Title: An Epidemiological Study of Lip and Palate Cleft in Taiwan: Prevalence Trend and Familial Clustering
Abstract: This study was carried out to estimate the birth prevalence of lip and palate cleft in Taiwan and to explore its familial clustering. In a survey of 130,821 births during 1980 to 1982 and 87,747 births during 1990 to 1992, the birth prevalence of cleft lip with or without cleft palate (CL/P) and isolated cleft palate (CP)show no significant change during the 13 years period. The birth prevalence of CL/P and of CP was found to be 1.12 and 0.47 per 1,000, respectively. The sex ratio (male to female) varied between the different types of clefts: CL/P had a sex ratio of 1.38 and CP had a ratio of 0.66. The prevalence of birthweight under 2500G for cleft infants was 15.3% which was more than twice higher than the average prevalence of low birthweight in Taiwan. Although only 9.55% of 136 intereviewed CL/P index cases had a family history of cleft, the frequency of clefts in the relatives was in excess of that for the general population. Among the 18 affected relatives of CL/p index cases, only one was affected with isolated cleft palate and the others with CL/P.
Publication Year: 1995
Publication Date: 1995-06-01
Language: en
Type: article
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Cited By Count: 1
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