Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2257959346', 'doi': 'https://doi.org/10.18632/oncotarget.6539', 'title': 'Autophagy induction causes a synthetic lethal sensitization to ribonucleotide reductase inhibition in breast cancer cells', 'display_name': 'Autophagy induction causes a synthetic lethal sensitization to ribonucleotide reductase inhibition in breast cancer cells', 'publication_year': 2015, 'publication_date': '2015-12-09', 'ids': {'openalex': 'https://openalex.org/W2257959346', 'doi': 'https://doi.org/10.18632/oncotarget.6539', 'mag': '2257959346', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26675256', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4811511'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.6539', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6539&path%5B%5D=18126', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6539&path%5B%5D=18126', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5019213324', 'display_name': 'Yun‐Ru Chen', 'orcid': 'https://orcid.org/0000-0002-6596-6338'}, 'institutions': [{'id': 'https://openalex.org/I1301076528', 'display_name': 'City Of Hope National Medical Center', 'ror': 'https://ror.org/00w6g5w60', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1301076528']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yun-Ru Chen', 'raw_affiliation_strings': ['Department of Diabetes and Metabolic Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA', 'Department of Molecular Pharmacology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Pharmacology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA', 'institution_ids': ['https://openalex.org/I1301076528']}, {'raw_affiliation_string': 'Department of Diabetes and Metabolic Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA', 'institution_ids': ['https://openalex.org/I1301076528']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063810314', 'display_name': 'Brittany C. Tsou', 'orcid': 'https://orcid.org/0009-0006-2986-4082'}, 'institutions': [{'id': 'https://openalex.org/I1301076528', 'display_name': 'City Of Hope National Medical Center', 'ror': 'https://ror.org/00w6g5w60', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1301076528']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Brittany Tsou', 'raw_affiliation_strings': ['Department of Diabetes and Metabolic Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA', 'Department of Molecular Pharmacology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Pharmacology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA', 'institution_ids': ['https://openalex.org/I1301076528']}, {'raw_affiliation_string': 'Department of Diabetes and Metabolic Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA', 'institution_ids': ['https://openalex.org/I1301076528']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102903114', 'display_name': 'Shuya Hu', 'orcid': 'https://orcid.org/0009-0002-0939-8361'}, 'institutions': [{'id': 'https://openalex.org/I1301076528', 'display_name': 'City Of Hope National Medical Center', 'ror': 'https://ror.org/00w6g5w60', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1301076528']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shuya Hu', 'raw_affiliation_strings': ['Department of Molecular Pharmacology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Pharmacology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA', 'institution_ids': ['https://openalex.org/I1301076528']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101852181', 'display_name': 'Huimin Ma', 'orcid': 'https://orcid.org/0000-0001-9376-2095'}, 'institutions': [{'id': 'https://openalex.org/I1301076528', 'display_name': 'City Of Hope National Medical Center', 'ror': 'https://ror.org/00w6g5w60', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1301076528']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Huimin Ma', 'raw_affiliation_strings': ['Department of Diabetes and Metabolic Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA', 'Department of Molecular Pharmacology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Diabetes and Metabolic Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA', 'institution_ids': ['https://openalex.org/I1301076528']}, {'raw_affiliation_string': 'Department of Molecular Pharmacology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA', 'institution_ids': ['https://openalex.org/I1301076528']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031124433', 'display_name': 'Xiyong Liu', 'orcid': 'https://orcid.org/0000-0002-0259-3669'}, 'institutions': [{'id': 'https://openalex.org/I1301076528', 'display_name': 'City Of Hope National Medical Center', 'ror': 'https://ror.org/00w6g5w60', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1301076528']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xiyong Liu', 'raw_affiliation_strings': ['Department of Molecular