Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2256875900', 'doi': 'https://doi.org/10.18632/oncotarget.7151', 'title': 'Reelin promotes the adhesion and drug resistance of multiple myeloma cells via integrin β1 signaling and STAT3', 'display_name': 'Reelin promotes the adhesion and drug resistance of multiple myeloma cells via integrin β1 signaling and STAT3', 'publication_year': 2016, 'publication_date': '2016-02-03', 'ids': {'openalex': 'https://openalex.org/W2256875900', 'doi': 'https://doi.org/10.18632/oncotarget.7151', 'mag': '2256875900', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26848618', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4891088'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.7151', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=7151&path%5B%5D=20367', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=7151&path%5B%5D=20367', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5069229172', 'display_name': 'Liang Lin', 'orcid': 'https://orcid.org/0000-0002-3965-4103'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Liang Lin', 'raw_affiliation_strings': ['Key Laboratory of Medical Immunology, Ministry of Health, Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Medical Immunology, Ministry of Health, Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China', 'institution_ids': ['https://openalex.org/I20231570']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048447893', 'display_name': 'Yan Fan', 'orcid': 'https://orcid.org/0000-0002-8099-3203'}, 'institutions': [{'id': 'https://openalex.org/I2802573037', 'display_name': 'Tianjin Medical University Cancer Institute and Hospital', 'ror': 'https://ror.org/0152hn881', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802573037']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Fan Yan', 'raw_affiliation_strings': ['Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China', 'institution_ids': ['https://openalex.org/I2802573037']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011480715', 'display_name': 'Dandan Zhao', 'orcid': 'https://orcid.org/0000-0001-5194-750X'}, 'institutions': [{'id': 'https://openalex.org/I4210136826', 'display_name': "Jining First People's Hospital", 'ror': 'https://ror.org/04gs6v336', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210136826']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Dandan Zhao', 'raw_affiliation_strings': ["Jining No.1 People's Hospital, Jining, Shandong 272011, China"], 'affiliations': [{'raw_affiliation_string': "Jining No.1 People's Hospital, Jining, Shandong 272011, China", 'institution_ids': ['https://openalex.org/I4210136826']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063835898', 'display_name': 'Meng Lv', 'orcid': 'https://orcid.org/0000-0001-6625-9523'}, 'institutions': [{'id': 'https://openalex.org/I4210124809', 'display_name': "Peking University People's Hospital", 'ror': 'https://ror.org/035adwg89', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210124809']}, {'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Meng Lv', 'raw_affiliation_strings': ["Peking University Institute of Hematology, People's Hospital, Beijing 100044, China"], 'affiliations': [{'raw_affiliation_string': "Peking University Institute of Hematology, People's Hospital, Beijing 100044, China", 'institution_ids': ['https://openalex.org/I4210124809', 'https://openalex.org/I20231570']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017362865', 'display_name': 'Xiaodong Liang', 'orcid': 'https://orcid.org/0000-0001-9479-0936'}, 'institutions': [{'id': 'https://openalex.org/I4210165815', 'display_name': 'Hangzhou Cancer Hospital', 'ror': 'https://ror.org/05psp9534', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210165815']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaodong Liang', 'raw_affiliation_strings': ['Hangzhou Cancer Hospital, Hang Zhou 310002, China'], 'affiliations': [{'raw_affiliation_string': 'Hangzhou Cancer Hospital, Hang Zhou 310002, China', 'institution_ids': ['https://openalex.org/I4210165815']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005993431', 'display_name': 'Hui Dai', 'orcid': 'https://orcid.org/0000-0003-3642-1758'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hui Dai', 'raw_affiliation_strings': ['Key Laboratory of Medical Immunology, Ministry of Health, Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Medical Immunology, Ministry of Health, Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China', 'institution_ids': ['https://openalex.org/I20231570']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045762317', 