AMPK and PKA interaction in the regulation of survival of liver cancer cells subjected to glucose starvation

Name: Work Video:
Duration: 3 min 30 s
Anabela C. Ferretti; Facundo M. Tonucci; Florencia Hidalgo; Evangelina Almada; M. Cecilia Larocca; Cristián Favre
{'id': 'https://openalex.org/W2277332640', 'doi': 'https://doi.org/10.18632/oncotarget.7404', 'title': 'AMPK and PKA interaction in the regulation of survival of liver cancer cells subjected to glucose starvation', 'display_name': 'AMPK and PKA interaction in the regulation of survival of liver cancer cells subjected to glucose starvation', 'publication_year': 2016, 'publication_date': '2016-02-15', 'ids': {'openalex': 'https://openalex.org/W2277332640', 'doi': 'https://doi.org/10.18632/oncotarget.7404', 'mag': '2277332640', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26894973', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4951252'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.7404', 'pdf_url': 'https://www.oncotarget.com/article/7404/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/7404/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5032993738', 'display_name': 'Anabela C. Ferretti', 'orcid': 'https://orcid.org/0000-0003-3723-0136'}, 'institutions': [{'id': 'https://openalex.org/I151201029', 'display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'ror': 'https://ror.org/03cqe8w59', 'country_code': 'AR', 'type': 'government', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4387155568']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'Anabela C. Ferretti', 'raw_affiliation_strings': ['Institute of Experimental Physiology, CONICET, School of Biochemical Sciences, University of Rosario, Rosario, Argentina'], 'affiliations': [{'raw_affiliation_string': 'Institute of Experimental Physiology, CONICET, School of Biochemical Sciences, University of Rosario, Rosario, Argentina', 'institution_ids': ['https://openalex.org/I151201029']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015077567', 'display_name': 'Facundo M. Tonucci', 'orcid': 'https://orcid.org/0000-0003-0372-6344'}, 'institutions': [{'id': 'https://openalex.org/I151201029', 'display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'ror': 'https://ror.org/03cqe8w59', 'country_code': 'AR', 'type': 'government', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4387155568']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'Facundo M. Tonucci', 'raw_affiliation_strings': ['Institute of Experimental Physiology, CONICET, School of Biochemical Sciences, University of Rosario, Rosario, Argentina'], 'affiliations': [{'raw_affiliation_string': 'Institute of Experimental Physiology, CONICET, School of Biochemical Sciences, University of Rosario, Rosario, Argentina', 'institution_ids': ['https://openalex.org/I151201029']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032097645', 'display_name': 'Florencia Hidalgo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I151201029', 'display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'ror': 'https://ror.org/03cqe8w59', 'country_code': 'AR', 'type': 'government', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4387155568']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'Florencia Hidalgo', 'raw_affiliation_strings': ['Institute of Experimental Physiology, CONICET, School of Biochemical Sciences, University of Rosario, Rosario, Argentina'], 'affiliations': [{'raw_affiliation_string': 'Institute of Experimental Physiology, CONICET, School of Biochemical Sciences, University of Rosario, Rosario, Argentina', 'institution_ids': ['https://openalex.org/I151201029']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087783850', 'display_name': 'Evangelina Almada', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I151201029', 'display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'ror': 'https://ror.org/03cqe8w59', 'country_code': 'AR', 'type': 'government', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4387155568']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'Evangelina