': ['Department of Basic Biology, Faculty of Life Science, SOKENDAI, (Graduate University for Advanced Studies, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi, 444-8787 Japan', 'Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi, 444-8787 Japan'], 'affiliations': [{'raw_affiliation_string': 'Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi, 444-8787 Japan', 'institution_ids': ['https://openalex.org/I199525922', 'https://openalex.org/I4210097088', 'https://openalex.org/I138804964']}, {'raw_affiliation_string': 'Department of Basic Biology, Faculty of Life Science, SOKENDAI, (Graduate University for Advanced Studies, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi, 444-8787 Japan', 'institution_ids': ['https://openalex.org/I200475212']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': ['https://openalex.org/A5005360431'], 'corresponding_institution_ids': ['https://openalex.org/I199525922', 'https://openalex.org/I4210097088', 'https://openalex.org/I138804964', 'https://openalex.org/I200475212'], 'apc_list': {'value': 4220, 'currency': 'USD', 'value_usd': 4220, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.081, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 41, 'citation_normalized_percentile': {'value': 0.999853, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '36', 'issue': '11', 'first_page': '1476', 'last_page': '1485'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10423', 'display_name': 'Neuroscience and Genetics of Drosophila Melanogaster', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10423', 'display_name': 'Neuroscience and Genetics of Drosophila Melanogaster', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10450', 'display_name': 'Metabolism and Nutrition in Aquaculture Feeds', 'score': 0.9892, 'subfield': {'id': 'https://openalex.org/subfields/1104', 'display_name': 'Aquatic Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12336', 'display_name': 'Potential of Edible Insects as Food and Feed', 'score': 0.9837, 'subfield': {'id': 'https://openalex.org/subfields/1109', 'display_name': 'Insect Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ecdysteroid', 'display_name': 'Ecdysteroid', 'score': 0.9741518}, {'id': 'https://openalex.org/keywords/daphnia-magna', 'display_name': 'Daphnia magna', 'score': 0.58504397}], 'concepts': [{'id': 'https://openalex.org/C2776905768', 'wikidata': 'https://www.wikidata.org/wiki/Q138983', 'display_name': 'Ecdysteroid', 'level': 3, 'score': 0.9741518}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.820477}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.6716481}, {'id': 'https://openalex.org/C87073359', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryogenesis', 'level': 3, 'score': 0.6591207}, {'id': 'https://openalex.org/C41905685', 'wikidata': 'https://www.wikidata.org/wiki/Q381084', 'display_name': 'Moulting', 'level': 3, 'score': 0.6423308}, {'id': 'https://openalex.org/C2777180181', 'wikidata': 'https://www.wikidata.org/wiki/Q139085', 'display_name': 'Ecdysone', 'level': 3, 'score': 0.6360662}, {'id': 'https://openalex.org/C2780158794', 'wikidata': 'https://www.wikidata.org/wiki/Q672531', 'display_name': 'Daphnia magna', 'level': 3, 'score': 0.58504397}, {'id': 'https://openalex.org/C196843134', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryo', 'level': 2, 'score': 0.5241478}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.509639}, {'id': 'https://openalex.org/C145103041', 'wikidata': 'https://www.wikidata.org/wiki/Q1151519', 'display_name': 'Embryonic stem cell', 'level': 3, 'score': 0.43518737}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.40302134}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.39544284}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.15567973}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.13699937}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.093777776}, {'id': 'https://openalex.org/C59822182', 'wikidata': 'https://www.wikidata.org/wiki/Q441', 'display_name': 'Botany', 'level': 1, 'score': 0.085797936}, {'id': 'https://openalex.org/C29730261', 'wikidata': 