Title: Tu1445 Correlation of Circulating Mirnas and Interleukin-10 Levels in Patients With and Without Chronic Abdominal Pain
Abstract: medically diagnosed IBS. The registry includes data collected on motion sickness symptoms and prior experience of nausea and vomiting immediately post-general anaesthetic. Results 3074 (94% female, age 56(17-85) years) cases were evaluable for IBS (96.9% with motion sickness data and 75.3% with post-general anaesthetic nausea data). The prevalence of IBS was 8% for limited Rome III IBS, 22.3% for extended Rome III IBS and 12.6% for medically diagnosed IBS. Motion sickness was associated with limited IBS, odds ratio 1.5(95%CI 1.122.01) (p=0.006) and medically diagnosed IBS, 1.4(95%CI 1.06-1.74) (p=0.015). Similarly nausea immediately post-general anaesthetic was associated with both (1.4(95%CI 1.031.84) (p=0.03) and 1.7(95%CI 1.34-2.17) (p=<0.005) respectively). However with extended criteria IBS the association with motion sickness was lost 1.2(95%CI 0.95-1.43) (p=NS) but maintained for post-general anaesthetic nausea 1.5(95%CI 1.22-1.80) (p=<0.005). Conclusions Post-general anaesthetic nausea is clearly associated with IBS. Motion sickness is associated with limited criteria Rome III and medically diagnosed IBS but not extended criteria IBS, a more heterogeneous phenotype with likely greater environmental influences. We suggest that these associations may indicate the common influence of altered central processing of stimuli in the generation of IBS, motion sickness and post-general anaesthetic nausea.