Publication Information

{'id': 'https://openalex.org/W227731750', 'doi': 'https://doi.org/10.1161/circ.116.suppl_16.ii_128-c', 'title': 'Abstract 689: Notch Signaling Stimulates Expression Of Wnts And Contributes To Cardiac Markers Gene Expression In Human Progenitor Cell', 'display_name': 'Abstract 689: Notch Signaling Stimulates Expression Of Wnts And Contributes To Cardiac Markers Gene Expression In Human Progenitor Cell', 'publication_year': 2007, 'publication_date': '2007-10-16', 'ids': {'openalex': 'https://openalex.org/W227731750', 'doi': 'https://doi.org/10.1161/circ.116.suppl_16.ii_128-c', 'mag': '227731750'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1161/circ.116.suppl_16.ii_128-c', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S116251202', 'display_name': 'Circulation', 'issn_l': '0009-7322', 'issn': ['0009-7322', '1524-4539'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5047587122', 'display_name': 'Masamichi Koyanagi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I114090438', 'display_name': 'Goethe University Frankfurt', 'ror': 'https://ror.org/04cvxnb49', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I114090438']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Masamichi Koyanagi', 'raw_affiliation_strings': ['University of Frankfurt, Frankfurt, Germany.'], 'affiliations': [{'raw_affiliation_string': 'University of Frankfurt, Frankfurt, Germany.', 'institution_ids': ['https://openalex.org/I114090438']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048954180', 'display_name': 'Philipp Bushoven', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I114090438', 'display_name': 'Goethe University Frankfurt', 'ror': 'https://ror.org/04cvxnb49', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I114090438']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Philipp Bushoven', 'raw_affiliation_strings': ['University of Frankfurt, Frankfurt, Germany.'], 'affiliations': [{'raw_affiliation_string': 'University of Frankfurt, Frankfurt, Germany.', 'institution_ids': ['https://openalex.org/I114090438']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101549133', 'display_name': 'Masayoshi Iwasaki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I114090438', 'display_name': 'Goethe University Frankfurt', 'ror': 'https://ror.org/04cvxnb49', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I114090438']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Masayoshi Iwasaki', 'raw_affiliation_strings': ['University of Frankfurt, Frankfurt, Germany.'], 'affiliations': [{'raw_affiliation_string': 'University of Frankfurt, Frankfurt, Germany.', 'institution_ids': ['https://openalex.org/I114090438']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056513847', 'display_name': 'Carmen Urbich', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I114090438', 'display_name': 'Goethe University Frankfurt', 'ror': 'https://ror.org/04cvxnb49', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I114090438']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Carmen Urbich', 'raw_affiliation_strings': ['University of Frankfurt, Frankfurt, Germany.'], 'affiliations': [{'raw_affiliation_string': 'University of Frankfurt, Frankfurt, Germany.', 'institution_ids': ['https://openalex.org/I114090438']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061907666', 'display_name': 'Andreas M. Zeiher', 'orcid': 'https://orcid.org/0000-0003-1711-5819'}, 'institutions': [{'id': 'https://openalex.org/I114090438', 'display_name': 'Goethe University Frankfurt', 'ror': 'https://ror.org/04cvxnb49', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I114090438']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Andreas M Zeiher', 'raw_affiliation_strings': ['University of Frankfurt, Frankfurt, Germany.'], 'affiliations': [{'raw_affiliation_string': 'University of Frankfurt, Frankfurt, Germany.', 'institution_ids': ['https://openalex.org/I114090438']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5025706940', 'display_name': 'Stefanie