Almada', 'raw_affiliation_strings': ['Institute of Experimental Physiology, CONICET, School of Biochemical Sciences, University of Rosario, Rosario, Argentina'], 'affiliations': [{'raw_affiliation_string': 'Institute of Experimental Physiology, CONICET, School of Biochemical Sciences, University of Rosario, Rosario, Argentina', 'institution_ids': ['https://openalex.org/I151201029']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071470838', 'display_name': 'M. Cecilia Larocca', 'orcid': 'https://orcid.org/0000-0002-6967-5431'}, 'institutions': [{'id': 'https://openalex.org/I151201029', 'display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'ror': 'https://ror.org/03cqe8w59', 'country_code': 'AR', 'type': 'government', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4387155568']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'Maria C. Larocca', 'raw_affiliation_strings': ['Institute of Experimental Physiology, CONICET, School of Biochemical Sciences, University of Rosario, Rosario, Argentina'], 'affiliations': [{'raw_affiliation_string': 'Institute of Experimental Physiology, CONICET, School of Biochemical Sciences, University of Rosario, Rosario, Argentina', 'institution_ids': ['https://openalex.org/I151201029']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5038689256', 'display_name': 'Cristián Favre', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I151201029', 'display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'ror': 'https://ror.org/03cqe8w59', 'country_code': 'AR', 'type': 'government', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4387155568']}], 'countries': ['AR'], 'is_corresponding': True, 'raw_author_name': 'Cristián Favre', 'raw_affiliation_strings': ['Institute of Experimental Physiology, CONICET, School of Biochemical Sciences, University of Rosario, Rosario, Argentina'], 'affiliations': [{'raw_affiliation_string': 'Institute of Experimental Physiology, CONICET, School of Biochemical Sciences, University of Rosario, Rosario, Argentina', 'institution_ids': ['https://openalex.org/I151201029']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5038689256'], 'corresponding_institution_ids': ['https://openalex.org/I151201029'], 'apc_list': None, 'apc_paid': None, 'fwci': 3.205, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 63, 'citation_normalized_percentile': {'value': 0.873848, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '7', 'issue': '14', 'first_page': '17815', 'last_page': '17828'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11339', 'display_name': 'Metabolism, Diabetes, and Cancer', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11339', 'display_name': 'Metabolism, Diabetes, and Cancer', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10839', 'display_name': 'Pancreatic function and diabetes', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/amp-activated-protein-kinase', 'display_name': 'AMP-Activated Protein Kinase', 'score': 0.49268657}, {'id': 'https://openalex.org/keywords/viability-assay', 'display_name': 'Viability assay', 'score': 0.47516152}], 'concepts': [{'id': 'https://openalex.org/C2780124434', 'wikidata': 'https://www.wikidata.org/wiki/Q12357464', 'display_name': 'AMPK', 'level': 4, 'score': 0.93874466}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.6643026}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.60712624}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.5388313}, {'id': 'https://openalex.org/C2776780712', 'wikidata': 'https://www.wikidata.org/wiki/Q295240', 'display_name': 'AMP-activated protein kinase', 'level': 5, 'score': 0.49268657}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.48351315}, {'id': 'https://openalex.org/C53227056', 'wikidata': 'https://www.wikidata.org/wiki/Q189152', 'display_name': 'Viability assay', 'level': 3, 'score': 