Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2274488081', 'doi': 'https://doi.org/10.1196/annals.1369.019', 'title': 'Overexpression of α‐Synuclein following Methamphetamine', 'display_name': 'Overexpression of α‐Synuclein following Methamphetamine', 'publication_year': 2006, 'publication_date': '2006-08-01', 'ids': {'openalex': 'https://openalex.org/W2274488081', 'doi': 'https://doi.org/10.1196/annals.1369.019', 'mag': '2274488081', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17105917'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1196/annals.1369.019', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S8802318', 'display_name': 'Annals of the New York Academy of Sciences', 'issn_l': '0077-8923', 'issn': ['0077-8923', '1749-6632'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5042096888', 'display_name': 'G Mauceli', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I108290504', 'display_name': 'University of Pisa', 'ror': 'https://ror.org/03ad39j10', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I108290504']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'GIUSEPPE MAUCELI', 'raw_affiliation_strings': ['Department of Human Morphology and Applied Biology, University of Pisa, I-56126 Pisa, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Human Morphology and Applied Biology, University of Pisa, I-56126 Pisa, Italy', 'institution_ids': ['https://openalex.org/I108290504']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082770087', 'display_name': 'Carla L. Busceti', 'orcid': 'https://orcid.org/0000-0002-1417-1893'}, 'institutions': [{'id': 'https://openalex.org/I3018288129', 'display_name': 'Istituto Neurologico Mediterraneo', 'ror': 'https://ror.org/00cpb6264', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018288129', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'CARLA I. BUSCETI', 'raw_affiliation_strings': ['Laboratory of Neurobiology of Movement Disorders I.R.C.C.S., I.N.M. Neuromed 86077 Pozzilli, Isernia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Neurobiology of Movement Disorders I.R.C.C.S., I.N.M. Neuromed 86077 Pozzilli, Isernia, Italy', 'institution_ids': ['https://openalex.org/I3018288129']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038850029', 'display_name': 'Antonio Pellegrini', 'orcid': 'https://orcid.org/0000-0003-2969-4897'}, 'institutions': [{'id': 'https://openalex.org/I108290504', 'display_name': 'University of Pisa', 'ror': 'https://ror.org/03ad39j10', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I108290504']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'ANTONIO PELLEGRINI', 'raw_affiliation_strings': ['Department of Human Morphology and Applied Biology, University of Pisa, I-56126 Pisa, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Human Morphology and Applied Biology, University of Pisa, I-56126 Pisa, Italy', 'institution_ids': ['https://openalex.org/I108290504']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054185380', 'display_name': 'Paola Soldani', 'orcid': 'https://orcid.org/0000-0003-1703-0962'}, 'institutions': [{'id': 'https://openalex.org/I108290504', 'display_name': 'University of Pisa', 'ror': 'https://ror.org/03ad39j10', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I108290504']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'PAOLA SOLDANI', 'raw_affiliation_strings': ['Department of Human Morphology and Applied Biology, University of Pisa, I-56126 Pisa, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Human Morphology and Applied Biology, University of Pisa, I-56126 Pisa, Italy', 'institution_ids': ['https://openalex.org/I108290504']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068984003', 'display_name': 'Paola Lenzi', 'orcid': 'https://orcid.org/0000-0002-4734-8798'}, 'institutions': [{'id': 'https://openalex.org/I108290504', 'display_name': 'University of Pisa', 'ror': 'https://ror.org/03ad39j10', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I108290504']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'PAOLA LENZI', 'raw_affiliation_strings': ['Department of Human Morphology and Applied Biology, University of Pisa, I-56126 Pisa, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Human Morphology and Applied Biology, University of Pisa, I-56126 Pisa, Italy', 'institution_ids': ['https://openalex.org/I108290504']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085880411', 'display_name': 'Antonio Paparelli', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I108290504', 'display_name': 'University of Pisa', 'ror': 'https://ror.org/03ad39j10', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I108290504']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'ANTONIO