Pharmacology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Pharmacology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA', 'institution_ids': ['https://openalex.org/I1301076528']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009104622', 'display_name': 'Yun Yen', 'orcid': 'https://orcid.org/0000-0003-0815-412X'}, 'institutions': [{'id': 'https://openalex.org/I1301076528', 'display_name': 'City Of Hope National Medical Center', 'ror': 'https://ror.org/00w6g5w60', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1301076528']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yun Yen', 'raw_affiliation_strings': ['Department of Molecular Pharmacology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Pharmacology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA', 'institution_ids': ['https://openalex.org/I1301076528']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5021530808', 'display_name': 'David K. Ann', 'orcid': 'https://orcid.org/0000-0001-6229-4241'}, 'institutions': [{'id': 'https://openalex.org/I1301076528', 'display_name': 'City Of Hope National Medical Center', 'ror': 'https://ror.org/00w6g5w60', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1301076528']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'David K. Ann', 'raw_affiliation_strings': ['Department of Diabetes and Metabolic Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA', 'Department of Molecular Pharmacology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Diabetes and Metabolic Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA', 'institution_ids': ['https://openalex.org/I1301076528']}, {'raw_affiliation_string': 'Department of Molecular Pharmacology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA', 'institution_ids': ['https://openalex.org/I1301076528']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5021530808'], 'corresponding_institution_ids': ['https://openalex.org/I1301076528'], 'apc_list': None, 'apc_paid': None, 'fwci': 1.132, 'has_fulltext': False, 'cited_by_count': 19, 'citation_normalized_percentile': {'value': 0.917331, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '7', 'issue': '2', 'first_page': '1984', 'last_page': '1999'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10587', 'display_name': 'Role of Autophagy in Disease and Health', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10587', 'display_name': 'Role of Autophagy in Disease and Health', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11747', 'display_name': 'Dioxygen Activation at Metalloenzyme Active Sites', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1604', 'display_name': 'Inorganic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA Methylation and Modification in Gene Expression', 'score': 0.9939, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ribonucleotide-reductase', 'display_name': 'Ribonucleotide reductase', 'score': 0.80960274}, {'id': 'https://openalex.org/keywords/autophagy', 'display_name': 'Autophagy', 'score': 0.581175}, {'id': 'https://openalex.org/keywords/mitophagy', 'display_name': 'Mitophagy', 'score': 0.517668}, {'id': 'https://openalex.org/keywords/cellular-self-digestion', 'display_name': 'Cellular Self-Digestion', 'score': 0.510241}, {'id': 'https://openalex.org/keywords/synthetic-lethality', 'display_name': 'Synthetic lethality', 'score': 0.4882541}], 'concepts': [{'id': 'https://openalex.org/C203522944', 'wikidata': 'https://www.wikidata.org/wiki/Q288322', 'display_name': 'Autophagy', 'level': 3, 'score': 0.9102281}, {'id': 'https://openalex.org/C4710235', 'wikidata': 'https://www.wikidata.org/wiki/Q420089', 'display_name': 'Ribonucleotide reductase', 'level': 4, 'score': 0.80960274}, {'id': 'https://openalex.org/C2781000418', 'wikidata': 'https://www.wikidata.org/wiki/Q18034312', 'display_name': 'ATG5', 'level': 4, 'score': 0.7126179}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5529007}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.49117014}, {'id': 'https://openalex.org/C2778502085', 'wikidata': 'https://www.wikidata.org/wiki/Q7662767', 'display_name': 'Synthetic lethality', 'level': 4, 'score': 0.4882541}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.47676045}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.42788762}, {'id': 'https://openalex.org/C2779343474', 'wikidata': 'https://www.wikidata.org/wiki/Q3109175', 'display_name': 'Context (archaeology)', 'level': 2, 'score': 0.41055825}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.4102615}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.40667766}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3765759}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.34909183}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.34321663}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.34216228}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.3026414}, {'id': 'https://openalex.org/C104292427', 'wikidata': 'https://www.wikidata.org/wiki/Q899781', 'display_name': 'Protein subunit', 'level': 3, 