Dimmeler', 'orcid': 'https://orcid.org/0000-0002-1045-2436'}, 'institutions': [{'id': 'https://openalex.org/I114090438', 'display_name': 'Goethe University Frankfurt', 'ror': 'https://ror.org/04cvxnb49', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I114090438']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Stefanie Dimmeler', 'raw_affiliation_strings': ['University of Frankfurt, Frankfurt, Germany.'], 'affiliations': [{'raw_affiliation_string': 'University of Frankfurt, Frankfurt, Germany.', 'institution_ids': ['https://openalex.org/I114090438']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 63}, 'biblio': {'volume': '116', 'issue': 'suppl_16', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11677', 'display_name': 'Congenital heart defects research', 'score': 0.9859, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11677', 'display_name': 'Congenital heart defects research', 'score': 0.9859, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10728', 'display_name': 'Pulmonary Hypertension Research and Treatments', 'score': 0.9815, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10300', 'display_name': 'Congenital Heart Disease Studies', 'score': 0.9267, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hes1', 'display_name': 'HES1', 'score': 0.85935783}, {'id': 'https://openalex.org/keywords/notch-proteins', 'display_name': 'Notch proteins', 'score': 0.81819975}, {'id': 'https://openalex.org/keywords/jag1', 'display_name': 'JAG1', 'score': 0.67055243}, {'id': 'https://openalex.org/keywords/notch-1', 'display_name': 'Notch 1', 'score': 0.65411127}, {'id': 'https://openalex.org/keywords/hes3-signaling-axis', 'display_name': 'Hes3 signaling axis', 'score': 0.6325535}], 'concepts': [{'id': 'https://openalex.org/C161879069', 'wikidata': 'https://www.wikidata.org/wiki/Q904082', 'display_name': 'Notch signaling pathway', 'level': 3, 'score': 0.96002936}, {'id': 'https://openalex.org/C2780283210', 'wikidata': 'https://www.wikidata.org/wiki/Q18027301', 'display_name': 'HES1', 'level': 4, 'score': 0.85935783}, {'id': 'https://openalex.org/C202769670', 'wikidata': 'https://www.wikidata.org/wiki/Q4045508', 'display_name': 'Notch proteins', 'level': 4, 'score': 0.81819975}, {'id': 'https://openalex.org/C2778668844', 'wikidata': 'https://www.wikidata.org/wiki/Q18251749', 'display_name': 'JAG1', 'level': 4, 'score': 0.67055243}, {'id': 'https://openalex.org/C2780645649', 'wikidata': 'https://www.wikidata.org/wiki/Q18252685', 'display_name': 'Notch 1', 'level': 4, 'score': 0.65411127}, {'id': 'https://openalex.org/C65114990', 'wikidata': 'https://www.wikidata.org/wiki/Q5745269', 'display_name': 'Hes3 signaling axis', 'level': 4, 'score': 0.6325535}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5969392}, {'id': 'https://openalex.org/C201750760', 'wikidata': 'https://www.wikidata.org/wiki/Q1896218', 'display_name': 'Progenitor cell', 'level': 3, 'score': 0.43472844}, {'id': 'https://openalex.org/C2776415932', 'wikidata': 'https://www.wikidata.org/wiki/Q48743', 'display_name': 'Western blot', 'level': 3, 'score': 0.4169093}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.39738265}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.38306418}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.37604922}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.29932895}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.19688666}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.13934228}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1161/circ.116.suppl_16.ii_128-c', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S116251202', 'display_name': 'Circulation', 'issn_l': '0009-7322', 'issn': ['0009-7322', '1524-4539'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4362420616', 'https://openalex.org/W4362291649', 'https://openalex.org/W3032590583', 'https://openalex.org/W3021744266', 'https://openalex.org/W2607329920', 'https://openalex.org/W2523515493', 'https://openalex.org/W227731750', 'https://openalex.org/W2275732895', 