PAPARELLI', 'raw_affiliation_strings': ['Department of Human Morphology and Applied Biology, University of Pisa, I-56126 Pisa, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Human Morphology and Applied Biology, University of Pisa, I-56126 Pisa, Italy', 'institution_ids': ['https://openalex.org/I108290504']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5089494044', 'display_name': 'Francesco Fornai', 'orcid': 'https://orcid.org/0000-0002-3883-5084'}, 'institutions': [{'id': 'https://openalex.org/I3018288129', 'display_name': 'Istituto Neurologico Mediterraneo', 'ror': 'https://ror.org/00cpb6264', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018288129', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I108290504', 'display_name': 'University of Pisa', 'ror': 'https://ror.org/03ad39j10', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I108290504']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'FRANCESCO FORNAI', 'raw_affiliation_strings': ['Department of Human Morphology and Applied Biology, University of Pisa, I-56126 Pisa, Italy', 'Laboratory of Neurobiology of Movement Disorders I.R.C.C.S., I.N.M. Neuromed 86077 Pozzilli, Isernia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Neurobiology of Movement Disorders I.R.C.C.S., I.N.M. Neuromed 86077 Pozzilli, Isernia, Italy', 'institution_ids': ['https://openalex.org/I3018288129']}, {'raw_affiliation_string': 'Department of Human Morphology and Applied Biology, University of Pisa, I-56126 Pisa, Italy', 'institution_ids': ['https://openalex.org/I108290504']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4840, 'currency': 'USD', 'value_usd': 4840, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.27, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 22, 'citation_normalized_percentile': {'value': 0.52233, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 88, 'max': 89}, 'biblio': {'volume': '1074', 'issue': '1', 'first_page': '191', 'last_page': '197'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10085', 'display_name': "Pathophysiology of Parkinson's Disease", 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10085', 'display_name': "Pathophysiology of Parkinson's Disease", 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10949', 'display_name': 'Molecular Mechanisms of Neurodegenerative Diseases', 'score': 0.9751, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10919', 'display_name': 'Deep Brain Stimulation for Neurological Disorders', 'score': 0.9746, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/synucleinopathies', 'display_name': 'Synucleinopathies', 'score': 0.9311147}, {'id': 'https://openalex.org/keywords/methamphetamine', 'display_name': 'Methamphetamine', 'score': 0.6736883}, {'id': 'https://openalex.org/keywords/a-synuclein', 'display_name': 'a-Synuclein', 'score': 0.568534}], 'concepts': [{'id': 'https://openalex.org/C2777440831', 'wikidata': 'https://www.wikidata.org/wiki/Q2376264', 'display_name': 'Synucleinopathies', 'level': 5, 'score': 0.9311147}, {'id': 'https://openalex.org/C2781449126', 'wikidata': 'https://www.wikidata.org/wiki/Q288591', 'display_name': 'Alpha-synuclein', 'level': 4, 'score': 0.83552545}, {'id': 'https://openalex.org/C2776925932', 'wikidata': 'https://www.wikidata.org/wiki/Q1755122', 'display_name': 'Neurodegeneration', 'level': 3, 'score': 0.7574308}, {'id': 'https://openalex.org/C2780376393', 'wikidata': 'https://www.wikidata.org/wiki/Q191924', 'display_name': 'Methamphetamine', 'level': 2, 'score': 0.6736883}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.63514906}, {'id': 'https://openalex.org/C2779734285', 'wikidata': 'https://www.wikidata.org/wiki/Q11085', 'display_name': "Parkinson's disease", 'level': 3, 'score': 0.58218926}, {'id': 'https://openalex.org/C2778548049', 'wikidata': 'https://www.wikidata.org/wiki/Q101245788', 'display_name': 'Dementia with Lewy bodies', 'level': 4, 'score': 0.56528467}, {'id': 'https://openalex.org/C2777193897', 'wikidata': 'https://www.wikidata.org/wiki/Q179452', 'display_name': 'Amphetamine', 'level': 3, 'score': 0.5259607}, {'id': 'https://openalex.org/C207886595', 'wikidata': 'https://www.wikidata.org/wiki/Q1456138', 'display_name': 'Pathological', 'level': 2, 'score': 0.43909383}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.38501036}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.37541887}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.35855484}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.34800306}, {'id': 'https://openalex.org/C2779483572', 'wikidata': 'https://www.wikidata.org/wiki/Q83030', 