Publication Information

{'id': 'https://openalex.org/W2255276839', 'doi': 'https://doi.org/10.18632/oncotarget.6933', 'title': 'High efficacy of intravesical treatment of metformin on bladder cancer in preclinical model', 'display_name': 'High efficacy of intravesical treatment of metformin on bladder cancer in preclinical model', 'publication_year': 2016, 'publication_date': '2016-01-18', 'ids': {'openalex': 'https://openalex.org/W2255276839', 'doi': 'https://doi.org/10.18632/oncotarget.6933', 'mag': '2255276839', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26802022', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4891029'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.6933', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=6933&path%5B%5D=19622', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=6933&path%5B%5D=19622', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5025994163', 'display_name': 'Mei Peng', 'orcid': 'https://orcid.org/0009-0002-7683-1268'}, 'institutions': [{'id': 'https://openalex.org/I173759888', 'display_name': 'Hunan Normal University', 'ror': 'https://ror.org/053w1zy07', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I173759888']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Mei Peng', 'raw_affiliation_strings': ['Department of Pharmacy, School of Medicine, Hunan Normal University, Changsha, Hunan, P.R. China 410013'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacy, School of Medicine, Hunan Normal University, Changsha, Hunan, P.R. China 410013', 'institution_ids': ['https://openalex.org/I173759888']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022534885', 'display_name': 'Qiongli Su', 'orcid': 'https://orcid.org/0000-0003-1602-0092'}, 'institutions': [{'id': 'https://openalex.org/I173759888', 'display_name': 'Hunan Normal University', 'ror': 'https://ror.org/053w1zy07', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I173759888']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qiongli Su', 'raw_affiliation_strings': ['Department of Pharmacy, School of Medicine, Hunan Normal University, Changsha, Hunan, P.R. China 410013'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacy, School of Medicine, Hunan Normal University, Changsha, Hunan, P.R. China 410013', 'institution_ids': ['https://openalex.org/I173759888']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103606745', 'display_name': 'Qing Zeng', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I139660479', 'display_name': 'Central South University', 'ror': 'https://ror.org/00f1zfq44', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I139660479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qing Zeng', 'raw_affiliation_strings': ['Department of Urology Surgery, Third Affiliated Hospital, Central South University, Changsha, Hunan, P.R. China 410023'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology Surgery, Third Affiliated Hospital, Central South University, Changsha, Hunan, P.R. China 410023', 'institution_ids': ['https://openalex.org/I139660479']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100450299', 'display_name': 'Le Li', 'orcid': 'https://orcid.org/0000-0002-9340-9061'}, 'institutions': [{'id': 'https://openalex.org/I139660479', 'display_name': 'Central South University', 'ror': 'https://ror.org/00f1zfq44', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I139660479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Le Li', 'raw_affiliation_strings': ['Third Affiliated Hospital and the Institute of Vascular Disease and Translational Medicine, Central South University, Changsha, Hunan, P.R. China 410023'], 'affiliations': [{'raw_affiliation_string': 'Third Affiliated Hospital and the Institute of Vascular Disease and Translational Medicine, Central South University, Changsha, Hunan, P.R. China 410023', 'institution_ids': ['https://openalex.org/I139660479']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100394554', 'display_name': 'Zhihong Liu', 'orcid': 'https://orcid.org/0000-0001-6093-0726'}, 'institutions': [{'id': 'https://openalex.org/I4210115624', 'display_name': 'Hunan Cancer Hospital', 