Title: Childhood wheeze phenotypes and atopy over adolescence
Abstract: Background Atopy is linked with asthma severity and persistence in childhood, but adolescent atopic outcomes of wheeze phenotypes defined by latent class analysis (LCA) are unknown. Aim Determine adolescent atopic outcomes of LCA defined childhood wheeze phenotypes (0-7 years) Method A high-atopy risk birth cohort recorded atopic outcomes (sensitization, eczema, hay fever and expired Nitric oxide [eNO]) at 12(N=375) and/or 18 years(N=411). Regression analyses investigated associations between atopic outcomes and phenotypes of: Early Transient, Early Persistent, Intermediate Onset and Late Onset wheeze, whilst adjusting for confounders including baseline 9atopic variables9. Results Although all persistent wheezing phenotypes had increased risk of atopy, Intermediate Onset (onset at ∼ 1.5-2years) was the most atopic group, whilst Early Transient had a reduced risk. Conclusion Adolescent atopy risk differs between childhood wheeze phenotypes. Intermediate onset wheeze is the most atopic, whilst findings on Early Transient wheeze may reflect protective effects of early life microbial exposure. These differences may inform long term prognosis and provide clues concerning aetiology.
Publication Year: 2014
Publication Date: 2014-09-01
Language: en
Type: article
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