0.47516152}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.4567853}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.45319992}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.4283163}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.40277517}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.3491664}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3490199}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3475659}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.21956867}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.2186029}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.13434985}], 'mesh': [{'descriptor_ui': 'D055372', 'descriptor_name': 'AMP-Activated Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D017868', 'descriptor_name': 'Cyclic AMP-Dependent Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005947', 'descriptor_name': 'Glucose', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': True}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D055372', 'descriptor_name': 'AMP-Activated Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017868', 'descriptor_name': 'Cyclic AMP-Dependent Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005947', 'descriptor_name': 'Glucose', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005947', 'descriptor_name': 'Glucose', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056945', 'descriptor_name': 'Hep G2 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.7404', 'pdf_url': 'https://www.oncotarget.com/article/7404/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4951252', 'pdf_url': 'https://europepmc.org/articles/pmc4951252?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951252', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26894973', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.7404', 'pdf_url': 'https://www.oncotarget.com/article/7404/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/2', 'score': 0.69, 'display_name': 'Zero hunger'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W1611419331', 'https://openalex.org/W1775749144', 'https://openalex.org/W1866746139', 'https://openalex.org/W1971837077', 'https://openalex.org/W1980180010', 'https://openalex.org/W1980407361', 'https://openalex.org/W1988198300', 'https://openalex.org/W1988439736', 'https://openalex.org/W1993283403', 'https://openalex.org/W2002901773', 'https://openalex.org/W2006707086', 'https://openalex.org/W2007047365', 'https://openalex.org/W2016752484', 'https://openalex.org/W2016940195', 'https://openalex.org/W2018289835', 'https://openalex.org/W2023911815', 'https://openalex.org/W2027095698', 'https://openalex.org/W2033355416', 'https://openalex.org/W2044057392', 'https://openalex.org/W2046939832', 'https://openalex.org/W2049413898', 'https://openalex.org/W2062176569', 'https://openalex.org/W2062682840', 'https://openalex.org/W2065649212', 'https://openalex.org/W2065850832', 'https://openalex.org/W2066606558', 'https://openalex.org/W2074027455', 'https://openalex.org/W2074467906', 'https://openalex.org/W2076002276', 'https://openalex.org/W2077949227', 'https://openalex.org/W2078693224', 'https://openalex.org/W2090267559', 'https://openalex.org/W2090335342', 'https://openalex.org/W2093557429', 'https://openalex.org/W2100837269', 'https://openalex.org/W2106823075', 'https://openalex.org/W2109653420', 'https://openalex.org/W2115750021', 'https://openalex.org/W2117275311', 'https://openalex.org/W2123143516', 'https://openalex.org/W2127527009', 'https://openalex.org/W2139271329', 'https://openalex.org/W2142091862', 'https://openalex.org/W2148672071', 'https://openalex.org/W2326080639', 'https://openalex.org/W2591655368'], 'related_works': ['https://openalex.org/W3003370377', 'https://openalex.org/W2605441508', 'https://openalex.org/W2553954977', 'https://openalex.org/W2357139224', 'https://openalex.org/W2098038478', 'https://openalex.org/W2071975518', 'https://openalex.org/W2035980304', 'https://openalex.org/W2009707697', 'https://openalex.org/W1993376998', 'https://openalex.org/W1502922710'], 'abstract_inverted_index': {'//': [0], 'Anabela': [1], 'C.': [2, 20], 'Ferretti': [3], '1': [4, 9, 13, 17, 22, 26, 27], ',': [5, 10, 14, 18, 23, 48], 'Facundo': [6], 'M.': [7], 'Tonucci': [8], 'Florencia': [11], 'Hidalgo': [12], 'Evangelina': [15], 