'ror': 'https://ror.org/025020z88', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115624']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhihong Liu', 'raw_affiliation_strings': ['Department of Pathology, Hunan Provincial Cancer Hospital, Changsha, Hunan, P.R. China 410023'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, Hunan Provincial Cancer Hospital, Changsha, Hunan, P.R. China 410023', 'institution_ids': ['https://openalex.org/I4210115624']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113840914', 'display_name': 'Lei Xue', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210115624', 'display_name': 'Hunan Cancer Hospital', 'ror': 'https://ror.org/025020z88', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115624']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lei Xue', 'raw_affiliation_strings': ['Department of Pathology, Hunan Provincial Cancer Hospital, Changsha, Hunan, P.R. China 410023'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, Hunan Provincial Cancer Hospital, Changsha, Hunan, P.R. China 410023', 'institution_ids': ['https://openalex.org/I4210115624']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100613015', 'display_name': 'Yan Cheng', 'orcid': 'https://orcid.org/0000-0002-7905-0443'}, 'institutions': [{'id': 'https://openalex.org/I139660479', 'display_name': 'Central South University', 'ror': 'https://ror.org/00f1zfq44', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I139660479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yan Cheng', 'raw_affiliation_strings': ['School of Pharmacy, Central South University, Changsha, Hunan, P.R. China 410023'], 'affiliations': [{'raw_affiliation_string': 'School of Pharmacy, Central South University, Changsha, Hunan, P.R. China 410023', 'institution_ids': ['https://openalex.org/I139660479']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014553834', 'display_name': 'Yanjun Huang', 'orcid': 'https://orcid.org/0000-0001-5270-0867'}, 'institutions': [{'id': 'https://openalex.org/I173759888', 'display_name': 'Hunan Normal University', 'ror': 'https://ror.org/053w1zy07', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I173759888']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yanjun Huang', 'raw_affiliation_strings': ['Department of Pharmacy, School of Medicine, Hunan Normal University, Changsha, Hunan, P.R. China 410013'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacy, School of Medicine, Hunan Normal University, Changsha, Hunan, P.R. China 410013', 'institution_ids': ['https://openalex.org/I173759888']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101738185', 'display_name': 'Ting Tao', 'orcid': 'https://orcid.org/0000-0002-6252-4139'}, 'institutions': [{'id': 'https://openalex.org/I173759888', 'display_name': 'Hunan Normal University', 'ror': 'https://ror.org/053w1zy07', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I173759888']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ting Tao', 'raw_affiliation_strings': ['Department of Pharmacy, School of Medicine, Hunan Normal University, Changsha, Hunan, P.R. China 410013'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacy, School of Medicine, Hunan Normal University, Changsha, Hunan, P.R. China 410013', 'institution_ids': ['https://openalex.org/I173759888']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023110622', 'display_name': 'Hongwei Lv', 'orcid': 'https://orcid.org/0000-0002-8971-8590'}, 'institutions': [{'id': 'https://openalex.org/I139660479', 'display_name': 'Central South University', 'ror': 'https://ror.org/00f1zfq44', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I139660479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hongwei Lv', 'raw_affiliation_strings': ['Third Affiliated Hospital and the Institute of Vascular Disease and Translational Medicine, Central South University, Changsha, Hunan, P.R. China 410023'], 'affiliations': [{'raw_affiliation_string': 'Third Affiliated Hospital and the Institute of Vascular Disease and Translational Medicine, Central South University, Changsha, Hunan, P.R. China 410023', 