'display_name': 'Xiaodan Qin', 'orcid': 'https://orcid.org/0000-0002-1573-7852'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaodan Qin', 'raw_affiliation_strings': ['Key Laboratory of Medical Immunology, Ministry of Health, Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Medical Immunology, Ministry of Health, Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China', 'institution_ids': ['https://openalex.org/I20231570']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100456362', 'display_name': 'Yan Zhang', 'orcid': 'https://orcid.org/0000-0003-0472-3399'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yan Zhang', 'raw_affiliation_strings': ['Key Laboratory of Medical Immunology, Ministry of Health, Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Medical Immunology, Ministry of Health, Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China', 'institution_ids': ['https://openalex.org/I20231570']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091305811', 'display_name': 'Jie Hao', 'orcid': 'https://orcid.org/0000-0001-5781-2534'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jie Hao', 'raw_affiliation_strings': ['Key Laboratory of Medical Immunology, Ministry of Health, Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Medical Immunology, Ministry of Health, Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China', 'institution_ids': ['https://openalex.org/I20231570']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070814503', 'display_name': 'Xiuyuan Sun', 'orcid': 'https://orcid.org/0000-0002-5401-2934'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiuyuan Sun', 'raw_affiliation_strings': ['Key Laboratory of Medical Immunology, Ministry of Health, Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Medical Immunology, Ministry of Health, Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China', 'institution_ids': ['https://openalex.org/I20231570']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101198659', 'display_name': 'Yanhui Yin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yanhui Yin', 'raw_affiliation_strings': ['Key Laboratory of Medical Immunology, Ministry of Health, Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Medical Immunology, Ministry of Health, Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China', 'institution_ids': ['https://openalex.org/I20231570']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037029781', 'display_name': 'Xiao‐Jun Huang', 'orcid': 'https://orcid.org/0000-0002-2145-6643'}, 'institutions': [{'id': 'https://openalex.org/I4210124809', 'display_name': "Peking University People's Hospital", 'ror': 'https://ror.org/035adwg89', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210124809']}, {'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaojun Huang', 'raw_affiliation_strings': ["Peking University Institute of Hematology, People's Hospital, Beijing 100044, China"], 'affiliations': [{'raw_affiliation_string': "Peking University Institute of Hematology, People's Hospital, Beijing 100044, China", 'institution_ids': ['https://openalex.org/I4210124809', 'https://openalex.org/I20231570']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100433068', 'display_name': 'Jun Zhang', 'orcid': 'https://orcid.org/0000-0001-7907-7235'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jun Zhang', 'raw_affiliation_strings': ['Key Laboratory of Medical Immunology, Ministry of Health, Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Medical Immunology, Ministry of Health, Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China', 'institution_ids': ['https://openalex.org/I20231570']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013530856', 'display_name': 'Jin Lu', 'orcid': 'https://orcid.org/0000-0001-5004-2741'}, 'institutions': [{'id': 'https://openalex.org/I4210124809', 'display_name': "Peking University People's Hospital", 'ror': 'https://ror.org/035adwg89', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210124809']}, {'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jin Lu', 'raw_affiliation_strings': ["Peking University Institute of Hematology, People's Hospital, Beijing 100044, China"], 'affiliations': [{'raw_affiliation_string': "Peking University Institute of Hematology, People's Hospital, Beijing 100044, China", 'institution_ids': ['https://openalex.org/I4210124809', 'https://openalex.org/I20231570']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5081514177', 'display_name': 'Qing Ge', 'orcid': 'https://orcid.org/0000-0002-6231-4545'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qing