'https://openalex.org/W2166980528', 'https://openalex.org/W1928547194'], 'abstract_inverted_index': {'It': [0], 'has': [1], 'been': [2, 211], 'demonstrated': [3, 135], 'that': [4, 74, 198, 269], 'adult': [5], 'human': [6, 124, 146, 237, 292], 'circulating': [7], 'endothelial': [8], 'progenitor': [9], 'cells': [10, 238, 293], '(EPC)': [11], 'can': [12], 'differentiate': [13], 'to': [14, 213, 309], 'a': [15, 25, 47, 136], 'cardiomyogenic': [16], 'phenotype.': [17], 'Notch': [18, 39, 68, 78, 85, 116, 129, 144, 157, 199, 223, 253, 270, 283], 'signaling': [19, 79, 254], 'promotes': [20], 'epithelial-to-mesenchymal': [21], 'transformation': [22], 'and': [23, 30, 60, 133, 159, 172, 184, 232, 244, 261, 294], 'plays': [24], 'prominent': [26], 'role': [27, 37], 'in': [28, 46, 89, 108, 145, 235, 264, 291, 305], 'heart': [29], 'vessel': [31], 'development.': [32], 'Here,': [33], 'we': [34, 72, 217], 'investigated': [35], 'the': [36, 57, 95, 123, 128, 140, 163, 166, 220, 226, 236, 242, 296], 'of': [38, 44, 67, 94, 99, 127, 139, 143, 153, 165, 188, 193, 222, 228, 252, 276, 298], 'activation': [40, 86, 138, 200, 224, 284], 'for': [41, 287], 'cardiac': [42, 167, 202, 215, 288, 312], 'differentiation': [43], 'EPC': [45, 55, 90, 109, 147, 277], 'co-culture': [48, 149, 243, 275], 'system': [49], 'with': [50, 150, 278], 'neonatal': [51, 279], 'rat': [52, 280], 'cardiomyocyte': [53], '(CM).': [54], 'expressed': [56, 64], 'receptors': [58], 'Notch-1': [59, 100], 'Notch-2,': [61], 'whereas': [62, 102], 'CM': [63, 75], 'high': [65], 'level': [66], 'ligand': [69], 'Jagged-1.': [70], 'Therefore,': [71], 'hypothesized': [73], 'may': [76, 303], 'activate': [77], 'within': [80], 'EPC.': [81, 265], 'Indeed,': [82], 'after': [83, 118, 148], 'co-culture,': [84], 'was': [87, 104, 175, 239, 245], 'detected': [88, 107], 'by': [91, 178, 241, 247, 255], 'immunohistochemical': [92], 'detection': [93], 'intracellular': [96], 'cleavage': [97, 117, 260], 'fragment': [98], '(NICD),': [101], 'NICD': [103, 160, 259], 'only': [105], 'rarely': [106], 'before': [110], 'co-culture.': [111, 119], 'Western': [112], 'blot': [113], 'analysis': [114], 'confirmed': [115], 'RT-PCR': [120], 'directed': [121], 'against': [122], 'specific': [125], 'sequences': [126], 'target': [130], 'genes': [131], 'Hey2': [132], 'Hes1': [134], 'transient': [137], 'transcriptional': [141], 'activity': [142], 'CM.': [151, 281], 'Inhibition': [152], 'γ-secretase': [154, 179, 248], 'significantly': [155, 176], 'blocked': [156, 246], 'cleavages': [158], 'translocations.': [161], 'Furthermore,': [162], 'expression': [164, 227, 263, 290, 297], 'marker': [168, 203], 'protein': [169], 'γ-sarcomeric': [170], 'actinin': [171], 'troponin': [173], 'T': [174], 'suppressed': [177], 'inhibition': [180], '(55.8': [181], '±': [182, 186], '8.1%': [183], '54.0': [185], '10.5%': [187], 'control,': [189], 'respectively)': [190], 'or': [191], 'addition': [192], 'soluble': [194], 'recombinant': [195], 'Jagged-1,': [196], 'indicating': [197], 'facilitates': [201], 'gene': [204, 289], 'expression.': [205], 'Because': [206], 'non-canonical': [207, 299], 'Wnts': [208], 'have': [209], 'previously': [210], 'shown': [212], 'promote': [214], 'differentiation,': [216], 'additionally': [218], 'determined': [219], 'influence': [221], 'on': [225], 'Wnt5a': [229, 231, 262], 'and.': [230], 'Wnt11': [233], 'expressions': [234], 'induced': [240], 'inhibitor.': [249], 'Likewise,': [250], 'stimulation': [251], 'immobilized': [256], 'Jagged-1': [257], 'promoted': [258], 'These': [266], 'data': [267], 'suggested': [268], 'is': [271, 285], 'transiently': [272], 'activated': [273], 'upon': [274], 'γ-Secretase-dependent': [282], 'required': [286], 'induces': [295], 'Wnt': [300], 'proteins,': [301], 'which': [302], 'act': [304], 'an': [306], 'paracrine': [307], 'manner': [308], 'further': [310], 'amplify': [311], 'differentiation.': [313]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W227731750', 'counts_by_year': [], 'updated_date': '2024-12-24T16:54:25.256093', 'created_date': '2016-06-24'}