Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2259075239', 'doi': 'https://doi.org/10.18632/oncotarget.5641', 'title': 'Changes in microRNA (miRNA) expression during pancreatic cancer development and progression in a genetically engineered KrasG12D;Pdx1-Cre mouse (KC) model', 'display_name': 'Changes in microRNA (miRNA) expression during pancreatic cancer development and progression in a genetically engineered KrasG12D;Pdx1-Cre mouse (KC) model', 'publication_year': 2015, 'publication_date': '2015-10-19', 'ids': {'openalex': 'https://openalex.org/W2259075239', 'doi': 'https://doi.org/10.18632/oncotarget.5641', 'mag': '2259075239', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26516699', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4741896'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.5641', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=5641&path%5B%5D=16591', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=5641&path%5B%5D=16591', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5002662464', 'display_name': 'Satyanarayana Rachagani', 'orcid': 'https://orcid.org/0000-0003-3949-8566'}, 'institutions': [{'id': 'https://openalex.org/I59130452', 'display_name': 'University of Nebraska Medical Center', 'ror': 'https://ror.org/00thqtb16', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I59130452']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Satyanarayana Rachagani', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA', 'institution_ids': ['https://openalex.org/I59130452']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059751626', 'display_name': 'Muzafar A. Macha', 'orcid': 'https://orcid.org/0000-0003-4468-4435'}, 'institutions': [{'id': 'https://openalex.org/I59130452', 'display_name': 'University of Nebraska Medical Center', 'ror': 'https://ror.org/00thqtb16', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I59130452']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Muzafar A. Macha', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA', 'institution_ids': ['https://openalex.org/I59130452']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026003143', 'display_name': 'Melanie Menning', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I59130452', 'display_name': 'University of Nebraska Medical Center', 'ror': 'https://ror.org/00thqtb16', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I59130452']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Melanie S. Menning', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA', 'institution_ids': ['https://openalex.org/I59130452']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006114608', 'display_name': 'Parama Dey', 'orcid': 'https://orcid.org/0000-0003-3529-7062'}, 'institutions': [{'id': 'https://openalex.org/I59130452', 'display_name': 'University of Nebraska Medical Center', 'ror': 'https://ror.org/00thqtb16', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I59130452']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Parama Dey', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA', 'institution_ids': ['https://openalex.org/I59130452']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032869860', 'display_name': 'Priya Pai', 'orcid': 'https://orcid.org/0000-0002-1126-6248'}, 'institutions': [{'id': 'https://openalex.org/I59130452', 'display_name': 'University of Nebraska Medical Center', 'ror': 'https://ror.org/00thqtb16', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I59130452']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Priya Pai', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA', 'institution_ids': ['https://openalex.org/I59130452']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041701143', 'display_name': 'Lynette M. Smith', 'orcid': 'https://orcid.org/0000-0002-0836-9932'}, 'institutions': [{'id': 'https://openalex.org/I59130452', 'display_name': 'University of Nebraska Medical Center', 'ror': 'https://ror.org/00thqtb16', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I59130452']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lynette M. Smith', 'raw_affiliation_strings': ['Department of Biostatistics, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biostatistics, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA', 'institution_ids': ['https://openalex.org/I59130452']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111622113', 'display_name': 'Yin-Yuan Mo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I29606459', 'display_name': 'University of Mississippi Medical Center', 'ror': 'https://ror.org/044pcn091', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I29606459', 