Ge', 'raw_affiliation_strings': ['Key Laboratory of Medical Immunology, Ministry of Health, Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Medical Immunology, Ministry of Health, Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China', 'institution_ids': ['https://openalex.org/I20231570']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.601, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 41, 'citation_normalized_percentile': {'value': 0.99987, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '7', 'issue': '9', 'first_page': '9844', 'last_page': '9858'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10649', 'display_name': 'Multiple Myeloma Research and Treatments', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10649', 'display_name': 'Multiple Myeloma Research and Treatments', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10608', 'display_name': 'Neurogenesis and neuroplasticity mechanisms', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12620', 'display_name': 'Signaling Pathways in Disease', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dab1', 'display_name': 'DAB1', 'score': 0.5609224}, {'id': 'https://openalex.org/keywords/cd49c', 'display_name': 'CD49c', 'score': 0.52318126}], 'concepts': [{'id': 'https://openalex.org/C2778063154', 'wikidata': 'https://www.wikidata.org/wiki/Q13561329', 'display_name': 'Reelin', 'level': 3, 'score': 0.8656069}, {'id': 'https://openalex.org/C195687474', 'wikidata': 'https://www.wikidata.org/wiki/Q409715', 'display_name': 'Integrin', 'level': 3, 'score': 0.610974}, {'id': 'https://openalex.org/C85789140', 'wikidata': 'https://www.wikidata.org/wiki/Q187640', 'display_name': 'Cell adhesion', 'level': 3, 'score': 0.58940965}, {'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.5851838}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5741178}, {'id': 'https://openalex.org/C188209991', 'wikidata': 'https://www.wikidata.org/wiki/Q14916487', 'display_name': 'DAB1', 'level': 4, 'score': 0.5609224}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.54929096}, {'id': 'https://openalex.org/C4894155', 'wikidata': 'https://www.wikidata.org/wiki/Q4201950', 'display_name': 'CD49c', 'level': 5, 'score': 0.52318126}, {'id': 'https://openalex.org/C16224149', 'wikidata': 'https://www.wikidata.org/wiki/Q187637', 'display_name': 'Cell adhesion molecule', 'level': 2, 'score': 0.50279975}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.44399074}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.42588362}, {'id': 'https://openalex.org/C151166631', 'wikidata': 'https://www.wikidata.org/wiki/Q904514', 'display_name': 'Focal adhesion', 'level': 3, 'score': 0.4209071}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.4138313}, {'id': 'https://openalex.org/C189165786', 'wikidata': 'https://www.wikidata.org/wiki/Q193825', 'display_name': 'Extracellular matrix', 'level': 2, 'score': 0.39958328}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3115905}, {'id': 'https://openalex.org/C156585808', 'wikidata': 'https://www.wikidata.org/wiki/Q18028043', 'display_name': 'Integrin, beta 6', 'level': 4, 'score': 0.2792642}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.26812637}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.22233555}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.09264547}], 'mesh': [{'descriptor_ui': 'D002448', 'descriptor_name': 'Cell Adhesion', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D015816', 'descriptor_name': 'Cell Adhesion Molecules, Neuronal', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D016326', 'descriptor_name': 'Extracellular Matrix Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D039081', 'descriptor_name': 'Integrin alpha5beta1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019012', 'descriptor_name': 'Integrin beta1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009101', 'descriptor_name': 'Multiple Myeloma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D050796', 'descriptor_name': 'STAT3 Transcription Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012697', 'descriptor_name': 'Serine Endopeptidases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002448', 'descriptor_name': 'Cell Adhesion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015816', 'descriptor_name': 'Cell Adhesion Molecules, Neuronal', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015816', 'descriptor_name': 'Cell Adhesion Molecules, Neuronal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D018572', 'descriptor_name': 'Disease-Free Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016326', 