Publication Information

{'id': 'https://openalex.org/W2274825449', 'doi': 'https://doi.org/10.1152/ajpregu.1996.271.3.r537', 'title': 'Immobilization increases norepinephrine release and reduces NK cytotoxicity in spleen of conscious rat', 'display_name': 'Immobilization increases norepinephrine release and reduces NK cytotoxicity in spleen of conscious rat', 'publication_year': 1996, 'publication_date': '1996-09-01', 'ids': {'openalex': 'https://openalex.org/W2274825449', 'doi': 'https://doi.org/10.1152/ajpregu.1996.271.3.r537', 'mag': '2274825449', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8853373'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajpregu.1996.271.3.r537', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S59702976', 'display_name': 'AJP Regulatory Integrative and Comparative Physiology', 'issn_l': '0363-6119', 'issn': ['0363-6119', '1522-1490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320155', 'host_organization_name': 'American Physiological Society', 'host_organization_lineage': ['https://openalex.org/P4310320155'], 'host_organization_lineage_names': ['American Physiological Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5113412568', 'display_name': 'N. Shimizu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I10091056', 'display_name': 'Kanazawa University', 'ror': 'https://ror.org/02hwp6a56', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I10091056']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'N. Shimizu', 'raw_affiliation_strings': ['Department of Chemistry and Chemical Engineering, Kanazawa University,Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Chemical Engineering, Kanazawa University,Japan.', 'institution_ids': ['https://openalex.org/I10091056']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110072514', 'display_name': 'Y. Kaizuka', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I10091056', 'display_name': 'Kanazawa University', 'ror': 'https://ror.org/02hwp6a56', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I10091056']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Y. Kaizuka', 'raw_affiliation_strings': ['Department of Chemistry and Chemical Engineering, Kanazawa University,Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Chemical Engineering, Kanazawa University,Japan.', 'institution_ids': ['https://openalex.org/I10091056']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003104475', 'display_name': 'Tatsuya HORI', 'orcid': 'https://orcid.org/0000-0003-4996-6327'}, 'institutions': [{'id': 'https://openalex.org/I10091056', 'display_name': 'Kanazawa University', 'ror': 'https://ror.org/02hwp6a56', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I10091056']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'T. Hori', 'raw_affiliation_strings': ['Department of Chemistry and Chemical Engineering, Kanazawa University,Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Chemical Engineering, Kanazawa University,Japan.', 'institution_ids': ['https://openalex.org/I10091056']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5062594907', 'display_name': 'Hideyuki Nakane', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I10091056', 'display_name': 'Kanazawa University', 'ror': 'https://ror.org/02hwp6a56', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I10091056']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'H. Nakane', 'raw_affiliation_strings': ['Department of Chemistry and Chemical Engineering, Kanazawa University,Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Chemical Engineering, Kanazawa University,Japan.', 'institution_ids': ['https://openalex.org/I10091056']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.386, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 34, 'citation_normalized_percentile': {'value': 0.659462, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '271', 'issue': '3', 'first_page': 'R537', 'last_page': 'R544'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10493', 'display_name': 'Ion channel regulation and function', 'score': 0.9675, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10493', 'display_name': 'Ion channel regulation and function', 'score': 0.9675, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13047', 'display_name': 'Pharmacological Receptor Mechanisms and Effects', 'score': 0.9532, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10814', 'display_name': 'Neuropeptides and Animal Physiology', 'score': 0.9423, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/microdialysis', 'display_name': 'Microdialysis', 'score': 0.7870953}], 'concepts': [{'id': 'https://openalex.org/C2778514916', 'wikidata': 'https://www.wikidata.org/wiki/Q186242', 'display_name': 'Norepinephrine', 'level': 3, 'score': 0.80505574}, {'id': 'https://openalex.org/C50156730', 'wikidata': 'https://www.wikidata.org/wiki/Q3856966', 'display_name': 'Microdialysis', 'level': 3, 'score': 0.7870953}, {'id': 'https://openalex.org/C109316439', 'wikidata': 'https://www.wikidata.org/wiki/Q246181', 'display_name': 'Cytotoxicity', 'level': 3, 'score': 0.70966506}, {'id': 'https://openalex.org/C2780931953', 'wikidata': 'https://www.wikidata.org/wiki/Q9371', 'display_name': 'Spleen', 'level': 2, 'score': 0.63693506}, {'id': 'https://openalex.org/C2775894120', 'wikidata': 'https://www.wikidata.org/wiki/Q271663', 'display_name': 'Catecholamine', 'level': 2, 'score': 0.56681484}, {'id': 'https://openalex.org/C154317977', 'wikidata': 'https://www.wikidata.org/wiki/Q376266', 'display_name': 'Cytotoxic T cell', 'level': 3, 'score': 0.50820684}, {'id': 'https://openalex.org/C2776805190', 'wikidata': 'https://www.wikidata.org/wiki/Q1187030', 'display_name': 'Denervation', 'level': 2, 'score': 0.5049222}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.45433906}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.42529637}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.42041764}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.4157388}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.36481756}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.34920672}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3415261}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.22636485}, {'id': 