'https://openalex.org/I4210141039']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yin-Yuan Mo', 'raw_affiliation_strings': ['Department of Pharmacology and Toxicology, University of Mississippi Medical center, Jackson, MS, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Toxicology, University of Mississippi Medical center, Jackson, MS, USA', 'institution_ids': ['https://openalex.org/I29606459']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5085256777', 'display_name': 'Surinder K. Batra', 'orcid': 'https://orcid.org/0000-0001-9470-9317'}, 'institutions': [{'id': 'https://openalex.org/I59130452', 'display_name': 'University of Nebraska Medical Center', 'ror': 'https://ror.org/00thqtb16', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I59130452']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Surinder K. Batra', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA', 'Department of Pathology and Microbiology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA', 'Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA'], 'affiliations': [{'raw_affiliation_string': 'Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA', 'institution_ids': ['https://openalex.org/I59130452']}, {'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA', 'institution_ids': ['https://openalex.org/I59130452']}, {'raw_affiliation_string': 'Department of Pathology and Microbiology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA', 'institution_ids': ['https://openalex.org/I59130452']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.408, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 52, 'citation_normalized_percentile': {'value': 0.746877, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '6', 'issue': '37', 'first_page': '40295', 'last_page': '40309'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10062', 'display_name': 'MicroRNA in disease regulation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10062', 'display_name': 'MicroRNA in disease regulation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10515', 'display_name': 'Cancer-related molecular mechanisms research', 'score': 0.9861, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2780210213', 'wikidata': 'https://www.wikidata.org/wiki/Q212961', 'display_name': 'Pancreatic cancer', 'level': 3, 'score': 0.69313264}, {'id': 'https://openalex.org/C145059251', 'wikidata': 'https://www.wikidata.org/wiki/Q310899', 'display_name': 'microRNA', 'level': 3, 'score': 0.67299926}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.5752632}, {'id': 'https://openalex.org/C2781187634', 'wikidata': 'https://www.wikidata.org/wiki/Q20969980', 'display_name': 'KRAS', 'level': 4, 'score': 0.5645391}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.45077986}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.3795852}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.35067087}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.32368797}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2870313}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.17958719}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.17492858}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.114171326}], 'mesh': [{'descriptor_ui': 'D018398', 'descriptor_name': 'Homeodomain Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D010190', 'descriptor_name': 'Pancreatic Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D016283', 'descriptor_name': 'Proto-Oncogene Proteins p21(ras)', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018450', 'descriptor_name': 'Disease Progression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020869', 'descriptor_name': 'Gene Expression Profiling', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D020869', 'descriptor_name': 'Gene Expression Profiling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005818', 'descriptor_name': 'Genetic Engineering', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D005818', 'descriptor_name': 'Genetic Engineering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057809', 'descriptor_name': 'HEK293 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018398', 'descriptor_name': 'Homeodomain Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018398', 'descriptor_name': 'Homeodomain Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015151', 'descriptor_name': 'Immunoblotting', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020411', 'descriptor_name': 'Oligonucleotide Array Sequence Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020411', 'descriptor_name': 'Oligonucleotide Array Sequence Analysis', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D010190', 'descriptor_name': 'Pancreatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010190', 'descriptor_name': 'Pancreatic Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010190', 'descriptor_name': 'Pancreatic Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D016283', 'descriptor_name': 'Proto-Oncogene Proteins p21(ras)', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016283', 'descriptor_name': 'Proto-Oncogene Proteins p21(ras)', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.5641', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=5641&path%5B%5D=16591', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4741896', 'pdf_url': 'https://europepmc.org/articles/pmc4741896?