Publication Information

{'id': 'https://openalex.org/W2274327856', 'doi': 'https://doi.org/10.18632/oncotarget.7092', 'title': 'Generation of functional hepatocytes from human spermatogonial stem cells', 'display_name': 'Generation of functional hepatocytes from human spermatogonial stem cells', 'publication_year': 2016, 'publication_date': '2016-01-31', 'ids': {'openalex': 'https://openalex.org/W2274327856', 'doi': 'https://doi.org/10.18632/oncotarget.7092', 'mag': '2274327856', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26840458', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4891011'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.7092', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=7092&path%5B%5D=20180', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=7092&path%5B%5D=20180', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5108047902', 'display_name': 'Zheng Chen', 'orcid': 'https://orcid.org/0000-0003-2161-6106'}, 'institutions': [{'id': 'https://openalex.org/I4210138900', 'display_name': 'State Key Laboratory of Oncogene and Related Genes', 'ror': 'https://ror.org/03xt1x768', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210138900']}, {'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zheng Chen', 'raw_affiliation_strings': ['State Key Laboratory of Oncogenes and Related Genes, Renji- Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncogenes and Related Genes, Renji- Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China', 'institution_ids': ['https://openalex.org/I4210138900', 'https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014541123', 'display_name': 'Min Sun', 'orcid': 'https://orcid.org/0000-0002-8528-0050'}, 'institutions': [{'id': 'https://openalex.org/I4210138900', 'display_name': 'State Key Laboratory of Oncogene and Related Genes', 'ror': 'https://ror.org/03xt1x768', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210138900']}, {'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Min Sun', 'raw_affiliation_strings': ['State Key Laboratory of Oncogenes and Related Genes, Renji- Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncogenes and Related Genes, Renji- Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China', 'institution_ids': ['https://openalex.org/I4210138900', 'https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101401863', 'display_name': 'Qingqing Yuan', 'orcid': 'https://orcid.org/0000-0002-0454-9960'}, 'institutions': [{'id': 'https://openalex.org/I4210138900', 'display_name': 'State Key Laboratory of Oncogene and Related Genes', 'ror': 'https://ror.org/03xt1x768', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210138900']}, {'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qingqing Yuan', 'raw_affiliation_strings': ['State Key Laboratory of Oncogenes and Related Genes, Renji- Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncogenes and Related Genes, Renji- Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China', 'institution_ids': ['https://openalex.org/I4210138900', 'https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076735202', 'display_name': 'Minghui Niu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210138900', 'display_name': 'State Key Laboratory of Oncogene and Related Genes', 'ror': 'https://ror.org/03xt1x768', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210138900']}, {'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Minghui Niu', 'raw_affiliation_strings': ['State Key Laboratory of Oncogenes and Related Genes, Renji- Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncogenes and Related Genes, Renji- Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China', 'institution_ids': ['https://openalex.org/I4210138900', 'https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059164179', 'display_name': 'Chencheng Yao', 'orcid': 'https://orcid.org/0000-0002-8820-7895'}, 'institutions': [{'id': 'https://openalex.org/I4210138900', 'display_name': 'State Key Laboratory of Oncogene and Related Genes', 'ror': 'https://ror.org/03xt1x768', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210138900']}, {'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chencheng Yao', 'raw_affiliation_strings': ['State Key Laboratory of Oncogenes and Related Genes, Renji- Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncogenes and Related Genes, Renji- Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China', 'institution_ids': ['https://openalex.org/I4210138900', 'https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063507717', 'display_name': 'Jingmei Hou', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210138900', 'display_name': 'State Key Laboratory of Oncogene and Related Genes', 'ror': 'https://ror.org/03xt1x768', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210138900']}, {'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jingmei Hou', 'raw_affiliation_strings': ['State Key Laboratory of Oncogenes and Related Genes, Renji- Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncogenes and Related Genes, Renji- Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China', 'institution_ids': ['https://openalex.org/I4210138900', 