'institution_ids': ['https://openalex.org/I139660479']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100338528', 'display_name': 'Xiaohui Li', 'orcid': 'https://orcid.org/0000-0002-0624-8811'}, 'institutions': [{'id': 'https://openalex.org/I139660479', 'display_name': 'Central South University', 'ror': 'https://ror.org/00f1zfq44', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I139660479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaohui Li', 'raw_affiliation_strings': ['School of Pharmacy, Central South University, Changsha, Hunan, P.R. China 410023'], 'affiliations': [{'raw_affiliation_string': 'School of Pharmacy, Central South University, Changsha, Hunan, P.R. China 410023', 'institution_ids': ['https://openalex.org/I139660479']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030104397', 'display_name': 'Xiaojun Tao', 'orcid': 'https://orcid.org/0000-0002-3451-9850'}, 'institutions': [{'id': 'https://openalex.org/I173759888', 'display_name': 'Hunan Normal University', 'ror': 'https://ror.org/053w1zy07', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I173759888']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaojun Tao', 'raw_affiliation_strings': ['Department of Pharmacy, School of Medicine, Hunan Normal University, Changsha, Hunan, P.R. China 410013'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacy, School of Medicine, Hunan Normal University, Changsha, Hunan, P.R. China 410013', 'institution_ids': ['https://openalex.org/I173759888']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085581217', 'display_name': 'Peng Guo', 'orcid': 'https://orcid.org/0000-0002-4575-8443'}, 'institutions': [{'id': 'https://openalex.org/I87445476', 'display_name': "Xi'an Jiaotong University", 'ror': 'https://ror.org/017zhmm22', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I87445476']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Peng Guo', 'raw_affiliation_strings': ["Institute of Urology, Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China 710061"], 'affiliations': [{'raw_affiliation_string': "Institute of Urology, Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China 710061", 'institution_ids': ['https://openalex.org/I87445476']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000755272', 'display_name': 'Alex F. Chen', 'orcid': 'https://orcid.org/0000-0002-9792-0916'}, 'institutions': [{'id': 'https://openalex.org/I139660479', 'display_name': 'Central South University', 'ror': 'https://ror.org/00f1zfq44', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I139660479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Alex F. Chen', 'raw_affiliation_strings': ['School of Pharmacy, Central South University, Changsha, Hunan, P.R. China 410023', 'Third Affiliated Hospital and the Institute of Vascular Disease and Translational Medicine, Central South University, Changsha, Hunan, P.R. China 410023'], 'affiliations': [{'raw_affiliation_string': 'Third Affiliated Hospital and the Institute of Vascular Disease and Translational Medicine, Central South University, Changsha, Hunan, P.R. China 410023', 'institution_ids': ['https://openalex.org/I139660479']}, {'raw_affiliation_string': 'School of Pharmacy, Central South University, Changsha, Hunan, P.R. China 410023', 'institution_ids': ['https://openalex.org/I139660479']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5058860533', 'display_name': 'Xiaoping Yang', 'orcid': 'https://orcid.org/0000-0003-1952-7227'}, 'institutions': [{'id': 'https://openalex.org/I173759888', 'display_name': 'Hunan Normal University', 'ror': 'https://ror.org/053w1zy07', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I173759888']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaoping Yang', 'raw_affiliation_strings': ['Department of Pharmacy, School of Medicine, Hunan Normal University, Changsha, Hunan, P.R. China 410013'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacy, School of Medicine, Hunan Normal University, Changsha, Hunan, P.R. China 410013', 'institution_ids': ['https://openalex.org/I173759888']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 6.467, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 27, 