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741896', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26516699', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.5641', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=5641&path%5B%5D=16591', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.41, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 75, 'referenced_works': ['https://openalex.org/W1648301895', 'https://openalex.org/W1916491745', 'https://openalex.org/W1920303762', 'https://openalex.org/W1969003435', 'https://openalex.org/W1972892962', 'https://openalex.org/W1973816411', 'https://openalex.org/W1976924899', 'https://openalex.org/W1979538859', 'https://openalex.org/W1992995822', 'https://openalex.org/W1994772304', 'https://openalex.org/W2000496185', 'https://openalex.org/W2008945738', 'https://openalex.org/W2009229545', 'https://openalex.org/W2012366039', 'https://openalex.org/W2014064723', 'https://openalex.org/W2015447772', 'https://openalex.org/W2020080445', 'https://openalex.org/W2035202125', 'https://openalex.org/W2035367710', 'https://openalex.org/W2035987476', 'https://openalex.org/W2037141750', 'https://openalex.org/W2040421463', 'https://openalex.org/W2040935952', 'https://openalex.org/W2044967196', 'https://openalex.org/W2050850788', 'https://openalex.org/W2051227958', 'https://openalex.org/W2053058658', 'https://openalex.org/W2056494524', 'https://openalex.org/W2060285499', 'https://openalex.org/W2062376760', 'https://openalex.org/W2066135299', 'https://openalex.org/W2066868410', 'https://openalex.org/W2071550135', 'https://openalex.org/W2076060004', 'https://openalex.org/W2079251691', 'https://openalex.org/W2083381199', 'https://openalex.org/W2084239507', 'https://openalex.org/W2084480556', 'https://openalex.org/W2085442947', 'https://openalex.org/W2099023480', 'https://openalex.org/W2101995865', 'https://openalex.org/W2104229806', 'https://openalex.org/W2107723175', 'https://openalex.org/W2112417639', 'https://openalex.org/W2113500818', 'https://openalex.org/W2121926635', 'https://openalex.org/W2123962115', 'https://openalex.org/W2124603636', 'https://openalex.org/W2126483923', 'https://openalex.org/W2126663928', 'https://openalex.org/W2128674168', 'https://openalex.org/W2130979840', 'https://openalex.org/W2136148915', 'https://openalex.org/W2138664009', 'https://openalex.org/W2142489285', 'https://openalex.org/W2144038313', 'https://openalex.org/W2152036735', 'https://openalex.org/W2152214346', 'https://openalex.org/W2155131748', 'https://openalex.org/W2158734599', 'https://openalex.org/W2159325140', 'https://openalex.org/W2160282097', 'https://openalex.org/W2161283857', 'https://openalex.org/W2161957137', 'https://openalex.org/W2162038712', 'https://openalex.org/W2162673078', 'https://openalex.org/W2162674813', 'https://openalex.org/W2165948908', 'https://openalex.org/W2167721651', 'https://openalex.org/W2170647698', 'https://openalex.org/W2171131178', 'https://openalex.org/W2171201030', 'https://openalex.org/W2171424189', 'https://openalex.org/W2412089845', 'https://openalex.org/W3145395549'], 'related_works': ['https://openalex.org/W4367603427', 'https://openalex.org/W4306404900', 'https://openalex.org/W4229832877', 'https://openalex.org/W4226309907', 'https://openalex.org/W3111812619', 'https://openalex.org/W3093086801', 'https://openalex.org/W3030972949', 'https://openalex.org/W3030550923', 'https://openalex.org/W2914997899', 'https://openalex.org/W2590035663'], 'abstract_inverted_index': {'//': [0], 'Satyanarayana': [1, 148], 'Rachagani': [2], '1': [3, 19, 23, 40], ',': [4, 10, 16, 20, 24, 29, 33], 'Muzafar': [5], 'A.': [6], 'Macha': [7], '1,': [8, 14, 37], '*': [9, 15, 137], 'Melanie': [11], 'S.': [12], 'Menning': [13], 'Parama': [17], 'Dey': [18], 'Priya': [21], 'Pai': [22], 'Lynette': [25], 'M.': [26], 'Smith': [27], '2': [28, 61], 'Yin-Yuan': [30], 'Mo': [31], '5': [32, 123], 'Surinder': [34, 152], 'K.': [35, 153], 'Batra': [36], '3,': [38], '4': [39, 99], 'Department': [41, 62, 80, 124], 