Publication Information

{'id': 'https://openalex.org/W2272033159', 'doi': 'https://doi.org/10.1200/jco.1986.4.7.1121', 'title': 'Lack of evidence for a role of chemotherapy in the routine management of locally advanced head and neck cancer.', 'display_name': 'Lack of evidence for a role of chemotherapy in the routine management of locally advanced head and neck cancer.', 'publication_year': 1986, 'publication_date': '1986-07-01', 'ids': {'openalex': 'https://openalex.org/W2272033159', 'doi': 'https://doi.org/10.1200/jco.1986.4.7.1121', 'mag': '2272033159', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/3522819'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1200/jco.1986.4.7.1121', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S15137598', 'display_name': 'Journal of Clinical Oncology', 'issn_l': '0732-183X', 'issn': ['0732-183X', '1527-7755'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5063846121', 'display_name': 'Ian F. Tannock', 'orcid': 'https://orcid.org/0000-0002-2636-7041'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'I F Tannock', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111837338', 'display_name': 'George P. Browman', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'G Browman', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.888, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 125, 'citation_normalized_percentile': {'value': 0.357143, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '4', 'issue': '7', 'first_page': '1121', 'last_page': '1126'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10307', 'display_name': 'Head and Neck Cancer Studies', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2733', 'display_name': 'Otorhinolaryngology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10307', 'display_name': 'Head and Neck Cancer Studies', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2733', 'display_name': 'Otorhinolaryngology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11395', 'display_name': 'Radiopharmaceutical Chemistry and Applications', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11600', 'display_name': 'Brain Metastases and Treatment', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.94983274}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.8034601}, {'id': 'https://openalex.org/C2776530083', 'wikidata': 'https://www.wikidata.org/wiki/Q1783924', 'display_name': 'Head and neck cancer', 'level': 3, 'score': 0.736168}, {'id': 'https://openalex.org/C509974204', 'wikidata': 'https://www.wikidata.org/wiki/Q180507', 'display_name': 'Radiation therapy', 'level': 2, 'score': 0.648487}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.58691967}, {'id': 'https://openalex.org/C3018411727', 'wikidata': 'https://www.wikidata.org/wiki/Q3867488', 'display_name': 'Head and neck', 'level': 2, 'score': 0.5602362}, {'id': 'https://openalex.org/C168563851', 'wikidata': 'https://www.wikidata.org/wiki/Q1436668', 'display_name': 'Randomized controlled trial', 'level': 2, 'score': 0.54520106}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.46444777}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.4563719}, {'id': 'https://openalex.org/C3019992690', 'wikidata': 'https://www.wikidata.org/wiki/Q92767510', 'display_name': 'Basal cell', 'level': 2, 'score': 0.45194533}, {'id': 'https://openalex.org/C2776833033', 'wikidata': 'https://www.wikidata.org/wiki/Q1783924', 'display_name': 'Head and neck squamous-cell carcinoma', 'level': 4, 'score': 0.45181587}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.36288524}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D006258', 'descriptor_name': 'Head and Neck Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002986', 'descriptor_name': 'Clinical Trials as Topic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003131', 'descriptor_name': 'Combined Modality Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006258', 'descriptor_name': 'Head and Neck Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011897', 'descriptor_name': 'Random Allocation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1200/jco.1986.4.7.1121', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S15137598', 'display_name': 'Journal of Clinical Oncology', 'issn_l': '0732-183X', 'issn': ['0732-183X', '1527-7755'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/3522819', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.6}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 20, 'referenced_works': ['https://openalex.org/W1807768357', 'https://openalex.org/W1969366993', 'https://openalex.org/W1981717673', 'https://openalex.org/W1983877177', 'https://openalex.org/W1996101068', 'https://openalex.org/W1999610552', 'https://openalex.org/W2008520438', 'https://openalex.org/W2043943046', 'https://openalex.org/W2055653548', 'https://openalex.org/W2070034126', 'https://openalex.org/W2073730951', 'https://openalex.org/W2082863696', 'https://openalex.org/W2089609493', 'https://openalex.org/W2096156091', 'https://openalex.org/W2124634362', 'https://openalex.org/W2138329937', 'https://openalex.org/W2146503091', 'https://openalex.org/W2180275997', 'https://openalex.org/W2412794805', 'https://openalex.org/W2418480388'], 'related_works': ['https://openalex.org/W4386267927', 'https://openalex.org/W4206801305', 'https://openalex.org/W3210497498', 'https://openalex.org/W3032375220', 'https://openalex.org/W2383628288', 'https://openalex.org/W2382476776', 'https://openalex.org/W2355955825', 'https://openalex.org/W2147863910', 'https://openalex.org/W2066639416', 'https://openalex.org/W2056534599'], 'abstract_inverted_index': {'Numerous': [0], 'single-arm': [1], 'studies': [2, 81, 106], 'have': [3], 'shown': [4], 'that': [5, 85], 'chemotherapy': [6, 56, 75, 89, 113, 131], 'may': [7], 'produce': [8], 'a': [9, 116, 120], 'high': [10, 37], 'rate': [11, 38], 'of': [12, 17, 30, 39, 67, 88, 100, 107, 112, 122, 139], 'response': [13], 'and': [14, 33, 74, 142], 'rapid': [15], 'shrinkage': [16], 'tumor': [18, 40], 'when': [19], 'used': [20], 'before': [21, 91], 'radiation': [22, 93, 125], 'and/or': [23, 126], 'surgery': [24, 95, 127], 'in': [25, 51, 82, 135], 'patients': [26, 54, 60, 68, 123], 'with': [27, 59, 119], 'squamous-cell': [28], 'carcinoma': [29], 'the': [31, 98, 136], 'head': [32, 141], 'neck.': [34], 'Despite': [35], 'this': [36], 'response,': [41], 'randomized': [42, 117], 'controlled': [43], 'trials': [44, 111], 'do': [45], 'not': [46], 'indicate': [47], 'any': [48], 'consistent': [49], 'improvement': [50], 'survival': [52], 'for': [53], 'receiving': [55, 61, 124], 'as': [57], 'compared': [58], 'local': [62, 92], 'treatment': [63], 'alone.': [64, 128], 'This': [65], 'population': [66], 'often': [69], 'has': [70, 132], 'poor': [71], 'performance': [72], 'status,': [73], 'invariable': [76], 'adds': [77], 'some': [78, 86], 'toxicity.': [79], 'Also,': [80], 'animals': [83], 'suggest': [84], 'types': [87], 'given': [90], 'or': [94], 'might': [96], 'increase': [97], 'probability': [99], 'distant': [101], 'metastases.': [102], 'Apart': [103], 'from': [104], 'pilot': [105], 'feasibility,': [108], 'all': [109], 'future': [110], 'should': [114], 'involve': [115], 'comparison': [118], 'group': [121], 'At': [129], 'present,': [130], 'no': [133], 'place': [134], 'routine': [137], 'management': [138], 'primary': [140], 'neck': [143], 'cancer.': [144]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2272033159', 'counts_by_year': [{'year': 2014, 'cited_by_count': 2}], 'updated_date': '2024-12-09T20:56:40.907265', 'created_date': '2016-06-24'}