'score': 0.2095297}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.19144544}, {'id': 'https://openalex.org/C134935766', 'wikidata': 'https://www.wikidata.org/wiki/Q210538', 'display_name': 'DNA repair', 'level': 3, 'score': 0.16779998}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.15167516}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C151730666', 'wikidata': 'https://www.wikidata.org/wiki/Q7205', 'display_name': 'Paleontology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D012262', 'descriptor_name': 'Ribonucleoside Diphosphate Reductase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D013629', 'descriptor_name': 'Tamoxifen', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018931', 'descriptor_name': 'Antineoplastic Agents, Hormonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018931', 'descriptor_name': 'Antineoplastic Agents, Hormonal', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001549', 'descriptor_name': 'Benzamides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D001549', 'descriptor_name': 'Benzamides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002738', 'descriptor_name': 'Chloroquine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D002738', 'descriptor_name': 'Chloroquine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004357', 'descriptor_name': 'Drug Synergism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004359', 'descriptor_name': 'Drug Therapy, Combination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007124', 'descriptor_name': 'Immunoenzyme Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016688', 'descriptor_name': 'Mice, Inbred NOD', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016513', 'descriptor_name': 'Mice, SCID', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D060888', 'descriptor_name': 'Real-Time Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012262', 'descriptor_name': 'Ribonucleoside Diphosphate Reductase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012262', 'descriptor_name': 'Ribonucleoside Diphosphate Reductase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012262', 'descriptor_name': 'Ribonucleoside Diphosphate Reductase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013629', 'descriptor_name': 'Tamoxifen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013844', 'descriptor_name': 'Thiazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D013844', 'descriptor_name': 'Thiazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023041', 'descriptor_name': 'Xenograft Model Antitumor Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.6539', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6539&path%5B%5D=18126', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4811511', 'pdf_url': 'https://europepmc.org/articles/pmc4811511?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811511', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26675256', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.6539', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6539&path%5B%5D=18126', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.86, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 67, 'referenced_works': ['https://openalex.org/W1523693806', 'https://openalex.org/W1525925743', 'https://openalex.org/W1534924266', 'https://openalex.org/W1550693054', 'https://openalex.org/W156604126', 'https://openalex.org/W1868407216', 'https://openalex.org/W1961026612', 'https://openalex.org/W1972582451', 'https://openalex.org/W1976881265', 'https://openalex.org/W1989016316', 'https://openalex.org/W1994823455', 'https://openalex.org/W2002551641', 'https://openalex.org/W2008924348', 'https://openalex.org/W2016278165', 'https://openalex.org/W2018066504', 'https://openalex.org/W2018667424', 'https://openalex.org/W2022236090', 'https://openalex.org/W2023282013', 'https://openalex.org/W2025364264', 'https://openalex.org/W2027169351', 'https://openalex.org/W2027638840', 'https://openalex.org/W2037035639', 'https://openalex.org/W2041604269', 'https://openalex.org/W2043538870', 'https://openalex.org/W2044985963', 'https://openalex.org/W2049636756', 'https://openalex.org/W2051950850', 'https://openalex.org/W2055810949', 'https://openalex.org/W2065520618', 'https://openalex.org/W2066964642', 'https://openalex.org/W2071146934', 'https://openalex.org/W2075345188', 'https://openalex.org/W2077560541', 'https://openalex.org/W2079355772', 'https://openalex.org/W2080849052', 'https://openalex.org/W2084202366', 'https://openalex.org/W2084590133', 'https://openalex.org/W2089995356', 'https://openalex.org/W2093048712', 'https://openalex.org/W2100506877', 'https://openalex.org/W2103041841', 'https://openalex.org/W2105114667', 'https://openalex.org/W2107078346', 'https://openalex.org/W2109037408', 'https://openalex.org/W2110025151', 'https://openalex.org/W2114323702', 'https://openalex.org/W2121949197', 'https://openalex.org/W2126046739', 'https://openalex.org/W2132151567', 