'descriptor_name': 'Extracellular Matrix Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016326', 'descriptor_name': 'Extracellular Matrix Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005353', 'descriptor_name': 'Fibronectins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005353', 'descriptor_name': 'Fibronectins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051416', 'descriptor_name': 'Focal Adhesion Protein-Tyrosine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051416', 'descriptor_name': 'Focal Adhesion Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D039081', 'descriptor_name': 'Integrin alpha5beta1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019012', 'descriptor_name': 'Integrin beta1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009101', 'descriptor_name': 'Multiple Myeloma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009101', 'descriptor_name': 'Multiple Myeloma', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D009101', 'descriptor_name': 'Multiple Myeloma', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016392', 'descriptor_name': 'Proto-Oncogene Proteins pp60(c-src)', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016392', 'descriptor_name': 'Proto-Oncogene Proteins pp60(c-src)', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D034622', 'descriptor_name': 'RNA Interference', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000091042', 'descriptor_name': 'Reelin Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050796', 'descriptor_name': 'STAT3 Transcription Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012697', 'descriptor_name': 'Serine Endopeptidases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012697', 'descriptor_name': 'Serine Endopeptidases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072377', 'descriptor_name': 'Syk Kinase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072377', 'descriptor_name': 'Syk Kinase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.7151', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=7151&path%5B%5D=20367', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4891088', 'pdf_url': 'https://europepmc.org/articles/pmc4891088?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891088', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26848618', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.7151', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=7151&path%5B%5D=20367', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.68}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 57, 'referenced_works': ['https://openalex.org/W1528751727', 'https://openalex.org/W1576773659', 'https://openalex.org/W1723444490', 'https://openalex.org/W1965027324', 'https://openalex.org/W1965570423', 'https://openalex.org/W1972792156', 'https://openalex.org/W1974021095', 'https://openalex.org/W1976058906', 'https://openalex.org/W1978473562', 'https://openalex.org/W1979890518', 'https://openalex.org/W1982074385', 'https://openalex.org/W1982723950', 'https://openalex.org/W1983319445', 'https://openalex.org/W1984942174', 'https://openalex.org/W1984957332', 'https://openalex.org/W1988013635', 'https://openalex.org/W1990518937', 'https://openalex.org/W1996439376', 'https://openalex.org/W1996991960', 'https://openalex.org/W1998973639', 'https://openalex.org/W2000763979', 'https://openalex.org/W2006057954', 'https://openalex.org/W2008488333', 'https://openalex.org/W2013953466', 'https://openalex.org/W2020724339', 'https://openalex.org/W2026459869', 'https://openalex.org/W2033588424', 'https://openalex.org/W2033822739', 'https://openalex.org/W2035745525', 'https://openalex.org/W2036695123', 'https://openalex.org/W2041262306', 'https://openalex.org/W2051185006', 'https://openalex.org/W2055181935', 'https://openalex.org/W2061928170', 'https://openalex.org/W2062087581', 'https://openalex.org/W2063453209', 'https://openalex.org/W2079396188', 'https://openalex.org/W2082726173', 'https://openalex.org/W2089678016', 'https://openalex.org/W2093781535', 'https://openalex.org/W2102153675', 'https://openalex.org/W2109110124', 'https://openalex.org/W2125656101', 'https://openalex.org/W2126369996', 'https://openalex.org/W2133699333', 'https://openalex.org/W2135326238', 'https://openalex.org/W2137900113', 'https://openalex.org/W2138853586', 'https://openalex.org/W2139111580', 'https://openalex.org/W2139474686', 'https://openalex.org/W2139816400', 'https://openalex.org/W2146052797', 'https://openalex.org/W2155580583', 'https://openalex.org/W2165057694', 'https://openalex.org/W2303045765', 'https://openalex.org/W2320983896', 