'https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100370968', 'display_name': 'Hong Wang', 'orcid': 'https://orcid.org/0000-0003-0212-5379'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}, {'id': 'https://openalex.org/I4210138900', 'display_name': 'State Key Laboratory of Oncogene and Related Genes', 'ror': 'https://ror.org/03xt1x768', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210138900']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hong Wang', 'raw_affiliation_strings': ['State Key Laboratory of Oncogenes and Related Genes, Renji- Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncogenes and Related Genes, Renji- Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China', 'institution_ids': ['https://openalex.org/I183067930', 'https://openalex.org/I4210138900']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101033725', 'display_name': 'Liping Wen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}, {'id': 'https://openalex.org/I4210138900', 'display_name': 'State Key Laboratory of Oncogene and Related Genes', 'ror': 'https://ror.org/03xt1x768', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210138900']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Liping Wen', 'raw_affiliation_strings': ['State Key Laboratory of Oncogenes and Related Genes, Renji- Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncogenes and Related Genes, Renji- Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China', 'institution_ids': ['https://openalex.org/I183067930', 'https://openalex.org/I4210138900']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054138565', 'display_name': 'Yun Liu', 'orcid': 'https://orcid.org/0000-0003-3593-2011'}, 'institutions': [{'id': 'https://openalex.org/I4210138900', 'display_name': 'State Key Laboratory of Oncogene and Related Genes', 'ror': 'https://ror.org/03xt1x768', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210138900']}, {'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yun Liu', 'raw_affiliation_strings': ['State Key Laboratory of Oncogenes and Related Genes, Renji- Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncogenes and Related Genes, Renji- Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China', 'institution_ids': ['https://openalex.org/I4210138900', 'https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100414947', 'display_name': 'Zheng Li', 'orcid': 'https://orcid.org/0000-0001-6735-1831'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zheng Li', 'raw_affiliation_strings': ['Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Andrology, Shanghai 200001, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Andrology, Shanghai 200001, China', 'institution_ids': ['https://openalex.org/I183067930']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103220952', 'display_name': 'Zuping He', 'orcid': 'https://orcid.org/0000-0003-3741-9350'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}, {'id': 'https://openalex.org/I4210138900', 'display_name': 'State Key Laboratory of Oncogene and Related Genes', 'ror': 'https://ror.org/03xt1x768', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210138900']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zuping He', 'raw_affiliation_strings': ['Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Andrology, Shanghai 200001, China', 'Shanghai Key Laboratory of Assisted Reproduction and Reproductive Genetics, Shanghai 200127, China', 'Shanghai Key Laboratory of Assisted Reproduction and Reproductive Genetics, Shanghai 200127, China; Shanghai Key Laboratory of Reproductive Medicine, Shanghai 200025, China; State Key Laboratory of Oncogenes and Related Genes, Renji- Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China', 'Shanghai Key Laboratory of Reproductive Medicine, Shanghai 200025, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Andrology, Shanghai 200001, China', 'institution_ids': ['https://openalex.org/I183067930']}, {'raw_affiliation_string': 'Shanghai Key Laboratory of Assisted Reproduction and Reproductive Genetics, Shanghai 200127, China; Shanghai Key Laboratory of Reproductive Medicine, Shanghai 200025, China; State Key Laboratory of Oncogenes and Related Genes, Renji- Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China', 'institution_ids': ['https://openalex.org/I4210138900', 'https://openalex.org/I183067930']}, {'raw_affiliation_string': 'Shanghai Key Laboratory of Assisted Reproduction and Reproductive Genetics, Shanghai 200127, China', 'institution_ids': []}, {'raw_affiliation_string': 'Shanghai Key Laboratory of Reproductive Medicine, Shanghai 200025, China', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.486, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 27, 'citation_normalized_percentile': {'value': 0.999825, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '7', 'issue': '8', 'first_page': '8879', 'last_page': '8895'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10966', 'display_name': 'Liver physiology and pathology', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10966', 'display_name': 'Liver physiology and