'https://www.wikidata.org/wiki/Q274160', 'display_name': 'Toxicity', 'level': 2, 'score': 0.07902187}, {'id': 'https://openalex.org/C173758957', 'wikidata': 'https://www.wikidata.org/wiki/Q129270', 'display_name': 'Larva', 'level': 2, 'score': 0.060319424}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003621', 'descriptor_name': 'Daphnia', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': True}, {'descriptor_ui': 'D026461', 'descriptor_name': 'Ecdysteroids', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D004625', 'descriptor_name': 'Embryo, Nonmammalian', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': True}, {'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D019476', 'descriptor_name': 'Insect Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D018978', 'descriptor_name': 'Molting', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003621', 'descriptor_name': 'Daphnia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003621', 'descriptor_name': 'Daphnia', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D026461', 'descriptor_name': 'Ecdysteroids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D026461', 'descriptor_name': 'Ecdysteroids', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004625', 'descriptor_name': 'Embryo, Nonmammalian', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004625', 'descriptor_name': 'Embryo, Nonmammalian', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004625', 'descriptor_name': 'Embryo, Nonmammalian', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D055785', 'descriptor_name': 'Gene Knockdown Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017344', 'descriptor_name': 'Genes, Insect', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019476', 'descriptor_name': 'Insect Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018978', 'descriptor_name': 'Molting', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D018978', 'descriptor_name': 'Molting', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jat.3306', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S81851855', 'display_name': 'Journal of Applied Toxicology', 'issn_l': '0260-437X', 'issn': ['0260-437X', '1099-1263'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26898244', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.84, 'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 53, 'referenced_works': ['https://openalex.org/W1577577364', 'https://openalex.org/W1585136903', 'https://openalex.org/W1743631456', 'https://openalex.org/W1953434579', 'https://openalex.org/W1967947254', 'https://openalex.org/W1978383473', 'https://openalex.org/W1979019741', 'https://openalex.org/W1982949723', 'https://openalex.org/W1988270224', 'https://openalex.org/W1988390755', 'https://openalex.org/W1995345065', 'https://openalex.org/W1999672301', 'https://openalex.org/W1999718240', 'https://openalex.org/W2000519009', 'https://openalex.org/W2002803923', 'https://openalex.org/W2007415064', 'https://openalex.org/W2008548841', 'https://openalex.org/W2015392497', 'https://openalex.org/W2017665051', 'https://openalex.org/W2018317034', 'https://openalex.org/W2025609229', 'https://openalex.org/W2025697998', 'https://openalex.org/W2026571338', 'https://openalex.org/W2033236668', 'https://openalex.org/W2033500368', 'https://openalex.org/W2036502668', 'https://openalex.org/W2037891690', 'https://openalex.org/W2040069098', 'https://openalex.org/W2052114499', 'https://openalex.org/W2055984320', 'https://openalex.org/W2063689436', 'https://openalex.org/W2066430476', 'https://openalex.org/W2066473288', 'https://openalex.org/W2076069532', 'https://openalex.org/W2077271480', 'https://openalex.org/W2086224863', 'https://openalex.org/W2087123094', 'https://openalex.org/W2105423509', 'https://openalex.org/W2109286448', 'https://openalex.org/W2110046092', 'https://openalex.org/W2115792493', 'https://openalex.org/W2119309482', 'https://openalex.org/W2125971661', 'https://openalex.org/W2127685697', 'https://openalex.org/W2127967104', 'https://openalex.org/W2141727957', 'https://openalex.org/W2143790141', 'https://openalex.org/W2161208204', 'https://openalex.org/W2265890753', 