'https://openalex.org/C513476851', 'wikidata': 'https://www.wikidata.org/wiki/Q170304', 'display_name': 'Dopamine', 'level': 2, 'score': 0.14407107}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.071323186}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003602', 'descriptor_name': 'Cytotoxicity, Immunologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D007103', 'descriptor_name': 'Immobilization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D007694', 'descriptor_name': 'Killer Cells, Natural', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D009638', 'descriptor_name': 'Norepinephrine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013154', 'descriptor_name': 'Spleen', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013154', 'descriptor_name': 'Spleen', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004558', 'descriptor_name': 'Electric Stimulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007552', 'descriptor_name': 'Isotonic Solutions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007552', 'descriptor_name': 'Isotonic Solutions', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007552', 'descriptor_name': 'Isotonic Solutions', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D007694', 'descriptor_name': 'Killer Cells, Natural', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009638', 'descriptor_name': 'Norepinephrine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009638', 'descriptor_name': 'Norepinephrine', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D011188', 'descriptor_name': 'Potassium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011188', 'descriptor_name': 'Potassium', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017208', 'descriptor_name': 'Rats, Wistar', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077331', 'descriptor_name': "Ringer's Solution", 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013154', 'descriptor_name': 'Spleen', 'qualifier_ui': 'Q000294', 'qualifier_name': 'innervation', 'is_major_topic': False}, {'descriptor_ui': 'D013154', 'descriptor_name': 'Spleen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013268', 'descriptor_name': 'Stimulation, Chemical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013312', 'descriptor_name': 'Stress, Physiological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013312', 'descriptor_name': 'Stress, Physiological', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D013312', 'descriptor_name': 'Stress, Physiological', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013312', 'descriptor_name': 'Stress, Physiological', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D013564', 'descriptor_name': 'Sympathetic Nervous System', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D013564', 'descriptor_name': 'Sympathetic Nervous System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013779', 'descriptor_name': 'Tetrodotoxin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013779', 'descriptor_name': 'Tetrodotoxin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajpregu.1996.271.3.r537', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S59702976', 'display_name': 'AJP Regulatory Integrative and Comparative Physiology', 'issn_l': '0363-6119', 'issn': ['0363-6119', '1522-1490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320155', 'host_organization_name': 'American Physiological Society', 'host_organization_lineage': ['https://openalex.org/P4310320155'], 'host_organization_lineage_names': ['American Physiological Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8853373', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.43, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2893250792', 'https://openalex.org/W2422405004', 'https://openalex.org/W2408145031', 'https://openalex.org/W2279356461', 'https://openalex.org/W2260393865', 'https://openalex.org/W2181579044', 'https://openalex.org/W2119512662', 'https://openalex.org/W2039914241', 'https://openalex.org/W1978857055', 'https://openalex.org/W1971106099'], 'abstract_inverted_index': {'The': [0, 56, 130], 'purpose': [1], 'of': [2, 16, 36, 52, 58, 79, 94, 101, 108, 113, 125, 136, 146], 'this': [3], 'study': [4], 'was': [5, 43, 72], 'to': [6, 45, 90], 'investigate': [7], 'whether': [8], 'immobilization': [9, 117], 'stress': [10, 85, 118], 'would': [11], 'affect': [12], 'the': [13, 22, 28, 50, 53, 59, 69, 76, 80, 99, 105, 111, 126, 147], 'cytotoxic': [14], 'activity': [15, 145], 'natural': [17], 'killer': [18], '(NK)': [19], 'cells': [20], 'through': [21, 143], 'changes': [23], 'in': [24, 27, 31, 49, 68, 96], 'norepinephrine': [25, 47, 66, 88, 109], 'release': [26], 'spleen.': [29], 'An': [30], 'vivo': [32], 'microdialysis': [33], 'technique': [34], 'consisting': [35], 'high-performance': [37], 'liquid': [38], 'chromatography': [39], 'with': [40, 98], 'electrochemical': [41], 'detection': [42], 'used': [44], 'examine': [46], 'levels': [48, 89, 107], 'spleen': [51], 'conscious': [54], 'rat.': [55], 'results': [57, 131], 'physiological': [60], 'and': [61, 110], 'pharmacological': [62], 'manipulations': [63], 'indicated': [64], 'that': [65, 133], 'recovered': [67], 'dialysis': [70], 'solution': [71], 'mainly': [73], 'derived': [74], 'from': [75], 'nerve': [77], 'terminals': [78], 'splenic': [81, 127, 137, 148], 'sympathetic': [82, 128, 149], 'nerve.': [83, 129, 150], 'Immobilization': [84], 'rapidly': [86], 'increased': [87, 106], '817.4': [91], '+/-': [92], '181.7%': [93], 'baseline': [95], 'conjunction': [97], 'suppression': [100, 135], 'NK': [102, 114, 138], 'cytotoxicity.': [103], 'Both': [104], 'immunosuppression': [112], 'cytotoxicity': [115, 139], 'by': [116], 'were': [119], 'significantly': [120], 'attenuated': [121], 'after': [122], 'surgical': [123], 'denervation': [124], 'suggest': [132], 'immobilization-induced': [134], 'is': [140], 'mediated': [141], 'predominantly': [142], 'enhanced': [144]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2274825449', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-28T14:48:57.132317', 'created_date': '2016-06-24'}