'https://openalex.org/W2332701617'], 'related_works': ['https://openalex.org/W3024820866', 'https://openalex.org/W2526341203', 'https://openalex.org/W2415568733', 'https://openalex.org/W2139474686', 'https://openalex.org/W2096205541', 'https://openalex.org/W2026459869', 'https://openalex.org/W2016327001', 'https://openalex.org/W1987474474', 'https://openalex.org/W1983319445', 'https://openalex.org/W1971133546'], 'abstract_inverted_index': {'//': [0], 'Liang': [1, 21], 'Lin': [2], '1,': [3], '*': [4, 9, 14, 130], ',': [5, 10, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59], 'Fan': [6], 'Yan': [7, 32], '3,': [8], 'Dandan': [11], 'Zhao': [12], '4,': [13], 'Meng': [16], 'Lv': [17], '2': [18, 50, 58, 88], 'Xiaodong': [20], '5': [22, 122], 'Hui': [24], 'Dai': [25], '1': [26, 30, 34, 38, 42, 46, 54, 62, 63], 'Xiaodan': [28], 'Qin': [29], 'Zhang': [33, 53], 'Jie': [36], 'Hao': [37], 'Xiuyuan': [40], 'Sun': [41], 'Yanhui': [44], 'Yin': [45], 'Xiaojun': [48], 'Huang': [49], 'Jun': [52, 149], 'Jin': [56, 145], 'Lu': [57], 'Qing': [60, 141], 'Ge': [61], 'Key': [64], 'Laboratory': [65], 'of': [66, 70, 73, 76, 92, 101, 190, 213, 216, 224, 232, 248, 255, 261, 270, 298, 311], 'Medical': [67, 78, 104], 'Immunology,': [68, 74, 102], 'Ministry': [69], 'Health,': [71], 'Department': [72, 100], 'School': [75], 'Basic': [77], 'Sciences,': [79], 'Peking': [80, 89], 'University': [81, 90, 105], 'Health': [82], 'Science': [83], 'Center,': [84], 'Beijing': [85, 96], '100191,': [86], 'China': [87, 98, 112, 121, 129], 'Institute': [91, 107], 'Hematology,': [93], "People's": [94, 116], 'Hospital,': [95, 109, 117, 125], '100044,': [97], '3': [99], 'Tianjin': [103, 110], 'Cancer': [106, 124], 'and': [108, 186, 197, 203, 210, 240, 272, 282, 300, 306], '300060,': [111], '4': [113], 'Jining': [114], 'No.1': [115], 'Jining,': [118], 'Shandong': [119], '272011,': [120], 'Hangzhou': [123], 'Hang': [126], 'Zhou': [127], '310002,': [128], 'These': [131, 289], 'authors': [132], 'have': [133], 'contributed': [134], 'equally': [135], 'to': [136, 220, 251, 267], 'this': [137], 'work': [138], 'Correspondence': [139], 'to:': [140], 'Ge,': [142], 'e-mail:': [143, 147, 151], '[email protected]': [144], 'Lu,': [146], '[email protected]': [148], 'Zhang,': [150], '[email protected]': [152], 'Keywords:': [153], 'multiple': [154, 193, 304], 'myeloma,': [155], 'reelin,': [156], 'adhesion,': [157], 'integrin,': [158], 'STAT3': [159], 'Received:': [160], 'September': [161], '02,': [162], '2015': [163], 'Accepted:': [164], 'January': [165], '23,': [166], '2016': [167, 171], 'Published:': [168], 'February': [169], '03,': [170], 'ABSTRACT': [172], 'Reelin': [173], 'is': [174, 181], 'an': [175], 'extracellular': [176], 'matrix': [177], '(ECM)': [178], 'protein': [179, 215], 'that': [180], 'essential': [182], 'for': [183], 'neuron': [184], 'migration': [185], 'positioning.': [187], 'The': [188, 258], 'expression': [189, 231], 'reelin': [191, 217, 225, 233, 244], 'in': [192, 226, 278, 295, 303], 'myeloma': [194, 305], '(MM)': [195], 'cells': [196, 250, 284], 'its': [198], 'association': [199], 'with': [200, 237], 'cell': [201, 280, 287], 'adhesion': [202, 247, 281], 'survival': [204, 239], 'were': [205, 218], 'investigated.': [206], 'Overexpression,': [207], 'siRNA': [208], 'knockdown,': [209], 'the': [211, 222, 246, 268, 296, 308], 'addition': [212], 'recombinant': [214], 'used': [219], 'examine': [221], 'function': [223], 'MM': [227, 249], 'cells.': [228], 'Clinically,': [229], 'high': [230], 'was': [234], 'negatively': [235], 'associated': [236], 'progression-free': [238], 'overall': [241], 'survival.': [242], 'Functionally,': [243], 'promoted': [245], 'fibronectin': [252], 'via': [253], 'activation': [254, 269, 297], 'α5β1': [256], 'integrin.': [257], 'resulting': [259], 'phosphorylation': [260], 'Focal': [262], 'Adhesion': [263], 'Kinase': [264], '(FAK)': [265], 'led': [266], 'Src/Syk/STAT3': [271], 'Akt,': [273], 'crucial': [274], 'signaling': [275], 'molecules': [276], 'involved': [277], 'enhancing': [279], 'protecting': [283], 'from': [285], 'drug-induced': [286], 'apoptosis.': [288], 'findings': [290], 'indicate': [291], "reelin's": [292], 'important': [293], 'role': [294], 'integrin-β1': [299], 'STAT3/Akt': [301], 'pathways': [302], 'highlight': [307], 'therapeutic': [309], 'potential': [310], 'targeting': [312], 'reelin/integrin/FAK': [313], 'axis.': [314]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2256875900', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 13}, {'year': 2016, 'cited_by_count': 4}], 'updated_date': '2024-12-17T03:35:25.462939', 'created_date': '2016-06-24'}