'of': [42, 54, 63, 72, 81, 92, 116, 125, 130, 179, 196, 201, 206, 251, 261, 276, 304, 309, 316, 331, 348, 368, 379, 391, 404], 'Biochemistry': [43], 'and': [44, 83, 106, 127, 211, 226, 257, 259, 266, 284, 290, 327, 329, 338, 363, 372, 381, 398, 406, 411], 'Molecular': [45], 'Biology,': [46], 'Fred': [47, 65, 85, 109], '&': [48, 66, 86, 110], 'Pamela': [49, 67, 87, 111], 'Buffett': [50, 68, 88, 112], 'Cancer': [51, 69, 89, 105, 113], 'Center,': [52, 57, 70, 75, 90, 95, 114, 119], 'University': [53, 71, 91, 115, 129], 'Nebraska': [55, 73, 93, 117], 'Medical': [56, 74, 94, 118, 132], 'Omaha,': [58, 76, 96, 120], 'NE,': [59, 77, 97, 121], 'USA': [60, 78, 98, 122, 136], 'Biostatistics,': [64], '3': [79], 'Pathology': [82], 'Microbiology,': [84], 'Eppley': [100], 'Institute': [101], 'for': [102], 'Research': [103], 'in': [104, 185, 268, 294, 311, 350, 358, 370, 376], 'Allied': [107], 'Diseases,': [108], 'Pharmacology': [126], 'Toxicology,': [128], 'Mississippi': [131], 'center,': [133], 'Jackson,': [134], 'MS,': [135], 'These': [138], 'authors': [139], 'have': [140], 'contributed': [141], 'equally': [142], 'to': [143, 193, 272, 301, 341, 400], 'this': [144, 217], 'work': [145], 'Correspondence': [146], 'to:': [147], 'Rachagani,': [149], 'e-mail:': [150, 155], '[email protected]': [151], 'Batra,': [154], '[email protected]': [156], 'Keywords:': [157], 'miRNA,': [158], 'pancreatic': [159, 189], 'cancer,': [160], 'KC': [161, 269, 295, 312], 'mouse': [162, 239], 'model': [163], 'Received:': [164], 'May': [165], '11,': [166], '2015': [167, 171, 175], 'Accepted:': [168], 'October': [169, 173], '09,': [170], 'Published:': [172], '19,': [174], 'ABSTRACT': [176], 'Differential': [177], 'expression': [178, 224, 275, 307, 347, 357, 367, 393], 'microRNAs': [180], '(miRNAs)': [181], 'has': [182], 'been': [183], 'demonstrated': [184], 'various': [186], 'cancers,': [187], 'including': [188, 280], 'cancer': [190], '(PC).': [191], 'Due': [192], 'the': [194, 203, 221, 234, 244, 345, 355, 377, 385, 402], 'lack': [195], 'tissue': [197, 364], 'samples': [198], 'from': [199, 299], 'early-stages': [200], 'PC,': [202], 'stage-specific': [204, 306], 'alteration': [205], 'miRNAs': [207], 'during': [208, 230, 395], 'PC': [209, 231, 360, 396], 'initiation': [210], 'progression': [212, 232], 'is': [213], 'largely': [214], 'unknown.': [215], 'In': [216, 297], 'study,': [218], 'we': [219], 'investigated': [220], 'global': [222], 'miRNA': [223, 245, 277, 310, 349, 356, 392], 'profile': [225], 'their': [227], 'processing': [228], 'machinery': [229, 279], 'using': [233], 'Kras': [235], 'G12D': [236], ';Pdx1-Cre': [237], '(KC)': [238], 'model.': [240], 'At': [241], '25': [242], 'weeks,': [243], 'microarray': [246], 'analysis': [247], 'revealed': [248, 314], 'significant': [249], 'downregulation': [250, 315, 378], 'miR-150,': [252, 324], 'miR-494,': [253], 'miR-138,': [254], 'miR-148a,': [255], 'miR-216a,': [256], 'miR-217': [258], 'upregulation': [260, 330], 'miR-146b,': [262, 334], 'miR-205,': [263, 333], 'miR-31,': [264], 'miR-192,': [265], 'miR-21': [267], 'mice': [270, 313, 351], 'compared': [271, 340], 'controls.': [273], 'Further,': [274], 'biosynthetic': [278], 'Dicer,': [281], 'Exportin-5,': [282], 'TRKRA,': [283], 'TARBP2': [285], 'were': [286, 292], 'downregulated,': [287], 'while': [288], 'DGCR8': [289], 'Ago2': [291], 'upregulated': [293], 'mice.': [296, 343], 'addition,': [298], '10': [300], '50': [302], 'weeks': [303], 'age,': [305], 'profiling': [308], 'miR-216,': [317], 'miR-217,': [318], 'miR-100,': [319], 'miR-345,': [320], 'miR-141,': [321], 'miR-483-3p,': [322], 'miR-26b,': [323], 'miR-195,': [325], 'Let-7b': [326, 369], 'Let-96': [328], 'miR-21,': [332], 'miR-34c,': [335], 'miR-1273,': [336], 'miR-223': [337], 'miR-195': [339], 'control': [342], 'Interestingly,': [344], 'differential': [346], 'also': [352], 'corroborated': [353], 'with': [354], 'human': [359], 'cell': [361], 'lines': [362], 'samples;': [365], 'ectopic': [366], 'CD18/HPAF': [371], 'Capan1': [373], 'cells': [374], 'resulted': [375], 'KRAS': [380], 'MSST1': [382], 'expression.': [383], 'Overall,': [384], 'present': [386], 'study': [387], 'aids': [388], 'an': [389], 'understanding': [390], 'patterns': [394], 'pathogenesis': [397], 'helps': [399], 'facilitate': [401], 'identification': [403], 'promising': [405], 'novel': [407], 'early': [408], 'diagnostic/prognostic': [409], 'markers': [410], 'therapeutic': [412], 'targets.': [413]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2259075239', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 12}, {'year': 2016, 'cited_by_count': 3}], 'updated_date': '2025-01-17T11:18:48.201761', 'created_date': '2016-06-24'}