'citation_normalized_percentile': {'value': 0.857776, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '7', 'issue': '8', 'first_page': '9102', 'last_page': '9117'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10458', 'display_name': 'Bladder and Urothelial Cancer Treatments', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10458', 'display_name': 'Bladder and Urothelial Cancer Treatments', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11339', 'display_name': 'Metabolism, Diabetes, and Cancer', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11411', 'display_name': 'Tea Polyphenols and Effects', 'score': 0.9857, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.7836845}, {'id': 'https://openalex.org/C2780352672', 'wikidata': 'https://www.wikidata.org/wiki/Q504775', 'display_name': 'Bladder cancer', 'level': 3, 'score': 0.6282787}, {'id': 'https://openalex.org/C104863432', 'wikidata': 'https://www.wikidata.org/wiki/Q614304', 'display_name': 'Pharmacy', 'level': 2, 'score': 0.59568274}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.42570361}, {'id': 'https://openalex.org/C2780323712', 'wikidata': 'https://www.wikidata.org/wiki/Q19484', 'display_name': 'Metformin', 'level': 3, 'score': 0.42142603}, {'id': 'https://openalex.org/C191935318', 'wikidata': 'https://www.wikidata.org/wiki/Q148', 'display_name': 'China', 'level': 2, 'score': 0.4156114}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.37038082}, {'id': 'https://openalex.org/C29456083', 'wikidata': 'https://www.wikidata.org/wiki/Q1221899', 'display_name': 'Gynecology', 'level': 1, 'score': 0.35710257}, {'id': 'https://openalex.org/C556039675', 'wikidata': 'https://www.wikidata.org/wiki/Q771035', 'display_name': 'Traditional medicine', 'level': 1, 'score': 0.34689167}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.3235665}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.3215732}, {'id': 'https://openalex.org/C512399662', 'wikidata': 'https://www.wikidata.org/wiki/Q3505712', 'display_name': 'Family medicine', 'level': 1, 'score': 0.19891867}, {'id': 'https://openalex.org/C17744445', 'wikidata': 'https://www.wikidata.org/wiki/Q36442', 'display_name': 'Political science', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C2779306644', 'wikidata': 'https://www.wikidata.org/wiki/Q2002370', 'display_name': 'Insulin', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C199539241', 'wikidata': 'https://www.wikidata.org/wiki/Q7748', 'display_name': 'Law', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D055372', 'descriptor_name': 'AMP-Activated Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D007004', 'descriptor_name': 'Hypoglycemic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D008687', 'descriptor_name': 'Metformin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D001749', 'descriptor_name': 'Urinary Bladder Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D055372', 'descriptor_name': 'AMP-Activated Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000283', 'descriptor_name': 'Administration, Intravesical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004353', 'descriptor_name': 'Drug Evaluation, Preclinical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D048049', 'descriptor_name': 'Extracellular Signal-Regulated MAP Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048049', 'descriptor_name': 'Extracellular Signal-Regulated MAP Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D048049', 'descriptor_name': 'Extracellular Signal-Regulated MAP Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007004', 'descriptor_name': 'Hypoglycemic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053208', 'descriptor_name': 'Kaplan-Meier Estimate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019344', 'descriptor_name': 'Lactic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019344', 'descriptor_name': 'Lactic Acid', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D008687', 'descriptor_name': 'Metformin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008687', 'descriptor_name': 'Metformin', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D038762', 