pathology', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10116', 'display_name': 'Sperm and Testicular Function', 'score': 0.9711, 'subfield': {'id': 'https://openalex.org/subfields/2743', 'display_name': 'Reproductive Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10999', 'display_name': 'Organ Transplantation Techniques and Outcomes', 'score': 0.9652, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.7185577}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.531563}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.41741922}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3961252}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.36547217}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.3362636}], 'mesh': [{'descriptor_ui': 'D053713', 'descriptor_name': 'Azoospermia', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019070', 'descriptor_name': 'Cell Lineage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D005854', 'descriptor_name': 'Germ Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D022781', 'descriptor_name': 'Hepatocytes', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D013093', 'descriptor_name': 'Spermatogonia', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D013737', 'descriptor_name': 'Testis', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D053713', 'descriptor_name': 'Azoospermia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D053713', 'descriptor_name': 'Azoospermia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054338', 'descriptor_name': 'Cell Transdifferentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017077', 'descriptor_name': 'Culture Media, Conditioned', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005434', 'descriptor_name': 'Flow Cytometry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005854', 'descriptor_name': 'Germ Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005854', 'descriptor_name': 'Germ Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D022781', 'descriptor_name': 'Hepatocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D022781', 'descriptor_name': 'Hepatocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007124', 'descriptor_name': 'Immunoenzyme Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D060888', 'descriptor_name': 'Real-Time Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013093', 'descriptor_name': 'Spermatogonia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013093', 'descriptor_name': 'Spermatogonia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013737', 'descriptor_name': 'Testis', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013737', 'descriptor_name': 'Testis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051176', 'descriptor_name': 'beta Catenin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051176', 'descriptor_name': 'beta Catenin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.7092', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=7092&path%5B%5D=20180', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4891011', 'pdf_url': 'https://europepmc.org/articles/pmc4891011?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891011', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26840458', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.7092', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=7092&path%5B%5D=20180', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 45, 'referenced_works': ['https://openalex.org/W1567553123', 'https://openalex.org/W1812358095', 'https://openalex.org/W1843736399', 'https://openalex.org/W1974652594', 'https://openalex.org/W1976226574', 'https://openalex.org/W1976435237', 'https://openalex.org/W1980776838', 'https://openalex.org/W1980956240', 'https://openalex.org/W1981979988', 'https://openalex.org/W1986947784', 'https://openalex.org/W1992365936', 'https://openalex.org/W1994807399', 'https://openalex.org/W2010888934', 'https://openalex.org/W2022527563', 'https://openalex.org/W2027011084', 'https://openalex.org/W2032537363', 'https://openalex.org/W2033042516', 'https://openalex.org/W2034745491', 'https://openalex.org/W2035478792', 'https://openalex.org/W2042837872', 'https://openalex.org/W2042962210', 'https://openalex.org/W2044612559', 'https://openalex.org/W2047654273', 'https://openalex.org/W2055373965', 'https://openalex.org/W2056239991', 'https://openalex.org/W2063746472', 'https://openalex.org/W2065571200', 'https://openalex.org/W2065927663', 'https://openalex.org/W2084575252', 'https://openalex.org/W2087538652', 'https://openalex.org/W2089676626', 'https://openalex.org/W2090497735', 'https://openalex.org/W2100499879', 'https://openalex.org/W2107893477', 'https://openalex.org/W2111354766', 'https://openalex.org/W2128786355', 'https://openalex.org/W2136230328', 'https://openalex.org/W2137909703', 'https://openalex.org/W2148247271', 'https://openalex.org/W2151201243', 'https://openalex.org/W2151623295', 'https://openalex.org/W2165475140', 'https://openalex.org/W2394820832', 'https://openalex.org/W4210973123', 'https://openalex.org/W4211105405'], 'related_works': ['https://openalex.org/W2788277189', 'https://openalex.org/W2130076355', 'https://openalex.org/W2119695867', 