'display_name': 'Dementia', 'level': 3, 'score': 0.1673454}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.13530704}, {'id': 'https://openalex.org/C513476851', 'wikidata': 'https://www.wikidata.org/wiki/Q170304', 'display_name': 'Dopamine', 'level': 2, 'score': 0.12584329}], 'mesh': [{'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D008694', 'descriptor_name': 'Methamphetamine', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D008694', 'descriptor_name': 'Methamphetamine', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D051844', 'descriptor_name': 'alpha-Synuclein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002479', 'descriptor_name': 'Inclusion Bodies', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002479', 'descriptor_name': 'Inclusion Bodies', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002479', 'descriptor_name': 'Inclusion Bodies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008694', 'descriptor_name': 'Methamphetamine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051844', 'descriptor_name': 'alpha-Synuclein', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D051844', 'descriptor_name': 'alpha-Synuclein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1196/annals.1369.019', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S8802318', 'display_name': 'Annals of the New York Academy of Sciences', 'issn_l': '0077-8923', 'issn': ['0077-8923', '1749-6632'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17105917', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.62}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 25, 'referenced_works': ['https://openalex.org/W1485468448', 'https://openalex.org/W1506988927', 'https://openalex.org/W1521854746', 'https://openalex.org/W1527671059', 'https://openalex.org/W1637321639', 'https://openalex.org/W1931656959', 'https://openalex.org/W1965111978', 'https://openalex.org/W1965778124', 'https://openalex.org/W1975330599', 'https://openalex.org/W1976316003', 'https://openalex.org/W1979527613', 'https://openalex.org/W1980110509', 'https://openalex.org/W2002548332', 'https://openalex.org/W2003770934', 'https://openalex.org/W2056675110', 'https://openalex.org/W2064127705', 'https://openalex.org/W2077797010', 'https://openalex.org/W2089462977', 'https://openalex.org/W2091265794', 'https://openalex.org/W2092967249', 'https://openalex.org/W2123431154', 'https://openalex.org/W2128672762', 'https://openalex.org/W2146222688', 'https://openalex.org/W2150656456', 'https://openalex.org/W2406629148'], 'related_works': ['https://openalex.org/W4317625871', 'https://openalex.org/W3216635505', 'https://openalex.org/W3021415691', 'https://openalex.org/W3020087588', 'https://openalex.org/W3005423196', 'https://openalex.org/W2980298807', 'https://openalex.org/W2322220731', 'https://openalex.org/W2125448834', 'https://openalex.org/W2099861207', 'https://openalex.org/W2083732405'], 'abstract_inverted_index': {'alpha-Synuclein': [0], 'is': [1, 44, 53], 'a': [2, 20, 56], 'presynaptic': [3], 'protein': [4], 'involved': [5], 'in': [6, 50, 81], 'various': [7], 'degenerative': [8], 'disorders': [9], 'now': [10], 'defined': [11], 'as': [12, 55], 'synucleinopathies.': [13], 'These': [14], 'include': [15], 'neurological': [16], 'diseases': [17], 'that': [18, 96], 'share': [19], 'few': [21], 'pathological': [22], 'features': [23], 'consisting': [24], 'of': [25, 27, 42, 59, 76, 79, 83, 90, 100], 'aggregates': [26], 'both': [28], 'normal': [29], 'and': [30, 92], 'altered': [31], 'alpha-synuclein': [32, 52, 80, 91, 101], 'within': [33], 'specific': [34], 'neuronal': [35, 60], 'populations': [36], 'and/or': [37], 'glial': [38], 'cells.': [39], 'The': [40], 'prototype': [41], 'synucleinopathies': [43], 'represented': [45], 'by': [46], "Parkinson's": [47], 'disease': [48], '(PD)': [49], 'which': [51], 'identified': [54], 'constant': [57], 'component': [58], 'pale': [61], 'eosinophilic': [62], 'inclusions:': [63], '"the': [64], 'Lewy': [65], 'Bodies."': [66], 'In': [67], 'the': [68, 73], 'present': [69], 'article,': [70], 'we': [71], 'discuss': [72], 'potential': [74], 'significance': [75], 'amphetamine-induced': [77], 'overexpression': [78, 89], 'light': [82], 'clinical': [84], 'findings': [85], 'showing': [86], 'neurodegeneration': [87], 'following': [88, 102], 'recent': [93], 'experimental': [94], 'studies': [95], 'measured': [97], 'increased': [98], 'expression': [99], 'amphetamine': [103], 'derivatives.': [104]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2274488081', 'counts_by_year': [{'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-09-01T05:04:25.215895', 'created_date': '2016-06-24'}