'descriptor_name': 'Ribosomal Protein S6 Kinases, 70-kDa', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D038762', 'descriptor_name': 'Ribosomal Protein S6 Kinases, 70-kDa', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001743', 'descriptor_name': 'Urinary Bladder', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D001743', 'descriptor_name': 'Urinary Bladder', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001749', 'descriptor_name': 'Urinary Bladder Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.6933', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=6933&path%5B%5D=19622', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4891029', 'pdf_url': 'https://europepmc.org/articles/pmc4891029?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891029', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26802022', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.6933', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=6933&path%5B%5D=19622', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.68}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 37, 'referenced_works': ['https://openalex.org/W1496178984', 'https://openalex.org/W1524063860', 'https://openalex.org/W1527555853', 'https://openalex.org/W1601876536', 'https://openalex.org/W1698712530', 'https://openalex.org/W1702196320', 'https://openalex.org/W1703681292', 'https://openalex.org/W1827857701', 'https://openalex.org/W1863201015', 'https://openalex.org/W1970955677', 'https://openalex.org/W1976655891', 'https://openalex.org/W1990467165', 'https://openalex.org/W2000779844', 'https://openalex.org/W2003968071', 'https://openalex.org/W2004023311', 'https://openalex.org/W2011735982', 'https://openalex.org/W2018639648', 'https://openalex.org/W2019683289', 'https://openalex.org/W2020474316', 'https://openalex.org/W2026967508', 'https://openalex.org/W2035297454', 'https://openalex.org/W2049833612', 'https://openalex.org/W2068523052', 'https://openalex.org/W2098167876', 'https://openalex.org/W2100349150', 'https://openalex.org/W2117692326', 'https://openalex.org/W2124573253', 'https://openalex.org/W2124745809', 'https://openalex.org/W2125292576', 'https://openalex.org/W2138791124', 'https://openalex.org/W2139919426', 'https://openalex.org/W2147203697', 'https://openalex.org/W2152407075', 'https://openalex.org/W2155839160', 'https://openalex.org/W2167195670', 'https://openalex.org/W2170398372', 'https://openalex.org/W2170552969'], 'related_works': ['https://openalex.org/W3030889368', 'https://openalex.org/W2996523451', 'https://openalex.org/W2472267654', 'https://openalex.org/W2464808367', 'https://openalex.org/W2280013044', 'https://openalex.org/W2072752555', 'https://openalex.org/W2069421413', 'https://openalex.org/W2033313326', 'https://openalex.org/W2005208424', 'https://openalex.org/W2005084305'], 'abstract_inverted_index': {'//': [0], 'Mei': [1], 'Peng': [2, 49], '1': [3, 7, 31, 35, 47, 61, 62], ',': [4, 8, 12, 16, 20, 24, 28, 32, 36, 40, 44, 48, 52, 58], 'Qiongli': [5], 'Su': [6], 'Qing': [9], 'Zeng': [10], '2': [11, 77], 'Le': [13], 'Li': [14, 42], '3': [15, 39, 93], 'Zhihong': [17], 'Liu': [18], '4': [19, 23, 114], 'Lei': [21], 'Xue': [22], 'Yan': [25], 'Cheng': [26], '5': [27, 43, 57, 127], 'Yanjun': [29], 'Huang': [30], 'Ting': [33], 'Tao': [34, 46], 'Hongwei': [37], 'Lv': [38], 'Xiaohui': [41], 'Xiaojun': [45], 'Guo': [50], '6': [51, 139], 'Alex': [53], 'F.': [54], 'Chen': [55], '3,': [56], 'Xiaoping': [59, 153], 'Yang': [60], 'Department': [63, 78, 115], 'of': [64, 67, 79, 100, 116, 129, 141, 181, 220, 224, 285, 298, 315, 321, 336, 355, 362, 371, 405], 'Pharmacy,': [65, 130], 'School': [66, 128], 'Medicine,': [68, 105], 'Hunan': [69, 118], 'Normal': [70], 'University,': [71, 87, 108, 133, 145], 'Changsha,': [72, 88, 109, 122, 134], 'Hunan,': [73, 89, 110, 123, 135], 'P.R.': [74, 90, 111, 124, 136, 148], 'China': [75, 91, 112, 125, 137, 149], '410013': [76], 'Urology': [80], 'Surgery,': [81], 'Third': [82, 94], 'Affiliated': [83, 95], 'Hospital,': [84, 121], 'Central': [85, 106, 131], 'South': [86, 107, 132], '410023': [92, 113, 126, 138], 'Hospital': [96], 'and': [97, 103, 