'https://openalex.org/W2117258802', 'https://openalex.org/W2082860237', 'https://openalex.org/W2046158694', 'https://openalex.org/W2013243191', 'https://openalex.org/W1993764875', 'https://openalex.org/W1990804418', 'https://openalex.org/W1971568933'], 'abstract_inverted_index': {'//': [0], 'Zheng': [1, 37], 'Chen': [2], '1': [3, 7, 11, 15, 19, 23, 27, 31, 35, 47], ',': [4, 8, 12, 16, 20, 24, 28, 32, 36, 40], 'Min': [5], 'Sun': [6], 'Qingqing': [9], 'Yuan': [10], 'Minghui': [13], 'Niu': [14], 'Chencheng': [17], 'Yao': [18], 'Jingmei': [21], 'Hou': [22], 'Hong': [25], 'Wang': [26], 'Liping': [29], 'Wen': [30], 'Yun': [33], 'Liu': [34], 'Li': [38], '2': [39, 77], 'Zuping': [41, 123], 'He': [42], '1,': [43], '2,': [44], '3,': [45], '4': [46, 111], 'State': [48], 'Key': [49, 100, 113], 'Laboratory': [50, 101, 114], 'of': [51, 68, 79, 85, 93, 102, 115, 169, 195, 218, 251, 283, 308, 326, 337, 361], 'Oncogenes': [52], 'and': [53, 105, 137, 187, 197, 223, 248, 254, 280, 290, 318, 320, 330, 351, 368, 372], 'Related': [54], 'Genes,': [55], 'Renji-': [56], 'Med': [57], 'X': [58], 'Clinical': [59], 'Stem': [60], 'Cell': [61], 'Research': [62], 'Center,': [63], 'Ren': [64, 81], 'Ji': [65, 82], 'Hospital,': [66, 83], 'School': [67, 84], 'Medicine,': [69, 86, 117], 'Shanghai': [70, 74, 87, 91, 95, 99, 108, 112, 118], 'Jiao': [71, 88], 'Tong': [72, 89], 'University,': [73, 90], '200127,': [75, 109], 'China': [76, 97, 110, 120], 'Department': [78], 'Urology,': [80], 'Institute': [92], 'Andrology,': [94], '200001,': [96], '3': [98], 'Assisted': [103], 'Reproduction': [104], 'Reproductive': [106, 116], 'Genetics,': [107], '200025,': [119], 'Correspondence': [121], 'to:': [122], 'He,': [124], 'e-mail:': [125], '[email protected]': [126], 'Keywords:': [127], 'human': [128, 156, 201, 219, 303, 309, 338, 344, 362, 379], 'spermatogonial': [129], 'stem': [130, 134, 159, 176, 241, 262, 265], 'cells,': [131, 135, 242], 'transdifferentiation,': [132], 'hepatic': [133, 240], 'mature': [136, 196, 222, 273, 299, 341, 350], 'functional': [138, 155, 198, 224, 306, 352], 'hepatocytes': [139, 157, 199, 225, 274, 300, 363], 'Received:': [140], 'August': [141], '18,': [142], '2015     ': [143], 'Accepted:': [144], 'January': [145, 149], '17,': [146], '2016     ': [147], 'Published:': [148], '31,': [150], '2016': [151], 'ABSTRACT': [152], 'To': [153], 'generate': [154], 'from': [158, 200, 302], 'cells': [160, 170, 177, 266], 'and/or': [161], 'extra-hepatic': [162], 'tissues': [163], 'could': [164, 313, 346, 356], 'provide': [165, 373], 'an': [166, 180, 358], 'important': [167], 'source': [168, 360], 'for': [171, 211, 260, 364], 'treating': [172], 'liver': [173, 366, 380], 'diseases.': [174], 'Spermatogonial': [175], '(SSCs)': [178], 'have': [179, 210], 'unlimited': [181], 'plasticity': [182], 'since': [183], 'they': [184, 312], 'can': [185], 'dedifferentiate': [186], 'transdifferentiate': [188, 348], 'to': [189, 221, 239, 270, 340, 349], 'other': [190], 'cell': [191], 'lineages.': [192], 'However,': [193], 'generation': [194], 'SSCs': [202, 220, 235, 304, 339, 345], 'has': [203], 'not': [204, 258], 'yet': [205], 'been': [206], 'achieved.': [207], 'Here': [208], 'we': [209], 'the': [212, 230, 335], 'first': [213, 237], 'time': [214], 'reported': [215], 'direct': [216], 'transdifferentiation': [217, 336], 'by': [226, 245, 276], 'three-step': [227], 'induction': [228], 'using': [229], 'defined': [231], 'condition': [232], 'medium.': [233], 'Human': [234], 'were': [236, 267], 'transdifferentiated': [238], 'as': [243], 'evidenced': [244], 'their': [246, 277], 'morphology': [247], 'biopotential': [249], 'nature': [250], 'co-expressing': [252], 'hepatocyte': [253], 'cholangiocyte': [255], 'markers': [256], 'but': [257], 'hallmarks': [259], 'embryonic': [261], 'cells.': [263], 'Hepatic': [264], 'further': [268], 'induced': [269], 'differentiate': [271], 'into': [272, 376], 'identified': [275], 'morphological': [278], 'traits': [279], 'strong': [281], 'expression': [282, 325], 'CK8,': [284], 'CK18,': [285], 'ALB,': [286], 'AAT,': [287], 'TF,': [288], 'TAT,': [289], 'cytochrome': [291], 'enzymes': [292], 'rather': [293], 'than': [294], 'CK7': [295], 'or': [296], 'CK19.': [297], 'Significantly,': [298], 'derived': [301], 'assumed': [305], 'attributes': [307], 'hepatocytes,': [310], 'because': [311], 'produce': [314], 'albumin,': [315], 'remove': [316], 'ammonia,': [317], 'uptake': [319], 'release': [321], 'indocyanine': [322], 'green.': [323], 'Moreover,': [324], 'β-CATENIN,': [327], 'HNF4A,': [328], 'FOXA1': [329], 'GATA4': [331], 'was': [332], 'upregulated': [333], 'during': [334], 'hepatocytes.': [342, 353], 'Collectively,': [343], 'directly': [347], 'This': [354], 'study': [355], 'offer': [357], 'invaluable': [359], 'curing': [365], 'disorders': [367], 'drug': [369], 'toxicology': [370], 'screening': [371], 'novel': [374], 'insights': [375], 'mechanisms': [377], 'underlying': [378], 'regeneration.': [381]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2274327856', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 3}], 'updated_date': '2025-01-09T01:59:41.505706', 'created_date': '2016-06-24'}