'Almada': [16], 'Maria': [19], 'Larocca': [21], 'Cristi&aacute;n': [24, 44], 'Favre': [25], 'Institute': [28], 'of': [29, 34, 38, 122, 204, 233, 248, 253, 279, 296, 310], 'Experimental': [30], 'Physiology,': [31], 'CONICET,': [32], 'School': [33], 'Biochemical': [35], 'Sciences,': [36], 'University': [37], 'Rosario,': [39, 40], 'Argentina': [41], 'Correspondence': [42], 'to:': [43], 'Favre,': [45], 'e-mail:': [46], '[email protected]': [47], '[email protected]': [49], 'Keywords:': [50], 'AMPK,': [51], 'apoptosis,': [52], 'cancer': [53, 81, 99, 291], 'cell': [54, 126, 139, 178, 218, 280], 'killing,': [55], 'hepatocellular': [56], 'carcinoma,': [57], 'signaling': [58, 73, 163, 274], 'Received:': [59], 'August': [60], '31,': [61], '2015&emsp;&emsp;&emsp;&emsp;': [62], 'Accepted:': [63], 'January': [64], '29,': [65], '2016&emsp;&emsp;&emsp;&emsp;': [66], 'Published:': [67], 'February': [68], '15,': [69], '2016': [70], 'ABSTRACT': [71], 'The': [72], 'pathways': [74], 'that': [75, 97, 227, 305], 'govern': [76], 'survival': [77], 'response': [78], 'in': [79, 106, 131, 145, 177, 195, 239, 262, 276, 289, 312], 'hepatic': [80, 290], 'cells': [82, 100, 136, 198, 240, 256], 'subjected': [83], 'to': [84], 'nutritional': [85], 'restriction': [86], 'have': [87], 'not': [88], 'been': [89], 'clarified': [90], 'yet.': [91], 'In': [92], 'this': [93, 183, 210, 234, 313], 'study': [94], 'we': [95, 213], 'showed': [96], 'liver': [98], 'undergoing': [101, 241], 'glucose': [102, 123, 150, 160, 169, 196, 242, 249, 287], 'deprivation': [103, 124], 'both': [104], 'arrested': [105], 'G0/G1': [107], 'and': [108, 142, 154, 199, 283], 'died': [109], 'mainly': [110], 'by': [111, 149, 190, 286], 'apoptosis.': [112], 'Treatment': [113], 'with': [114, 202], 'the': [115, 120, 138, 143, 251, 258, 272, 277, 307], 'AMPK': [116, 129, 153, 187, 205, 224, 270, 311], 'activator': [117], 'AICAR': [118], 'phenocopied': [119], 'effect': [121], 'on': [125], 'survival,': [127], 'whereas': [128, 171], 'silencing': [130], 'HepG2/C3A,': [132], 'HuH-7': [133], 'or': [134], 'SK-Hep-1': [135], 'blocked': [137], 'cycle': [140, 281], 'arrest': [141, 282], 'increase': [144], 'apoptotic': [146, 255, 259], 'death': [147, 284], 'induced': [148, 285], 'starvation.': [151, 243], 'Both': [152], 'PKA': [155, 162, 228, 294], 'were': [156], 'promptly': [157], 'activated': [158], 'after': [159, 245], 'withdrawal.': [161], 'had': [164], 'a': [165, 215, 301], 'dual': [166], 'role': [167], 'during': [168], 'starvation:': [170], 'it': [172, 180], 'elicited': [173], 'an': [174, 223], 'early': [175], 'decreased': [176, 237], 'viability,': [179], 'later': [181], 'improved': [182], 'parameter.': [184], 'We': [185], 'detected': [186], 'phosphorylation': [188, 229, 295], '(AMPK&alpha;(Ser173))': [189], 'PKA,': [191], 'which': [192, 220], 'was': [193, 200], 'increased': [194], 'starved': [197], 'associated': [201], 'diminution': [203], 'activation.': [206], 'To': [207], 'better': [208], 'explore': [209], 'inhibitory': [211], 'effect,': [212], 'constructed': [214], 'hepatocarcinoma': [216], 'derived': [217], 'line': [219], 'stably': [221], 'expressed': [222], 'mutant': [225, 235], 'lacking': [226], 'site:': [230], 'AMPK&alpha;1(S173C).': [231], 'Expression': [232], 'significantly': [236], 'viability': [238], 'Furthermore,': [244], '36': [246], 'h': [247], 'deprivation,': [250], 'index': [252, 260], 'AMPK&alpha;1(S173C)': [254], 'doubled': [257], 'observed': [261], 'control': [263, 303], 'cells.': [264], 'Two': [265], 'main': [266], 'remarks': [267], 'arise:': [268], '1.': [269], 'is': [271], 'central': [273], 'kinase': [275], 'scenario': [278], 'starvation': [288], 'cells;': [292], '2.': [293], 'Ser173': [297], 'comes': [298], 'out': [299], 'as': [300], 'strong': [302], 'point': [304], 'limits': [306], 'antitumor': [308], 'effects': [309], 'situation.': [314]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2277332640', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 3}], 'updated_date': '2025-01-17T11:06:04.412844', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