233, 249, 257, 264, 283, 287, 295, 312, 317, 338, 345, 396], 'the': [98, 218, 334, 356, 381, 401], 'Institute': [99, 140], 'Vascular': [101], 'Disease': [102], 'Translational': [104], 'Pathology,': [117], 'Provincial': [119], 'Cancer': [120], 'Urology,': [142], "Xi'an": [143], 'Jiaotong': [144], "Xi'an,": [146], 'Shaanxi,': [147], '710061': [150], 'Correspondence': [151], 'to:': [152], 'Yang,': [154], 'e-mail:': [155], '[email protected]': [156], 'Keywords:': [157], 'metformin,': [158], 'bladder': [159, 236, 288, 392], 'cancer,': [160], 'localized': [161], 'administration,': [162], 'AMPK,': [163], 'preclinical': [164, 229, 398], 'model': [165], 'Received:': [166], 'August': [167], '19,': [168], '2015': [169], 'Accepted:': [170], 'January': [171, 175], '02,': [172], '2016': [173, 177], 'Published:': [174], '18,': [176], 'ABSTRACT': [178], 'Anticancer': [179], 'potential': [180], 'metformin': [182, 225, 296, 309, 322, 343, 387, 406], 'has': [183], 'been': [184], 'extensively': [185], 'studied.': [186], 'However,': [187], 'its': [188], 'anticancer': [189], 'clinical': [190], 'use': [191], 'remains': [192], 'yet': [193], 'to': [194, 216], 'be': [195, 205], 'approved': [196], 'since': [197], 'sufficient': [198], 'concentration': [199], 'on': [200, 226, 391], 'target': [201], 'organs': [202], 'could': [203], 'not': [204], 'achieved': [206], 'via': [207, 410], 'conventional': [208], 'administration.': [209], 'To': [210], 'overcome': [211], 'this': [212, 397], 'drawback,': [213], 'we': [214], 'aim': [215], 'examine': [217], 'efficiency': [219], 'novel': [221], 'intravesical': [222, 386, 411], 'treatment': [223, 367], 'syngeneic': [227], 'orthotopic': [228], 'model.': [230], 'Three': [231], 'human': [232], 'one': [234], 'murine': [235], 'cancer': [237, 331, 393], 'cell': [238], 'lines': [239], 'were': [240, 300], 'tested': [241], 'in': [242, 394], 'vitro': [243, 395], 'for': [244], 'inhibitory': [245], 'sensitivity': [246], 'by': [247, 261, 267, 279, 302], 'MTT': [248], 'cologenic': [250], 'assays.': [251], 'AMPK': [252, 311], 'pathway': [253], 'including': [254], 'AKT,': [255], 'Erk': [256, 327], 'S6K': [258], 'was': [259, 277], 'examined': [260], 'western': [262], 'blot': [263], 'further': [265], 'explored': [266], 'regulating': [268], 'activated': [269, 310], 'levels': [270, 297], 'using': [271], 'specific': [272], 'inhibitors.': [273], 'In': [274, 364], 'vivo': [275], 'efficacy': [276, 375], 'determined': [278], 'Kaplan-Meier': [280], 'survival': [281], 'curves': [282], 'measurements': [284], 'body': [286], 'weights': [289], 'plus': [290], 'tumor': [291, 358], 'biomarkers.': [292], 'Lactic': [293], 'acid': [294], 'plasma': [299], 'measured': [301], 'standard': [303], 'procedures.': [304], 'The': [305], 'results': [306], 'demonstrated': [307, 351], 'that': [308], 'decreased': [313], 'phosphorylation': [314], 'Akt': [316, 325], 'Erk.': [318], 'Furthermore,': [319], 'combinations': [320], 'with': [323, 407], 'either': [324], 'or': [326], 'inhibitors': [328], 'synergistically': [329], 'diminished': [330], 'proliferation,': [332], 'suggesting': [333], 'involvement': [335], 'Akt-': [337], 'Erk-': [339], 'related': [340], 'pathways.': [341], 'Intravesical': [342], '26': [344], '104': [346], 'mg/kg,': [347], 'twice': [348], 'per': [349], 'week': [350], 'a': [352, 369], 'rapid': [353], 'elimination': [354], 'implanted': [357], 'without': [359], 'any': [360], 'evidence': [361], 'toxicity.': [363], 'contrast,': [365], 'oral': [366], 'at': [368], 'dose': [370], '800mg/kg/d': [372], 'exhibited': [373], 'little': [374], 'whereas': [376], 'severe': [377], 'toxicity': [378], 'existed': [379], 'if': [380], 'dosage': [382], 'is': [383], 'higher.': [384], 'Collectively,': [385], 'displays': [388], 'potent': [389], 'inhibition': [390], 'study': [399], 'reveals': [400], 'profound': [402], 'therapeutic': [403], 'application': [404], 'durable': [408], 'tolerance': [409], 'administration': [412], 'route.': [413]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2255276839', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 6}], 'updated_date': '2024-12-24T07:01:39.016040', 'created_date': '2016-06-24'}