'https://openalex.org/W2330744685', 'https://openalex.org/W2615657811', 'https://openalex.org/W4252363703', 'https://openalex.org/W621438018'], 'related_works': ['https://openalex.org/W2413306657', 'https://openalex.org/W2093249307', 'https://openalex.org/W2078637312', 'https://openalex.org/W2042650565', 'https://openalex.org/W2031262510', 'https://openalex.org/W2014003227', 'https://openalex.org/W1989284398', 'https://openalex.org/W1982316931', 'https://openalex.org/W1978600505', 'https://openalex.org/W1967579685'], 'abstract_inverted_index': {'Embryo': [0], 'development': [1, 247], 'in': [2, 53, 65, 77, 132, 144, 155, 162, 171, 181, 213], 'arthropods': [3], 'is': [4, 221], 'accompanied': [5], 'by': [6, 139, 211], 'a': [7, 194, 233], 'series': [8], 'of': [9, 75, 87, 99, 121, 135, 159, 192, 196], 'moltings.': [10], 'A': [11], 'cladoceran': [12], 'crustacean': [13], 'Daphnia': [14], 'magna': [15, 33, 79, 225], 'molts': [16], 'three': [17], 'times': [18], 'before': [19, 128, 166], 'reaching': [20], 'first': [21, 110, 130, 168], 'instar': [22], 'neonate': [23], 'during': [24, 94], 'embryogenesis.': [25, 34], 'Previous': [26], 'studies': [27], 'argued': [28], 'ecdysteroids': [29, 41, 76, 92, 100, 151], 'might': [30], 'regulate': [31], 'D.': [32, 78, 224], 'However,': [35], 'no': [36], 'direct': [37], 'evidence': [38], 'between': [39], 'innate': [40, 91], 'fluctuation': [42], 'and': [43, 59, 62, 64, 84, 104, 111, 123, 147, 200, 248], 'functions': [44], 'has': [45], 'been': [46], 'forthcoming.': [47], 'Recently,': [48], 'we': [49, 81], 'identified': [50], 'genes': [51], 'involved': [52], 'ecdysteroid': [54, 67, 118, 209], 'synthesis': [55, 210], 'called,': [56], 'neverland': [57, 60, 231], '(neverland1': [58], '2)': [61], 'shade': [63, 124, 138], 'the': [66, 72, 129, 167, 186, 214], 'degradation': [68], '(Cyp18a1).': [69], 'To': [70], 'understand': [71], 'physiological': [73], 'roles': [74], 'embryos,': [80], 'performed': [82], 'expression': [83], 'functional': [85], 'analyzes': [86], 'those': [88], 'genes.': [89], 'Examining': [90], 'titer': [93, 101, 152], 'embryogenesis': [95], 'showed': [96], 'two': [97], 'surges': [98], 'at': [102, 116], '41': [103], '61': [105], 'h': [106], 'after': [107], 'oviposition.': [108], 'The': [109, 150], 'second': [112], 'embryonic': [113, 145, 164, 182], 'moltings': [114, 146], 'occurred': [115], 'each': [117], 'surge.': [119], 'Expression': [120], 'neverland1': [122, 136], 'began': [125], 'to': [126, 198, 244], 'increase': [127], 'peak': [131], 'ecdysteroid.': [133], 'Knockdown': [134, 158], 'or': [137], 'RNAi': [140], 'technique': [141], 'caused': [142], 'defects': [143], 'subsequent': [148], 'development.': [149, 227], 'seemingly': [153], 'decreased': [154], 'nvd1-knowckdown': [156], 'embryos.': [157], 'Cyp18a1': [160], 'resulted': [161], 'early': [163], 'lethality': [165], 'molting.': [169], 'Our': [170], 'situ': [172], 'hybridization': [173], 'analysis': [174], 'revealed': [175], 'that': [176, 241], 'nvd1': [177, 212], 'was': [178], 'prominently': [179], 'expressed': [180], 'gut': [183, 215], 'epithelium': [184], 'suggesting': [185], 'site': [187], 'for': [188, 202, 223, 236], 'an': [189], 'initial': [190], 'step': [191], 'ecdysteroidgenesis,': [193], 'conversion': [195], 'cholesterol': [197], '7-dehydrocholesterol': [199], 'possibly': [201], 'ecdysone': [203], 'production.': [204], 'Taken': [205], 'together,': [206], 'de': [207], 'novo': [208], 'epithelial': [216], 'cells': [217], 'stimulates': [218], 'molting,': [219, 246], 'which': [220], 'indispensable': [222], 'embryo': [226], 'These': [228], 'findings': [229], 'identify': [230], 'as': [232], 'possible': [234], 'target': [235], 'chemicals,': [237], 'including': [238], 'various': [239], 'pesticides': [240], 'are': [242], 'known': [243], 'disrupt': [245], 'reproduction.': [249], 'Copyright': [250], '©': [251], '2016': [252], 'John': [253], 'Wiley': [254], '&': [255], 'Sons,': [256], 'Ltd.': [257]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2280219571', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-08-15T13:58:40.528763', 'created_date': '2016-06-24'}