'https://openalex.org/W2142393970', 'https://openalex.org/W2142939796', 'https://openalex.org/W2143180849', 'https://openalex.org/W2147442577', 'https://openalex.org/W2149464340', 'https://openalex.org/W2150510390', 'https://openalex.org/W2151227939', 'https://openalex.org/W2156797519', 'https://openalex.org/W2163147674', 'https://openalex.org/W2164660906', 'https://openalex.org/W2166957980', 'https://openalex.org/W2168212241', 'https://openalex.org/W2168735777', 'https://openalex.org/W2181830444', 'https://openalex.org/W2321112275', 'https://openalex.org/W2346398506', 'https://openalex.org/W2746090638', 'https://openalex.org/W4256321774'], 'related_works': ['https://openalex.org/W3131581930', 'https://openalex.org/W2793620527', 'https://openalex.org/W2613152245', 'https://openalex.org/W2402111299', 'https://openalex.org/W2078444317', 'https://openalex.org/W2052473015', 'https://openalex.org/W2009177687', 'https://openalex.org/W1982407702', 'https://openalex.org/W1877748042', 'https://openalex.org/W1563936556'], 'abstract_inverted_index': {'//': [0, 70, 75], 'Yun-Ru': [1], 'Chen': [2], '1,2': [3, 7, 15, 28], ',': [4, 8, 12, 16, 20], 'Brittany': [5], 'Tsou': [6], 'Shuya': [9], 'Hu': [10], '1': [11, 19, 23, 29], 'Huimin': [13], 'Ma': [14], 'Xiyong': [17], 'Liu': [18], 'Yun': [21, 67], 'Yen': [22], 'and': [24, 50, 114, 208, 240], 'David': [25, 71], 'K.': [26, 72], 'Ann': [27], 'Department': [30, 47], 'of': [31, 38, 48, 57, 154, 159, 163, 174, 221, 228, 289], 'Molecular': [32], 'Pharmacology,': [33], 'Beckman': [34, 53], 'Research': [35, 54], 'Institute,': [36, 55], 'City': [37, 56], 'Hope': [39, 58], 'National': [40, 59], 'Medical': [41, 60], 'Center,': [42, 61], 'Duarte,': [43, 62], 'CA,': [44, 63], 'USA': [45, 64], '2': [46], 'Diabetes': [49], 'Metabolic': [51], 'Research,': [52], 'Correspondence': [65], 'to:': [66], 'Yen,': [68], 'email:': [69, 74], 'Ann,': [73], 'Keywords': [76], ':': [77, 87, 92, 97], 'autophagy,': [78], 'ribonucleotide': [79, 164], 'reductase,': [80], 'synthetic': [81], 'lethality,': [82], 'breast': [83, 138], 'cancer,': [84], 'tamoxifen': [85, 143], 'Received': [86], 'June': [88], '22,': [89], '2015': [90, 95, 100], 'Accepted': [91], 'November': [93], '21,': [94], 'Published': [96], 'December': [98], '09,': [99], 'Abstract': [101], 'Macroautophagy': [102], 'can': [103, 255], 'promote': [104], 'cellular': [105, 112, 157], 'survival': [106], 'or': [107, 226], 'death': [108], 'depending': [109], 'on': [110, 204], 'the': [111, 129, 167, 172, 222, 287], 'context': [113], 'its': [115], 'extent.': [116], 'We': [117, 264], 'hypothesized': [118], 'that': [119, 191, 248, 266], 'autophagy': [120, 147, 155, 179, 223, 231, 250, 278], 'induction': [121, 251, 279], 'would': [122], 'synergize': [123], 'with': [124, 142, 183, 252], 'a': [125, 161, 195, 282], 'therapeutic': [126], 'agent': [127], 'targeting': [128], 'autophagic': [130], 'cargo.': [131], 'To': [132], 'test': [133], 'this': [134, 267], 'hypothesis,': [135], 'we': [136], 'treated': [137], 'cancer': [139], 'MDA-MB-231': [140], 'cells': [141], '(TMX),': [144], 'which': [145], 'induces': [146], 'through': [148, 194], 'an': [149, 185, 210, 230], 'estrogen': [150], 'receptor-independent': [151], 'pathway.': [152], 'Induction': [153], 'reduced': [156], 'levels': [158], 'RRM2,': [160], 'subunit': [162], 'reductase': [165], '(RR),': [166], 'rate': [168], 'limiting': [169], 'enzyme': [170], 'in': [171, 188, 206, 209, 211, 260], 'production': [173], 'deoxyribonucleotide': [175], 'triphosphates': [176], '(dNTPs).': [177], 'This': [178, 215], 'inducer': [180], 'was': [181, 217], 'combined': [182, 234, 271], 'COH29,': [184], 'inhibitor': [186], 'developed': [187], 'our': [189], 'laboratory': [190], 'targets': [192], 'RR': [193, 253], 'novel': [196], 'mechanism.': [197], 'The': [198, 233], 'combination': [199], 'therapy': [200, 235, 272], 'showed': [201], 'synergistic': [202], 'effects': [203, 288], 'cytotoxicity': [205, 216], 'vitro': [207], 'vivo': [212], 'xenograft': [213], 'model.': [214], 'blocked': [218], 'by': [219], 'knockdown': [220], 'protein': [224], 'ATG5': [225], 'addition': [227], 'chloroquine,': [229], 'inhibitor.': [232], 'also': [236], 'induced': [237], 'dNTP': [238], 'depletion': [239], 'massive': [241], 'genomic': [242], 'instability,': [243], 'leading': [244], 'us': [245], 'to': [246, 257], 'hypothesize': [247], 'combining': [249], 'inhibition': [254], 'lead': [256], 'mitotic': [258], 'catastrophe': [259], 'rapidly': [261], 'dividing': [262], 'cells.': [263], 'propose': [265], 'TMX': [268], '+': [269], 'COH29': [270], 'may': [273, 280], 'have': [274], 'clinical': [275], 'benefit.': [276], 'Furthermore,': [277], 'be': [281], 'general': [283], 'mechanism': [284], 'for': [285], 'augmenting': [286], 'chemotherapeutic': [290], 'agents': [291]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2257959346', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-09-09T19:50:39.521495', 'created_date': '2016-06-24'}